GREMLIN Database
Q9HR40 - Uncharacterized protein
UniProt: Q9HR40 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 116 (109)
Sequences: 177 (145)
Seq/√Len: 13.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_G91_W3.7600.99
77_M96_Y3.6920.99
37_L99_S3.6140.99
30_R34_L3.5380.99
46_L65_G2.6360.94
81_G86_A2.5560.93
50_S65_G2.2860.88
21_V72_L2.1780.86
47_G70_V2.1670.85
17_A21_V2.0750.83
12_G16_A1.9860.80
46_L50_S1.9630.79
32_N89_L1.8630.75
4_L27_I1.7580.70
36_A70_V1.7430.70
22_H32_N1.7060.68
77_M90_E1.6670.66
23_H36_A1.6670.66
41_L44_V1.6480.65
35_I72_L1.6270.64
73_A92_S1.4920.57
25_G28_T1.4600.56
17_A20_A1.4240.54
32_N36_A1.4210.54
22_H42_M1.3940.52
25_G80_F1.3580.50
20_A72_L1.3480.50
46_L95_A1.3160.48
5_A18_P1.3050.47
77_M103_T1.2960.47
2_L68_I1.2820.46
83_L108_V1.2580.45
14_L70_V1.2480.44
100_A104_I1.2410.44
23_H87_T1.2160.43
27_I32_N1.2130.42
31_E73_A1.2120.42
49_V64_W1.1470.39
31_E46_L1.1310.38
53_V61_V1.1310.38
105_G109_L1.1070.37
37_L95_A1.1000.37
16_A20_A1.0920.36
55_V105_G1.0730.35
46_L62_G1.0650.35
14_L83_L1.0590.35
53_V60_R1.0590.35
77_M99_S1.0540.34
52_V92_S1.0430.34
25_G81_G1.0420.34
71_L77_M1.0300.33
7_A45_V1.0210.33
11_A34_L1.0110.32
4_L28_T0.9970.32
15_F68_I0.9890.31
3_G70_V0.9700.30
13_F18_P0.9690.30
22_H71_L0.9630.30
51_L55_V0.9530.30
15_F69_N0.9480.29
58_A78_I0.9400.29
56_T61_V0.9370.29
49_V78_I0.9310.29
51_L104_I0.9300.29
57_V80_F0.9080.28
36_A88_V0.9070.28
32_N87_T0.8960.27
28_T62_G0.8960.27
5_A65_G0.8820.26
71_L74_G0.8800.26
82_P97_A0.8790.26
10_L64_W0.8710.26
74_G78_I0.8510.25
21_V82_P0.8500.25
53_V100_A0.8480.25
6_V57_V0.8450.25
26_Y108_V0.8370.25
7_A52_V0.8360.25
10_L36_A0.8350.25
3_G8_G0.8330.24
44_V77_M0.8300.24
36_A87_T0.8300.24
21_V35_I0.8240.24
42_M96_Y0.8000.23
38_A52_V0.7950.23
17_A35_I0.7910.23
53_V64_W0.7900.23
8_G14_L0.7870.23
68_I72_L0.7850.23
14_L35_I0.7820.22
15_F20_A0.7790.22
74_G96_Y0.7770.22
5_A35_I0.7650.22
25_G33_G0.7540.21
55_V86_A0.7500.21
12_G17_A0.7400.21
36_A73_A0.7350.21
3_G87_T0.7320.21
51_L99_S0.7290.21
5_A17_A0.7270.20
62_G107_A0.7240.20
78_I86_A0.7220.20
36_A72_L0.7160.20
25_G91_W0.7110.20
18_P46_L0.7020.20
70_V110_F0.6950.19
41_L47_G0.6910.19
53_V97_A0.6870.19
21_V25_G0.6670.18
86_A106_P0.6670.18
53_V102_V0.6660.18
49_V53_V0.6650.18
2_L16_A0.6590.18
26_Y42_M0.6570.18
41_L108_V0.6560.18
50_S95_A0.6560.18
74_G101_V0.6540.18
38_A98_L0.6440.18
67_F96_Y0.6380.18
8_G81_G0.6340.17
86_A93_T0.6300.17
63_Y105_G0.6280.17
6_V103_T0.6280.17
13_F83_L0.6270.17
80_F83_L0.6270.17
37_L104_I0.6250.17
70_V102_V0.6250.17
61_V94_T0.6180.17
62_G65_G0.6160.17
7_A104_I0.6070.17
9_G96_Y0.6030.16
70_V101_V0.6000.16
95_A104_I0.5960.16
21_V27_I0.5960.16
36_A45_V0.5910.16
47_G72_L0.5880.16
89_L95_A0.5720.16
10_L54_L0.5700.15
14_L48_A0.5660.15
53_V57_V0.5630.15
10_L16_A0.5590.15
88_V91_W0.5580.15
90_E93_T0.5570.15
8_G36_A0.5560.15
12_G20_A0.5560.15
44_V99_S0.5460.15
41_L45_V0.5440.15
96_Y100_A0.5430.15
63_Y67_F0.5420.15
42_M56_T0.5400.15
95_A107_A0.5390.15
10_L68_I0.5360.15
7_A11_A0.5290.14
17_A73_A0.5290.14
12_G50_S0.5260.14
15_F94_T0.5250.14
82_P110_F0.5170.14
63_Y107_A0.5170.14
6_V53_V0.5110.14
90_E96_Y0.5090.14
26_Y94_T0.5080.14
41_L67_F0.5050.14
28_T77_M0.5020.14
53_V109_L0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b4rA 2 0.8621 99.2 0.685 Contact Map
3x29A 1 0.8103 4.6 0.948 Contact Map
4p79A 1 0.8448 3.4 0.951 Contact Map
4l6vi 1 0.2672 2.1 0.956 Contact Map
1scfA 4 0 1.9 0.957 Contact Map
1ciiA 1 0.4224 1.6 0.959 Contact Map
4i0uA 4 0.4138 1.3 0.961 Contact Map
4ltoA 3 0.7155 1 0.963 Contact Map
2pjvA 1 0.2069 1 0.963 Contact Map
4gd3A 2 0.2759 1 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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