GREMLIN Database
Y879 - UPF0212 protein VNG_0879C
UniProt: Q9HR37 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 121 (112)
Sequences: 105 (36)
Seq/√Len: 3.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_A14_V3.4480.65
10_A75_L3.1690.58
12_W30_E2.6970.45
82_A91_I2.6110.43
41_D79_V2.4390.39
9_E16_D2.4330.38
9_E21_D2.0450.29
42_Y78_T1.9680.28
34_R73_L1.9650.28
31_A34_R1.9480.27
38_Q77_L1.8720.26
44_E59_L1.8170.25
25_G94_S1.7900.24
39_D63_F1.7390.23
31_A73_L1.7040.22
3_N57_E1.6960.22
24_I99_A1.6940.22
52_C55_C1.6780.22
20_S46_E1.6570.22
40_L79_V1.6560.22
30_E34_R1.6550.21
12_W31_A1.6480.21
77_L96_V1.6180.21
10_A101_R1.5400.19
13_L65_A1.5210.19
26_V77_L1.4980.19
39_D95_E1.4910.19
44_E76_E1.4820.19
79_V96_V1.4450.18
26_V45_V1.4420.18
54_A65_A1.3820.17
10_A59_L1.3700.17
26_V40_L1.3670.17
25_G29_S1.2920.16
29_S94_S1.2700.15
46_E108_I1.2470.15
7_A81_N1.2330.15
19_N63_F1.2320.15
18_E73_L1.2250.15
9_E46_E1.2230.15
64_L109_D1.2210.15
22_D33_K1.2180.15
16_D21_D1.2140.15
68_T103_V1.2050.15
61_A109_D1.1690.14
9_E106_E1.1690.14
38_Q79_V1.1680.14
12_W34_R1.1640.14
8_M80_F1.1470.14
26_V38_Q1.1330.14
99_A103_V1.1270.14
44_E101_R1.1180.13
57_E60_D1.1090.13
40_L81_N1.0880.13
73_L101_R1.0840.13
25_G98_G1.0610.13
42_Y81_N1.0550.13
34_R44_E1.0540.13
90_R100_L1.0300.12
14_V47_A1.0090.12
45_V77_L1.0080.12
67_N96_V1.0010.12
12_W22_D0.9840.12
64_L67_N0.9800.12
57_E66_A0.9760.12
73_L95_E0.9670.12
28_V83_D0.9540.12
78_T98_G0.9530.11
8_M98_G0.9310.11
16_D29_S0.9270.11
50_T58_G0.9220.11
49_V83_D0.9100.11
58_G81_N0.9060.11
22_D30_E0.8970.11
75_L101_R0.8880.11
64_L75_L0.8770.11
68_T72_G0.8690.11
62_A74_V0.8550.10
103_V106_E0.8490.10
3_N7_A0.8460.10
18_E39_D0.8430.10
71_V86_E0.8420.10
38_Q78_T0.8390.10
16_D46_E0.8200.10
48_G104_P0.8140.10
19_N38_Q0.8090.10
40_L77_L0.8060.10
84_S114_G0.8050.10
67_N95_E0.7940.10
40_L110_V0.7910.10
17_V103_V0.7860.10
36_N84_S0.7780.10
90_R104_P0.7560.10
15_R72_G0.7530.10
4_Y72_G0.7530.10
96_V111_I0.7490.09
15_R26_V0.7440.09
17_V24_I0.7410.09
52_C93_K0.7340.09
3_N79_V0.7320.09
77_L85_D0.7280.09
62_A70_L0.7260.09
44_E73_L0.7210.09
29_S46_E0.7200.09
11_A21_D0.7200.09
26_V41_D0.7170.09
14_V56_G0.7130.09
74_V103_V0.7090.09
21_D85_D0.7070.09
21_D49_V0.7070.09
50_T54_A0.6900.09
32_G69_A0.6890.09
28_V62_A0.6870.09
11_A66_A0.6840.09
99_A102_D0.6830.09
3_N26_V0.6780.09
29_S60_D0.6750.09
19_N67_N0.6730.09
18_E75_L0.6720.09
13_L94_S0.6670.09
26_V60_D0.6610.09
8_M35_L0.6450.09
25_G83_D0.6410.09
16_D94_S0.6320.08
20_S96_V0.6290.08
31_A101_R0.6260.08
62_A73_L0.6260.08
14_V40_L0.6220.08
81_N107_V0.6200.08
50_T60_D0.6140.08
20_S47_A0.6100.08
9_E103_V0.6090.08
28_V95_E0.6060.08
40_L58_G0.6000.08
85_D90_R0.5980.08
34_R45_V0.5960.08
36_N42_Y0.5880.08
31_A44_E0.5760.08
75_L102_D0.5730.08
46_E91_I0.5730.08
4_Y82_A0.5690.08
21_D90_R0.5640.08
15_R45_V0.5580.08
4_Y77_L0.5550.08
3_N60_D0.5540.08
59_L76_E0.5520.08
44_E62_A0.5500.08
35_L53_P0.5460.08
13_L54_A0.5430.08
52_C72_G0.5430.08
69_A110_V0.5400.08
10_A18_E0.5390.08
7_A95_E0.5310.08
89_Q109_D0.5310.08
9_E14_V0.5290.08
18_E44_E0.5250.08
94_S98_G0.5220.08
26_V58_G0.5160.08
62_A75_L0.5160.08
42_Y83_D0.5130.08
72_G93_K0.5130.08
3_N113_D0.5120.08
34_R101_R0.5090.07
78_T91_I0.5060.07
47_A66_A0.5050.07
20_S62_A0.5050.07
13_L45_V0.5010.07
22_D52_C0.5000.07
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vxaA 5 0.5207 43.5 0.939 Contact Map
3vpbE 1 0.4298 18.7 0.949 Contact Map
4mwaA 4 0.3058 15.7 0.951 Contact Map
2i5oA 1 0.2397 14.4 0.952 Contact Map
2ux9A 5 0.5455 14.1 0.952 Contact Map
4u3eA 2 0.7438 10.3 0.955 Contact Map
3ga8A 1 0.4628 9.5 0.956 Contact Map
1tfeA 2 0.3884 7.4 0.958 Contact Map
4g38A 1 0.9174 7 0.958 Contact Map
2lcqA 1 0.5455 6.7 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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