GREMLIN Database
Q9HR47 - Asparagine synthetase
UniProt: Q9HR47 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 360 (313)
Sequences: 5773 (4167)
Seq/√Len: 235.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_P162_D3.9511.00
101_A284_A3.3441.00
127_L307_A3.2991.00
14_Q17_D3.2101.00
151_R165_V3.0281.00
116_A210_Y3.0271.00
152_E314_A3.0141.00
117_V129_A2.9681.00
39_L282_V2.9321.00
11_D18_P2.8511.00
34_L44_C2.7231.00
41_R274_T2.6791.00
99_R309_S2.6291.00
91_G305_E2.5511.00
305_E308_R2.5101.00
26_A34_L2.5081.00
69_V79_R2.4931.00
102_V131_A2.4041.00
204_R208_D2.3261.00
15_S19_L2.2831.00
68_H80_P2.2621.00
135_P164_R2.2431.00
38_V279_D2.1891.00
64_L70_R2.1831.00
151_R155_A2.1761.00
295_S301_R2.1491.00
65_P68_H2.1491.00
265_L272_P2.1461.00
108_G280_D2.1241.00
97_R101_A2.1221.00
313_D317_D2.1021.00
20_P280_D2.0701.00
91_G292_W2.0431.00
104_G280_D1.9951.00
33_R74_A1.9661.00
223_F285_A1.9481.00
25_F35_A1.9331.00
20_P108_G1.9151.00
136_L159_R1.9081.00
126_A153_S1.9011.00
308_R317_D1.8671.00
65_P78_G1.8421.00
103_A131_A1.8401.00
16_G69_V1.8361.00
34_L70_R1.8341.00
13_V79_R1.8321.00
20_P279_D1.7921.00
202_A265_L1.7791.00
68_H78_G1.7291.00
28_E33_R1.7271.00
13_V71_A1.7271.00
97_R100_D1.7171.00
99_R306_A1.7101.00
104_G108_G1.7041.00
98_V223_F1.6991.00
95_V305_E1.6821.00
150_A154_A1.6791.00
149_A318_R1.6791.00
23_G35_A1.6741.00
20_P278_H1.6741.00
91_G95_V1.6681.00
46_V62_T1.6491.00
110_P132_L1.6241.00
99_R310_W1.6081.00
301_R305_E1.6081.00
219_A276_L1.5991.00
97_R284_A1.5981.00
138_V150_A1.5801.00
99_R103_A1.5791.00
48_G62_T1.5771.00
29_L32_G1.5591.00
309_S313_D1.5521.00
129_A159_R1.5371.00
16_G35_A1.5281.00
279_D283_R1.5261.00
179_T203_A1.5221.00
91_G301_R1.5151.00
41_R109_V1.5131.00
22_T109_V1.4971.00
229_V249_E1.4971.00
129_A157_M1.4871.00
308_R313_D1.4801.00
136_L163_L1.4721.00
98_V284_A1.4661.00
105_A109_V1.4641.00
73_G76_G1.4631.00
101_A281_V1.4411.00
22_T41_R1.4351.00
169_T172_D1.4211.00
104_G107_G1.4091.00
80_P83_S1.4061.00
82_W283_R1.4011.00
171_A175_A1.3901.00
94_P292_W1.3871.00
63_L186_R1.3851.00
159_R163_L1.3831.00
131_A310_W1.3801.00
94_P288_L1.3611.00
183_A267_A1.3361.00
212_R273_V1.3331.00
91_G295_S1.3261.00
137_Y209_G1.3231.00
16_G25_F1.3221.00
142_A167_E1.3111.00
15_S25_F1.3031.00
20_P104_G1.2991.00
95_V306_A1.2961.00
108_G111_A1.2871.00
132_L214_V1.2761.00
96_E100_D1.2751.00
147_I165_V1.2641.00
142_A169_T1.2541.00
20_P109_V1.2521.00
289_P292_W1.2501.00
8_A15_S1.2471.00
96_E309_S1.2321.00
140_G147_I1.2281.00
8_A27_G1.2271.00
280_D283_R1.2221.00
221_E226_Y1.2031.00
218_G277_L1.1891.00
137_Y208_D1.1741.00
128_A214_V1.1741.00
284_A288_L1.1641.00
102_V276_L1.1601.00
126_A311_L1.1551.00
172_D203_A1.1331.00
215_V272_P1.1251.00
35_A69_V1.1251.00
288_L302_A1.1131.00
117_V136_L1.0941.00
176_A200_L1.0861.00
133_D162_D1.0821.00
199_F268_A1.0761.00
262_L266_R1.0741.00
95_V99_R1.0591.00
118_A205_A1.0571.00
239_D290_G1.0551.00
320_K323_V1.0531.00
101_A280_D1.0471.00
105_A278_H1.0401.00
22_T42_R1.0331.00
127_L306_A1.0231.00
115_L212_R1.0161.00
153_S315_V1.0151.00
149_A152_E1.0091.00
184_I264_A1.0071.00
11_D15_S1.0041.00
276_L303_L1.0021.00
140_G167_E1.0001.00
261_D272_P1.0001.00
98_V303_L0.9981.00
30_P33_R0.9971.00
8_A12_A0.9871.00
217_Q260_R0.9841.00
147_I167_E0.9831.00
176_A203_A0.9821.00
116_A213_L0.9781.00
207_A211_S0.9751.00
98_V281_V0.9731.00
152_E155_A0.9671.00
166_H204_R0.9661.00
172_D175_A0.9661.00
12_A15_S0.9651.00
298_T304_R0.9621.00
102_V127_L0.9561.00
179_T182_R0.9521.00
102_V281_V0.9501.00
129_A136_L0.9481.00
130_A310_W0.9441.00
71_A77_S0.9361.00
128_A276_L0.9341.00
95_V309_S0.9341.00
205_A213_L0.9331.00
224_G294_V0.9291.00
91_G94_P0.9271.00
67_G82_W0.9271.00
222_L282_V0.9171.00
164_R209_G0.9161.00
97_R287_A0.9141.00
217_Q261_D0.9121.00
200_L203_A0.9101.00
126_A149_A0.9081.00
100_D103_A0.9051.00
99_R131_A0.9041.00
262_L271_E0.9021.00
83_S251_V0.8981.00
23_G38_V0.8950.99
32_G73_G0.8890.99
109_V278_H0.8880.99
152_E156_A0.8840.99
117_V132_L0.8830.99
190_M194_I0.8830.99
106_L131_A0.8810.99
94_P289_P0.8780.99
103_A107_G0.8780.99
94_P284_A0.8770.99
309_S316_A0.8720.99
98_V285_A0.8720.99
101_A104_G0.8650.99
201_V205_A0.8650.99
112_G115_L0.8640.99
130_A157_M0.8550.99
130_A311_L0.8540.99
45_Y263_R0.8520.99
224_G246_A0.8500.99
149_A153_S0.8490.99
137_Y210_Y0.8470.99
204_R207_A0.8470.99
42_R262_L0.8460.99
176_A179_T0.8450.99
86_E286_L0.8410.99
241_D244_R0.8370.99
285_A288_L0.8360.99
15_S35_A0.8350.99
185_G263_R0.8340.99
9_V31_D0.8280.99
70_R78_G0.8270.99
307_A310_W0.8200.99
156_A314_A0.8180.99
24_G44_C0.8170.99
194_I197_P0.8140.99
281_V284_A0.8120.99
105_A108_G0.8110.99
103_A310_W0.8070.99
64_L78_G0.8070.99
38_V81_V0.7990.99
14_Q18_P0.7970.99
36_R40_G0.7970.99
117_V128_A0.7880.99
203_A207_A0.7870.99
234_T237_R0.7840.99
95_V98_V0.7820.99
247_R251_V0.7810.99
199_F267_A0.7770.99
179_T183_A0.7760.99
94_P97_R0.7750.99
184_I190_M0.7750.99
54_D65_P0.7720.98
114_D211_S0.7660.98
243_V293_L0.7650.98
98_V102_V0.7650.98
306_A309_S0.7640.98
281_V285_A0.7620.98
106_L128_A0.7620.98
109_V274_T0.7590.98
222_L285_A0.7580.98
118_A202_A0.7570.98
198_L261_D0.7560.98
44_C64_L0.7550.98
258_L277_L0.7530.98
42_R266_R0.7530.98
257_Q261_D0.7480.98
266_R271_E0.7480.98
8_A11_D0.7460.98
38_V82_W0.7460.98
73_G77_S0.7450.98
36_R44_C0.7430.98
118_A213_L0.7430.98
284_A287_A0.7420.98
192_V260_R0.7390.98
150_A165_V0.7390.98
180_V264_A0.7380.98
259_E263_R0.7330.98
155_A158_G0.7310.98
57_D186_R0.7300.98
13_V69_V0.7290.98
298_T317_D0.7280.98
102_V307_A0.7270.98
239_D243_V0.7260.98
313_D316_A0.7220.98
184_I195_A0.7220.98
236_P239_D0.7190.98
191_A194_I0.7190.98
307_A311_L0.7180.98
190_M193_Q0.7160.98
98_V306_A0.7110.97
299_R304_R0.7090.97
92_D95_V0.7050.97
95_V301_R0.7040.97
71_A79_R0.7030.97
119_F136_L0.7020.97
283_R287_A0.7000.97
189_A192_V0.6980.97
164_R208_D0.6950.97
192_V195_A0.6920.97
148_A152_E0.6910.97
213_L270_V0.6880.97
22_T271_E0.6870.97
56_R61_P0.6860.97
218_G221_E0.6850.97
39_L250_T0.6850.97
93_E97_R0.6790.97
85_P88_A0.6780.97
176_A196_L0.6740.96
228_K249_E0.6730.96
46_V70_R0.6730.96
136_L165_V0.6720.96
98_V302_A0.6710.96
314_A317_D0.6700.96
215_V274_T0.6680.96
138_V147_I0.6670.96
145_S148_A0.6670.96
233_P238_T0.6670.96
154_A159_R0.6650.96
194_I260_R0.6650.96
52_S55_P0.6590.96
284_A302_A0.6580.96
137_Y164_R0.6560.96
37_D40_G0.6560.96
298_T301_R0.6500.96
67_G81_V0.6490.96
175_A178_P0.6450.95
108_G278_H0.6410.95
106_L132_L0.6360.95
100_D107_G0.6350.95
191_A195_A0.6340.95
295_S305_E0.6320.95
127_L223_F0.6320.95
219_A222_L0.6310.95
158_G162_D0.6290.95
119_F153_S0.6290.95
126_A318_R0.6270.95
116_A205_A0.6260.95
80_P251_V0.6250.95
305_E317_D0.6250.95
8_A29_L0.6230.95
205_A210_Y0.6230.95
16_G81_V0.6210.94
300_K320_K0.6210.94
51_W54_D0.6200.94
58_L61_P0.6190.94
95_V302_A0.6190.94
22_T274_T0.6180.94
234_T238_T0.6180.94
243_V290_G0.6160.94
140_G150_A0.6150.94
16_G19_L0.6140.94
154_A158_G0.6130.94
181_A184_I0.6110.94
84_L250_T0.6110.94
62_T78_G0.6100.94
150_A163_L0.6100.94
98_V101_A0.6090.94
199_F203_A0.6070.94
189_A193_Q0.6060.94
47_D61_P0.6060.94
135_P210_Y0.5980.93
203_A268_A0.5980.93
228_K232_A0.5980.93
15_S69_V0.5950.93
235_D238_T0.5940.93
48_G60_A0.5940.93
112_G212_R0.5930.93
34_L72_P0.5920.93
28_E74_A0.5920.93
19_L23_G0.5920.93
243_V246_A0.5920.93
318_R321_K0.5920.93
213_L265_L0.5920.93
151_R154_A0.5910.93
220_D300_K0.5900.93
186_R189_A0.5890.93
249_E253_S0.5880.93
120_S124_D0.5870.93
176_A180_V0.5860.93
306_A310_W0.5840.92
304_R316_A0.5820.92
23_G81_V0.5820.92
217_Q257_Q0.5800.92
321_K324_Q0.5790.92
118_A215_V0.5790.92
17_D79_R0.5780.92
25_F34_L0.5780.92
211_S271_E0.5750.92
292_W301_R0.5740.92
113_D211_S0.5730.92
311_L316_A0.5710.92
83_S247_R0.5700.92
230_A299_R0.5680.91
130_A156_A0.5680.91
192_V198_L0.5670.91
15_S27_G0.5670.91
89_P287_A0.5660.91
128_A215_V0.5650.91
39_L82_W0.5640.91
242_T245_G0.5640.91
106_L214_V0.5640.91
83_S86_E0.5640.91
100_D104_G0.5630.91
54_D63_L0.5620.91
72_P76_G0.5610.91
177_V181_A0.5600.91
194_I323_V0.5590.91
298_T305_E0.5560.91
294_V301_R0.5560.91
94_P287_A0.5550.90
302_A305_E0.5550.90
190_M217_Q0.5540.90
312_P315_V0.5540.90
243_V247_R0.5530.90
302_A306_A0.5520.90
123_V304_R0.5520.90
223_F303_L0.5490.90
147_I151_R0.5470.90
22_T266_R0.5460.90
102_V128_A0.5460.90
234_T239_D0.5450.90
198_L264_A0.5450.90
135_P209_G0.5440.90
256_A259_E0.5430.90
41_R259_E0.5420.89
228_K231_K0.5410.89
49_D60_A0.5410.89
91_G302_A0.5400.89
311_L315_V0.5390.89
115_L211_S0.5380.89
26_A70_R0.5370.89
147_I150_A0.5370.89
105_A281_V0.5350.89
36_R43_L0.5350.89
300_K303_L0.5340.89
175_A179_T0.5340.89
148_A151_R0.5330.89
211_S266_R0.5330.89
118_A192_V0.5300.88
32_G71_A0.5300.88
124_D300_K0.5290.88
114_D135_P0.5290.88
14_Q31_D0.5280.88
247_R286_L0.5270.88
157_M163_L0.5260.88
138_V163_L0.5250.88
90_T287_A0.5240.88
164_R204_R0.5230.88
48_G75_T0.5230.88
230_A294_V0.5200.87
193_Q228_K0.5200.87
182_R185_G0.5200.87
121_G138_V0.5190.87
123_V307_A0.5190.87
39_L281_V0.5190.87
34_L64_L0.5190.87
242_T290_G0.5190.87
179_T199_F0.5190.87
42_R274_T0.5170.87
201_V204_R0.5170.87
192_V197_P0.5170.87
285_A302_A0.5150.87
232_A245_G0.5150.87
121_G318_R0.5150.87
111_A115_L0.5140.87
156_A309_S0.5140.87
89_P94_P0.5130.87
236_P241_D0.5120.87
113_D271_E0.5120.87
56_R146_D0.5120.87
162_D165_V0.5090.86
84_L286_L0.5060.86
179_T267_A0.5060.86
249_E256_A0.5040.86
102_V303_L0.5040.86
45_Y254_L0.5030.86
121_G153_S0.5030.86
119_F163_L0.5010.85
229_V246_A0.5010.85
253_S257_Q0.5010.85
209_G270_V0.5010.85
153_S157_M0.5010.85
127_L309_S0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ct9A 2 0.9778 100 0.28 Contact Map
1q15A 3 0.9333 100 0.293 Contact Map
1jgtA 2 0.95 100 0.312 Contact Map
3sdbA 6 0.8861 99.4 0.834 Contact Map
4q16A 2 0.6611 99.3 0.841 Contact Map
3k32A 2 0.5028 99.3 0.844 Contact Map
4f4hA 2 0.8167 99.2 0.846 Contact Map
3p52A 3 0.5917 99.2 0.846 Contact Map
1ao0A 3 0.7889 99.1 0.854 Contact Map
3n05A 2 0.7889 99.1 0.856 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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