Q9HR47 - HALSA - GREMLIN Contacts

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Q9HR47 - Asparagine synthetase

UniProt:	Q9HR47	Sequences: MRGAAPDAVLDAVQSGDPLPGTGGFAGELPDGRLARDVLGRRLCYVDGDEWSHDPRDLAAPTLLPAGHVRAPGATGSGRPVWSLPEPAPTGDEPVERVRDAVAGALGGVPAGDDLAVAFSGGVDSALAAAALDAPLYVVGYADSSDIAAARESAAAMGRADDLRVHEVTLADIEAAVPTVARAIGRTNAMAVQIALPLFLVAARAAADGYSRLVVGQGADELFGGYAKVAKAPTDPRTDADTVRGARRETVQSLPAQLERDLRALRAAGVEPVTPLLHDDVVRAALALPGEWLVSGDTRKRALREAARSWLPDAVADRDKKAVQYGSLVAREVDRLARQAGFKRRMDDHVTQYVEARIEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	360 (313)
Sequences:	5773 (4167)
Seq/√Len:	235.6

ECOLI - ASNB
BACSU - ASNH ASNB ASNO
HALSA - Q9HR47

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
135_P	162_D	3.951	1.00
101_A	284_A	3.344	1.00
127_L	307_A	3.299	1.00
14_Q	17_D	3.210	1.00
151_R	165_V	3.028	1.00
116_A	210_Y	3.027	1.00
152_E	314_A	3.014	1.00
117_V	129_A	2.968	1.00
39_L	282_V	2.932	1.00
11_D	18_P	2.851	1.00
34_L	44_C	2.723	1.00
41_R	274_T	2.679	1.00
99_R	309_S	2.629	1.00
91_G	305_E	2.551	1.00
305_E	308_R	2.510	1.00
26_A	34_L	2.508	1.00
69_V	79_R	2.493	1.00
102_V	131_A	2.404	1.00
204_R	208_D	2.326	1.00
15_S	19_L	2.283	1.00
68_H	80_P	2.262	1.00
135_P	164_R	2.243	1.00
38_V	279_D	2.189	1.00
64_L	70_R	2.183	1.00
151_R	155_A	2.176	1.00
295_S	301_R	2.149	1.00
65_P	68_H	2.149	1.00
265_L	272_P	2.146	1.00
108_G	280_D	2.124	1.00
97_R	101_A	2.122	1.00
313_D	317_D	2.102	1.00
20_P	280_D	2.070	1.00
91_G	292_W	2.043	1.00
104_G	280_D	1.995	1.00
33_R	74_A	1.966	1.00
223_F	285_A	1.948	1.00
25_F	35_A	1.933	1.00
20_P	108_G	1.915	1.00
136_L	159_R	1.908	1.00
126_A	153_S	1.901	1.00
308_R	317_D	1.867	1.00
65_P	78_G	1.842	1.00
103_A	131_A	1.840	1.00
16_G	69_V	1.836	1.00
34_L	70_R	1.834	1.00
13_V	79_R	1.832	1.00
20_P	279_D	1.792	1.00
202_A	265_L	1.779	1.00
68_H	78_G	1.729	1.00
28_E	33_R	1.727	1.00
13_V	71_A	1.727	1.00
97_R	100_D	1.717	1.00
99_R	306_A	1.710	1.00
104_G	108_G	1.704	1.00
98_V	223_F	1.699	1.00
95_V	305_E	1.682	1.00
150_A	154_A	1.679	1.00
149_A	318_R	1.679	1.00
23_G	35_A	1.674	1.00
20_P	278_H	1.674	1.00
91_G	95_V	1.668	1.00
46_V	62_T	1.649	1.00
110_P	132_L	1.624	1.00
99_R	310_W	1.608	1.00
301_R	305_E	1.608	1.00
219_A	276_L	1.599	1.00
97_R	284_A	1.598	1.00
138_V	150_A	1.580	1.00
99_R	103_A	1.579	1.00
48_G	62_T	1.577	1.00
29_L	32_G	1.559	1.00
309_S	313_D	1.552	1.00
129_A	159_R	1.537	1.00
16_G	35_A	1.528	1.00
279_D	283_R	1.526	1.00
179_T	203_A	1.522	1.00
91_G	301_R	1.515	1.00
41_R	109_V	1.513	1.00
22_T	109_V	1.497	1.00
229_V	249_E	1.497	1.00
129_A	157_M	1.487	1.00
308_R	313_D	1.480	1.00
136_L	163_L	1.472	1.00
98_V	284_A	1.466	1.00
105_A	109_V	1.464	1.00
73_G	76_G	1.463	1.00
101_A	281_V	1.441	1.00
22_T	41_R	1.435	1.00
169_T	172_D	1.421	1.00
104_G	107_G	1.409	1.00
80_P	83_S	1.406	1.00
82_W	283_R	1.401	1.00
171_A	175_A	1.390	1.00
94_P	292_W	1.387	1.00
63_L	186_R	1.385	1.00
159_R	163_L	1.383	1.00
131_A	310_W	1.380	1.00
94_P	288_L	1.361	1.00
183_A	267_A	1.336	1.00
212_R	273_V	1.333	1.00
91_G	295_S	1.326	1.00
137_Y	209_G	1.323	1.00
16_G	25_F	1.322	1.00
142_A	167_E	1.311	1.00
15_S	25_F	1.303	1.00
20_P	104_G	1.299	1.00
95_V	306_A	1.296	1.00
108_G	111_A	1.287	1.00
132_L	214_V	1.276	1.00
96_E	100_D	1.275	1.00
147_I	165_V	1.264	1.00
142_A	169_T	1.254	1.00
20_P	109_V	1.252	1.00
289_P	292_W	1.250	1.00
8_A	15_S	1.247	1.00
96_E	309_S	1.232	1.00
140_G	147_I	1.228	1.00
8_A	27_G	1.227	1.00
280_D	283_R	1.222	1.00
221_E	226_Y	1.203	1.00
218_G	277_L	1.189	1.00
137_Y	208_D	1.174	1.00
128_A	214_V	1.174	1.00
284_A	288_L	1.164	1.00
102_V	276_L	1.160	1.00
126_A	311_L	1.155	1.00
172_D	203_A	1.133	1.00
215_V	272_P	1.125	1.00
35_A	69_V	1.125	1.00
288_L	302_A	1.113	1.00
117_V	136_L	1.094	1.00
176_A	200_L	1.086	1.00
133_D	162_D	1.082	1.00
199_F	268_A	1.076	1.00
262_L	266_R	1.074	1.00
95_V	99_R	1.059	1.00
118_A	205_A	1.057	1.00
239_D	290_G	1.055	1.00
320_K	323_V	1.053	1.00
101_A	280_D	1.047	1.00
105_A	278_H	1.040	1.00
22_T	42_R	1.033	1.00
127_L	306_A	1.023	1.00
115_L	212_R	1.016	1.00
153_S	315_V	1.015	1.00
149_A	152_E	1.009	1.00
184_I	264_A	1.007	1.00
11_D	15_S	1.004	1.00
276_L	303_L	1.002	1.00
140_G	167_E	1.000	1.00
261_D	272_P	1.000	1.00
98_V	303_L	0.998	1.00
30_P	33_R	0.997	1.00
8_A	12_A	0.987	1.00
217_Q	260_R	0.984	1.00
147_I	167_E	0.983	1.00
176_A	203_A	0.982	1.00
116_A	213_L	0.978	1.00
207_A	211_S	0.975	1.00
98_V	281_V	0.973	1.00
152_E	155_A	0.967	1.00
166_H	204_R	0.966	1.00
172_D	175_A	0.966	1.00
12_A	15_S	0.965	1.00
298_T	304_R	0.962	1.00
102_V	127_L	0.956	1.00
179_T	182_R	0.952	1.00
102_V	281_V	0.950	1.00
129_A	136_L	0.948	1.00
130_A	310_W	0.944	1.00
71_A	77_S	0.936	1.00
128_A	276_L	0.934	1.00
95_V	309_S	0.934	1.00
205_A	213_L	0.933	1.00
224_G	294_V	0.929	1.00
91_G	94_P	0.927	1.00
67_G	82_W	0.927	1.00
222_L	282_V	0.917	1.00
164_R	209_G	0.916	1.00
97_R	287_A	0.914	1.00
217_Q	261_D	0.912	1.00
200_L	203_A	0.910	1.00
126_A	149_A	0.908	1.00
100_D	103_A	0.905	1.00
99_R	131_A	0.904	1.00
262_L	271_E	0.902	1.00
83_S	251_V	0.898	1.00
23_G	38_V	0.895	0.99
32_G	73_G	0.889	0.99
109_V	278_H	0.888	0.99
152_E	156_A	0.884	0.99
117_V	132_L	0.883	0.99
190_M	194_I	0.883	0.99
106_L	131_A	0.881	0.99
94_P	289_P	0.878	0.99
103_A	107_G	0.878	0.99
94_P	284_A	0.877	0.99
309_S	316_A	0.872	0.99
98_V	285_A	0.872	0.99
101_A	104_G	0.865	0.99
201_V	205_A	0.865	0.99
112_G	115_L	0.864	0.99
130_A	157_M	0.855	0.99
130_A	311_L	0.854	0.99
45_Y	263_R	0.852	0.99
224_G	246_A	0.850	0.99
149_A	153_S	0.849	0.99
137_Y	210_Y	0.847	0.99
204_R	207_A	0.847	0.99
42_R	262_L	0.846	0.99
176_A	179_T	0.845	0.99
86_E	286_L	0.841	0.99
241_D	244_R	0.837	0.99
285_A	288_L	0.836	0.99
15_S	35_A	0.835	0.99
185_G	263_R	0.834	0.99
9_V	31_D	0.828	0.99
70_R	78_G	0.827	0.99
307_A	310_W	0.820	0.99
156_A	314_A	0.818	0.99
24_G	44_C	0.817	0.99
194_I	197_P	0.814	0.99
281_V	284_A	0.812	0.99
105_A	108_G	0.811	0.99
103_A	310_W	0.807	0.99
64_L	78_G	0.807	0.99
38_V	81_V	0.799	0.99
14_Q	18_P	0.797	0.99
36_R	40_G	0.797	0.99
117_V	128_A	0.788	0.99
203_A	207_A	0.787	0.99
234_T	237_R	0.784	0.99
95_V	98_V	0.782	0.99
247_R	251_V	0.781	0.99
199_F	267_A	0.777	0.99
179_T	183_A	0.776	0.99
94_P	97_R	0.775	0.99
184_I	190_M	0.775	0.99
54_D	65_P	0.772	0.98
114_D	211_S	0.766	0.98
243_V	293_L	0.765	0.98
98_V	102_V	0.765	0.98
306_A	309_S	0.764	0.98
281_V	285_A	0.762	0.98
106_L	128_A	0.762	0.98
109_V	274_T	0.759	0.98
222_L	285_A	0.758	0.98
118_A	202_A	0.757	0.98
198_L	261_D	0.756	0.98
44_C	64_L	0.755	0.98
258_L	277_L	0.753	0.98
42_R	266_R	0.753	0.98
257_Q	261_D	0.748	0.98
266_R	271_E	0.748	0.98
8_A	11_D	0.746	0.98
38_V	82_W	0.746	0.98
73_G	77_S	0.745	0.98
36_R	44_C	0.743	0.98
118_A	213_L	0.743	0.98
284_A	287_A	0.742	0.98
192_V	260_R	0.739	0.98
150_A	165_V	0.739	0.98
180_V	264_A	0.738	0.98
259_E	263_R	0.733	0.98
155_A	158_G	0.731	0.98
57_D	186_R	0.730	0.98
13_V	69_V	0.729	0.98
298_T	317_D	0.728	0.98
102_V	307_A	0.727	0.98
239_D	243_V	0.726	0.98
313_D	316_A	0.722	0.98
184_I	195_A	0.722	0.98
236_P	239_D	0.719	0.98
191_A	194_I	0.719	0.98
307_A	311_L	0.718	0.98
190_M	193_Q	0.716	0.98
98_V	306_A	0.711	0.97
299_R	304_R	0.709	0.97
92_D	95_V	0.705	0.97
95_V	301_R	0.704	0.97
71_A	79_R	0.703	0.97
119_F	136_L	0.702	0.97
283_R	287_A	0.700	0.97
189_A	192_V	0.698	0.97
164_R	208_D	0.695	0.97
192_V	195_A	0.692	0.97
148_A	152_E	0.691	0.97
213_L	270_V	0.688	0.97
22_T	271_E	0.687	0.97
56_R	61_P	0.686	0.97
218_G	221_E	0.685	0.97
39_L	250_T	0.685	0.97
93_E	97_R	0.679	0.97
85_P	88_A	0.678	0.97
176_A	196_L	0.674	0.96
228_K	249_E	0.673	0.96
46_V	70_R	0.673	0.96
136_L	165_V	0.672	0.96
98_V	302_A	0.671	0.96
314_A	317_D	0.670	0.96
215_V	274_T	0.668	0.96
138_V	147_I	0.667	0.96
145_S	148_A	0.667	0.96
233_P	238_T	0.667	0.96
154_A	159_R	0.665	0.96
194_I	260_R	0.665	0.96
52_S	55_P	0.659	0.96
284_A	302_A	0.658	0.96
137_Y	164_R	0.656	0.96
37_D	40_G	0.656	0.96
298_T	301_R	0.650	0.96
67_G	81_V	0.649	0.96
175_A	178_P	0.645	0.95
108_G	278_H	0.641	0.95
106_L	132_L	0.636	0.95
100_D	107_G	0.635	0.95
191_A	195_A	0.634	0.95
295_S	305_E	0.632	0.95
127_L	223_F	0.632	0.95
219_A	222_L	0.631	0.95
158_G	162_D	0.629	0.95
119_F	153_S	0.629	0.95
126_A	318_R	0.627	0.95
116_A	205_A	0.626	0.95
80_P	251_V	0.625	0.95
305_E	317_D	0.625	0.95
8_A	29_L	0.623	0.95
205_A	210_Y	0.623	0.95
16_G	81_V	0.621	0.94
300_K	320_K	0.621	0.94
51_W	54_D	0.620	0.94
58_L	61_P	0.619	0.94
95_V	302_A	0.619	0.94
22_T	274_T	0.618	0.94
234_T	238_T	0.618	0.94
243_V	290_G	0.616	0.94
140_G	150_A	0.615	0.94
16_G	19_L	0.614	0.94
154_A	158_G	0.613	0.94
181_A	184_I	0.611	0.94
84_L	250_T	0.611	0.94
62_T	78_G	0.610	0.94
150_A	163_L	0.610	0.94
98_V	101_A	0.609	0.94
199_F	203_A	0.607	0.94
189_A	193_Q	0.606	0.94
47_D	61_P	0.606	0.94
135_P	210_Y	0.598	0.93
203_A	268_A	0.598	0.93
228_K	232_A	0.598	0.93
15_S	69_V	0.595	0.93
235_D	238_T	0.594	0.93
48_G	60_A	0.594	0.93
112_G	212_R	0.593	0.93
34_L	72_P	0.592	0.93
28_E	74_A	0.592	0.93
19_L	23_G	0.592	0.93
243_V	246_A	0.592	0.93
318_R	321_K	0.592	0.93
213_L	265_L	0.592	0.93
151_R	154_A	0.591	0.93
220_D	300_K	0.590	0.93
186_R	189_A	0.589	0.93
249_E	253_S	0.588	0.93
120_S	124_D	0.587	0.93
176_A	180_V	0.586	0.93
306_A	310_W	0.584	0.92
304_R	316_A	0.582	0.92
23_G	81_V	0.582	0.92
217_Q	257_Q	0.580	0.92
321_K	324_Q	0.579	0.92
118_A	215_V	0.579	0.92
17_D	79_R	0.578	0.92
25_F	34_L	0.578	0.92
211_S	271_E	0.575	0.92
292_W	301_R	0.574	0.92
113_D	211_S	0.573	0.92
311_L	316_A	0.571	0.92
83_S	247_R	0.570	0.92
230_A	299_R	0.568	0.91
130_A	156_A	0.568	0.91
192_V	198_L	0.567	0.91
15_S	27_G	0.567	0.91
89_P	287_A	0.566	0.91
128_A	215_V	0.565	0.91
39_L	82_W	0.564	0.91
242_T	245_G	0.564	0.91
106_L	214_V	0.564	0.91
83_S	86_E	0.564	0.91
100_D	104_G	0.563	0.91
54_D	63_L	0.562	0.91
72_P	76_G	0.561	0.91
177_V	181_A	0.560	0.91
194_I	323_V	0.559	0.91
298_T	305_E	0.556	0.91
294_V	301_R	0.556	0.91
94_P	287_A	0.555	0.90
302_A	305_E	0.555	0.90
190_M	217_Q	0.554	0.90
312_P	315_V	0.554	0.90
243_V	247_R	0.553	0.90
302_A	306_A	0.552	0.90
123_V	304_R	0.552	0.90
223_F	303_L	0.549	0.90
147_I	151_R	0.547	0.90
22_T	266_R	0.546	0.90
102_V	128_A	0.546	0.90
234_T	239_D	0.545	0.90
198_L	264_A	0.545	0.90
135_P	209_G	0.544	0.90
256_A	259_E	0.543	0.90
41_R	259_E	0.542	0.89
228_K	231_K	0.541	0.89
49_D	60_A	0.541	0.89
91_G	302_A	0.540	0.89
311_L	315_V	0.539	0.89
115_L	211_S	0.538	0.89
26_A	70_R	0.537	0.89
147_I	150_A	0.537	0.89
105_A	281_V	0.535	0.89
36_R	43_L	0.535	0.89
300_K	303_L	0.534	0.89
175_A	179_T	0.534	0.89
148_A	151_R	0.533	0.89
211_S	266_R	0.533	0.89
118_A	192_V	0.530	0.88
32_G	71_A	0.530	0.88
124_D	300_K	0.529	0.88
114_D	135_P	0.529	0.88
14_Q	31_D	0.528	0.88
247_R	286_L	0.527	0.88
157_M	163_L	0.526	0.88
138_V	163_L	0.525	0.88
90_T	287_A	0.524	0.88
164_R	204_R	0.523	0.88
48_G	75_T	0.523	0.88
230_A	294_V	0.520	0.87
193_Q	228_K	0.520	0.87
182_R	185_G	0.520	0.87
121_G	138_V	0.519	0.87
123_V	307_A	0.519	0.87
39_L	281_V	0.519	0.87
34_L	64_L	0.519	0.87
242_T	290_G	0.519	0.87
179_T	199_F	0.519	0.87
42_R	274_T	0.517	0.87
201_V	204_R	0.517	0.87
192_V	197_P	0.517	0.87
285_A	302_A	0.515	0.87
232_A	245_G	0.515	0.87
121_G	318_R	0.515	0.87
111_A	115_L	0.514	0.87
156_A	309_S	0.514	0.87
89_P	94_P	0.513	0.87
236_P	241_D	0.512	0.87
113_D	271_E	0.512	0.87
56_R	146_D	0.512	0.87
162_D	165_V	0.509	0.86
84_L	286_L	0.506	0.86
179_T	267_A	0.506	0.86
249_E	256_A	0.504	0.86
102_V	303_L	0.504	0.86
45_Y	254_L	0.503	0.86
121_G	153_S	0.503	0.86
119_F	163_L	0.501	0.85
229_V	246_A	0.501	0.85
253_S	257_Q	0.501	0.85
209_G	270_V	0.501	0.85
153_S	157_M	0.501	0.85
127_L	309_S	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ct9A	2	0.9778	100	0.28	Contact Map
1q15A	3	0.9333	100	0.293	Contact Map
1jgtA	2	0.95	100	0.312	Contact Map
3sdbA	6	0.8861	99.4	0.834	Contact Map
4q16A	2	0.6611	99.3	0.841	Contact Map
3k32A	2	0.5028	99.3	0.844	Contact Map
4f4hA	2	0.8167	99.2	0.846	Contact Map
3p52A	3	0.5917	99.2	0.846	Contact Map
1ao0A	3	0.7889	99.1	0.854	Contact Map
3n05A	2	0.7889	99.1	0.856	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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