GREMLIN Database
Q9HR38 - Inosine-5'-monophosphate dehydrogenase-like
UniProt: Q9HR38 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 110 (104)
Sequences: 11485 (8628)
Seq/√Len: 846.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_D16_D2.9611.00
8_V12_D2.4751.00
10_P38_V2.3021.00
73_A77_E2.2331.00
8_V31_V2.1771.00
10_P33_S2.1551.00
69_V73_A2.1421.00
28_Q87_A2.0671.00
9_A12_D1.9781.00
6_V24_A1.9731.00
67_P85_Y1.9151.00
30_P37_P1.8831.00
70_S73_A1.8511.00
69_V90_V1.8111.00
71_A97_V1.8021.00
8_V29_L1.7981.00
71_A92_E1.7911.00
33_S36_V1.7661.00
8_V17_A1.7251.00
17_A29_L1.6581.00
10_P59_R1.6501.00
17_A41_I1.6281.00
17_A58_V1.5811.00
20_R24_A1.5461.00
56_H60_E1.5341.00
33_S38_V1.5261.00
13_A16_D1.5261.00
43_D47_V1.4971.00
28_Q40_S1.4721.00
57_A60_E1.4671.00
81_L85_Y1.3391.00
19_A23_N1.3361.00
41_I46_I1.3051.00
89_M96_T1.2791.00
15_S19_A1.2571.00
77_E81_L1.2461.00
97_V101_T1.2451.00
69_V78_I1.2231.00
7_S32_I1.2121.00
80_S84_H1.2101.00
27_S43_D1.1861.00
92_E95_E1.1801.00
41_I58_V1.1651.00
37_P66_F1.1251.00
70_S92_E1.1251.00
6_V20_R1.1251.00
6_V26_Y1.1131.00
54_G57_A1.0891.00
12_D20_R1.0851.00
30_P96_T1.0701.00
18_V46_I1.0691.00
68_T91_T1.0631.00
21_M29_L1.0541.00
74_T77_E1.0541.00
67_P81_L1.0531.00
16_D19_A1.0391.00
8_V58_V1.0231.00
9_A33_S1.0141.00
52_D55_D1.0081.00
11_D59_R1.0021.00
78_I88_V0.9901.00
53_V56_H0.9861.00
41_I61_V0.9621.00
35_G95_E0.9551.00
27_S44_N0.9161.00
15_S54_G0.9141.00
32_I38_V0.9111.00
75_L105_I0.9051.00
20_R23_N0.8891.00
15_S55_D0.8891.00
45_D63_S0.8861.00
78_I100_I0.8731.00
26_Y29_L0.8701.00
8_V20_R0.8621.00
58_V62_M0.8581.00
51_E54_G0.8521.00
78_I82_L0.8361.00
56_H61_V0.8271.00
73_A81_L0.8211.00
27_S102_Q0.8111.00
51_E56_H0.8061.00
56_H64_E0.8041.00
50_G53_V0.7981.00
87_A102_Q0.7631.00
87_A101_T0.7561.00
87_A99_I0.7541.00
57_A61_V0.7501.00
91_T96_T0.7461.00
14_V61_V0.7451.00
76_D80_S0.7421.00
77_E80_S0.7351.00
14_V18_V0.7331.00
43_D103_A0.7311.00
37_P96_T0.7251.00
49_A53_V0.7211.00
18_V43_D0.7181.00
82_L86_K0.7151.00
20_R29_L0.7131.00
69_V88_V0.7081.00
101_T104_D0.7041.00
32_I35_G0.7031.00
28_Q42_S0.6971.00
18_V47_V0.6911.00
28_Q99_I0.6891.00
92_E97_V0.6831.00
40_S87_A0.6781.00
75_L79_S0.6761.00
39_G62_M0.6741.00
14_V46_I0.6721.00
40_S89_M0.6681.00
27_S87_A0.6651.00
83_D86_K0.6641.00
52_D56_H0.6621.00
75_L100_I0.6591.00
31_V62_M0.6571.00
36_V94_G0.6571.00
9_A32_I0.6561.00
16_D20_R0.6561.00
37_P89_M0.6491.00
17_A21_M0.6481.00
49_A61_V0.6421.00
79_S87_A0.6361.00
27_S103_A0.6281.00
69_V81_L0.5971.00
44_N48_H0.5751.00
58_V63_S0.5741.00
5_L30_P0.5721.00
77_E84_H0.5691.00
75_L78_I0.5691.00
96_T99_I0.5661.00
22_Q48_H0.5631.00
103_A106_A0.5581.00
28_Q102_Q0.5571.00
22_Q43_D0.5561.00
79_S105_I0.5561.00
9_A35_G0.5561.00
81_L88_V0.5551.00
7_S29_L0.5531.00
68_T94_G0.5521.00
102_Q106_A0.5461.00
43_D49_A0.5431.00
32_I37_P0.5321.00
49_A56_H0.5271.00
12_D29_L0.5221.00
26_Y30_P0.5201.00
27_S30_P0.5191.00
74_T78_I0.5181.00
20_R30_P0.5151.00
31_V38_V0.5131.00
79_S106_A0.5121.00
62_M66_F0.5101.00
88_V91_T0.5091.00
70_S94_G0.5081.00
30_P89_M0.5051.00
27_S42_S0.5001.00
36_V95_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pc3A 2 1 99.8 0.214 Contact Map
4cooA 2 1 99.8 0.215 Contact Map
3l2bA 2 0.9364 99.8 0.215 Contact Map
3k6eA 2 1 99.7 0.253 Contact Map
1vr9A 1 0.9727 99.7 0.255 Contact Map
2o16A 2 1 99.7 0.256 Contact Map
2qrdG 1 1 99.7 0.26 Contact Map
4uuuA 2 1 99.7 0.26 Contact Map
3orgA 2 0.9545 99.7 0.264 Contact Map
2zy9A 2 0.9727 99.7 0.268 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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