PURL - HALSA - GREMLIN Contacts

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PURL - Phosphoribosylformylglycinamidine synthase subunit PurL

UniProt:	Q9HR49	Sequences: MSLGDSDRERVVAALGRDPTPAEAALFENLWSEHCAYRSSRSLLSAFDSDSEAVVVGPGDDAAVVRVPGTDQLVTVGVESHNHPSYVDPYDGAATGVGGIVRDTLSMGAYPIALADALYFGDFDDEHARYLLDGVVEGISDYGNAIGVPTVAGATQFHDGYTGNPLVNVACVGLVTEDRLVTAAAKSPGNKLVLVGNATGRDGLGGASFASEDLAEDAETADRPAVQVGDPYTEKLLIEANETLLDRDLVVAARDLGAAGLGGASSEMVAQGELGARITLDAVHQREPEMNAMEILLAESQERMCYEVAPADVDAVREVATRYDLGCSVIGEVTTGNYVCEFDGETVVDAPATVLADGAPATDQPSTVPQAPATDRPDPALGTAIDAVLSAPNTASNEWVYRQYDHEVGARTVQRPGEDAAGLALHEADDGTTVALSAGANPGWTACQPYAGAYATAVENATNLAAAGAEPLAAVDCLNGGNPEDPDVYGGFEAMVAGLADGCRAIDTPVVGGNVSLYNDSATGPIAPTPTLAVVGYRDQHPVPGSGLAGDGDLVLVGGHADGLGGSVYLQALGGTDQFPAADAAGVDAVREAATRADTLAVHDISDGGLAVTLAEMVTADAGATVTVPGLAALFSECPGRAVVETRDADALQAALDVPVVRLGSATTDGTLSVTVDDETVTRDAATIRDHRGVIARELD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	700 (684)
Sequences:	3177 (1599)
Seq/√Len:	61.2

ECOLI - PUR4
BACSU - PURL
HALSA - PURL
SULSO - PURL

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
337_N	349_D	4.791	1.00
614_L	626_V	4.663	1.00
277_R	332_E	4.605	1.00
548_L	554_L	4.538	1.00
90_Y	141_D	4.482	1.00
622_A	666_A	4.064	1.00
464_L	469_A	3.966	1.00
605_I	643_V	3.631	1.00
346_T	349_D	3.586	1.00
613_T	643_V	3.541	1.00
279_T	282_A	3.521	1.00
277_R	341_E	3.374	1.00
317_R	321_T	3.198	1.00
671_T	682_T	3.189	1.00
265_S	330_I	3.151	1.00
198_A	326_G	3.143	1.00
555_V	662_R	3.080	1.00
314_D	318_E	2.940	1.00
545_G	549_A	2.939	1.00
314_D	317_R	2.891	1.00
388_V	394_T	2.842	1.00
341_E	346_T	2.835	1.00
647_R	650_D	2.772	1.00
451_A	454_Y	2.759	1.00
555_V	652_L	2.694	1.00
554_L	624_A	2.686	1.00
380_A	383_T	2.658	1.00
207_A	258_A	2.653	1.00
624_A	672_L	2.648	1.00
155_T	400_V	2.643	1.00
391_A	568_V	2.634	1.00
625_T	673_S	2.632	1.00
593_A	652_L	2.630	1.00
544_P	594_A	2.620	1.00
281_D	343_D	2.511	1.00
193_V	308_V	2.471	1.00
555_V	653_Q	2.470	1.00
601_A	617_M	2.456	1.00
492_F	517_L	2.448	1.00
455_A	639_P	2.447	1.00
450_Y	501_D	2.443	1.00
312_D	315_A	2.431	1.00
555_V	660_V	2.420	1.00
615_A	672_L	2.381	1.00
385_I	611_A	2.379	1.00
625_T	665_S	2.344	1.00
383_T	387_A	2.330	1.00
151_V	421_A	2.328	1.00
433_T	540_Q	2.315	1.00
284_H	328_S	2.309	1.00
386_D	691_H	2.287	1.00
191_K	329_V	2.275	1.00
315_A	318_E	2.275	1.00
499_L	532_L	2.264	1.00
414_Q	545_G	2.256	1.00
460_N	532_L	2.242	1.00
460_N	534_V	2.231	1.00
548_L	624_A	2.216	1.00
146_I	238_I	2.208	1.00
66_R	177_E	2.177	1.00
589_A	656_L	2.176	1.00
601_A	645_E	2.164	1.00
292_A	342_F	2.142	1.00
644_V	652_L	2.116	1.00
557_V	644_V	2.106	1.00
590_V	644_V	2.079	1.00
114_L	171_C	2.063	1.00
418_E	467_A	2.048	1.00
656_L	660_V	2.022	1.00
480_G	495_M	2.021	1.00
285_Q	295_I	2.004	1.00
277_R	339_V	1.984	1.00
72_Q	176_T	1.980	1.00
74_V	434_V	1.957	1.00
7_D	38_R	1.954	1.00
445_T	495_M	1.937	1.00
317_R	327_C	1.936	1.00
382_G	386_D	1.934	1.00
592_E	596_R	1.934	1.00
419_D	603_H	1.929	1.00
112_I	423_L	1.923	1.00
569_Y	631_L	1.920	1.00
553_D	645_E	1.915	1.00
614_L	643_V	1.914	1.00
11_V	27_F	1.912	1.00
444_W	455_A	1.903	1.00
168_N	531_T	1.902	1.00
55_V	73_L	1.899	1.00
553_D	666_A	1.890	1.00
494_A	497_A	1.887	1.00
339_V	346_T	1.886	1.00
610_L	643_V	1.880	1.00
431_G	541_H	1.859	1.00
243_T	322_R	1.847	1.00
465_A	591_R	1.847	1.00
590_V	599_T	1.846	1.00
584_A	588_D	1.835	1.00
618_V	624_A	1.833	1.00
42_S	363_D	1.831	1.00
614_L	624_A	1.829	1.00
398_E	693_G	1.829	1.00
617_M	645_E	1.828	1.00
279_T	341_E	1.819	1.00
683_R	687_T	1.813	1.00
367_T	487_D	1.813	1.00
101_V	146_I	1.805	1.00
366_S	493_E	1.805	1.00
689_R	693_G	1.798	1.00
600_L	647_R	1.773	0.99
313_V	329_V	1.760	0.99
205_G	208_S	1.753	0.99
554_L	645_E	1.749	0.99
553_D	600_L	1.748	0.99
46_A	497_A	1.747	0.99
281_D	342_F	1.740	0.99
191_K	332_E	1.731	0.99
594_A	599_T	1.722	0.99
191_K	313_V	1.720	0.99
615_A	619_T	1.717	0.99
555_V	644_V	1.704	0.99
382_G	687_T	1.702	0.99
603_H	616_E	1.693	0.99
458_V	639_P	1.687	0.99
9_E	13_A	1.687	0.99
542_P	595_T	1.677	0.99
385_I	615_A	1.671	0.99
683_R	688_I	1.662	0.99
270_A	356_A	1.659	0.99
160_G	527_A	1.658	0.99
101_V	171_C	1.655	0.99
122_D	159_D	1.645	0.99
431_G	539_D	1.643	0.99
386_D	687_T	1.625	0.99
542_P	597_A	1.621	0.99
191_K	308_V	1.611	0.99
673_S	682_T	1.603	0.99
411_R	424_A	1.599	0.99
448_Q	579_F	1.586	0.99
600_L	645_E	1.574	0.99
548_L	617_M	1.574	0.99
625_T	667_T	1.574	0.99
488_V	525_P	1.572	0.99
556_L	605_I	1.565	0.99
684_D	687_T	1.558	0.99
116_D	139_I	1.549	0.99
368_V	490_G	1.530	0.98
621_D	689_R	1.528	0.98
64_V	75_T	1.524	0.98
329_V	332_E	1.510	0.98
154_A	397_N	1.503	0.98
646_T	652_L	1.496	0.98
475_V	509_P	1.491	0.98
209_F	214_L	1.489	0.98
53_A	470_E	1.481	0.98
390_S	691_H	1.481	0.98
393_N	568_V	1.481	0.98
598_D	650_D	1.473	0.98
386_D	683_R	1.470	0.98
385_I	612_V	1.461	0.98
611_A	674_V	1.453	0.98
295_I	342_F	1.453	0.98
599_T	644_V	1.450	0.98
401_Y	417_G	1.442	0.98
15_L	351_P	1.430	0.98
394_T	612_V	1.429	0.98
551_D	668_T	1.424	0.97
191_K	310_P	1.418	0.97
539_D	542_P	1.411	0.97
382_G	683_R	1.409	0.97
599_T	602_V	1.405	0.97
336_G	339_V	1.401	0.97
453_A	491_G	1.396	0.97
660_V	663_L	1.389	0.97
447_C	579_F	1.388	0.97
110_Y	239_E	1.385	0.97
247_R	315_A	1.384	0.97
472_L	475_V	1.381	0.97
4_G	362_T	1.379	0.97
368_V	372_P	1.379	0.97
386_D	688_I	1.378	0.97
448_Q	578_Q	1.376	0.97
589_A	655_A	1.375	0.97
70_T	432_T	1.375	0.97
339_V	349_D	1.371	0.97
193_V	317_R	1.364	0.97
500_A	504_R	1.360	0.97
409_G	412_T	1.360	0.97
690_D	694_V	1.360	0.97
391_A	572_A	1.359	0.97
168_N	438_A	1.358	0.97
66_R	71_D	1.357	0.97
25_A	293_M	1.341	0.96
398_E	402_R	1.340	0.96
256_L	264_A	1.338	0.96
390_S	694_V	1.338	0.96
619_T	692_R	1.336	0.96
115_A	436_L	1.335	0.96
555_V	646_T	1.334	0.96
86_Y	214_L	1.332	0.96
618_V	672_L	1.330	0.96
424_A	540_Q	1.325	0.96
444_W	639_P	1.323	0.96
422_G	543_V	1.321	0.96
450_Y	494_A	1.308	0.96
188_P	335_T	1.307	0.96
194_L	256_L	1.303	0.96
10_R	13_A	1.303	0.96
318_E	321_T	1.299	0.96
48_D	56_V	1.296	0.96
501_D	505_A	1.294	0.96
459_E	606_S	1.292	0.96
396_S	693_G	1.285	0.95
563_G	638_C	1.284	0.95
466_A	602_V	1.282	0.95
481_G	491_G	1.280	0.95
470_E	595_T	1.279	0.95
73_L	177_E	1.276	0.95
244_L	316_V	1.274	0.95
71_D	177_E	1.273	0.95
51_S	65_V	1.270	0.95
550_G	553_D	1.267	0.95
308_V	313_V	1.267	0.95
378_D	631_L	1.258	0.95
605_I	613_T	1.257	0.95
604_D	616_E	1.254	0.95
593_A	599_T	1.243	0.94
201_R	294_E	1.239	0.94
292_A	347_V	1.238	0.94
364_Q	484_E	1.230	0.94
562_D	636_S	1.226	0.94
190_N	251_V	1.216	0.94
192_L	276_A	1.215	0.94
463_N	604_D	1.214	0.94
65_V	473_A	1.210	0.94
249_L	312_D	1.207	0.94
352_A	356_A	1.206	0.94
420_A	435_A	1.204	0.93
379_P	384_A	1.201	0.93
435_A	464_L	1.198	0.93
195_V	320_A	1.197	0.93
192_L	307_E	1.196	0.93
251_V	309_A	1.195	0.93
550_G	600_L	1.190	0.93
611_A	615_A	1.188	0.93
309_A	312_D	1.187	0.93
548_L	645_E	1.187	0.93
190_N	333_V	1.183	0.93
279_T	343_D	1.180	0.93
625_T	675_T	1.163	0.92
125_D	162_T	1.162	0.92
27_F	354_V	1.160	0.92
120_F	132_L	1.160	0.92
437_S	460_N	1.148	0.92
168_N	477_C	1.148	0.92
176_T	179_R	1.141	0.91
614_L	663_L	1.139	0.91
170_A	533_A	1.138	0.91
598_D	651_A	1.138	0.91
560_H	638_C	1.137	0.91
389_L	615_A	1.131	0.91
461_A	508_T	1.129	0.91
399_W	403_Q	1.129	0.91
459_E	604_D	1.128	0.91
607_D	616_E	1.127	0.91
461_A	587_V	1.125	0.91
78_V	438_A	1.125	0.91
78_V	531_T	1.122	0.91
340_C	348_V	1.120	0.91
612_V	616_E	1.118	0.91
549_A	645_E	1.116	0.91
115_A	170_A	1.115	0.91
158_H	446_A	1.115	0.91
66_R	69_G	1.115	0.91
475_V	533_A	1.104	0.90
130_Y	134_G	1.102	0.90
490_G	494_A	1.101	0.90
560_H	563_G	1.098	0.90
498_G	502_G	1.097	0.90
5_D	9_E	1.096	0.90
85_S	135_V	1.094	0.90
560_H	641_R	1.093	0.90
161_Y	440_A	1.088	0.89
435_A	469_A	1.087	0.89
86_Y	209_F	1.084	0.89
158_H	443_G	1.079	0.89
448_Q	451_A	1.079	0.89
433_T	543_V	1.077	0.89
277_R	336_G	1.075	0.89
652_L	656_L	1.074	0.89
26_L	350_A	1.072	0.89
627_T	675_T	1.072	0.89
43_L	47_F	1.072	0.89
653_Q	660_V	1.070	0.89
414_Q	422_G	1.069	0.89
122_D	162_T	1.065	0.88
46_A	500_A	1.063	0.88
445_T	456_T	1.063	0.88
557_V	586_G	1.063	0.88
268_M	307_E	1.062	0.88
392_P	395_A	1.061	0.88
114_L	146_I	1.059	0.88
193_V	329_V	1.056	0.88
133_D	137_E	1.055	0.88
450_Y	497_A	1.053	0.88
464_L	475_V	1.053	0.88
554_L	626_V	1.052	0.88
557_V	656_L	1.052	0.88
411_R	426_H	1.050	0.88
548_L	666_A	1.050	0.88
73_L	175_V	1.048	0.88
287_E	290_M	1.047	0.88
216_E	522_A	1.046	0.87
283_V	295_I	1.044	0.87
251_V	312_D	1.044	0.87
387_A	573_L	1.043	0.87
596_R	651_A	1.042	0.87
44_L	47_F	1.041	0.87
437_S	464_L	1.040	0.87
687_T	691_H	1.040	0.87
477_C	531_T	1.038	0.87
667_T	670_G	1.038	0.87
447_C	577_D	1.032	0.87
441_N	459_E	1.027	0.87
296_L	340_C	1.022	0.86
546_S	620_A	1.017	0.86
134_G	137_E	1.017	0.86
75_T	109_A	1.015	0.86
552_G	666_A	1.014	0.86
265_S	338_Y	1.010	0.86
606_S	616_E	1.009	0.86
651_A	655_A	1.005	0.85
101_V	148_V	1.004	0.85
9_E	12_V	1.003	0.85
605_I	610_L	1.001	0.85
501_D	504_R	1.001	0.85
492_F	496_V	0.997	0.85
367_T	486_P	0.992	0.85
308_V	316_V	0.992	0.85
187_S	309_A	0.992	0.85
538_R	595_T	0.991	0.84
670_G	685_A	0.991	0.84
651_A	654_A	0.989	0.84
488_V	492_F	0.989	0.84
449_P	487_D	0.988	0.84
58_P	185_A	0.979	0.84
353_T	357_D	0.977	0.84
691_H	694_V	0.975	0.84
413_V	424_A	0.974	0.83
554_L	614_L	0.971	0.83
53_A	472_L	0.970	0.83
622_A	668_T	0.968	0.83
389_L	394_T	0.968	0.83
686_A	689_R	0.967	0.83
425_L	432_T	0.965	0.83
22_A	348_V	0.965	0.83
243_T	319_V	0.963	0.83
388_V	612_V	0.961	0.83
209_F	225_A	0.961	0.83
61_D	106_S	0.955	0.82
86_Y	165_P	0.955	0.82
377_P	380_A	0.950	0.82
249_L	315_A	0.949	0.82
140_S	169_V	0.948	0.82
280_L	342_F	0.947	0.82
354_V	358_G	0.947	0.82
319_V	322_R	0.947	0.82
554_L	557_V	0.947	0.82
646_T	649_A	0.946	0.82
414_Q	418_E	0.945	0.82
350_A	356_A	0.945	0.82
137_E	141_D	0.942	0.81
201_R	287_E	0.942	0.81
187_S	251_V	0.940	0.81
426_H	430_D	0.937	0.81
688_I	692_R	0.936	0.81
281_D	344_G	0.935	0.81
470_E	538_R	0.935	0.81
590_V	594_A	0.934	0.81
470_E	591_R	0.934	0.81
406_H	416_P	0.933	0.81
662_R	665_S	0.933	0.81
687_T	690_D	0.931	0.81
131_L	165_P	0.930	0.81
46_A	504_R	0.930	0.81
188_P	274_L	0.929	0.80
8_R	12_V	0.927	0.80
627_T	678_D	0.922	0.80
619_T	689_R	0.918	0.80
624_A	664_G	0.917	0.80
132_L	400_V	0.914	0.79
187_S	190_N	0.912	0.79
43_L	489_Y	0.911	0.79
557_V	590_V	0.910	0.79
550_G	666_A	0.906	0.79
628_V	633_A	0.905	0.79
109_A	172_V	0.905	0.79
244_L	306_Y	0.905	0.79
193_V	327_C	0.905	0.79
553_D	648_D	0.904	0.79
653_Q	662_R	0.904	0.79
654_A	657_D	0.904	0.79
593_A	598_D	0.904	0.79
101_V	114_L	0.899	0.78
459_E	616_E	0.897	0.78
457_A	499_L	0.896	0.78
646_T	650_D	0.891	0.78
46_A	496_V	0.890	0.78
386_D	390_S	0.889	0.77
445_T	452_G	0.887	0.77
550_G	647_R	0.887	0.77
463_N	616_E	0.887	0.77
110_Y	242_E	0.885	0.77
596_R	655_A	0.884	0.77
285_Q	290_M	0.883	0.77
593_A	644_V	0.880	0.77
273_E	353_T	0.879	0.77
468_G	538_R	0.877	0.76
368_V	494_A	0.877	0.76
548_L	622_A	0.874	0.76
90_Y	229_G	0.873	0.76
128_A	162_T	0.871	0.76
341_E	344_G	0.871	0.76
554_L	663_L	0.870	0.76
306_Y	316_V	0.870	0.76
318_E	322_R	0.870	0.76
61_D	254_R	0.868	0.76
58_P	252_A	0.866	0.76
53_A	65_V	0.864	0.75
549_A	552_G	0.863	0.75
442_P	531_T	0.863	0.75
407_E	415_R	0.863	0.75
121_G	162_T	0.862	0.75
321_T	327_C	0.859	0.75
293_M	297_L	0.859	0.75
591_R	595_T	0.858	0.75
193_V	313_V	0.858	0.75
598_D	655_A	0.856	0.75
152_A	437_S	0.855	0.75
270_A	353_T	0.854	0.75
453_A	495_M	0.853	0.74
365_P	486_P	0.853	0.74
567_S	580_P	0.851	0.74
612_V	615_A	0.848	0.74
112_I	434_V	0.847	0.74
556_L	643_V	0.847	0.74
682_T	687_T	0.846	0.74
618_V	645_E	0.845	0.74
618_V	685_A	0.842	0.73
568_V	571_Q	0.840	0.73
643_V	663_L	0.837	0.73
458_V	462_T	0.836	0.73
685_A	689_R	0.835	0.73
123_F	132_L	0.835	0.73
3_L	11_V	0.835	0.73
150_T	421_A	0.834	0.73
414_Q	543_V	0.834	0.73
477_C	499_L	0.833	0.73
589_A	593_A	0.833	0.73
507_D	584_A	0.831	0.73
315_A	319_V	0.831	0.73
48_D	54_V	0.830	0.72
115_A	152_A	0.830	0.72
172_V	535_V	0.828	0.72
485_D	520_D	0.828	0.72
43_L	492_F	0.828	0.72
557_V	589_A	0.828	0.72
603_H	606_S	0.828	0.72
72_Q	174_L	0.827	0.72
459_E	463_N	0.825	0.72
651_A	675_T	0.825	0.72
463_N	603_H	0.825	0.72
558_G	562_D	0.822	0.72
627_T	630_G	0.822	0.72
419_D	606_S	0.820	0.72
592_E	655_A	0.819	0.71
378_D	569_Y	0.816	0.71
448_Q	494_A	0.815	0.71
381_L	635_F	0.815	0.71
689_R	692_R	0.813	0.71
67_V	425_L	0.812	0.71
24_A	61_D	0.811	0.71
593_A	655_A	0.810	0.71
465_A	594_A	0.809	0.70
378_D	381_L	0.809	0.70
464_L	534_V	0.807	0.70
461_A	534_V	0.807	0.70
70_T	176_T	0.807	0.70
310_P	332_E	0.804	0.70
413_V	540_Q	0.803	0.70
474_A	510_V	0.801	0.70
117_A	154_A	0.796	0.69
39_S	489_Y	0.795	0.69
459_E	603_H	0.795	0.69
537_Y	543_V	0.794	0.69
282_A	343_D	0.792	0.69
335_T	386_D	0.789	0.69
586_G	641_R	0.789	0.69
413_V	433_T	0.787	0.68
589_A	592_E	0.787	0.68
39_S	364_Q	0.787	0.68
189_G	332_E	0.787	0.68
381_L	385_I	0.786	0.68
670_G	686_A	0.785	0.68
112_I	425_L	0.785	0.68
388_V	611_A	0.784	0.68
547_G	620_A	0.782	0.68
240_A	320_A	0.781	0.68
209_F	489_Y	0.780	0.68
465_A	587_V	0.779	0.68
338_Y	350_A	0.776	0.67
146_I	171_C	0.776	0.67
588_D	592_E	0.774	0.67
544_P	602_V	0.774	0.67
463_N	606_S	0.773	0.67
48_D	507_D	0.772	0.67
618_V	674_V	0.771	0.67
669_D	681_V	0.771	0.67
604_D	607_D	0.770	0.67
653_Q	656_L	0.770	0.67
269_V	276_A	0.769	0.67
406_H	415_R	0.767	0.66
160_G	446_A	0.764	0.66
559_G	659_P	0.763	0.66
122_D	571_Q	0.762	0.66
473_A	508_T	0.762	0.66
508_T	534_V	0.761	0.66
450_Y	453_A	0.760	0.66
410_A	426_H	0.760	0.66
544_P	599_T	0.759	0.66
156_Q	607_D	0.759	0.66
263_G	512_G	0.755	0.65
686_A	690_D	0.754	0.65
648_D	651_A	0.754	0.65
419_D	463_N	0.753	0.65
551_D	622_A	0.750	0.65
439_G	463_N	0.742	0.64
600_L	650_D	0.742	0.64
683_R	686_A	0.741	0.64
431_G	540_Q	0.740	0.64
685_A	688_I	0.740	0.64
105_L	238_I	0.740	0.64
589_A	652_L	0.738	0.63
43_L	46_A	0.738	0.63
172_V	436_L	0.736	0.63
54_V	58_P	0.735	0.63
141_D	145_A	0.734	0.63
53_A	475_V	0.733	0.63
561_A	638_C	0.732	0.63
283_V	330_I	0.731	0.63
90_Y	140_S	0.731	0.63
192_L	278_I	0.731	0.63
179_R	246_D	0.729	0.62
74_V	172_V	0.727	0.62
549_A	622_A	0.725	0.62
593_A	597_A	0.725	0.62
454_Y	501_D	0.725	0.62
240_A	319_V	0.725	0.62
55_V	64_V	0.724	0.62
624_A	666_A	0.724	0.62
420_A	543_V	0.724	0.62
435_A	537_Y	0.723	0.62
492_F	498_G	0.723	0.62
353_T	358_G	0.722	0.62
622_A	667_T	0.721	0.62
77_G	169_V	0.721	0.62
670_G	684_D	0.721	0.62
563_G	581_A	0.720	0.61
553_D	601_A	0.719	0.61
98_G	142_Y	0.719	0.61
611_A	635_F	0.719	0.61
170_A	436_L	0.718	0.61
6_S	363_D	0.716	0.61
59_G	181_V	0.715	0.61
451_A	581_A	0.715	0.61
223_R	287_E	0.712	0.61
437_S	467_A	0.708	0.60
485_D	488_V	0.708	0.60
186_K	190_N	0.708	0.60
652_L	662_R	0.708	0.60
342_F	347_V	0.707	0.60
122_D	128_A	0.707	0.60
229_G	286_R	0.705	0.60
652_L	658_V	0.705	0.60
591_R	594_A	0.703	0.60
313_V	317_R	0.703	0.60
585_A	651_A	0.703	0.60
252_A	274_L	0.703	0.60
353_T	356_A	0.703	0.60
489_Y	496_V	0.703	0.60
83_H	210_A	0.702	0.60
87_V	209_F	0.700	0.59
465_A	640_G	0.700	0.59
538_R	542_P	0.700	0.59
258_A	261_L	0.700	0.59
553_D	622_A	0.700	0.59
67_V	74_V	0.699	0.59
643_V	647_R	0.699	0.59
65_V	74_V	0.698	0.59
384_A	388_V	0.698	0.59
88_D	91_D	0.697	0.59
85_S	134_G	0.697	0.59
384_A	573_L	0.697	0.59
67_V	434_V	0.695	0.59
256_L	305_C	0.694	0.59
119_Y	154_A	0.694	0.59
61_D	77_G	0.693	0.59
266_S	338_Y	0.693	0.59
437_S	533_A	0.693	0.59
440_A	445_T	0.692	0.58
215_A	218_A	0.690	0.58
586_G	658_V	0.689	0.58
286_R	300_S	0.689	0.58
37_Y	40_S	0.689	0.58
320_A	327_C	0.687	0.58
337_N	351_P	0.687	0.58
385_I	683_R	0.685	0.58
41_R	361_A	0.684	0.58
73_L	180_L	0.684	0.58
398_E	689_R	0.684	0.58
48_D	51_S	0.683	0.57
676_V	681_V	0.682	0.57
382_G	682_T	0.682	0.57
161_Y	529_T	0.682	0.57
677_D	681_V	0.681	0.57
423_L	434_V	0.681	0.57
554_L	605_I	0.679	0.57
369_P	487_D	0.679	0.57
181_V	184_A	0.678	0.57
495_M	532_L	0.678	0.57
654_A	665_S	0.677	0.57
105_L	304_M	0.677	0.57
90_Y	231_P	0.676	0.57
76_V	533_A	0.676	0.57
553_D	647_R	0.676	0.57
307_E	333_V	0.675	0.57
472_L	588_D	0.675	0.57
55_V	180_L	0.674	0.56
653_Q	657_D	0.673	0.56
646_T	655_A	0.672	0.56
337_N	350_A	0.672	0.56
320_A	325_L	0.671	0.56
90_Y	145_A	0.670	0.56
269_V	333_V	0.670	0.56
471_P	474_A	0.670	0.56
441_N	607_D	0.668	0.56
110_Y	409_G	0.667	0.56
65_V	425_L	0.667	0.56
112_I	174_L	0.666	0.56
37_Y	80_S	0.666	0.56
118_L	139_I	0.666	0.56
159_D	574_G	0.665	0.55
200_G	286_R	0.665	0.55
464_L	467_A	0.665	0.55
561_A	583_D	0.665	0.55
554_L	666_A	0.664	0.55
194_L	265_S	0.663	0.55
490_G	493_E	0.662	0.55
280_L	340_C	0.659	0.55
249_L	319_V	0.658	0.55
608_G	637_E	0.658	0.55
461_A	474_A	0.657	0.55
170_A	438_A	0.656	0.54
376_R	379_P	0.653	0.54
29_N	208_S	0.653	0.54
64_V	175_V	0.653	0.54
121_G	158_H	0.653	0.54
54_V	57_G	0.652	0.54
555_V	658_V	0.652	0.54
318_E	625_T	0.652	0.54
441_N	604_D	0.651	0.54
41_R	45_S	0.651	0.54
482_N	485_D	0.650	0.54
119_Y	442_P	0.649	0.54
275_G	335_T	0.649	0.54
645_E	666_A	0.648	0.53
90_Y	137_E	0.647	0.53
628_V	663_L	0.647	0.53
64_V	180_L	0.647	0.53
675_T	678_D	0.647	0.53
192_L	265_S	0.647	0.53
478_L	482_N	0.646	0.53
265_S	278_I	0.645	0.53
248_D	309_A	0.644	0.53
437_S	534_V	0.643	0.53
433_T	539_D	0.643	0.53
450_Y	491_G	0.643	0.53
552_G	665_S	0.642	0.53
183_A	252_A	0.642	0.53
590_V	656_L	0.642	0.53
270_A	357_D	0.641	0.53
563_G	639_P	0.640	0.53
447_C	565_G	0.640	0.53
603_H	607_D	0.639	0.52
492_F	495_M	0.639	0.52
334_T	339_V	0.639	0.52
29_N	32_S	0.638	0.52
10_R	360_P	0.637	0.52
554_L	646_T	0.637	0.52
457_A	502_G	0.635	0.52
615_A	624_A	0.635	0.52
285_Q	342_F	0.634	0.52
467_A	544_P	0.634	0.52
199_T	285_Q	0.634	0.52
420_A	467_A	0.634	0.52
652_L	655_A	0.632	0.52
378_D	384_A	0.632	0.52
488_V	491_G	0.632	0.52
296_L	338_Y	0.631	0.52
29_N	205_G	0.631	0.52
275_G	336_G	0.630	0.51
36_A	39_S	0.630	0.51
633_A	661_V	0.630	0.51
560_H	636_S	0.630	0.51
212_E	222_D	0.629	0.51
585_A	589_A	0.629	0.51
673_S	684_D	0.629	0.51
372_P	375_D	0.628	0.51
585_A	599_T	0.628	0.51
598_D	648_D	0.628	0.51
570_L	631_L	0.627	0.51
148_V	409_G	0.627	0.51
680_T	687_T	0.627	0.51
123_F	392_P	0.627	0.51
667_T	673_S	0.627	0.51
175_V	180_L	0.626	0.51
564_L	636_S	0.626	0.51
199_T	300_S	0.626	0.51
243_T	323_Y	0.625	0.51
630_G	677_D	0.625	0.51
389_L	612_V	0.625	0.51
310_P	313_V	0.624	0.51
205_G	236_L	0.624	0.51
222_D	225_A	0.624	0.51
553_D	617_M	0.623	0.51
56_V	106_S	0.623	0.51
394_T	459_E	0.623	0.51
447_C	576_T	0.622	0.51
550_G	625_T	0.621	0.50
190_N	259_A	0.621	0.50
321_T	669_D	0.621	0.50
556_L	661_V	0.621	0.50
137_E	403_Q	0.619	0.50
188_P	332_E	0.619	0.50
51_S	54_V	0.618	0.50
76_V	535_V	0.617	0.50
629_P	676_V	0.617	0.50
151_V	419_D	0.616	0.50
168_N	514_N	0.616	0.50
152_A	438_A	0.616	0.50
174_L	425_L	0.615	0.50
671_T	684_D	0.614	0.50
78_V	476_D	0.613	0.50
22_A	296_L	0.612	0.49
213_D	520_D	0.612	0.49
120_F	135_V	0.610	0.49
435_A	467_A	0.609	0.49
443_G	446_A	0.609	0.49
647_R	662_R	0.608	0.49
373_A	577_D	0.607	0.49
457_A	532_L	0.607	0.49
565_G	580_P	0.606	0.49
606_S	637_E	0.606	0.49
465_A	599_T	0.606	0.49
241_N	253_A	0.605	0.49
557_V	593_A	0.605	0.49
552_G	668_T	0.604	0.49
45_S	48_D	0.604	0.49
603_H	613_T	0.603	0.48
587_V	640_G	0.603	0.48
278_I	330_I	0.602	0.48
489_Y	492_F	0.602	0.48
157_F	163_G	0.601	0.48
234_E	300_S	0.601	0.48
382_G	385_I	0.601	0.48
538_R	543_V	0.601	0.48
246_D	319_V	0.600	0.48
12_V	18_D	0.600	0.48
579_F	681_V	0.600	0.48
493_E	497_A	0.599	0.48
441_N	444_W	0.598	0.48
624_A	663_L	0.598	0.48
548_L	618_V	0.598	0.48
460_N	508_T	0.597	0.48
185_A	252_A	0.597	0.48
484_E	492_F	0.596	0.48
65_V	76_V	0.595	0.47
625_T	651_A	0.595	0.47
86_Y	521_S	0.595	0.47
453_A	530_P	0.595	0.47
281_D	292_A	0.594	0.47
655_A	658_V	0.592	0.47
454_Y	569_Y	0.592	0.47
595_T	598_D	0.590	0.47
549_A	666_A	0.590	0.47
380_A	384_A	0.589	0.47
376_R	380_A	0.589	0.47
630_G	649_A	0.589	0.47
585_A	663_L	0.588	0.47
593_A	596_R	0.587	0.47
562_D	632_A	0.587	0.47
440_A	531_T	0.586	0.46
285_Q	288_P	0.586	0.46
158_H	527_A	0.586	0.46
234_E	264_A	0.586	0.46
318_E	596_R	0.584	0.46
55_V	224_P	0.584	0.46
270_A	352_A	0.583	0.46
684_D	692_R	0.582	0.46
277_R	346_T	0.582	0.46
262_G	316_V	0.581	0.46
650_D	661_V	0.581	0.46
462_T	618_V	0.581	0.46
50_D	65_V	0.580	0.46
204_L	222_D	0.580	0.46
105_L	111_P	0.579	0.46
468_G	542_P	0.579	0.46
618_V	622_A	0.579	0.46
380_A	677_D	0.579	0.46
201_R	293_M	0.577	0.45
281_D	576_T	0.577	0.45
217_D	221_A	0.577	0.45
589_A	660_V	0.576	0.45
570_L	574_G	0.576	0.45
200_G	304_M	0.575	0.45
489_Y	498_G	0.575	0.45
407_E	410_A	0.574	0.45
205_G	499_L	0.574	0.45
53_A	474_A	0.574	0.45
560_H	605_I	0.574	0.45
451_A	582_A	0.572	0.45
248_D	315_A	0.572	0.45
56_V	194_L	0.571	0.45
526_I	533_A	0.570	0.45
394_T	608_G	0.570	0.45
644_V	684_D	0.570	0.45
284_H	327_C	0.570	0.45
454_Y	566_G	0.570	0.45
692_R	695_I	0.568	0.44
475_V	536_G	0.567	0.44
47_F	453_A	0.566	0.44
464_L	474_A	0.566	0.44
168_N	479_N	0.566	0.44
673_S	680_T	0.565	0.44
444_W	565_G	0.564	0.44
194_L	264_A	0.563	0.44
222_D	395_A	0.563	0.44
219_E	423_L	0.562	0.44
432_T	538_R	0.562	0.44
377_P	676_V	0.562	0.44
231_P	453_A	0.562	0.44
86_Y	489_Y	0.562	0.44
496_V	499_L	0.562	0.44
113_A	436_L	0.561	0.44
53_A	473_A	0.560	0.44
380_A	612_V	0.560	0.44
599_T	654_A	0.560	0.44
582_A	640_G	0.560	0.44
117_A	152_A	0.559	0.43
369_P	490_G	0.559	0.43
406_H	412_T	0.559	0.43
569_Y	573_L	0.559	0.43
22_A	293_M	0.559	0.43
148_V	238_I	0.559	0.43
261_L	283_V	0.558	0.43
129_R	133_D	0.558	0.43
7_D	205_G	0.558	0.43
556_L	641_R	0.556	0.43
460_N	478_L	0.555	0.43
556_L	625_T	0.555	0.43
625_T	694_V	0.554	0.43
387_A	572_A	0.553	0.43
54_V	199_T	0.551	0.43
659_P	662_R	0.551	0.43
40_S	80_S	0.551	0.43
131_L	619_T	0.551	0.43
190_N	265_S	0.550	0.42
300_S	330_I	0.550	0.42
192_L	256_L	0.550	0.42
457_A	498_G	0.550	0.42
673_S	676_V	0.550	0.42
377_P	663_L	0.550	0.42
233_T	236_L	0.549	0.42
551_D	596_R	0.549	0.42
252_A	276_A	0.549	0.42
265_S	269_V	0.549	0.42
438_A	531_T	0.549	0.42
217_D	224_P	0.548	0.42
168_N	515_V	0.548	0.42
550_G	622_A	0.547	0.42
470_E	588_D	0.547	0.42
603_H	637_E	0.547	0.42
558_G	638_C	0.544	0.42
378_D	383_T	0.544	0.42
585_A	588_D	0.544	0.42
599_T	656_L	0.544	0.42
2_S	212_E	0.543	0.42
181_V	253_A	0.543	0.42
314_D	592_E	0.543	0.42
71_D	178_D	0.542	0.42
282_A	328_S	0.542	0.42
279_T	292_A	0.541	0.41
478_L	532_L	0.541	0.41
39_S	86_Y	0.541	0.41
669_D	673_S	0.541	0.41
235_K	239_E	0.539	0.41
496_V	532_L	0.539	0.41
175_V	179_R	0.538	0.41
651_A	662_R	0.538	0.41
634_L	674_V	0.538	0.41
602_V	644_V	0.538	0.41
201_R	297_L	0.538	0.41
39_S	365_P	0.538	0.41
556_L	610_L	0.536	0.41
500_A	503_C	0.535	0.41
14_A	353_T	0.535	0.41
550_G	673_S	0.534	0.41
589_A	599_T	0.534	0.41
143_G	150_T	0.534	0.41
683_R	691_H	0.533	0.41
132_L	155_T	0.533	0.41
127_H	130_Y	0.533	0.41
596_R	601_A	0.533	0.41
195_V	237_L	0.532	0.40
291_N	447_C	0.532	0.40
578_Q	581_A	0.532	0.40
87_V	101_V	0.532	0.40
244_L	248_D	0.531	0.40
213_D	484_E	0.531	0.40
13_A	370_Q	0.531	0.40
380_A	631_L	0.530	0.40
39_S	43_L	0.530	0.40
56_V	263_G	0.530	0.40
454_Y	505_A	0.530	0.40
503_C	510_V	0.530	0.40
557_V	660_V	0.529	0.40
467_A	594_A	0.528	0.40
469_A	536_G	0.528	0.40
25_A	297_L	0.528	0.40
665_S	675_T	0.528	0.40
154_A	438_A	0.528	0.40
471_P	536_G	0.528	0.40
262_G	338_Y	0.527	0.40
600_L	666_A	0.526	0.40
629_P	633_A	0.526	0.40
258_A	517_L	0.526	0.40
69_G	684_D	0.525	0.40
419_D	616_E	0.525	0.40
184_A	251_V	0.523	0.39
350_A	355_L	0.523	0.39
598_D	652_L	0.523	0.39
140_S	145_A	0.522	0.39
488_V	496_V	0.522	0.39
87_V	519_N	0.522	0.39
241_N	244_L	0.522	0.39
336_G	349_D	0.522	0.39
86_Y	115_A	0.521	0.39
611_A	634_L	0.521	0.39
329_V	643_V	0.521	0.39
263_G	511_V	0.520	0.39
649_A	653_Q	0.520	0.39
229_G	468_G	0.520	0.39
370_Q	592_E	0.519	0.39
655_A	673_S	0.519	0.39
633_A	663_L	0.518	0.39
13_A	687_T	0.518	0.39
205_G	293_M	0.518	0.39
455_A	582_A	0.518	0.39
97_V	142_Y	0.517	0.39
496_V	500_A	0.517	0.39
598_D	654_A	0.517	0.39
644_V	660_V	0.516	0.39
558_G	563_G	0.516	0.39
114_L	139_I	0.516	0.39
643_V	671_T	0.516	0.39
28_E	36_A	0.515	0.39
603_H	617_M	0.515	0.39
38_R	77_G	0.515	0.39
488_V	498_G	0.515	0.39
10_R	14_A	0.515	0.39
49_S	54_V	0.515	0.39
627_T	654_A	0.514	0.39
615_A	626_V	0.514	0.39
75_T	175_V	0.513	0.38
551_D	647_R	0.513	0.38
598_D	656_L	0.513	0.38
672_L	678_D	0.512	0.38
321_T	332_E	0.512	0.38
600_L	617_M	0.512	0.38
231_P	558_G	0.511	0.38
83_H	94_A	0.511	0.38
669_D	684_D	0.510	0.38
145_A	404_Y	0.510	0.38
395_A	554_L	0.510	0.38
683_R	692_R	0.510	0.38
282_A	430_D	0.510	0.38
156_Q	393_N	0.509	0.38
614_L	618_V	0.509	0.38
548_L	551_D	0.508	0.38
390_S	592_E	0.508	0.38
276_A	333_V	0.507	0.38
457_A	474_A	0.507	0.38
317_R	328_S	0.507	0.38
293_M	453_A	0.507	0.38
470_E	473_A	0.506	0.38
558_G	636_S	0.506	0.38
557_V	658_V	0.506	0.38
582_A	686_A	0.505	0.38
244_L	319_V	0.505	0.38
85_S	167_V	0.505	0.38
240_A	532_L	0.504	0.37
385_I	626_V	0.504	0.37
50_D	507_D	0.504	0.37
675_T	681_V	0.503	0.37
564_L	569_Y	0.503	0.37
26_L	355_L	0.503	0.37
207_A	261_L	0.502	0.37
419_D	604_D	0.502	0.37
195_V	306_Y	0.502	0.37
28_E	253_A	0.502	0.37
101_V	238_I	0.501	0.37
555_V	615_A	0.501	0.37
363_D	366_S	0.501	0.37
16_G	553_D	0.501	0.37
468_G	594_A	0.501	0.37
208_S	212_E	0.500	0.37
520_D	525_P	0.500	0.37

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4lgyA	1	0.9714	100	0.348	Contact Map
3viuA	1	0.9586	100	0.352	Contact Map
1vk3A	1	0.8214	100	0.457	Contact Map
2zodA	2	0.4114	100	0.841	Contact Map
3u0oA	2	0.4257	100	0.846	Contact Map
3fd5A	2	0.4614	100	0.858	Contact Map
2rb9A	2	0.4271	100	0.858	Contact Map
3vtiC	2	0.4114	100	0.863	Contact Map
3wjpA	2	0.4429	100	0.864	Contact Map
2z01A	2	0.4014	100	0.865	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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