Q9HR48 - HALSA - GREMLIN Contacts

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Q9HR48 - Uncharacterized protein

UniProt:	Q9HR48	Sequences: MLLEQAQAVGLDALAVTDHDEIDASLRAAELAADYDLVGIPGMEVTSADGHVLAIGVERAVPAGLPFAETLAEIRDRGGIAIVPHPFQSSRSGVAPHISRRELASADAIEVYNSRLLTGLANRKAETFAEHNDCPMTAGSDAHIAEMVGQAVTRIDADGHTVEAILDAIRAGETTVNGKRTPWHISFRQAAGGAKRRITNRLAEFF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	206 (171)
Sequences:	1971 (1604)
Seq/√Len:	122.6

ECOLI - PHPDC
HALSA - Q9HR48 Q9HML2
SULSO - Q97ZL9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
75_R	107_D	5.444	1.00
17_T	42_G	5.305	1.00
74_I	79_G	5.259	1.00
53_L	84_P	3.323	1.00
81_A	107_D	3.322	1.00
75_R	81_A	3.053	1.00
111_V	136_M	2.901	1.00
32_A	39_G	2.529	1.00
54_A	74_I	2.457	1.00
7_Q	36_D	2.324	1.00
82_I	108_A	2.315	1.00
7_Q	37_L	2.202	1.00
5_Q	8_A	2.167	1.00
6_A	11_L	2.012	1.00
46_T	51_H	1.991	1.00
74_I	81_A	1.956	1.00
31_L	34_D	1.868	1.00
82_I	137_T	1.841	1.00
55_I	82_I	1.839	1.00
122_N	125_A	1.839	1.00
73_E	76_D	1.787	1.00
68_A	72_A	1.783	1.00
5_Q	9_V	1.769	1.00
66_P	69_E	1.734	1.00
4_E	31_L	1.680	1.00
47_S	52_V	1.660	1.00
126_E	136_M	1.612	1.00
167_D	171_A	1.591	1.00
45_V	54_A	1.570	1.00
7_Q	35_Y	1.564	1.00
20_D	46_T	1.537	1.00
149_G	152_V	1.516	1.00
155_I	159_G	1.501	1.00
30_E	34_D	1.497	1.00
53_L	137_T	1.485	1.00
108_A	135_P	1.473	1.00
87_F	125_A	1.471	1.00
130_E	136_M	1.466	1.00
52_V	74_I	1.398	1.00
43_M	54_A	1.364	1.00
138_A	153_T	1.330	1.00
166_L	170_R	1.312	1.00
117_L	121_A	1.308	1.00
29_A	33_A	1.298	1.00
95_A	131_H	1.295	1.00
72_A	76_D	1.287	1.00
32_A	36_D	1.285	1.00
25_S	39_G	1.276	1.00
19_H	143_H	1.271	1.00
65_L	70_T	1.271	1.00
11_L	14_L	1.264	1.00
21_E	24_A	1.256	1.00
148_V	151_A	1.242	0.99
83_V	106_A	1.219	0.99
69_E	72_A	1.197	0.99
52_V	67_F	1.177	0.99
47_S	50_G	1.160	0.99
111_V	126_E	1.159	0.99
16_V	24_A	1.153	0.99
106_A	134_C	1.147	0.99
159_G	165_I	1.128	0.99
73_E	77_R	1.125	0.99
2_L	16_V	1.113	0.99
72_A	105_S	1.104	0.99
45_V	70_T	1.096	0.99
129_A	136_M	1.096	0.99
13_A	38_V	1.086	0.99
101_R	105_S	1.080	0.99
149_G	153_T	1.077	0.98
6_A	14_L	1.058	0.98
13_A	40_I	1.054	0.98
71_L	105_S	1.051	0.98
4_E	7_Q	1.029	0.98
54_A	57_V	1.022	0.98
5_Q	142_A	1.007	0.98
167_D	170_R	1.000	0.98
14_L	148_V	0.988	0.97
126_E	129_A	0.982	0.97
26_L	30_E	0.981	0.97
113_N	116_L	0.981	0.97
4_E	8_A	0.978	0.97
7_Q	34_D	0.975	0.97
29_A	41_P	0.961	0.97
14_L	39_G	0.958	0.97
71_L	81_A	0.953	0.97
3_L	39_G	0.953	0.97
113_N	138_A	0.952	0.97
53_L	139_G	0.948	0.97
85_H	143_H	0.946	0.97
58_E	61_V	0.942	0.96
148_V	152_V	0.934	0.96
22_I	57_V	0.930	0.96
15_A	55_I	0.919	0.96
111_V	129_A	0.916	0.96
56_G	166_L	0.915	0.96
135_P	172_G	0.914	0.96
54_A	70_T	0.911	0.96
128_F	132_N	0.907	0.96
147_M	150_Q	0.902	0.95
75_R	80_I	0.901	0.95
25_S	41_P	0.899	0.95
53_L	82_I	0.898	0.95
19_H	85_H	0.880	0.95
163_E	167_D	0.878	0.95
117_L	120_L	0.876	0.95
151_A	155_I	0.866	0.94
32_A	37_L	0.858	0.94
29_A	39_G	0.857	0.94
25_S	29_A	0.837	0.93
15_A	40_I	0.836	0.93
159_G	162_V	0.835	0.93
152_V	155_I	0.834	0.93
99_S	132_N	0.828	0.93
48_A	66_P	0.825	0.93
68_A	100_R	0.823	0.93
71_L	75_R	0.823	0.93
6_A	20_D	0.820	0.93
124_K	127_T	0.817	0.92
156_D	159_G	0.814	0.92
87_F	121_A	0.809	0.92
54_A	71_L	0.804	0.92
139_G	153_T	0.801	0.92
159_G	164_A	0.796	0.91
3_L	37_L	0.794	0.91
43_M	57_V	0.793	0.91
54_A	79_G	0.793	0.91
157_A	164_A	0.789	0.91
157_A	162_V	0.785	0.91
137_T	153_T	0.785	0.91
121_A	124_K	0.784	0.91
47_S	67_F	0.783	0.91
28_A	32_A	0.781	0.91
123_R	127_T	0.776	0.90
53_L	108_A	0.775	0.90
52_V	106_A	0.768	0.90
40_I	56_G	0.765	0.90
127_T	130_E	0.764	0.90
41_P	51_H	0.764	0.90
3_L	32_A	0.761	0.90
157_A	161_T	0.750	0.89
3_L	31_L	0.743	0.88
149_G	156_D	0.743	0.88
54_A	81_A	0.742	0.88
162_V	166_L	0.741	0.88
80_I	166_L	0.740	0.88
55_I	166_L	0.737	0.88
118_T	123_R	0.732	0.88
50_G	87_F	0.729	0.87
155_I	158_D	0.722	0.87
33_A	131_H	0.719	0.87
115_R	147_M	0.716	0.86
144_I	147_M	0.716	0.86
57_V	79_G	0.713	0.86
80_I	107_D	0.711	0.86
3_L	35_Y	0.707	0.86
158_D	164_A	0.706	0.86
32_A	35_Y	0.704	0.86
4_E	35_Y	0.700	0.85
87_F	122_N	0.699	0.85
24_A	28_A	0.688	0.84
160_H	164_A	0.688	0.84
111_V	125_A	0.687	0.84
38_V	160_H	0.686	0.84
4_E	33_A	0.679	0.83
11_L	92_S	0.675	0.83
38_V	165_I	0.673	0.83
51_H	85_H	0.672	0.83
114_S	122_N	0.672	0.83
113_N	122_N	0.671	0.83
74_I	166_L	0.669	0.83
157_A	165_I	0.668	0.82
55_I	137_T	0.667	0.82
15_A	165_I	0.665	0.82
19_H	141_D	0.662	0.82
30_E	120_L	0.662	0.82
40_I	83_V	0.662	0.82
112_Y	122_N	0.662	0.82
9_V	150_Q	0.661	0.82
28_A	35_Y	0.656	0.81
51_H	55_I	0.654	0.81
11_L	140_S	0.654	0.81
108_A	140_S	0.653	0.81
3_L	28_A	0.647	0.80
86_P	113_N	0.643	0.80
31_L	35_Y	0.643	0.80
68_A	71_L	0.640	0.80
10_G	13_A	0.640	0.80
83_V	139_G	0.639	0.80
46_T	84_P	0.639	0.80
142_A	148_V	0.637	0.79
98_I	101_R	0.628	0.78
16_V	25_S	0.619	0.77
58_E	125_A	0.618	0.77
108_A	169_I	0.618	0.77
50_G	114_S	0.617	0.77
72_A	107_D	0.616	0.77
53_L	116_L	0.613	0.77
161_T	164_A	0.612	0.77
87_F	116_L	0.611	0.77
148_V	155_I	0.611	0.77
74_I	80_I	0.610	0.76
138_A	144_I	0.608	0.76
41_P	57_V	0.605	0.76
86_P	138_A	0.602	0.75
98_I	109_I	0.600	0.75
74_I	77_R	0.597	0.75
2_L	5_Q	0.596	0.75
111_V	133_D	0.596	0.75
6_A	55_I	0.595	0.75
7_Q	32_A	0.593	0.74
151_A	154_R	0.591	0.74
155_I	161_T	0.590	0.74
83_V	92_S	0.590	0.74
26_L	29_A	0.581	0.73
21_E	47_S	0.580	0.73
18_D	141_D	0.578	0.73
3_L	16_V	0.577	0.72
150_Q	155_I	0.577	0.72
51_H	84_P	0.576	0.72
148_V	153_T	0.572	0.72
49_D	65_L	0.569	0.71
25_S	74_I	0.569	0.71
9_V	151_A	0.564	0.71
41_P	162_V	0.563	0.71
163_E	168_A	0.562	0.70
111_V	116_L	0.561	0.70
87_F	128_F	0.558	0.70
13_A	157_A	0.556	0.70
154_R	157_A	0.551	0.69
25_S	51_H	0.547	0.68
89_S	124_K	0.547	0.68
43_M	51_H	0.546	0.68
91_R	94_V	0.542	0.68
70_T	74_I	0.540	0.67
22_I	25_S	0.540	0.67
116_L	125_A	0.540	0.67
85_H	141_D	0.536	0.67
55_I	165_I	0.536	0.67
65_L	73_E	0.530	0.66
75_R	105_S	0.530	0.66
45_V	52_V	0.528	0.66
9_V	148_V	0.527	0.66
90_S	93_G	0.523	0.65
12_D	38_V	0.522	0.65
84_P	117_L	0.517	0.64
102_E	133_D	0.515	0.64
116_L	150_Q	0.514	0.64
91_R	95_A	0.511	0.63
6_A	140_S	0.511	0.63
63_A	146_E	0.508	0.63
169_I	173_E	0.506	0.62
47_S	140_S	0.505	0.62
156_D	173_E	0.503	0.62
129_A	133_D	0.503	0.62
128_F	131_H	0.501	0.62
71_L	79_G	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3o0fA	1	0.8398	100	0.47	Contact Map
2yb1A	1	0.8544	100	0.473	Contact Map
3e38A	4	0.9806	99.9	0.488	Contact Map
2anuA	5	0.8107	99.9	0.491	Contact Map
2wjeA	1	0.8786	99.8	0.618	Contact Map
1m65A	3	0.9029	99.8	0.627	Contact Map
2w9mA	1	0.835	99.7	0.632	Contact Map
3qy7A	1	0.9369	99.7	0.636	Contact Map
2yxoA	3	0.8738	99.7	0.653	Contact Map
4gc3A	1	0.8398	99.7	0.66	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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