GREMLIN Database
Q9HR42 - Acyl-CoA hydrolase
UniProt: Q9HR42 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 155 (140)
Sequences: 3223 (1831)
Seq/√Len: 154.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_M112_F3.8131.00
85_S125_P3.2171.00
52_S124_I2.9921.00
42_A114_F2.8601.00
45_A78_A2.6601.00
39_D56_T2.6581.00
66_T105_R2.5191.00
35_L62_V2.4811.00
29_A34_V2.2141.00
35_L59_M2.1931.00
134_D137_T2.1891.00
144_M148_E2.1861.00
23_T70_M2.1471.00
22_D33_T2.1221.00
75_V104_T2.0791.00
81_F91_K2.0111.00
68_I107_T1.9211.00
33_T36_H1.8451.00
118_D122_S1.8241.00
72_E98_D1.7951.00
30_L36_H1.7791.00
18_L29_A1.7531.00
145_E148_E1.7201.00
72_E105_R1.6991.00
106_K109_S1.6391.00
137_T141_A1.6331.00
50_A88_I1.6151.00
16_E40_I1.6041.00
96_A105_R1.5641.00
10_S49_F1.5141.00
48_R97_E1.5101.00
98_D101_E1.4701.00
97_E104_T1.4471.00
77_E95_H1.4101.00
45_A80_V1.3691.00
69_E72_E1.3321.00
76_V92_V1.3321.00
133_S136_E1.3181.00
131_C136_E1.3161.00
36_H40_I1.3101.00
58_S113_T1.3051.00
24_N31_G1.2981.00
43_A47_M1.2931.00
50_A54_C1.2871.00
13_E77_E1.2731.00
81_F89_D1.2601.00
44_I73_V1.2321.00
24_N30_L1.2201.00
91_K139_L1.2181.00
68_I74_A1.1801.00
11_Y77_E1.1731.00
81_F139_L1.1441.00
93_D106_K1.1351.00
55_V117_V1.1181.00
82_D144_M1.1110.99
135_A138_G1.1100.99
13_E75_V1.1030.99
141_A144_M1.1000.99
49_F88_I1.0900.99
16_E37_W1.0890.99
41_C76_V1.0880.99
22_D37_W1.0860.99
49_F80_V1.0860.99
82_D89_D1.0690.99
91_K111_F1.0670.99
46_S54_C1.0590.99
84_G87_S1.0580.99
87_S115_V1.0570.99
95_H104_T1.0440.99
11_Y79_Y1.0250.99
60_D111_F1.0230.99
49_F128_D1.0180.99
86_T123_P1.0140.99
131_C140_R1.0070.99
41_C78_A0.9920.99
72_E96_A0.9770.99
88_I126_V0.9720.99
117_V123_P0.9660.99
140_R143_A0.9650.99
80_V88_I0.9630.99
81_F111_F0.9610.99
49_F129_L0.9600.99
134_D138_G0.9440.98
141_A145_E0.9420.98
45_A90_V0.9320.98
143_A146_A0.9310.98
92_V112_F0.9210.98
89_D146_A0.9070.98
89_D113_T0.8980.98
12_T45_A0.8940.98
142_A145_E0.8710.97
60_D113_T0.8640.97
138_G142_A0.8600.97
31_G64_F0.8570.97
83_T131_C0.8500.97
39_D55_V0.8490.97
95_H106_K0.8490.97
29_A33_T0.8480.97
59_M112_F0.8410.97
34_V108_T0.8400.97
42_A92_V0.8380.97
38_M110_S0.8310.96
91_K109_S0.8250.96
34_V68_I0.8180.96
75_V95_H0.8150.96
82_D140_R0.8100.96
77_E93_D0.7970.95
19_L40_I0.7960.95
34_V74_A0.7920.95
27_G71_G0.7880.95
19_L30_L0.7830.95
37_W76_V0.7800.95
93_D109_S0.7800.95
37_W40_I0.7740.95
132_E136_E0.7730.95
89_D111_F0.7710.94
37_W74_A0.7650.94
79_Y91_K0.7650.94
26_L117_V0.7650.94
73_V99_P0.7630.94
131_C137_T0.7630.94
28_R69_E0.7540.94
142_A146_A0.7510.94
34_V94_V0.7500.94
14_M40_I0.7500.94
42_A90_V0.7400.93
14_M41_C0.7400.93
82_D143_A0.7270.93
42_A112_F0.7230.92
57_A63_D0.7230.92
15_T18_L0.7210.92
133_S137_T0.7060.91
58_S63_D0.6950.91
60_D89_D0.6920.91
29_A68_I0.6900.91
57_A87_S0.6870.90
132_E137_T0.6800.90
47_M99_P0.6760.90
98_D103_A0.6740.89
57_A115_V0.6670.89
85_S141_A0.6660.89
46_S90_V0.6640.89
35_L112_F0.6490.88
135_A139_L0.6480.88
21_N36_H0.6450.87
134_D141_A0.6420.87
143_A147_H0.6390.87
33_T37_W0.6370.87
90_V114_F0.6340.86
99_P102_G0.6340.86
78_A92_V0.6330.86
23_T71_G0.6290.86
20_P113_T0.6190.85
43_A114_F0.6170.85
25_N28_R0.6130.85
28_R108_T0.6120.84
64_F71_G0.6110.84
68_I94_V0.6050.84
55_V87_S0.6000.83
19_L25_N0.5950.83
29_A37_W0.5930.83
52_S116_A0.5880.82
62_V110_S0.5860.82
80_V83_T0.5860.82
84_G115_V0.5830.82
138_G145_E0.5820.81
98_D124_I0.5810.81
46_S114_F0.5760.81
117_V135_A0.5690.80
119_D124_I0.5680.80
118_D124_I0.5590.79
58_S61_H0.5570.79
85_S123_P0.5560.78
118_D123_P0.5560.78
34_V59_M0.5530.78
98_D105_R0.5520.78
45_A49_F0.5520.78
18_L99_P0.5510.78
51_G102_G0.5470.77
130_A137_T0.5470.77
93_D111_F0.5450.77
81_F93_D0.5450.77
60_D65_I0.5430.77
38_M94_V0.5430.77
40_I44_I0.5420.77
56_T127_P0.5410.77
38_M76_V0.5410.77
94_V109_S0.5400.76
120_D123_P0.5400.76
38_M62_V0.5340.76
39_D84_G0.5310.75
46_S88_I0.5300.75
20_P70_M0.5280.75
49_F83_T0.5270.75
16_E62_V0.5260.75
100_R119_D0.5230.74
28_R33_T0.5220.74
75_V97_E0.5220.74
50_A126_V0.5170.73
18_L114_F0.5170.73
44_I48_R0.5170.73
80_V90_V0.5160.73
139_L142_A0.5160.73
50_A53_Q0.5150.73
13_E78_A0.5140.73
48_R75_V0.5130.73
49_F126_V0.5130.73
84_G147_H0.5110.72
49_F110_S0.5030.71
26_L53_Q0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mobA 3 0.9355 100 0.32 Contact Map
4ncpA 5 0.9871 100 0.325 Contact Map
4zv3A 3 0.9548 100 0.38 Contact Map
1y7uA 5 0.9806 99.9 0.409 Contact Map
2qq2A 5 0.9871 99.9 0.417 Contact Map
2q2bA 5 0.9097 99.9 0.422 Contact Map
1vpmA 5 1 99.9 0.43 Contact Map
4ienA 5 0.9677 99.9 0.468 Contact Map
2v1oA 5 0.9032 99.9 0.495 Contact Map
2gvhA 3 0.7935 99.8 0.55 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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