GREMLIN Database
HIS6 - Imidazole glycerol phosphate synthase subunit HisF
UniProt: Q9HR52 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 273 (235)
Sequences: 6021 (3120)
Seq/√Len: 203.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_I122_G3.2991.00
163_H167_E2.6001.00
120_D183_R2.5161.00
115_D121_R2.4511.00
181_Q216_T2.4411.00
135_V177_V2.3941.00
91_D94_D2.3421.00
133_I180_A2.3301.00
179_E183_R2.3101.00
43_K78_E2.2971.00
24_Y198_T2.2901.00
159_E168_G2.2621.00
43_K47_E2.2091.00
253_S256_E2.1421.00
96_R100_R2.1231.00
114_A163_H2.0871.00
159_E172_D2.0601.00
228_G231_A2.0361.00
44_R48_A1.9871.00
199_Q251_E1.9711.00
228_G232_D1.9641.00
89_I98_T1.9111.00
122_G131_I1.9071.00
22_A34_Y1.8701.00
159_E170_G1.8521.00
95_I131_I1.8491.00
46_N80_F1.8311.00
62_A166_R1.8291.00
208_A212_D1.7881.00
69_L97_E1.7551.00
172_D175_E1.7531.00
190_V206_L1.7511.00
96_R125_A1.7371.00
113_I162_V1.7071.00
37_D40_E1.6751.00
181_Q215_S1.6751.00
53_F81_I1.6341.00
231_A260_T1.6261.00
92_T122_G1.6231.00
204_V232_D1.5861.00
48_A255_A1.5701.00
227_P252_Y1.5471.00
171_M179_E1.5341.00
224_C233_A1.5271.00
243_A247_F1.5201.00
37_D74_A1.5161.00
68_M71_T1.5101.00
17_D59_T1.5041.00
105_K132_V1.4931.00
226_A229_D1.4871.00
243_A246_I1.4851.00
134_S189_F1.4721.00
70_D73_S1.4691.00
246_I252_Y1.4631.00
178_Q213_A1.4591.00
179_E182_R1.4371.00
108_I111_G1.4351.00
231_A235_D1.4281.00
117_S121_R1.4111.00
28_N62_A1.4001.00
76_A83_L1.3841.00
111_G118_L1.3821.00
8_I52_E1.3581.00
99_L130_C1.3531.00
74_A77_D1.3471.00
14_D17_D1.3451.00
9_P50_A1.3361.00
93_D96_R1.3361.00
212_D237_G1.3281.00
92_T121_R1.3251.00
211_C218_V1.3241.00
227_P260_T1.3191.00
92_T125_A1.3161.00
252_Y257_T1.3151.00
229_D232_D1.3111.00
27_V30_E1.2961.00
161_T168_G1.2911.00
52_E105_K1.2831.00
230_M246_I1.2821.00
55_F75_V1.2811.00
192_S203_D1.2681.00
117_S120_D1.2581.00
35_T41_M1.2541.00
6_R52_E1.2531.00
120_D124_K1.2521.00
95_I106_V1.2091.00
134_S191_N1.2061.00
162_V167_E1.2001.00
112_A133_I1.1961.00
230_M243_A1.1911.00
14_D31_E1.1891.00
73_S77_D1.1881.00
190_V210_V1.1871.00
137_A190_V1.1811.00
113_I171_M1.1801.00
234_Y241_A1.1791.00
48_A253_S1.1711.00
255_A259_E1.1681.00
44_R47_E1.1551.00
177_V210_V1.1471.00
73_S101_A1.1311.00
24_Y30_E1.1281.00
110_S114_A1.1211.00
25_T198_T1.1181.00
72_V85_V1.1071.00
174_I213_A1.1051.00
132_V189_F1.1051.00
44_R250_D1.0941.00
209_A212_D1.0941.00
186_G217_P1.0921.00
137_A206_L1.0921.00
188_L216_T1.0901.00
189_F242_L1.0891.00
140_R159_E1.0861.00
123_A128_S1.0801.00
140_R161_T1.0781.00
210_V218_V1.0681.00
202_Y224_C1.0621.00
178_Q182_R1.0571.00
52_E82_P1.0511.00
5_K234_Y1.0491.00
133_I185_A1.0461.00
181_Q214_V1.0381.00
139_R194_D1.0381.00
209_A213_A1.0381.00
204_V208_A1.0271.00
6_R51_D1.0251.00
85_V98_T1.0241.00
205_P208_A1.0221.00
114_A167_E1.0201.00
39_V71_T1.0151.00
256_E259_E1.0051.00
48_A254_I1.0051.00
233_A241_A1.0011.00
177_V214_V0.9921.00
96_R126_F0.9911.00
137_A173_A0.9901.00
76_A103_A0.9881.00
233_A238_A0.9881.00
115_D118_L0.9851.00
207_T211_C0.9821.00
139_R205_P0.9811.00
173_A177_V0.9771.00
85_V103_A0.9751.00
211_C236_A0.9660.99
227_P257_T0.9650.99
118_L122_G0.9600.99
39_V74_A0.9590.99
173_A210_V0.9560.99
232_D235_D0.9560.99
70_D74_A0.9480.99
61_S110_S0.9450.99
116_P179_E0.9410.99
123_A185_A0.9380.99
211_C238_A0.9370.99
46_N79_V0.9360.99
208_A236_A0.9320.99
175_E179_E0.9280.99
187_E217_P0.9270.99
52_E132_V0.9250.99
41_M44_R0.9210.99
114_A162_V0.9140.99
132_V187_E0.9120.99
174_I209_A0.9060.99
66_E97_E0.8970.99
14_D32_L0.8930.99
73_S97_E0.8930.99
119_V133_I0.8890.99
93_D97_E0.8880.99
245_S249_F0.8880.99
108_I122_G0.8850.99
45_Y248_H0.8840.99
227_P231_A0.8830.99
84_T107_S0.8770.99
119_V180_A0.8760.99
227_P256_E0.8610.99
56_L189_F0.8600.99
76_A104_D0.8560.99
162_V169_T0.8550.99
43_K46_N0.8550.99
95_I126_F0.8500.99
97_E101_A0.8450.99
99_L126_F0.8370.99
51_D82_P0.8350.99
66_E94_D0.8300.98
79_V82_P0.8250.98
74_A78_E0.8230.98
234_Y261_L0.8220.98
253_S257_T0.8190.98
138_R194_D0.8130.98
138_R161_T0.8110.98
211_C239_D0.8100.98
14_D28_N0.8050.98
120_D179_E0.8030.98
72_V103_A0.7960.98
204_V236_A0.7880.98
187_E239_D0.7860.98
28_N198_T0.7850.98
205_P209_A0.7810.98
174_I178_Q0.7810.98
94_D97_E0.7770.98
226_A230_M0.7770.98
92_T96_R0.7740.98
82_P104_D0.7720.98
212_D236_A0.7720.98
226_A251_E0.7690.97
225_G229_D0.7680.97
22_A245_S0.7660.97
92_T126_F0.7650.97
178_Q181_Q0.7630.97
46_N81_I0.7560.97
39_V78_E0.7540.97
161_T193_I0.7530.97
259_E262_A0.7480.97
113_I176_W0.7460.97
173_A206_L0.7460.97
230_M252_Y0.7440.97
174_I177_V0.7380.97
7_V243_A0.7290.97
224_C241_A0.7290.97
195_A200_D0.7270.96
105_K186_G0.7260.96
56_L191_N0.7250.96
24_Y245_S0.7240.96
207_T218_V0.7240.96
59_T64_G0.7220.96
195_A198_T0.7180.96
175_E178_Q0.7130.96
14_D59_T0.7130.96
230_M257_T0.7080.96
66_E90_R0.7050.96
50_A254_I0.7010.96
8_I219_I0.7000.96
140_R209_A0.6980.96
6_R240_A0.6970.96
69_L98_T0.6950.95
217_P239_D0.6950.95
71_T75_V0.6940.95
219_I240_A0.6920.95
230_M241_A0.6890.95
60_A67_T0.6860.95
40_E44_R0.6840.95
160_C176_W0.6830.95
67_T72_V0.6800.95
107_S189_F0.6780.95
140_R172_D0.6740.95
189_F219_I0.6740.95
124_K182_R0.6730.95
127_G187_E0.6710.95
97_E100_R0.6700.94
111_G115_D0.6700.94
203_D206_L0.6690.94
181_Q188_L0.6670.94
76_A101_A0.6650.94
254_I258_K0.6610.94
133_I188_L0.6600.94
95_I99_L0.6580.94
22_A196_D0.6580.94
104_D129_Q0.6520.94
210_V214_V0.6480.93
5_K241_A0.6480.93
207_T233_A0.6480.93
121_R124_K0.6480.93
25_T194_D0.6460.93
69_L73_S0.6450.93
135_V176_W0.6440.93
202_Y225_G0.6420.93
140_R168_G0.6410.93
8_I132_V0.6390.93
95_I108_I0.6370.93
225_G251_E0.6370.93
89_I95_I0.6360.93
33_A36_G0.6330.93
75_V83_L0.6330.93
236_A239_D0.6320.93
7_V241_A0.6310.93
162_V166_R0.6290.92
178_Q214_V0.6180.92
211_C237_G0.6160.92
40_E43_K0.6150.92
42_A75_V0.6140.92
8_I84_T0.6080.91
35_T249_F0.6070.91
230_M247_F0.6030.91
66_E69_L0.6010.91
36_G40_E0.6010.91
233_A236_A0.5960.90
105_K187_E0.5950.90
139_R203_D0.5930.90
95_I130_C0.5920.90
63_E67_T0.5900.90
66_E98_T0.5890.90
90_R114_A0.5890.90
224_C243_A0.5890.90
108_I119_V0.5880.90
123_A127_G0.5870.90
73_S100_R0.5870.90
135_V160_C0.5810.89
197_G223_G0.5800.89
93_D100_R0.5790.89
72_V75_V0.5780.89
59_T68_M0.5780.89
111_G122_G0.5760.89
177_V188_L0.5740.89
51_D258_K0.5740.89
89_I108_I0.5720.88
50_A257_T0.5710.88
187_E219_I0.5680.88
64_G68_M0.5670.88
8_I105_K0.5660.88
24_Y32_L0.5660.88
207_T220_A0.5650.88
6_R239_D0.5650.88
247_F257_T0.5600.87
12_D26_G0.5580.87
13_V75_V0.5550.87
55_F83_L0.5550.87
224_C252_Y0.5530.87
123_A133_I0.5480.86
13_V71_T0.5450.86
71_T83_L0.5410.86
128_S186_G0.5400.85
71_T74_A0.5400.85
79_V83_L0.5390.85
244_A248_H0.5380.85
85_V89_I0.5340.85
60_A66_E0.5340.85
202_Y230_M0.5310.84
25_T30_E0.5280.84
65_R94_D0.5280.84
202_Y229_D0.5260.84
28_N31_E0.5250.84
207_T238_A0.5240.84
230_M234_Y0.5210.83
201_G223_G0.5200.83
220_A233_A0.5180.83
120_D182_R0.5170.83
171_M175_E0.5150.83
134_S219_I0.5130.82
23_V41_M0.5130.82
122_G126_F0.5120.82
13_V55_F0.5120.82
135_V180_A0.5110.82
42_A79_V0.5110.82
129_Q187_E0.5100.82
14_D62_A0.5080.82
53_F75_V0.5080.82
41_M247_F0.5080.82
95_I118_L0.5070.82
253_S259_E0.5050.81
52_E104_D0.5050.81
44_R255_A0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jvnA 1 0.9524 100 0.3 Contact Map
2agkA 1 0.7985 100 0.326 Contact Map
1qo2A 1 0.8608 100 0.487 Contact Map
4gj1A 1 0.8242 100 0.501 Contact Map
1thfD 2 0.9267 100 0.524 Contact Map
2y88A 1 0.8828 100 0.534 Contact Map
4evzA 1 0.9267 100 0.537 Contact Map
4u28A 1 0.8462 100 0.551 Contact Map
1h5yA 1 0.9194 100 0.554 Contact Map
2w6rA 1 0.8059 100 0.555 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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