GREMLIN Database
Q9HR48 - Uncharacterized protein
UniProt: Q9HR48 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 206 (171)
Sequences: 1971 (1604)
Seq/√Len: 122.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_R107_D5.4441.00
17_T42_G5.3051.00
74_I79_G5.2591.00
53_L84_P3.3231.00
81_A107_D3.3221.00
75_R81_A3.0531.00
111_V136_M2.9011.00
32_A39_G2.5291.00
54_A74_I2.4571.00
7_Q36_D2.3241.00
82_I108_A2.3151.00
7_Q37_L2.2021.00
5_Q8_A2.1671.00
6_A11_L2.0121.00
46_T51_H1.9911.00
74_I81_A1.9561.00
31_L34_D1.8681.00
82_I137_T1.8411.00
55_I82_I1.8391.00
122_N125_A1.8391.00
73_E76_D1.7871.00
68_A72_A1.7831.00
5_Q9_V1.7691.00
66_P69_E1.7341.00
4_E31_L1.6801.00
47_S52_V1.6601.00
126_E136_M1.6121.00
167_D171_A1.5911.00
45_V54_A1.5701.00
7_Q35_Y1.5641.00
20_D46_T1.5371.00
149_G152_V1.5161.00
155_I159_G1.5011.00
30_E34_D1.4971.00
53_L137_T1.4851.00
108_A135_P1.4731.00
87_F125_A1.4711.00
130_E136_M1.4661.00
52_V74_I1.3981.00
43_M54_A1.3641.00
138_A153_T1.3301.00
166_L170_R1.3121.00
117_L121_A1.3081.00
29_A33_A1.2981.00
95_A131_H1.2951.00
72_A76_D1.2871.00
32_A36_D1.2851.00
25_S39_G1.2761.00
19_H143_H1.2711.00
65_L70_T1.2711.00
11_L14_L1.2641.00
21_E24_A1.2561.00
148_V151_A1.2420.99
83_V106_A1.2190.99
69_E72_A1.1970.99
52_V67_F1.1770.99
47_S50_G1.1600.99
111_V126_E1.1590.99
16_V24_A1.1530.99
106_A134_C1.1470.99
159_G165_I1.1280.99
73_E77_R1.1250.99
2_L16_V1.1130.99
72_A105_S1.1040.99
45_V70_T1.0960.99
129_A136_M1.0960.99
13_A38_V1.0860.99
101_R105_S1.0800.99
149_G153_T1.0770.98
6_A14_L1.0580.98
13_A40_I1.0540.98
71_L105_S1.0510.98
4_E7_Q1.0290.98
54_A57_V1.0220.98
5_Q142_A1.0070.98
167_D170_R1.0000.98
14_L148_V0.9880.97
126_E129_A0.9820.97
26_L30_E0.9810.97
113_N116_L0.9810.97
4_E8_A0.9780.97
7_Q34_D0.9750.97
29_A41_P0.9610.97
14_L39_G0.9580.97
71_L81_A0.9530.97
3_L39_G0.9530.97
113_N138_A0.9520.97
53_L139_G0.9480.97
85_H143_H0.9460.97
58_E61_V0.9420.96
148_V152_V0.9340.96
22_I57_V0.9300.96
15_A55_I0.9190.96
111_V129_A0.9160.96
56_G166_L0.9150.96
135_P172_G0.9140.96
54_A70_T0.9110.96
128_F132_N0.9070.96
147_M150_Q0.9020.95
75_R80_I0.9010.95
25_S41_P0.8990.95
53_L82_I0.8980.95
19_H85_H0.8800.95
163_E167_D0.8780.95
117_L120_L0.8760.95
151_A155_I0.8660.94
32_A37_L0.8580.94
29_A39_G0.8570.94
25_S29_A0.8370.93
15_A40_I0.8360.93
159_G162_V0.8350.93
152_V155_I0.8340.93
99_S132_N0.8280.93
48_A66_P0.8250.93
68_A100_R0.8230.93
71_L75_R0.8230.93
6_A20_D0.8200.93
124_K127_T0.8170.92
156_D159_G0.8140.92
87_F121_A0.8090.92
54_A71_L0.8040.92
139_G153_T0.8010.92
159_G164_A0.7960.91
3_L37_L0.7940.91
43_M57_V0.7930.91
54_A79_G0.7930.91
157_A164_A0.7890.91
157_A162_V0.7850.91
137_T153_T0.7850.91
121_A124_K0.7840.91
47_S67_F0.7830.91
28_A32_A0.7810.91
123_R127_T0.7760.90
53_L108_A0.7750.90
52_V106_A0.7680.90
40_I56_G0.7650.90
127_T130_E0.7640.90
41_P51_H0.7640.90
3_L32_A0.7610.90
157_A161_T0.7500.89
3_L31_L0.7430.88
149_G156_D0.7430.88
54_A81_A0.7420.88
162_V166_L0.7410.88
80_I166_L0.7400.88
55_I166_L0.7370.88
118_T123_R0.7320.88
50_G87_F0.7290.87
155_I158_D0.7220.87
33_A131_H0.7190.87
115_R147_M0.7160.86
144_I147_M0.7160.86
57_V79_G0.7130.86
80_I107_D0.7110.86
3_L35_Y0.7070.86
158_D164_A0.7060.86
32_A35_Y0.7040.86
4_E35_Y0.7000.85
87_F122_N0.6990.85
24_A28_A0.6880.84
160_H164_A0.6880.84
111_V125_A0.6870.84
38_V160_H0.6860.84
4_E33_A0.6790.83
11_L92_S0.6750.83
38_V165_I0.6730.83
51_H85_H0.6720.83
114_S122_N0.6720.83
113_N122_N0.6710.83
74_I166_L0.6690.83
157_A165_I0.6680.82
55_I137_T0.6670.82
15_A165_I0.6650.82
19_H141_D0.6620.82
30_E120_L0.6620.82
40_I83_V0.6620.82
112_Y122_N0.6620.82
9_V150_Q0.6610.82
28_A35_Y0.6560.81
51_H55_I0.6540.81
11_L140_S0.6540.81
108_A140_S0.6530.81
3_L28_A0.6470.80
86_P113_N0.6430.80
31_L35_Y0.6430.80
68_A71_L0.6400.80
10_G13_A0.6400.80
83_V139_G0.6390.80
46_T84_P0.6390.80
142_A148_V0.6370.79
98_I101_R0.6280.78
16_V25_S0.6190.77
58_E125_A0.6180.77
108_A169_I0.6180.77
50_G114_S0.6170.77
72_A107_D0.6160.77
53_L116_L0.6130.77
161_T164_A0.6120.77
87_F116_L0.6110.77
148_V155_I0.6110.77
74_I80_I0.6100.76
138_A144_I0.6080.76
41_P57_V0.6050.76
86_P138_A0.6020.75
98_I109_I0.6000.75
74_I77_R0.5970.75
2_L5_Q0.5960.75
111_V133_D0.5960.75
6_A55_I0.5950.75
7_Q32_A0.5930.74
151_A154_R0.5910.74
155_I161_T0.5900.74
83_V92_S0.5900.74
26_L29_A0.5810.73
21_E47_S0.5800.73
18_D141_D0.5780.73
3_L16_V0.5770.72
150_Q155_I0.5770.72
51_H84_P0.5760.72
148_V153_T0.5720.72
49_D65_L0.5690.71
25_S74_I0.5690.71
9_V151_A0.5640.71
41_P162_V0.5630.71
163_E168_A0.5620.70
111_V116_L0.5610.70
87_F128_F0.5580.70
13_A157_A0.5560.70
154_R157_A0.5510.69
25_S51_H0.5470.68
89_S124_K0.5470.68
43_M51_H0.5460.68
91_R94_V0.5420.68
70_T74_I0.5400.67
22_I25_S0.5400.67
116_L125_A0.5400.67
85_H141_D0.5360.67
55_I165_I0.5360.67
65_L73_E0.5300.66
75_R105_S0.5300.66
45_V52_V0.5280.66
9_V148_V0.5270.66
90_S93_G0.5230.65
12_D38_V0.5220.65
84_P117_L0.5170.64
102_E133_D0.5150.64
116_L150_Q0.5140.64
91_R95_A0.5110.63
6_A140_S0.5110.63
63_A146_E0.5080.63
169_I173_E0.5060.62
47_S140_S0.5050.62
156_D173_E0.5030.62
129_A133_D0.5030.62
128_F131_H0.5010.62
71_L79_G0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o0fA 1 0.8398 100 0.47 Contact Map
2yb1A 1 0.8544 100 0.473 Contact Map
3e38A 4 0.9806 99.9 0.488 Contact Map
2anuA 5 0.8107 99.9 0.491 Contact Map
2wjeA 1 0.8786 99.8 0.618 Contact Map
1m65A 3 0.9029 99.8 0.627 Contact Map
2w9mA 1 0.835 99.7 0.632 Contact Map
3qy7A 1 0.9369 99.7 0.636 Contact Map
2yxoA 3 0.8738 99.7 0.653 Contact Map
4gc3A 1 0.8398 99.7 0.66 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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