GREMLIN Database
Q9HR39 - Phosphoribosylformylglycinamidine cyclo-ligase
UniProt: Q9HR39 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (310)
Sequences: 3412 (1798)
Seq/√Len: 102.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_Y149_F3.6481.00
39_T128_D3.5511.00
183_I191_A3.4251.00
169_A238_A3.0051.00
211_E219_E2.8061.00
125_A129_A2.6691.00
171_A320_D2.6111.00
74_V214_G2.5841.00
176_V312_G2.5841.00
130_A223_I2.5461.00
175_L295_V2.5231.00
42_D98_E2.5031.00
125_A128_D2.4761.00
51_D161_D2.4701.00
259_E317_R2.4581.00
54_D162_A2.4491.00
292_T315_V2.4131.00
239_A294_F2.3791.00
175_L297_A2.3501.00
194_A279_V2.2931.00
307_A312_G2.2561.00
17_A22_D2.2391.00
54_D161_D2.1861.00
259_E319_A2.1441.00
176_V307_A2.0721.00
32_A117_A2.0551.00
76_D215_D2.0401.00
72_E148_G2.0401.00
177_G292_T2.0371.00
253_M297_A2.0061.00
257_R319_A2.0051.00
298_L306_L2.0031.00
28_A32_A1.9921.00
258_Y318_V1.9661.00
175_L258_Y1.9551.00
237_H299_P1.9281.00
171_A256_F1.9131.00
92_L155_A1.8821.00
48_G135_V1.8711.00
211_E216_A1.8461.00
255_G321_G1.8431.00
142_M146_V1.8291.00
173_D237_H1.8121.00
168_R237_H1.8111.00
222_R310_T1.7391.00
247_W250_L1.7271.00
238_A253_M1.6861.00
27_E248_T1.6771.00
183_I188_L1.6711.00
257_R324_V1.6571.00
159_A164_L1.6471.00
194_A273_V1.6411.00
78_S121_D1.6321.00
56_Y164_L1.6231.00
285_H290_M1.6201.00
200_G203_E1.6121.00
303_A314_V1.6121.00
126_G223_I1.6111.00
274_Q281_D1.5851.00
108_V116_A1.5851.00
299_P302_A1.5811.00
24_A286_R1.5751.00
234_H306_L1.5511.00
239_A296_V1.5491.00
216_A219_E1.5351.00
94_A239_A1.5241.00
29_A33_L1.5231.00
82_I126_G1.5101.00
304_A308_S1.5021.00
36_A121_D1.5001.00
68_L145_V1.4951.00
60_A92_L1.4911.00
121_D125_A1.4891.00
15_T18_D1.4821.00
247_W295_V1.4741.00
31_A34_V1.4721.00
257_R321_G1.4661.00
307_A314_V1.4581.00
106_L116_A1.4571.00
25_D113_E1.4541.00
44_T50_V1.4481.00
69_L148_G1.4411.00
29_A116_A1.4311.00
265_P313_E1.4221.00
256_F318_V1.4081.00
235_G302_A1.4001.00
179_P313_E1.3921.00
176_V314_V1.3901.00
82_I129_A1.3881.00
32_A114_R1.3841.00
169_A253_M1.3751.00
274_Q284_M1.3640.99
227_L296_V1.3640.99
302_A305_A1.3600.99
305_A308_S1.3510.99
129_A223_I1.3460.99
175_L260_V1.3430.99
70_V74_V1.3420.99
250_L260_V1.3360.99
36_A117_A1.3310.99
265_P271_D1.3190.99
80_V151_I1.3130.99
49_L58_A1.3070.99
303_A307_A1.3030.99
75_G115_R1.3010.99
70_V201_Y1.2980.99
300_E317_R1.2750.99
207_Y210_Y1.2720.99
59_L101_A1.2700.99
51_D54_D1.2520.99
73_A196_T1.2510.99
266_A271_D1.2470.99
211_E215_D1.2440.99
321_G324_V1.2280.99
26_S30_T1.2240.99
169_A318_V1.2190.99
230_A306_L1.2140.99
55_Q160_T1.1940.99
181_A219_E1.1870.99
183_I269_V1.1840.98
87_M185_S1.1760.98
42_D50_V1.1750.98
160_T163_E1.1660.98
174_A303_A1.1650.98
229_D232_R1.1560.98
178_F294_F1.1520.98
87_M221_T1.1490.98
227_L294_F1.1450.98
179_P311_D1.1370.98
284_M288_F1.1300.98
118_E121_D1.1220.98
126_G130_A1.1180.98
170_E299_P1.1170.98
69_L73_A1.1170.98
174_A314_V1.1150.98
296_V306_L1.1040.98
280_S283_E1.1020.98
102_F153_G1.1000.98
116_A119_L1.0920.97
36_A124_A1.0830.97
111_P116_A1.0770.97
177_G265_P1.0760.97
131_G226_H1.0750.97
56_Y159_A1.0720.97
196_T199_G1.0690.97
28_A31_A1.0680.97
185_S221_T1.0490.97
279_V284_M1.0470.97
88_N155_A1.0440.97
212_T215_D1.0340.96
179_P312_G1.0330.96
15_T283_E1.0300.96
209_G216_A1.0280.96
174_A300_E1.0240.96
49_L164_L1.0240.96
271_D275_D1.0220.96
89_V155_A1.0200.96
93_L294_F1.0140.96
98_E131_G1.0140.96
131_G228_L1.0110.96
106_L119_L1.0110.96
14_L18_D1.0050.96
72_E145_V1.0050.96
24_A27_E0.9930.96
101_A156_A0.9900.95
47_A58_A0.9890.95
56_Y161_D0.9890.95
204_P210_Y0.9850.95
266_A290_M0.9840.95
59_L156_A0.9800.95
175_L318_V0.9730.95
168_R235_G0.9700.95
129_A226_H0.9670.95
101_A135_V0.9640.95
126_G129_A0.9580.95
196_T201_Y0.9530.94
225_T228_L0.9490.94
58_A97_V0.9470.94
257_R322_D0.9450.94
195_A272_Y0.9430.94
283_E287_T0.9370.94
82_I125_A0.9340.94
227_L239_A0.9340.94
93_L227_L0.9310.94
27_E286_R0.9310.94
270_F284_M0.9270.94
38_S41_T0.9250.93
257_R323_G0.9200.93
93_L229_D0.9170.93
271_D274_Q0.9170.93
29_A113_E0.9150.93
98_E228_L0.9140.93
248_T251_D0.9130.93
86_A223_I0.9130.93
98_E232_R0.9040.93
292_T313_E0.9030.93
233_E305_A0.9030.93
265_P311_D0.9020.93
119_L151_I0.9020.93
265_P268_P0.9010.93
250_L258_Y0.8990.93
227_L231_F0.8890.92
87_M223_I0.8890.92
195_A198_D0.8870.92
277_G284_M0.8800.92
229_D233_E0.8800.92
69_L72_E0.8760.92
204_P212_T0.8730.91
173_D299_P0.8690.91
290_M321_G0.8650.91
29_A120_G0.8610.91
169_A237_H0.8560.91
179_P309_Q0.8410.90
23_I286_R0.8380.90
178_F310_T0.8370.90
250_L295_V0.8310.89
264_L292_T0.8290.89
195_A201_Y0.8280.89
176_V298_L0.8270.89
204_P209_G0.8260.89
44_T98_E0.8170.88
69_L145_V0.8160.88
246_G249_N0.8160.88
231_F239_A0.8120.88
47_A95_A0.8120.88
22_D25_D0.8120.88
33_L37_A0.8110.88
228_L232_R0.8090.88
261_S317_R0.8090.88
304_A314_V0.8090.88
61_T154_T0.8080.88
230_A234_H0.8040.88
234_H305_A0.8020.87
86_A221_T0.8010.87
170_E237_H0.8010.87
84_C151_I0.7990.87
272_Y276_A0.7940.87
201_Y213_V0.7880.87
53_G161_D0.7880.87
52_L158_V0.7860.86
86_A185_S0.7850.86
113_E117_A0.7840.86
240_A247_W0.7840.86
106_L151_I0.7820.86
145_V148_G0.7800.86
165_F239_A0.7770.86
53_G160_T0.7770.86
298_L303_A0.7770.86
114_R118_E0.7760.86
88_N102_F0.7760.86
229_D235_G0.7760.86
177_G313_E0.7740.86
207_Y275_D0.7720.85
23_I26_S0.7710.85
314_V317_R0.7700.85
227_L230_A0.7650.85
185_S223_I0.7640.85
50_V158_V0.7630.85
240_A295_V0.7590.84
124_A128_D0.7590.84
78_S118_E0.7520.84
29_A37_A0.7500.84
59_L135_V0.7440.83
23_I27_E0.7430.83
201_Y214_G0.7420.83
174_A317_R0.7360.83
14_L194_A0.7350.83
142_M145_V0.7320.82
205_Y216_A0.7320.82
50_V101_A0.7320.82
58_A159_A0.7280.82
60_A93_L0.7280.82
80_V119_L0.7240.82
169_A256_F0.7240.82
204_P207_Y0.7220.81
230_A296_V0.7210.81
195_A273_V0.7200.81
213_V217_L0.7190.81
25_D28_A0.7170.81
25_D110_E0.7150.81
51_D158_V0.7150.81
274_Q279_V0.7130.81
236_V306_L0.7130.81
36_A39_T0.7100.80
247_W285_H0.7090.80
28_A114_R0.7090.80
283_E286_R0.7040.80
14_L279_V0.7030.80
266_A274_Q0.7020.80
109_D147_R0.7020.80
39_T125_A0.6950.79
209_G212_T0.6940.79
176_V306_L0.6930.79
14_L287_T0.6870.78
23_I287_T0.6860.78
126_G225_T0.6860.78
163_E235_G0.6840.78
303_A312_G0.6830.78
198_D276_A0.6820.78
295_V315_V0.6820.78
112_N115_R0.6820.78
127_A134_L0.6810.77
29_A119_L0.6800.77
86_A126_G0.6780.77
144_D189_T0.6760.77
193_E197_R0.6760.77
201_Y217_L0.6760.77
26_S141_V0.6750.77
44_T51_D0.6740.77
231_F236_V0.6740.77
165_F238_A0.6690.76
29_A84_C0.6660.76
175_L296_V0.6660.76
165_F294_F0.6650.76
30_T141_V0.6620.75
177_G315_V0.6610.75
273_V279_V0.6590.75
216_A269_V0.6580.75
123_L155_A0.6570.75
29_A106_L0.6560.75
74_V218_L0.6560.75
266_A285_H0.6550.75
32_A113_E0.6540.75
300_E303_A0.6530.74
28_A113_E0.6520.74
261_S314_V0.6510.74
119_L123_L0.6510.74
266_A281_D0.6490.74
75_G118_E0.6480.74
171_A317_R0.6470.74
209_G269_V0.6470.74
23_I283_E0.6450.74
209_G272_Y0.6450.74
92_L157_G0.6440.73
37_A48_G0.6340.72
284_M290_M0.6300.72
270_F277_G0.6290.72
71_A80_V0.6280.72
258_Y297_A0.6260.71
196_T272_Y0.6240.71
230_A236_V0.6240.71
49_L56_Y0.6230.71
179_P310_T0.6220.71
300_E314_V0.6210.71
103_V154_T0.6200.71
51_D56_Y0.6200.71
15_T286_R0.6170.70
45_A95_A0.6140.70
84_C247_W0.6130.70
195_A199_G0.6100.69
37_A41_T0.6070.69
16_Y20_G0.6070.69
163_E232_R0.6050.69
105_Y150_D0.6040.69
174_A177_G0.6030.69
40_G124_A0.6020.68
37_A124_A0.6010.68
76_D214_G0.6000.68
256_F259_E0.5990.68
80_V145_V0.5980.68
115_R118_E0.5980.68
93_L228_L0.5970.68
88_N248_T0.5960.68
181_A216_A0.5950.68
234_H302_A0.5940.67
106_L148_G0.5920.67
79_T122_G0.5880.67
87_M155_A0.5880.67
102_F154_T0.5820.66
115_R119_L0.5790.65
84_C111_P0.5790.65
191_A273_V0.5790.65
115_R149_F0.5770.65
155_A221_T0.5750.65
70_V191_A0.5750.65
273_V284_M0.5740.65
231_F306_L0.5740.65
53_G158_V0.5740.65
14_L283_E0.5740.65
195_A217_L0.5730.65
60_A88_N0.5710.64
66_T142_M0.5710.64
231_F235_G0.5710.64
15_T287_T0.5700.64
139_T142_M0.5690.64
177_G295_V0.5680.64
86_A220_P0.5680.64
247_W260_V0.5680.64
199_G276_A0.5680.64
15_T279_V0.5660.64
41_T44_T0.5650.64
33_L120_G0.5650.64
33_L36_A0.5640.63
257_R318_V0.5630.63
111_P151_I0.5630.63
80_V126_G0.5620.63
195_A276_A0.5620.63
68_L146_V0.5620.63
186_N244_G0.5610.63
73_A201_Y0.5600.63
212_T216_A0.5600.63
178_F222_R0.5590.63
311_D314_V0.5590.63
52_L160_T0.5580.63
70_V183_I0.5580.63
183_I217_L0.5550.62
268_P271_D0.5540.62
177_G264_L0.5540.62
262_D265_P0.5530.62
191_A196_T0.5520.62
117_A121_D0.5520.62
235_G299_P0.5500.61
191_A194_A0.5490.61
228_L231_F0.5470.61
51_D160_T0.5450.61
183_I270_F0.5450.61
250_L285_H0.5450.61
108_V115_R0.5440.61
76_D79_T0.5430.60
205_Y272_Y0.5420.60
35_D38_S0.5420.60
175_L253_M0.5410.60
29_A290_M0.5400.60
87_M220_P0.5380.60
48_G59_L0.5370.60
209_G215_D0.5350.59
42_D133_A0.5350.59
35_D117_A0.5340.59
33_L111_P0.5320.59
72_E149_F0.5290.59
111_P141_V0.5280.58
86_A130_A0.5270.58
77_Y115_R0.5250.58
193_E196_T0.5250.58
15_T280_S0.5240.58
173_D300_E0.5230.58
194_A276_A0.5230.58
266_A284_M0.5220.58
195_A213_V0.5220.58
70_V214_G0.5210.57
59_L154_T0.5200.57
262_D266_A0.5200.57
62_D186_N0.5190.57
86_A225_T0.5160.57
14_L197_R0.5120.56
213_V269_V0.5120.56
253_M295_V0.5110.56
308_S320_D0.5100.56
82_I86_A0.5100.56
120_G123_L0.5100.56
170_E233_E0.5100.56
31_A35_D0.5090.56
42_D132_V0.5090.56
69_L147_R0.5080.56
155_A185_S0.5060.55
256_F321_G0.5050.55
174_A179_P0.5050.55
203_E213_V0.5050.55
55_Q59_L0.5040.55
167_G238_A0.5040.55
45_A49_L0.5020.55
163_E231_F0.5010.54
89_V130_A0.5010.54
82_I223_I0.5000.54
178_F296_V0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kizA 2 0.8852 100 0.447 Contact Map
3mdoA 2 0.8761 100 0.457 Contact Map
2btuA 2 0.9063 100 0.488 Contact Map
2z01A 2 0.864 100 0.5 Contact Map
3m84A 2 0.9668 100 0.517 Contact Map
3p4eA 2 0.9033 100 0.519 Contact Map
2v9yA 2 0.8429 100 0.573 Contact Map
3wjpA 2 0.8761 100 0.684 Contact Map
4lgyA 1 0.9033 100 0.691 Contact Map
3u0oA 2 0.8792 100 0.696 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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