GREMLIN Database
Q9HR46 - Uncharacterized protein
UniProt: Q9HR46 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 157 (127)
Sequences: 2360 (1701)
Seq/√Len: 151.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_N18_A5.8171.00
52_S58_E4.4321.00
37_V46_A4.1431.00
33_P55_L3.5131.00
60_T107_T3.4571.00
11_V47_G3.3931.00
51_V59_P2.9571.00
11_V106_G2.9391.00
11_V51_V2.9181.00
13_V51_V2.6881.00
23_E124_A2.5641.00
42_L45_E2.2971.00
18_A129_S1.9381.00
129_S132_A1.8701.00
23_E28_G1.7451.00
62_L107_T1.7131.00
10_T32_P1.6731.00
48_L52_S1.5741.00
17_G130_P1.5591.00
22_H33_P1.5211.00
57_Q108_V1.5041.00
23_E123_D1.5001.00
28_G123_D1.4451.00
14_V105_F1.4421.00
128_Y134_R1.4381.00
31_I34_G1.3671.00
61_L106_G1.3631.00
21_L128_Y1.3621.00
145_R149_E1.3411.00
79_P102_H1.3141.00
30_T128_Y1.3041.00
132_A135_A1.2921.00
10_T103_V1.2421.00
10_T101_D1.2321.00
37_V43_P1.2201.00
126_E132_A1.1921.00
9_A46_A1.1721.00
48_L59_P1.1621.00
90_H94_S1.1581.00
58_E110_T1.1481.00
128_Y137_A1.1451.00
40_D45_E1.1281.00
24_H31_I1.1230.99
22_H125_W1.0790.99
83_L87_I1.0760.99
7_F37_V1.0640.99
44_H61_L1.0630.99
81_Y85_Y1.0390.99
81_Y103_V1.0390.99
37_V100_I1.0330.99
84_C87_I1.0030.99
24_H27_L0.9930.99
108_V127_W0.9880.99
8_T36_H0.9870.99
36_H99_H0.9790.99
110_T113_V0.9770.99
24_H36_H0.9690.98
79_P82_Q0.9650.98
84_C89_V0.9610.98
116_D122_P0.9590.98
82_Q85_Y0.9560.98
85_Y88_N0.9480.98
115_P118_G0.9400.98
83_L86_D0.9320.98
62_L105_F0.9280.98
22_H122_P0.9070.98
134_R137_A0.8970.98
25_A123_D0.8930.97
15_N112_T0.8780.97
34_G38_D0.8750.97
16_D107_T0.8690.97
39_R43_P0.8660.97
117_D122_P0.8600.97
139_V143_T0.8590.97
60_T63_G0.8580.97
82_Q90_H0.8580.97
32_P103_V0.8480.97
41_E49_R0.8480.97
33_P125_W0.8470.96
82_Q89_V0.8380.96
19_T133_L0.8310.96
81_Y84_C0.8260.96
29_L138_A0.8260.96
57_Q113_V0.8220.96
86_D89_V0.8160.96
31_I142_D0.8140.96
47_G51_V0.8050.95
95_V98_Q0.8050.95
145_R148_I0.8020.95
135_A138_A0.7970.95
130_P151_I0.7910.95
12_Y32_P0.7910.95
131_A135_A0.7880.95
50_E53_E0.7800.94
96_G99_H0.7770.94
82_Q87_I0.7760.94
88_N94_S0.7660.94
14_V130_P0.7610.94
134_R148_I0.7600.94
109_P112_T0.7600.94
50_E54_E0.7530.93
46_A49_R0.7480.93
94_S97_H0.7480.93
144_A148_I0.7440.93
85_Y90_H0.7400.93
36_H101_D0.7220.92
10_T121_P0.7210.92
45_E48_L0.7110.91
87_I97_H0.7080.91
47_G61_L0.7070.91
81_Y87_I0.7000.91
86_D98_Q0.6910.90
147_G150_A0.6870.90
7_F102_H0.6840.90
59_P106_G0.6830.90
10_T36_H0.6800.89
90_H95_V0.6800.89
33_P51_V0.6780.89
48_L61_L0.6760.89
60_T109_P0.6760.89
10_T143_T0.6740.89
81_Y86_D0.6710.89
19_T151_I0.6620.88
47_G106_G0.6610.88
51_V106_G0.6590.88
43_P46_A0.6570.88
13_V108_V0.6470.87
26_R122_P0.6390.86
14_V56_G0.6380.86
25_A121_P0.6370.86
103_V146_I0.6340.86
111_R116_D0.6280.85
139_V144_A0.6270.85
10_T146_I0.6250.85
44_H48_L0.6240.85
140_D143_T0.6230.85
8_T101_D0.6190.84
144_A147_G0.6170.84
84_C88_N0.6160.84
122_P125_W0.6140.84
58_E61_L0.6100.84
12_Y146_I0.6080.83
107_T110_T0.6060.83
80_R149_E0.6040.83
64_D135_A0.6040.83
48_L106_G0.6020.83
27_L97_H0.6010.83
29_L140_D0.6010.83
45_E49_R0.6000.83
13_V106_G0.6000.83
19_T147_G0.5960.82
81_Y100_I0.5930.82
141_P144_A0.5910.82
11_V33_P0.5910.82
111_R114_A0.5890.81
15_N110_T0.5850.81
113_V116_D0.5820.81
17_G131_A0.5820.81
24_H121_P0.5810.80
32_P101_D0.5730.80
18_A111_R0.5720.79
30_T126_E0.5720.79
9_A32_P0.5670.79
63_G105_F0.5590.78
35_G50_E0.5570.78
87_I90_H0.5560.78
11_V61_L0.5550.77
66_P149_E0.5520.77
12_Y150_A0.5520.77
24_H122_P0.5490.77
83_L88_N0.5490.77
19_T150_A0.5470.76
12_Y151_I0.5470.76
44_H63_G0.5410.76
59_P63_G0.5410.76
89_V95_V0.5370.75
36_H121_P0.5370.75
142_D145_R0.5340.75
24_H99_H0.5330.75
52_S111_R0.5320.74
126_E137_A0.5280.74
84_C98_Q0.5270.74
23_E29_L0.5220.73
13_V57_Q0.5210.73
43_P104_Y0.5110.71
21_L25_A0.5070.71
36_H97_H0.5050.71
111_R123_D0.5030.70
85_Y89_V0.5010.70
82_Q88_N0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f6aA 2 0.9236 99.9 0.392 Contact Map
1k2eA 2 0.8854 99.9 0.407 Contact Map
3fcmA 2 0.8917 99.9 0.415 Contact Map
2qjtB 2 0.8854 99.9 0.417 Contact Map
2qjoA 3 0.8854 99.9 0.426 Contact Map
3i7uA 4 0.8408 99.9 0.429 Contact Map
4mpoA 4 0.8662 99.9 0.431 Contact Map
2azwA 1 0.8471 99.9 0.433 Contact Map
4dywA 2 0.7898 99.9 0.443 Contact Map
3i9xA 2 0.8599 99.9 0.443 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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