GREMLIN Database
GATA - Glutamyl-tRNA(Gln) amidotransferase subunit A
UniProt: Q9HR43 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 423 (386)
Sequences: 14618 (10096)
Seq/√Len: 513.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_N61_L4.5051.00
234_A237_R3.3101.00
347_V417_A3.0851.00
53_N58_E3.0721.00
82_T105_G3.0601.00
95_D98_R3.0531.00
215_Q245_D3.0421.00
118_L175_L3.0271.00
388_I418_A3.0241.00
407_P410_G2.9071.00
107_S119_A2.8711.00
166_A172_A2.8531.00
7_I21_D2.7431.00
410_G413_T2.7011.00
58_E62_A2.6991.00
137_V165_I2.5791.00
380_A405_V2.5171.00
406_G410_G2.4701.00
128_V139_G2.4441.00
244_V345_V2.4371.00
212_G345_V2.3501.00
60_L65_G2.3171.00
25_V118_L2.2961.00
138_V172_A2.2671.00
18_G21_D2.1741.00
170_E419_A2.1701.00
210_T242_T2.1641.00
27_V57_V2.1601.00
10_T21_D2.1591.00
226_V230_E2.1171.00
406_G414_I2.0791.00
82_T90_T2.0621.00
93_P135_C2.0531.00
173_A419_A2.0531.00
404_L414_I2.0311.00
211_I347_V2.0281.00
26_A71_T2.0031.00
320_H323_Y2.0011.00
140_L411_E1.9271.00
19_P63_A1.8701.00
168_T171_G1.8591.00
387_A405_V1.8491.00
37_P47_D1.8411.00
138_V169_V1.8311.00
98_R398_L1.8301.00
59_D181_G1.8231.00
213_V233_L1.8231.00
32_S38_T1.7941.00
111_V165_I1.7401.00
26_A116_A1.7321.00
98_R359_K1.7161.00
25_V67_I1.7151.00
24_T117_D1.6821.00
349_A404_L1.6781.00
38_T70_K1.6721.00
138_V388_I1.6721.00
359_K362_E1.6681.00
97_T359_K1.6431.00
141_K381_N1.6411.00
29_D70_K1.6321.00
146_L176_L1.6271.00
352_T389_S1.6201.00
40_C153_V1.6191.00
10_T17_D1.6161.00
235_D238_A1.6131.00
30_N73_M1.6101.00
233_L243_T1.6091.00
356_L394_D1.5961.00
216_E247_A1.5801.00
26_A110_A1.5661.00
31_I162_I1.5661.00
140_L415_I1.5551.00
63_A178_V1.5481.00
147_V179_I1.5421.00
152_L162_I1.5241.00
17_D21_D1.5131.00
30_N77_G1.5021.00
55_T58_E1.4951.00
134_Y353_M1.4911.00
228_R400_V1.4841.00
61_L67_I1.4811.00
339_D408_K1.4761.00
224_R395_A1.4471.00
121_G165_I1.4461.00
230_E234_A1.4451.00
108_A135_C1.4401.00
31_I120_L1.4341.00
350_S405_V1.4331.00
138_V422_E1.4191.00
233_L349_A1.4111.00
83_E361_G1.4101.00
208_G242_T1.4041.00
91_K360_L1.4041.00
8_T12_I1.4021.00
72_N84_T1.4011.00
215_Q230_E1.3951.00
101_G130_A1.3681.00
228_R393_G1.3581.00
234_A238_A1.3531.00
385_L405_V1.3331.00
104_S107_S1.3291.00
91_K96_E1.3271.00
172_A415_I1.3271.00
206_V241_A1.3261.00
32_S50_P1.3241.00
43_K46_A1.3201.00
132_A165_I1.3141.00
109_A113_N1.3131.00
228_R392_A1.3111.00
232_A402_V1.3071.00
244_V344_D1.3061.00
227_E231_A1.3061.00
55_T59_D1.3011.00
387_A403_Q1.2991.00
33_T38_T1.2951.00
56_V120_L1.2941.00
190_R409_F1.2841.00
123_D129_R1.2841.00
6_F9_E1.2821.00
6_F10_T1.2811.00
340_E343_A1.2761.00
164_P175_L1.2741.00
33_T50_P1.2721.00
210_T244_V1.2671.00
36_V50_P1.2601.00
221_A376_N1.2581.00
120_L179_I1.2521.00
208_G241_A1.2501.00
20_L65_G1.2461.00
305_T309_L1.2411.00
26_A107_S1.2351.00
110_A115_D1.2301.00
143_T408_K1.2261.00
146_L180_A1.2261.00
257_A330_A1.2241.00
388_I414_I1.2211.00
89_P360_L1.2181.00
9_E13_Q1.2061.00
250_S337_D1.2051.00
114_G167_P1.2051.00
32_S48_Y1.1951.00
128_V164_P1.1921.00
33_T36_V1.1881.00
140_L176_L1.1861.00
296_R299_G1.1811.00
33_T70_K1.1751.00
58_E61_L1.1651.00
59_D62_A1.1601.00
232_A421_V1.1571.00
10_T15_A1.1531.00
225_V400_V1.1521.00
211_I241_A1.1461.00
389_S401_G1.1421.00
121_G128_V1.1381.00
333_W337_D1.1361.00
90_T109_A1.1351.00
111_V119_A1.1311.00
337_D340_E1.1281.00
73_M77_G1.1271.00
223_D227_E1.1271.00
209_L417_A1.1241.00
42_S76_F1.1181.00
7_I10_T1.1141.00
233_L237_R1.1121.00
324_Y328_Q1.1121.00
215_Q247_A1.1091.00
229_F233_L1.1091.00
209_L413_T1.1051.00
158_S265_E1.1031.00
26_A119_A1.0961.00
27_V67_I1.0951.00
224_R394_D1.0881.00
122_S162_I1.0861.00
380_A387_A1.0831.00
7_I11_T1.0831.00
235_D239_E1.0831.00
140_L388_I1.0821.00
56_V162_I1.0811.00
8_T11_T1.0781.00
246_V341_T1.0771.00
11_T14_G1.0751.00
143_T411_E1.0731.00
231_A234_A1.0701.00
212_G341_T1.0661.00
336_Q340_E1.0641.00
253_Y330_A1.0641.00
134_Y357_P1.0581.00
237_R242_T1.0581.00
90_T100_P1.0561.00
36_V70_K1.0561.00
37_P49_E1.0551.00
138_V390_V1.0551.00
211_I349_A1.0521.00
116_A119_A1.0481.00
34_K53_N1.0451.00
209_L241_A1.0451.00
328_Q331_R1.0411.00
72_N87_F1.0391.00
221_A226_V1.0381.00
52_Y58_E1.0361.00
124_T160_E1.0301.00
201_A416_N1.0301.00
55_T150_Y1.0281.00
141_K161_Q1.0261.00
11_T21_D1.0261.00
404_L417_A1.0211.00
71_T107_S1.0211.00
132_A139_G1.0171.00
390_V404_L1.0141.00
147_V176_L1.0021.00
330_A333_W1.0011.00
140_L172_A0.9961.00
206_V209_L0.9951.00
201_A412_E0.9911.00
93_P109_A0.9901.00
143_T409_F0.9881.00
335_K339_D0.9881.00
231_A235_D0.9831.00
228_R231_A0.9831.00
236_L421_V0.9831.00
39_T47_D0.9821.00
213_V229_F0.9791.00
412_E416_N0.9781.00
91_K97_T0.9771.00
392_A400_V0.9761.00
169_V418_A0.9751.00
16_A21_D0.9751.00
169_V422_E0.9731.00
366_D369_Q0.9701.00
235_D421_V0.9701.00
31_I152_L0.9691.00
25_V65_G0.9671.00
54_A57_V0.9621.00
260_V327_A0.9611.00
58_E185_H0.9601.00
133_A353_M0.9561.00
407_P413_T0.9541.00
331_R335_K0.9511.00
157_N269_N0.9481.00
99_V134_Y0.9481.00
9_E12_I0.9461.00
212_G246_V0.9461.00
306_R309_L0.9401.00
332_A336_Q0.9361.00
56_V147_V0.9341.00
209_L347_V0.9281.00
55_T148_S0.9261.00
33_T53_N0.9231.00
31_I54_A0.9211.00
33_T67_I0.9091.00
301_G304_V0.9071.00
98_R357_P0.9071.00
26_A69_G0.9041.00
175_L179_I0.9011.00
146_L411_E0.9011.00
176_L411_E0.8981.00
120_L162_I0.8961.00
128_V163_G0.8941.00
25_V175_L0.8941.00
72_N88_G0.8891.00
125_G258_Y0.8871.00
150_Y185_H0.8871.00
31_I122_S0.8851.00
365_D368_V0.8791.00
394_D400_V0.8791.00
42_S75_E0.8791.00
339_D385_L0.8781.00
347_V413_T0.8741.00
404_L421_V0.8721.00
117_D171_G0.8701.00
343_A407_P0.8671.00
111_V137_V0.8651.00
23_T117_D0.8651.00
71_T110_A0.8651.00
222_D356_L0.8631.00
413_T416_N0.8631.00
133_A401_G0.8631.00
182_P189_T0.8621.00
100_P109_A0.8591.00
392_A402_V0.8571.00
52_Y150_Y0.8551.00
211_I236_L0.8531.00
138_V418_A0.8511.00
11_T17_D0.8501.00
170_E422_E0.8461.00
80_T130_A0.8431.00
27_V33_T0.8401.00
134_Y373_A0.8391.00
146_L412_E0.8311.00
32_S52_Y0.8301.00
108_A165_I0.8271.00
36_V67_I0.8261.00
100_P135_C0.8211.00
11_T16_A0.8201.00
223_D226_V0.8191.00
307_R311_G0.8191.00
340_E344_D0.8141.00
325_K329_E0.8141.00
30_N122_S0.8101.00
27_V120_L0.8101.00
59_D148_S0.8061.00
57_V67_I0.8041.00
388_I415_I0.8041.00
171_G174_E0.7991.00
411_E414_I0.7981.00
229_F392_A0.7941.00
323_Y326_Q0.7921.00
68_V116_A0.7911.00
173_A177_D0.7891.00
170_E174_E0.7861.00
46_A86_Y0.7831.00
31_I56_V0.7811.00
74_D79_G0.7811.00
202_A419_A0.7801.00
32_S70_K0.7771.00
336_Q339_D0.7751.00
385_L408_K0.7741.00
339_D407_P0.7721.00
335_K408_K0.7711.00
230_E237_R0.7701.00
338_F383_A0.7691.00
224_R396_D0.7691.00
210_T345_V0.7651.00
71_T119_A0.7651.00
20_L174_E0.7641.00
347_V404_L0.7611.00
329_E333_W0.7571.00
130_A353_M0.7561.00
357_P398_L0.7531.00
227_E230_E0.7501.00
14_G18_G0.7491.00
349_A402_V0.7491.00
342_F407_P0.7441.00
107_S110_A0.7421.00
380_A385_L0.7401.00
140_L414_I0.7371.00
239_E420_A0.7371.00
342_F385_L0.7341.00
299_G302_D0.7301.00
222_D355_V0.7291.00
33_T61_L0.7291.00
155_Y262_A0.7281.00
19_P178_V0.7261.00
23_T171_G0.7251.00
54_A151_G0.7231.00
98_R358_P0.7231.00
230_E245_D0.7201.00
332_A335_K0.7191.00
164_P179_I0.7191.00
28_K127_S0.7191.00
37_P46_A0.7161.00
173_A416_N0.7151.00
112_A137_V0.7151.00
250_S253_Y0.7141.00
355_V373_A0.7131.00
321_D324_Y0.7121.00
99_V360_L0.7101.00
10_T13_Q0.7101.00
7_I17_D0.7081.00
147_V164_P0.7071.00
30_N40_C0.7031.00
239_E421_V0.7031.00
168_T172_A0.7031.00
321_D325_K0.7021.00
34_K52_Y0.7001.00
237_R243_T0.7001.00
271_A275_G0.7001.00
248_L341_T0.6991.00
82_T100_P0.6981.00
222_D225_V0.6971.00
94_V399_P0.6971.00
210_T346_D0.6971.00
40_C45_L0.6901.00
267_S271_A0.6871.00
94_V136_G0.6871.00
69_G110_A0.6861.00
365_D369_Q0.6841.00
174_E177_D0.6831.00
236_L417_A0.6831.00
45_L48_Y0.6741.00
224_R356_L0.6741.00
143_T386_P0.6711.00
28_K103_S0.6711.00
77_G160_E0.6701.00
225_V356_L0.6691.00
21_D64_G0.6681.00
270_L300_F0.6671.00
213_V243_T0.6671.00
411_E415_I0.6671.00
121_G164_P0.6671.00
253_Y256_A0.6661.00
169_V419_A0.6661.00
78_M266_A0.6651.00
306_R310_L0.6641.00
94_V112_A0.6641.00
81_T99_V0.6641.00
410_G414_I0.6631.00
176_L415_I0.6631.00
213_V245_D0.6611.00
319_Y324_Y0.6601.00
319_Y323_Y0.6591.00
120_L175_L0.6581.00
122_S152_L0.6561.00
224_R228_R0.6551.00
208_G420_A0.6551.00
118_L166_A0.6541.00
392_A421_V0.6521.00
236_L241_A0.6521.00
406_G413_T0.6511.00
209_L416_N0.6511.00
108_A112_A0.6501.00
258_Y262_A0.6481.00
338_F385_L0.6481.00
419_A422_E0.6481.00
10_T64_G0.6471.00
241_A420_A0.6461.00
68_V115_D0.6451.00
246_V345_V0.6451.00
333_W336_Q0.6451.00
149_R162_I0.6431.00
298_D302_D0.6411.00
130_A377_T0.6401.00
270_L273_F0.6391.00
204_G416_N0.6391.00
212_G346_D0.6381.00
232_A392_A0.6371.00
341_T344_D0.6361.00
18_G63_A0.6351.00
206_V420_A0.6351.00
350_S387_A0.6341.00
348_V405_V0.6331.00
144_Y384_N0.6331.00
134_Y358_P0.6331.00
92_N100_P0.6321.00
43_K86_Y0.6321.00
144_Y161_Q0.6271.00
34_K51_P0.6271.00
55_T185_H0.6261.00
107_S120_L0.6261.00
182_P191_D0.6261.00
413_T417_A0.6241.00
74_D82_T0.6231.00
77_G124_T0.6221.00
83_E89_P0.6201.00
205_D416_N0.6201.00
110_A116_A0.6191.00
356_L396_D0.6181.00
72_N90_T0.6171.00
352_T377_T0.6161.00
352_T401_G0.6161.00
149_R186_D0.6161.00
237_R245_D0.6161.00
89_P100_P0.6141.00
84_T88_G0.6131.00
211_I243_T0.6121.00
356_L398_L0.6101.00
390_V402_V0.6091.00
150_Y183_D0.6081.00
14_G21_D0.6051.00
74_D105_G0.6041.00
74_D81_T0.6020.99
91_K95_D0.6020.99
35_G49_E0.5990.99
19_P177_D0.5970.99
38_T50_P0.5950.99
352_T403_Q0.5950.99
261_I327_A0.5940.99
24_T171_G0.5940.99
128_V165_I0.5920.99
322_K326_Q0.5920.99
33_T57_V0.5910.99
272_R275_G0.5910.99
227_E395_A0.5900.99
174_E178_V0.5900.99
212_G245_D0.5880.99
414_I417_A0.5860.99
70_K73_M0.5860.99
262_A266_A0.5860.99
275_G317_A0.5860.99
109_A135_C0.5850.99
167_P171_G0.5810.99
50_P70_K0.5790.99
133_A352_T0.5760.99
264_S321_D0.5740.99
271_A326_Q0.5740.99
60_L175_L0.5730.99
394_D397_G0.5720.99
230_E233_L0.5710.99
212_G342_F0.5700.99
302_D305_T0.5700.99
358_P373_A0.5700.99
248_L251_C0.5690.99
77_G122_S0.5680.99
201_A204_G0.5660.99
214_P248_L0.5640.99
98_R396_D0.5640.99
257_A334_V0.5610.99
224_R227_E0.5610.99
43_K299_G0.5590.99
237_R240_G0.5580.99
300_F304_V0.5580.99
26_A115_D0.5550.99
24_T68_V0.5540.99
65_G175_L0.5530.99
254_A334_V0.5520.99
246_V348_V0.5510.99
347_V406_G0.5510.99
107_S116_A0.5510.99
41_G73_M0.5510.99
15_A21_D0.5500.99
81_T363_S0.5500.99
224_R400_V0.5490.99
297_A309_L0.5480.99
229_F349_A0.5470.99
53_N56_V0.5440.99
229_F402_V0.5430.99
300_F303_E0.5410.99
55_T183_D0.5410.99
45_L273_F0.5400.99
260_V323_Y0.5400.99
128_V132_A0.5400.99
10_T16_A0.5390.99
39_T46_A0.5390.99
169_V388_I0.5390.99
298_D305_T0.5370.99
169_V172_A0.5370.99
19_P64_G0.5350.99
29_D73_M0.5340.99
176_L180_A0.5340.99
236_L349_A0.5330.99
90_T105_G0.5320.99
233_L402_V0.5310.99
252_E256_A0.5300.99
15_A18_G0.5290.99
24_T66_T0.5290.99
164_P172_A0.5280.99
84_T89_P0.5270.99
267_S317_A0.5250.99
218_T229_F0.5250.99
203_T419_A0.5250.99
326_Q329_E0.5250.99
93_P96_E0.5250.99
380_A383_A0.5240.99
166_A171_G0.5240.99
308_I311_G0.5230.99
53_N57_V0.5230.99
353_M357_P0.5230.99
132_A137_V0.5220.99
331_R382_L0.5200.99
7_I64_G0.5200.99
350_S376_N0.5190.99
169_V415_I0.5190.99
297_A301_G0.5190.99
46_A49_E0.5180.99
386_P406_G0.5170.98
338_F348_V0.5160.98
27_V60_L0.5150.98
134_Y355_V0.5150.98
39_T72_N0.5130.98
81_T358_P0.5130.98
139_G388_I0.5120.98
205_D208_G0.5110.98
173_A415_I0.5100.98
59_D178_V0.5090.98
348_V380_A0.5090.98
77_G155_Y0.5090.98
107_S111_V0.5080.98
7_I15_A0.5070.98
177_D412_E0.5070.98
236_L239_E0.5060.98
341_T345_V0.5060.98
393_G400_V0.5050.98
57_V61_L0.5040.98
214_P350_S0.5040.98
65_G118_L0.5030.98
141_K380_A0.5030.98
95_D398_L0.5000.98
251_C338_F0.5000.98
32_S54_A0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ip4A 1 0.9953 100 0.045 Contact Map
4wj3A 1 0.9953 100 0.048 Contact Map
3h0lA 1 0.9835 100 0.057 Contact Map
3kfuE 1 0.9716 100 0.061 Contact Map
2gi3A 2 0.9267 100 0.076 Contact Map
2dc0A 2 0.9007 100 0.085 Contact Map
1m22A 1 0.9527 100 0.087 Contact Map
3a2qA 2 0.9409 100 0.095 Contact Map
3a1kA 2 0.9953 100 0.095 Contact Map
4cp8A 2 0.9314 100 0.099 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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