GREMLIN Database
PSB - Proteasome subunit beta
UniProt: Q9HR36 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 243 (193)
Sequences: 4168 (2332)
Seq/√Len: 167.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_T198_D5.3771.00
63_A203_A3.9551.00
53_G62_M3.1911.00
57_Q193_D3.1001.00
157_H169_S2.5601.00
53_G158_V2.5061.00
56_T199_A2.4661.00
196_M227_T2.4611.00
51_I93_S2.4511.00
56_T59_G2.4061.00
189_E205_H2.3881.00
90_A125_I2.3481.00
196_M232_T2.3261.00
116_E122_Y2.3191.00
85_E88_P2.1391.00
196_M200_E2.1141.00
54_L203_A2.1131.00
91_A231_L2.0531.00
171_T192_E2.0341.00
62_M149_G2.0311.00
152_D155_G1.9931.00
140_P143_R1.9601.00
58_D228_H1.9561.00
57_Q195_T1.9201.00
191_S198_D1.8311.00
87_Q116_E1.8211.00
55_T169_S1.7811.00
125_I150_G1.7291.00
194_L202_V1.7241.00
147_I173_T1.7101.00
89_N122_Y1.6871.00
61_L203_A1.6841.00
60_V149_G1.6471.00
90_A128_L1.6471.00
56_T227_T1.6451.00
189_E202_V1.6421.00
61_L200_E1.6341.00
200_E223_I1.6191.00
54_L199_A1.5931.00
227_T232_T1.5261.00
227_T230_G1.5231.00
61_L225_K1.5221.00
50_T178_G1.4771.00
124_S127_A1.4751.00
108_L132_A1.4671.00
145_V163_P1.4601.00
58_D196_M1.4471.00
56_T196_M1.4191.00
224_T231_L1.4181.00
112_A128_L1.4071.00
191_S194_L1.4001.00
63_A223_I1.3671.00
190_Y193_D1.3631.00
83_V224_T1.3391.00
200_E225_K1.3331.00
92_L148_L1.3301.00
94_I101_A1.3281.00
59_G199_A1.3251.00
55_T171_T1.3101.00
159_F169_S1.3031.00
201_Q205_H1.2951.00
224_T233_T1.2861.00
190_Y194_L1.2551.00
60_V158_V1.2521.00
92_L105_I1.2481.00
87_Q122_Y1.2291.00
83_V93_S1.2231.00
107_S111_E1.2191.00
86_I112_A1.2091.00
91_A226_I1.2081.00
123_M128_L1.2061.00
185_V189_E1.1851.00
147_I175_Q1.1751.00
111_E114_L1.1641.00
107_S135_L1.1551.00
81_Q222_H1.1481.00
225_K232_T1.1411.00
68_A80_V1.1381.00
174_A186_L1.1361.00
59_G196_M1.1311.00
50_T182_A1.1271.00
115_Y119_R1.1191.00
151_V228_H1.1131.00
136_L146_P1.1131.00
129_S167_S1.1081.00
185_V206_A1.1021.00
61_L199_A1.0961.00
111_E131_M1.0961.00
131_M135_L1.0901.00
66_M220_G1.0530.99
136_L161_L1.0290.99
125_I157_H1.0280.99
52_V186_L1.0240.99
84_E105_I1.0180.99
62_M91_A1.0000.99
197_A201_Q0.9970.99
148_L161_L0.9920.99
55_T156_G0.9850.99
205_H208_K0.9840.99
201_Q204_A0.9810.99
186_L206_A0.9770.99
162_D166_S0.9700.99
110_A114_L0.9700.99
135_L138_G0.9600.99
204_A221_I0.9540.99
70_L76_S0.9540.99
62_M224_T0.9510.99
91_A224_T0.9450.99
204_A223_I0.9360.99
86_I92_L0.9340.99
123_M131_M0.9240.99
160_S173_T0.9070.98
66_M222_H0.9060.98
84_E94_I0.8990.98
105_I109_R0.8950.98
60_V156_G0.8930.98
81_Q233_T0.8920.98
95_S175_Q0.8910.98
170_D173_T0.8770.98
115_Y127_A0.8770.98
185_V202_V0.8760.98
60_V63_A0.8750.98
87_Q90_A0.8720.98
67_R218_G0.8640.98
172_Y186_L0.8640.98
197_A200_E0.8620.98
135_L142_F0.8620.98
62_M93_S0.8580.98
124_S129_S0.8480.97
67_R75_I0.8410.97
53_G149_G0.8400.97
151_V156_G0.8370.97
174_A182_A0.8350.97
114_L118_R0.8240.97
89_N153_D0.8180.97
206_A210_A0.8150.97
104_F144_V0.8120.97
84_E103_S0.8040.97
160_S170_D0.8030.97
132_A148_L0.7990.96
52_V74_V0.7980.96
101_A144_V0.7970.96
198_D201_Q0.7930.96
113_N116_E0.7920.96
110_A113_N0.7920.96
187_E213_R0.7860.96
92_L146_P0.7830.96
101_A105_I0.7760.96
205_H209_S0.7750.96
43_T46_K0.7740.96
222_H233_T0.7710.96
194_L198_D0.7660.95
88_P122_Y0.7650.95
214_D217_S0.7620.95
123_M127_A0.7600.95
56_T225_K0.7600.95
64_S95_S0.7560.95
89_N123_M0.7490.95
69_S75_I0.7460.95
94_I99_G0.7400.95
182_A206_A0.7380.94
124_S153_D0.7370.94
132_A161_L0.7360.94
49_T65_D0.7350.94
152_D157_H0.7340.94
149_G226_I0.7310.94
50_T207_V0.7290.94
47_T184_G0.7270.94
104_F132_A0.7220.94
194_L199_A0.7200.94
98_V101_A0.7200.94
51_I64_S0.7180.94
142_F163_P0.7160.93
67_R177_S0.7130.93
172_Y183_L0.7110.93
61_L196_M0.7110.93
107_S110_A0.7100.93
232_T235_G0.7080.93
196_M199_A0.7040.93
153_D228_H0.7030.93
57_Q192_E0.7030.93
134_N138_G0.7020.93
100_G141_F0.6990.93
139_G142_F0.6970.93
121_E153_D0.6970.93
196_M225_K0.6940.92
90_A148_L0.6930.92
82_K190_Y0.6900.92
195_T199_A0.6880.92
214_D218_G0.6840.92
95_S166_S0.6840.92
64_S83_V0.6810.92
115_Y123_M0.6770.91
52_V63_A0.6730.91
154_D157_H0.6710.91
208_K211_S0.6680.91
115_Y124_S0.6680.91
127_A130_T0.6590.90
147_I158_V0.6590.90
151_V226_I0.6580.90
129_S159_F0.6540.90
198_D202_V0.6530.90
114_L117_A0.6520.90
94_I146_P0.6480.90
126_D154_D0.6460.89
85_E233_T0.6450.89
144_V186_L0.6450.89
67_R214_D0.6410.89
154_D228_H0.6360.89
83_V91_A0.6340.89
133_S167_S0.6290.88
50_T75_I0.6270.88
204_A208_K0.6260.88
213_R230_G0.6260.88
115_Y121_E0.6220.88
145_V175_Q0.6180.87
232_T236_H0.6160.87
130_T134_N0.6120.87
211_S214_D0.6100.87
107_S131_M0.6100.87
88_P201_Q0.6100.87
54_L202_V0.6090.87
96_G100_G0.6040.86
83_V222_H0.6030.86
86_I128_L0.6010.86
108_L131_M0.5960.85
58_D195_T0.5950.85
115_Y136_L0.5950.85
210_A214_D0.5910.85
163_P175_Q0.5850.84
49_T95_S0.5840.84
99_G166_S0.5840.84
86_I109_R0.5840.84
196_M215_T0.5800.84
197_A229_D0.5790.84
132_A165_G0.5760.83
209_S220_G0.5750.83
139_G161_L0.5740.83
113_N118_R0.5720.83
51_I94_I0.5710.83
117_A128_L0.5680.83
151_V157_H0.5680.83
57_Q88_P0.5660.82
73_R76_S0.5640.82
97_S100_G0.5640.82
167_S170_D0.5620.82
96_G165_G0.5610.82
59_G178_G0.5600.82
97_S103_S0.5570.81
82_K177_S0.5570.81
200_E234_V0.5550.81
104_F141_F0.5550.81
172_Y190_Y0.5540.81
84_E101_A0.5530.81
185_V209_S0.5500.80
84_E95_S0.5500.80
51_I147_I0.5460.80
78_K81_Q0.5460.80
233_T236_H0.5420.80
219_N236_H0.5370.79
97_S143_R0.5370.79
156_G228_H0.5320.78
210_A217_S0.5320.78
173_T183_L0.5300.78
129_S148_L0.5300.78
130_T133_S0.5300.78
116_E120_G0.5280.78
227_T231_L0.5260.78
60_V226_I0.5220.77
106_R109_R0.5220.77
126_D130_T0.5210.77
75_I78_K0.5180.76
159_F167_S0.5170.76
187_E209_S0.5170.76
48_G82_K0.5160.76
85_E229_D0.5150.76
197_A236_H0.5140.76
177_S214_D0.5120.76
120_G127_A0.5100.75
106_R180_P0.5100.75
86_I108_L0.5090.75
82_K95_S0.5090.75
229_D232_T0.5080.75
178_G181_Y0.5050.75
58_D227_T0.5050.75
81_Q105_I0.5040.74
60_V147_I0.5020.74
204_A207_V0.5010.74
91_A174_A0.5000.74
183_L213_R0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rypC 1 0.9259 100 0.158 Contact Map
4r3oB 1 0.9177 100 0.159 Contact Map
1rypF 1 0.9136 100 0.163 Contact Map
4r3oC 1 0.9218 100 0.166 Contact Map
4r3oA 1 0.93 100 0.172 Contact Map
4r3oE 1 0.9012 100 0.174 Contact Map
1rypB 1 0.9177 100 0.176 Contact Map
1rypA 1 0.9095 100 0.176 Contact Map
1yarA 3 0.8807 100 0.176 Contact Map
4r3oF 1 0.9053 100 0.176 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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