HIS6 - HALSA - GREMLIN Contacts

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HIS6 - Imidazole glycerol phosphate synthase subunit HisF

UniProt:	Q9HR52	Sequences: MTLTKRVIPCIDVDLDDDGEPAVYTGVNFEELAYTGDPVEMAKRYNEAGADEFVFLDITASAEGRETMLDTVSAVADEVFIPLTVGGGIRDTDDIRETLRAGADKVSINSGAIADPSLVDRGAKAFGSQCIVISVDARRRFDEQGQHYTQVDGESCWFECTVHGGREGTGMDAIEWVQEAQRRGAGELFVNSIDADGTQDGYDVPLTAAVCDAVSTPVIASSGCGAPGDMADAYDAGADAALAASIFHFDEYSIAETKETLADAGYPIRAPDA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	273 (235)
Sequences:	6021 (3120)
Seq/√Len:	203.5

ECOLI - HIS6 HIS4
BACSU - HIS6 HIS4
HALSA - HIS6 HIS4
SULSO - HIS6 HIS4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
95_I	122_G	3.299	1.00
163_H	167_E	2.600	1.00
120_D	183_R	2.516	1.00
115_D	121_R	2.451	1.00
181_Q	216_T	2.441	1.00
135_V	177_V	2.394	1.00
91_D	94_D	2.342	1.00
133_I	180_A	2.330	1.00
179_E	183_R	2.310	1.00
43_K	78_E	2.297	1.00
24_Y	198_T	2.290	1.00
159_E	168_G	2.262	1.00
43_K	47_E	2.209	1.00
253_S	256_E	2.142	1.00
96_R	100_R	2.123	1.00
114_A	163_H	2.087	1.00
159_E	172_D	2.060	1.00
228_G	231_A	2.036	1.00
44_R	48_A	1.987	1.00
199_Q	251_E	1.971	1.00
228_G	232_D	1.964	1.00
89_I	98_T	1.911	1.00
122_G	131_I	1.907	1.00
22_A	34_Y	1.870	1.00
159_E	170_G	1.852	1.00
95_I	131_I	1.849	1.00
46_N	80_F	1.831	1.00
62_A	166_R	1.829	1.00
208_A	212_D	1.788	1.00
69_L	97_E	1.755	1.00
172_D	175_E	1.753	1.00
190_V	206_L	1.751	1.00
96_R	125_A	1.737	1.00
113_I	162_V	1.707	1.00
37_D	40_E	1.675	1.00
181_Q	215_S	1.675	1.00
53_F	81_I	1.634	1.00
231_A	260_T	1.626	1.00
92_T	122_G	1.623	1.00
204_V	232_D	1.586	1.00
48_A	255_A	1.570	1.00
227_P	252_Y	1.547	1.00
171_M	179_E	1.534	1.00
224_C	233_A	1.527	1.00
243_A	247_F	1.520	1.00
37_D	74_A	1.516	1.00
68_M	71_T	1.510	1.00
17_D	59_T	1.504	1.00
105_K	132_V	1.493	1.00
226_A	229_D	1.487	1.00
243_A	246_I	1.485	1.00
134_S	189_F	1.472	1.00
70_D	73_S	1.469	1.00
246_I	252_Y	1.463	1.00
178_Q	213_A	1.459	1.00
179_E	182_R	1.437	1.00
108_I	111_G	1.435	1.00
231_A	235_D	1.428	1.00
117_S	121_R	1.411	1.00
28_N	62_A	1.400	1.00
76_A	83_L	1.384	1.00
111_G	118_L	1.382	1.00
8_I	52_E	1.358	1.00
99_L	130_C	1.353	1.00
74_A	77_D	1.347	1.00
14_D	17_D	1.345	1.00
9_P	50_A	1.336	1.00
93_D	96_R	1.336	1.00
212_D	237_G	1.328	1.00
92_T	121_R	1.325	1.00
211_C	218_V	1.324	1.00
227_P	260_T	1.319	1.00
92_T	125_A	1.316	1.00
252_Y	257_T	1.315	1.00
229_D	232_D	1.311	1.00
27_V	30_E	1.296	1.00
161_T	168_G	1.291	1.00
52_E	105_K	1.283	1.00
230_M	246_I	1.282	1.00
55_F	75_V	1.281	1.00
192_S	203_D	1.268	1.00
117_S	120_D	1.258	1.00
35_T	41_M	1.254	1.00
6_R	52_E	1.253	1.00
120_D	124_K	1.252	1.00
95_I	106_V	1.209	1.00
134_S	191_N	1.206	1.00
162_V	167_E	1.200	1.00
112_A	133_I	1.196	1.00
230_M	243_A	1.191	1.00
14_D	31_E	1.189	1.00
73_S	77_D	1.188	1.00
190_V	210_V	1.187	1.00
137_A	190_V	1.181	1.00
113_I	171_M	1.180	1.00
234_Y	241_A	1.179	1.00
48_A	253_S	1.171	1.00
255_A	259_E	1.168	1.00
44_R	47_E	1.155	1.00
177_V	210_V	1.147	1.00
73_S	101_A	1.131	1.00
24_Y	30_E	1.128	1.00
110_S	114_A	1.121	1.00
25_T	198_T	1.118	1.00
72_V	85_V	1.107	1.00
174_I	213_A	1.105	1.00
132_V	189_F	1.105	1.00
44_R	250_D	1.094	1.00
209_A	212_D	1.094	1.00
186_G	217_P	1.092	1.00
137_A	206_L	1.092	1.00
188_L	216_T	1.090	1.00
189_F	242_L	1.089	1.00
140_R	159_E	1.086	1.00
123_A	128_S	1.080	1.00
140_R	161_T	1.078	1.00
210_V	218_V	1.068	1.00
202_Y	224_C	1.062	1.00
178_Q	182_R	1.057	1.00
52_E	82_P	1.051	1.00
5_K	234_Y	1.049	1.00
133_I	185_A	1.046	1.00
181_Q	214_V	1.038	1.00
139_R	194_D	1.038	1.00
209_A	213_A	1.038	1.00
204_V	208_A	1.027	1.00
6_R	51_D	1.025	1.00
85_V	98_T	1.024	1.00
205_P	208_A	1.022	1.00
114_A	167_E	1.020	1.00
39_V	71_T	1.015	1.00
256_E	259_E	1.005	1.00
48_A	254_I	1.005	1.00
233_A	241_A	1.001	1.00
177_V	214_V	0.992	1.00
96_R	126_F	0.991	1.00
137_A	173_A	0.990	1.00
76_A	103_A	0.988	1.00
233_A	238_A	0.988	1.00
115_D	118_L	0.985	1.00
207_T	211_C	0.982	1.00
139_R	205_P	0.981	1.00
173_A	177_V	0.977	1.00
85_V	103_A	0.975	1.00
211_C	236_A	0.966	0.99
227_P	257_T	0.965	0.99
118_L	122_G	0.960	0.99
39_V	74_A	0.959	0.99
173_A	210_V	0.956	0.99
232_D	235_D	0.956	0.99
70_D	74_A	0.948	0.99
61_S	110_S	0.945	0.99
116_P	179_E	0.941	0.99
123_A	185_A	0.938	0.99
211_C	238_A	0.937	0.99
46_N	79_V	0.936	0.99
208_A	236_A	0.932	0.99
175_E	179_E	0.928	0.99
187_E	217_P	0.927	0.99
52_E	132_V	0.925	0.99
41_M	44_R	0.921	0.99
114_A	162_V	0.914	0.99
132_V	187_E	0.912	0.99
174_I	209_A	0.906	0.99
66_E	97_E	0.897	0.99
14_D	32_L	0.893	0.99
73_S	97_E	0.893	0.99
119_V	133_I	0.889	0.99
93_D	97_E	0.888	0.99
245_S	249_F	0.888	0.99
108_I	122_G	0.885	0.99
45_Y	248_H	0.884	0.99
227_P	231_A	0.883	0.99
84_T	107_S	0.877	0.99
119_V	180_A	0.876	0.99
227_P	256_E	0.861	0.99
56_L	189_F	0.860	0.99
76_A	104_D	0.856	0.99
162_V	169_T	0.855	0.99
43_K	46_N	0.855	0.99
95_I	126_F	0.850	0.99
97_E	101_A	0.845	0.99
99_L	126_F	0.837	0.99
51_D	82_P	0.835	0.99
66_E	94_D	0.830	0.98
79_V	82_P	0.825	0.98
74_A	78_E	0.823	0.98
234_Y	261_L	0.822	0.98
253_S	257_T	0.819	0.98
138_R	194_D	0.813	0.98
138_R	161_T	0.811	0.98
211_C	239_D	0.810	0.98
14_D	28_N	0.805	0.98
120_D	179_E	0.803	0.98
72_V	103_A	0.796	0.98
204_V	236_A	0.788	0.98
187_E	239_D	0.786	0.98
28_N	198_T	0.785	0.98
205_P	209_A	0.781	0.98
174_I	178_Q	0.781	0.98
94_D	97_E	0.777	0.98
226_A	230_M	0.777	0.98
92_T	96_R	0.774	0.98
82_P	104_D	0.772	0.98
212_D	236_A	0.772	0.98
226_A	251_E	0.769	0.97
225_G	229_D	0.768	0.97
22_A	245_S	0.766	0.97
92_T	126_F	0.765	0.97
178_Q	181_Q	0.763	0.97
46_N	81_I	0.756	0.97
39_V	78_E	0.754	0.97
161_T	193_I	0.753	0.97
259_E	262_A	0.748	0.97
113_I	176_W	0.746	0.97
173_A	206_L	0.746	0.97
230_M	252_Y	0.744	0.97
174_I	177_V	0.738	0.97
7_V	243_A	0.729	0.97
224_C	241_A	0.729	0.97
195_A	200_D	0.727	0.96
105_K	186_G	0.726	0.96
56_L	191_N	0.725	0.96
24_Y	245_S	0.724	0.96
207_T	218_V	0.724	0.96
59_T	64_G	0.722	0.96
195_A	198_T	0.718	0.96
175_E	178_Q	0.713	0.96
14_D	59_T	0.713	0.96
230_M	257_T	0.708	0.96
66_E	90_R	0.705	0.96
50_A	254_I	0.701	0.96
8_I	219_I	0.700	0.96
140_R	209_A	0.698	0.96
6_R	240_A	0.697	0.96
69_L	98_T	0.695	0.95
217_P	239_D	0.695	0.95
71_T	75_V	0.694	0.95
219_I	240_A	0.692	0.95
230_M	241_A	0.689	0.95
60_A	67_T	0.686	0.95
40_E	44_R	0.684	0.95
160_C	176_W	0.683	0.95
67_T	72_V	0.680	0.95
107_S	189_F	0.678	0.95
140_R	172_D	0.674	0.95
189_F	219_I	0.674	0.95
124_K	182_R	0.673	0.95
127_G	187_E	0.671	0.95
97_E	100_R	0.670	0.94
111_G	115_D	0.670	0.94
203_D	206_L	0.669	0.94
181_Q	188_L	0.667	0.94
76_A	101_A	0.665	0.94
254_I	258_K	0.661	0.94
133_I	188_L	0.660	0.94
95_I	99_L	0.658	0.94
22_A	196_D	0.658	0.94
104_D	129_Q	0.652	0.94
210_V	214_V	0.648	0.93
5_K	241_A	0.648	0.93
207_T	233_A	0.648	0.93
121_R	124_K	0.648	0.93
25_T	194_D	0.646	0.93
69_L	73_S	0.645	0.93
135_V	176_W	0.644	0.93
202_Y	225_G	0.642	0.93
140_R	168_G	0.641	0.93
8_I	132_V	0.639	0.93
95_I	108_I	0.637	0.93
225_G	251_E	0.637	0.93
89_I	95_I	0.636	0.93
33_A	36_G	0.633	0.93
75_V	83_L	0.633	0.93
236_A	239_D	0.632	0.93
7_V	241_A	0.631	0.93
162_V	166_R	0.629	0.92
178_Q	214_V	0.618	0.92
211_C	237_G	0.616	0.92
40_E	43_K	0.615	0.92
42_A	75_V	0.614	0.92
8_I	84_T	0.608	0.91
35_T	249_F	0.607	0.91
230_M	247_F	0.603	0.91
66_E	69_L	0.601	0.91
36_G	40_E	0.601	0.91
233_A	236_A	0.596	0.90
105_K	187_E	0.595	0.90
139_R	203_D	0.593	0.90
95_I	130_C	0.592	0.90
63_E	67_T	0.590	0.90
66_E	98_T	0.589	0.90
90_R	114_A	0.589	0.90
224_C	243_A	0.589	0.90
108_I	119_V	0.588	0.90
123_A	127_G	0.587	0.90
73_S	100_R	0.587	0.90
135_V	160_C	0.581	0.89
197_G	223_G	0.580	0.89
93_D	100_R	0.579	0.89
72_V	75_V	0.578	0.89
59_T	68_M	0.578	0.89
111_G	122_G	0.576	0.89
177_V	188_L	0.574	0.89
51_D	258_K	0.574	0.89
89_I	108_I	0.572	0.88
50_A	257_T	0.571	0.88
187_E	219_I	0.568	0.88
64_G	68_M	0.567	0.88
8_I	105_K	0.566	0.88
24_Y	32_L	0.566	0.88
207_T	220_A	0.565	0.88
6_R	239_D	0.565	0.88
247_F	257_T	0.560	0.87
12_D	26_G	0.558	0.87
13_V	75_V	0.555	0.87
55_F	83_L	0.555	0.87
224_C	252_Y	0.553	0.87
123_A	133_I	0.548	0.86
13_V	71_T	0.545	0.86
71_T	83_L	0.541	0.86
128_S	186_G	0.540	0.85
71_T	74_A	0.540	0.85
79_V	83_L	0.539	0.85
244_A	248_H	0.538	0.85
85_V	89_I	0.534	0.85
60_A	66_E	0.534	0.85
202_Y	230_M	0.531	0.84
25_T	30_E	0.528	0.84
65_R	94_D	0.528	0.84
202_Y	229_D	0.526	0.84
28_N	31_E	0.525	0.84
207_T	238_A	0.524	0.84
230_M	234_Y	0.521	0.83
201_G	223_G	0.520	0.83
220_A	233_A	0.518	0.83
120_D	182_R	0.517	0.83
171_M	175_E	0.515	0.83
134_S	219_I	0.513	0.82
23_V	41_M	0.513	0.82
122_G	126_F	0.512	0.82
13_V	55_F	0.512	0.82
135_V	180_A	0.511	0.82
42_A	79_V	0.511	0.82
129_Q	187_E	0.510	0.82
14_D	62_A	0.508	0.82
53_F	75_V	0.508	0.82
41_M	247_F	0.508	0.82
95_I	118_L	0.507	0.82
253_S	259_E	0.505	0.81
52_E	104_D	0.505	0.81
44_R	255_A	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1jvnA	1	0.9524	100	0.3	Contact Map
2agkA	1	0.7985	100	0.326	Contact Map
1qo2A	1	0.8608	100	0.487	Contact Map
4gj1A	1	0.8242	100	0.501	Contact Map
1thfD	2	0.9267	100	0.524	Contact Map
2y88A	1	0.8828	100	0.534	Contact Map
4evzA	1	0.9267	100	0.537	Contact Map
4u28A	1	0.8462	100	0.551	Contact Map
1h5yA	1	0.9194	100	0.554	Contact Map
2w6rA	1	0.8059	100	0.555	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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