GREMLIN Database
Q9HR33 - Uncharacterized protein
UniProt: Q9HR33 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (222)
Sequences: 4817 (3298)
Seq/√Len: 221.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_V155_C3.5631.00
18_T216_I3.4891.00
160_T165_T3.1831.00
130_A160_T2.9701.00
134_T158_T2.9621.00
21_E27_V2.8971.00
186_L210_P2.8721.00
89_T116_R2.8651.00
205_A213_A2.8201.00
70_T168_W2.7431.00
123_R130_A2.7411.00
199_T234_A2.6211.00
174_A207_R2.6001.00
158_T183_C2.5141.00
26_T127_A2.4791.00
132_T160_T2.3441.00
28_A66_L2.3161.00
196_M204_L2.2871.00
97_D117_R2.2441.00
9_T21_E2.2001.00
184_D211_A2.1711.00
125_R130_A2.1551.00
187_L214_V2.1331.00
57_A60_R2.1291.00
166_V187_L2.0871.00
192_R197_G2.0401.00
123_R132_T2.0131.00
134_T156_G2.0021.00
169_P189_P1.9591.00
30_T70_T1.9531.00
179_D207_R1.8891.00
18_T187_L1.8571.00
19_R27_V1.8511.00
97_D101_T1.8431.00
68_V157_Y1.8401.00
68_V159_L1.8261.00
10_V185_V1.8101.00
139_A194_I1.8011.00
118_V133_V1.7231.00
229_R233_C1.7211.00
203_D206_D1.7081.00
203_D207_R1.6941.00
169_P188_A1.6601.00
205_A210_P1.6551.00
66_L89_T1.6111.00
230_R234_A1.5611.00
165_T183_C1.5461.00
185_V214_V1.5331.00
35_Y76_D1.5221.00
67_V90_V1.5181.00
22_W161_R1.4741.00
30_T168_W1.4141.00
168_W216_I1.4101.00
187_L216_I1.3951.00
121_G135_E1.3741.00
234_A237_S1.3571.00
125_R128_G1.3511.00
66_L91_V1.3431.00
72_A99_A1.3151.00
77_P81_A1.3111.00
94_D119_E1.3071.00
190_I201_A1.3041.00
206_D242_V1.3001.00
116_R124_Q1.2851.00
66_L126_A1.2831.00
20_I166_V1.2821.00
119_E139_A1.2671.00
131_L157_Y1.2661.00
30_T159_L1.2511.00
11_D21_E1.2141.00
201_A213_A1.2071.00
13_L55_P1.2031.00
238_S241_P1.2001.00
91_V118_V1.1991.00
197_G200_E1.1951.00
133_V157_Y1.1911.00
202_A238_S1.1851.00
10_V18_T1.1811.00
26_T129_V1.1781.00
61_A64_G1.1781.00
233_C237_S1.1711.00
59_Y82_R1.1431.00
10_V187_L1.1331.00
159_L166_V1.1201.00
174_A203_D1.1201.00
68_V131_L1.1091.00
156_G169_P1.1051.00
17_T30_T1.0841.00
91_V124_Q1.0771.00
169_P186_L1.0771.00
78_H82_R1.0701.00
205_A235_V1.0651.00
93_Y155_C1.0451.00
206_D238_S1.0451.00
26_T65_D1.0451.00
234_A238_S1.0411.00
185_V212_L1.0391.00
34_R58_E1.0391.00
149_H152_G1.0361.00
13_L17_T1.0321.00
230_R233_C1.0301.00
176_A180_A1.0171.00
79_G83_V1.0101.00
20_I30_T1.0071.00
188_A208_L1.0051.00
188_A204_L1.0051.00
119_E122_A0.9891.00
79_G82_R0.9831.00
19_R64_G0.9831.00
79_G84_A0.9801.00
94_D98_A0.9801.00
134_T167_F0.9781.00
118_V122_A0.9631.00
28_A129_V0.9601.00
148_L151_P0.9601.00
227_D230_R0.9591.00
33_G38_L0.9591.00
98_A101_T0.9581.00
29_Y64_G0.9501.00
146_T149_H0.9501.00
71_H171_A0.9471.00
186_L208_L0.9441.00
178_H181_I0.9421.00
13_L34_R0.9421.00
66_L131_L0.9381.00
27_V63_D0.9341.00
90_V105_V0.9321.00
8_V164_T0.9250.99
91_V131_L0.9250.99
100_T103_R0.9200.99
92_V96_I0.9190.99
27_V64_G0.9140.99
116_R193_R0.9120.99
92_V97_D0.9120.99
30_T68_V0.9080.99
218_Y232_A0.9040.99
91_V157_Y0.9020.99
12_W216_I0.9020.99
18_T214_V0.9010.99
28_A131_L0.8970.99
75_Y80_I0.8910.99
186_L205_A0.8800.99
169_P172_S0.8750.99
97_D115_V0.8680.99
13_L19_R0.8640.99
136_A172_S0.8630.99
19_R29_Y0.8570.99
34_R79_G0.8500.99
167_F204_L0.8470.99
80_I105_V0.8470.99
118_V124_Q0.8330.99
17_T34_R0.8310.99
164_T184_D0.8280.99
229_R232_A0.8240.99
198_E226_G0.8210.99
212_L215_P0.8100.99
78_H83_V0.8070.99
87_D106_T0.8070.99
226_G231_F0.8050.99
26_T66_L0.8030.99
165_T184_D0.8020.99
175_L178_H0.7990.99
190_I218_Y0.7970.98
71_H217_H0.7950.98
106_T114_D0.7900.98
132_T158_T0.7870.98
131_L159_L0.7870.98
167_F208_L0.7840.98
16_A189_P0.7840.98
147_S151_P0.7830.98
92_V157_Y0.7830.98
147_S152_G0.7800.98
161_R164_T0.7770.98
141_D150_P0.7770.98
27_V65_D0.7750.98
68_V155_C0.7740.98
158_T181_I0.7720.98
24_D161_R0.7720.98
198_E230_R0.7670.98
192_R226_G0.7660.98
188_A196_M0.7650.98
232_A236_A0.7540.98
172_S178_H0.7500.98
197_G201_A0.7480.98
200_E203_D0.7480.98
171_A217_H0.7410.98
89_T114_D0.7390.98
178_H204_L0.7390.98
24_D163_D0.7370.98
10_V214_V0.7350.97
22_W28_A0.7350.97
137_Q175_L0.7330.97
120_Y173_D0.7270.97
20_I28_A0.7190.97
228_G231_F0.7180.97
82_R86_A0.7180.97
13_L54_P0.7160.97
91_V126_A0.7150.97
76_D79_G0.7100.97
81_A84_A0.7080.97
147_S150_P0.7080.97
22_W159_L0.7070.97
161_R166_V0.7040.97
50_A53_H0.7020.97
236_A241_P0.7000.97
37_V48_E0.6990.97
176_A179_D0.6950.96
121_G134_T0.6940.96
182_D211_A0.6910.96
93_Y96_I0.6870.96
238_S242_V0.6810.96
99_A103_R0.6760.96
138_T217_H0.6730.96
165_T182_D0.6700.96
240_V243_A0.6650.95
22_W162_G0.6640.95
136_A156_G0.6630.95
26_T128_G0.6600.95
90_V100_T0.6590.95
99_A102_S0.6560.95
231_F235_V0.6560.95
202_A235_V0.6550.95
37_V47_F0.6510.95
94_D117_R0.6480.95
166_V185_V0.6420.95
36_G49_G0.6410.94
204_L208_L0.6400.94
8_V22_W0.6380.94
237_S240_V0.6380.94
56_G61_A0.6370.94
121_G181_I0.6360.94
182_D209_D0.6310.94
17_T33_G0.6290.94
93_Y157_Y0.6240.94
12_W219_N0.6220.94
69_I75_Y0.6220.94
175_L181_I0.6210.93
210_P213_A0.6210.93
77_P80_I0.6210.93
71_H138_T0.6210.93
188_A205_A0.6210.93
189_P201_A0.6190.93
75_Y96_I0.6140.93
169_P178_H0.6130.93
183_C186_L0.6130.93
177_S180_A0.6120.93
120_Y153_V0.6070.93
190_I215_P0.6070.93
120_Y155_C0.6050.93
138_T171_A0.6030.92
11_D19_R0.6030.92
93_Y133_V0.6000.92
192_R223_R0.5990.92
145_G148_L0.5980.92
24_D164_T0.5970.92
215_P218_Y0.5970.92
56_G60_R0.5960.92
137_Q173_D0.5950.92
148_L152_G0.5950.92
239_G244_L0.5940.92
66_L127_A0.5930.92
156_G167_F0.5900.92
67_V83_V0.5890.92
77_P82_R0.5890.92
146_T150_P0.5890.92
215_P231_F0.5870.91
178_H207_R0.5840.91
105_V115_V0.5840.91
198_E234_A0.5830.91
145_G149_H0.5810.91
126_A129_V0.5810.91
158_T165_T0.5800.91
172_S196_M0.5790.91
83_V88_A0.5780.91
87_D114_D0.5760.91
194_I224_L0.5750.91
146_T151_P0.5750.91
72_A96_I0.5720.90
92_V117_R0.5700.90
168_W187_L0.5690.90
202_A206_D0.5670.90
16_A216_I0.5660.90
80_I103_R0.5650.90
221_V224_L0.5650.90
202_A234_A0.5620.90
173_D200_E0.5600.89
121_G180_A0.5590.89
235_V244_L0.5570.89
12_W218_Y0.5570.89
158_T167_F0.5570.89
160_T163_D0.5570.89
39_T46_G0.5550.89
237_S241_P0.5540.89
140_P154_G0.5530.89
215_P226_G0.5520.89
135_E153_V0.5490.89
77_P103_R0.5470.88
69_I96_I0.5450.88
202_A239_G0.5450.88
72_A140_P0.5380.88
81_A105_V0.5360.87
215_P228_G0.5350.87
18_T30_T0.5330.87
80_I90_V0.5330.87
64_G67_V0.5330.87
58_E82_R0.5320.87
74_H171_A0.5310.87
24_D162_G0.5290.87
71_H74_H0.5290.87
101_T115_V0.5290.87
78_H84_A0.5280.87
47_F50_A0.5280.87
198_E202_A0.5240.86
10_V20_I0.5220.86
87_D90_V0.5220.86
134_T181_I0.5210.86
92_V115_V0.5200.86
63_D86_A0.5200.86
233_C236_A0.5200.86
74_H79_G0.5200.86
29_Y61_A0.5170.85
22_W129_V0.5150.85
141_D151_P0.5140.85
84_A105_V0.5100.85
52_E220_T0.5090.85
94_D153_V0.5080.84
206_D209_D0.5050.84
172_S189_P0.5040.84
51_H222_E0.5040.84
83_V86_A0.5030.84
17_T54_P0.5020.84
35_Y78_H0.5000.83
85_S88_A0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qn9A 2 0.928 100 0.436 Contact Map
3rpcA 2 0.9053 100 0.484 Contact Map
3bv6A 5 0.9811 100 0.537 Contact Map
2wylA 5 0.9356 100 0.553 Contact Map
4jo0A 2 0.8447 100 0.569 Contact Map
3kl7A 1 0.7917 100 0.59 Contact Map
1zkpA 2 0.8182 99.9 0.634 Contact Map
2cbnA 2 0.8182 99.9 0.646 Contact Map
1vjnA 1 0.6818 99.9 0.661 Contact Map
1y44A 2 0.8295 99.9 0.661 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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