GREMLIN Database
Q9HR34 - p-nitrophenyl phosphatase
UniProt: Q9HR34 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (202)
Sequences: 3724 (2590)
Seq/√Len: 182.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_G180_T5.0571.00
160_L181_A3.5411.00
101_G122_V3.2371.00
171_A175_A3.0481.00
179_T198_D2.9381.00
142_E146_R2.8541.00
126_A132_D2.8071.00
42_A61_A2.6381.00
154_V159_C2.5451.00
126_A133_P2.4421.00
5_S20_P2.4081.00
203_S206_E2.2621.00
170_V180_T2.1631.00
45_P55_L1.9471.00
149_V159_C1.9181.00
202_D206_E1.9131.00
106_I127_G1.8461.00
161_V178_M1.8361.00
30_T73_V1.8151.00
77_D84_D1.8051.00
181_A201_L1.7901.00
123_Q127_G1.7661.00
184_R200_V1.7581.00
123_Q126_A1.7441.00
81_G84_D1.7141.00
145_A172_L1.7021.00
92_F125_V1.6931.00
30_T100_V1.6901.00
155_P158_E1.6321.00
9_A13_G1.6271.00
48_A78_P1.6261.00
99_L133_P1.6121.00
49_D53_T1.6021.00
174_A198_D1.5651.00
31_I58_A1.5521.00
37_S98_A1.5431.00
8_A20_P1.5281.00
42_A70_D1.5271.00
146_R156_P1.5031.00
108_I117_G1.4851.00
8_A12_E1.4761.00
29_A144_T1.4681.00
100_V137_L1.4621.00
41_A70_D1.4611.00
145_A161_V1.4581.00
5_S9_A1.4381.00
90_D112_D1.4211.00
141_S175_A1.4031.00
43_V60_V1.3961.00
110_A115_K1.3751.00
3_P6_E1.3731.00
147_L150_D1.3721.00
4_A28_D1.3411.00
85_L124_A1.3261.00
55_L73_V1.3211.00
6_E9_A1.3151.00
9_A12_E1.2981.00
98_A135_A1.2971.00
24_L147_L1.2891.00
12_E20_P1.2841.00
179_T199_H1.2801.00
27_T31_I1.2781.00
32_T36_R1.2751.00
32_T147_L1.2741.00
92_F129_A1.2671.00
5_S53_T1.2641.00
36_R150_D1.2631.00
145_A178_M1.2411.00
4_A54_Q1.2391.00
90_D93_A1.2291.00
190_A202_D1.2281.00
56_R62_I1.2251.00
53_T56_R1.2181.00
165_R168_T1.2061.00
148_A152_L1.2031.00
19_T22_E1.1971.00
160_L179_T1.1931.00
184_R202_D1.1911.00
10_R14_L1.1911.00
106_I123_Q1.1881.00
182_L188_D1.1711.00
92_F95_G1.1621.00
69_A91_A1.1591.00
33_Y137_L1.1481.00
184_R188_D1.1451.00
10_R13_G1.1411.00
122_V136_V1.1351.00
201_L207_I1.1211.00
8_A23_V1.1211.00
18_A22_E1.1031.00
46_I88_A1.1001.00
35_Q60_V1.0891.00
86_Q115_K1.0881.00
90_D115_K1.0861.00
74_A122_V1.0861.00
24_L151_R1.0651.00
38_H41_A1.0621.00
87_A91_A1.0591.00
71_V98_A1.0531.00
89_V128_V1.0521.00
88_A125_V1.0501.00
171_A195_A1.0461.00
184_R190_A1.0381.00
165_R187_V1.0301.00
106_I167_D1.0291.00
86_Q116_P1.0231.00
44_Y91_A1.0180.99
74_A99_L1.0150.99
105_D168_T1.0120.99
12_E17_D1.0110.99
135_A143_T1.0110.99
146_R150_D1.0080.99
101_G136_V0.9970.99
49_D52_T0.9940.99
118_S122_V0.9930.99
182_L200_V0.9890.99
30_T102_T0.9880.99
24_L148_A0.9850.99
44_Y88_A0.9740.99
7_H23_V0.9700.99
107_T114_A0.9620.99
30_T137_L0.9580.99
33_Y100_V0.9490.99
96_T131_R0.9450.99
31_I35_Q0.9450.99
86_Q90_D0.9430.99
180_T198_D0.9340.99
54_Q57_A0.9340.99
101_G118_S0.9260.99
34_L73_V0.9250.99
120_A124_A0.9240.99
83_Q87_A0.9230.99
149_V156_P0.9170.99
33_Y37_S0.9130.99
167_D187_V0.9080.99
47_A51_I0.8990.99
120_A127_G0.8970.99
76_F80_F0.8910.99
160_L199_H0.8900.99
74_A121_I0.8890.99
145_A173_G0.8850.99
80_F85_L0.8850.99
192_P195_A0.8840.99
149_V178_M0.8760.98
148_A172_L0.8760.98
37_S135_A0.8750.98
66_P69_A0.8710.98
50_A54_Q0.8690.98
105_D109_P0.8660.98
76_F108_I0.8570.98
6_E53_T0.8510.98
174_A180_T0.8440.98
6_E50_A0.8430.98
154_V158_E0.8280.98
7_H25_T0.8260.98
147_L151_R0.8250.98
104_P126_A0.8240.98
103_D168_T0.8200.98
53_T57_A0.8180.98
28_D54_Q0.8090.97
26_A102_T0.8070.97
92_F99_L0.8040.97
45_P52_T0.8030.97
104_P136_V0.8030.97
161_V172_L0.8030.97
38_H71_V0.7990.97
32_T151_R0.7900.97
43_V73_V0.7850.97
42_A68_A0.7820.97
52_T62_I0.7790.97
44_Y72_V0.7730.97
79_A83_Q0.7680.96
174_A195_A0.7660.96
156_P178_M0.7600.96
27_T30_T0.7570.96
34_L60_V0.7560.96
89_V125_V0.7540.96
29_A147_L0.7480.96
29_A137_L0.7460.96
107_T165_R0.7430.96
80_F124_A0.7400.96
76_F121_I0.7400.96
51_I102_T0.7340.95
80_F121_I0.7330.95
92_F131_R0.7320.95
145_A176_A0.7280.95
24_L29_A0.7270.95
31_I54_Q0.7260.95
52_T56_R0.7250.95
21_G151_R0.7110.95
32_T58_A0.7080.94
33_Y135_A0.7060.94
145_A148_A0.7000.94
24_L145_A0.6990.94
82_F116_P0.6960.94
41_A60_V0.6950.94
35_Q58_A0.6940.94
69_A75_G0.6930.94
142_E175_A0.6890.94
170_V174_A0.6790.93
98_A131_R0.6770.93
193_A196_Q0.6770.93
42_A63_T0.6760.93
107_T187_V0.6740.93
89_V129_A0.6720.93
27_T51_I0.6690.93
73_V100_V0.6680.93
32_T35_Q0.6660.92
49_D56_R0.6620.92
109_P113_G0.6550.92
72_V88_A0.6500.92
31_I55_L0.6450.91
104_P122_V0.6390.91
131_R135_A0.6370.91
22_E151_R0.6320.90
114_A187_V0.6310.90
143_T146_R0.6310.90
149_V176_A0.6290.90
99_L131_R0.6270.90
166_P193_A0.6260.90
5_S57_A0.6240.90
26_A105_D0.6240.90
17_D22_E0.6220.90
89_V121_I0.6220.90
41_A61_A0.6220.90
86_Q89_V0.6210.90
182_L185_T0.6200.90
90_D114_A0.6180.89
29_A32_T0.6150.89
89_V107_T0.6100.89
166_P195_A0.6090.89
48_A51_I0.6070.89
47_A75_G0.6060.88
197_P200_V0.6060.88
161_V173_G0.6040.88
172_L176_A0.6040.88
166_P174_A0.6020.88
105_D163_G0.5970.88
31_I60_V0.5960.88
103_D118_S0.5950.88
165_R185_T0.5940.87
171_A174_A0.5930.87
66_P75_G0.5920.87
125_V129_A0.5880.87
68_A94_D0.5880.87
86_Q112_D0.5860.87
8_A19_T0.5850.87
120_A128_V0.5830.86
65_D68_A0.5830.86
117_G187_V0.5820.86
201_L206_E0.5790.86
71_V74_A0.5740.86
93_A129_A0.5690.85
24_L144_T0.5680.85
26_A103_D0.5680.85
155_P159_C0.5660.85
161_V176_A0.5650.85
166_P170_V0.5650.85
142_E176_A0.5630.85
40_G61_A0.5610.84
170_V173_G0.5600.84
181_A207_I0.5570.84
46_I80_F0.5550.84
108_I118_S0.5540.84
144_T172_L0.5490.83
11_L25_T0.5490.83
8_A17_D0.5490.83
47_A168_T0.5480.83
190_A200_V0.5460.83
80_F84_D0.5450.83
44_Y84_D0.5450.83
148_A159_C0.5430.82
162_V205_G0.5410.82
3_P53_T0.5400.82
170_V198_D0.5400.82
77_D80_F0.5390.82
166_P188_D0.5390.82
121_I124_A0.5380.82
159_C178_M0.5360.82
74_A101_G0.5310.81
72_V92_F0.5310.81
144_T148_A0.5290.81
102_T168_T0.5260.80
183_V201_L0.5220.80
28_D151_R0.5200.80
40_G70_D0.5200.80
19_T132_D0.5170.79
92_F96_T0.5170.79
124_A127_G0.5160.79
7_H165_R0.5150.79
88_A91_A0.5100.78
156_P176_A0.5080.78
110_A113_G0.5060.78
103_D108_I0.5050.78
34_L98_A0.5050.78
95_G177_G0.5030.77
28_D32_T0.5030.77
7_H108_I0.5020.77
85_L125_V0.5020.77
111_A114_A0.5020.77
28_D71_V0.5010.77
42_A66_P0.5010.77
45_P51_I0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kc2A 2 0.967 100 0.43 Contact Map
2ho4A 1 0.9528 100 0.485 Contact Map
1zjjA 2 0.9811 100 0.499 Contact Map
4i9fA 2 0.9811 100 0.531 Contact Map
2oycA 2 0.9906 99.9 0.541 Contact Map
3pdwA 1 0.9528 99.9 0.552 Contact Map
3eprA 3 0.9811 99.9 0.555 Contact Map
1vjrA 1 0.9858 99.9 0.56 Contact Map
1yv9A 2 0.9764 99.9 0.577 Contact Map
2c4nA 3 0.9528 99.9 0.578 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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