Q9HR33 - HALSA - GREMLIN Contacts

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Q9HR33 - Uncharacterized protein

UniProt:	Q9HR33	Sequences: MTVTAAGVTVDWLGYATTRIEWADGTVAYTDPGRYGVLTGEWTPGGFEGAHEHPPGAEYRAQDGDLVVITHAHHYDPHGIARVASADATVVVYDAIDAATTSRDVTPVDALDYDVRRVEYGARQRAAGVALTVTEAQTAPDEPGGTSLHPPGVGCGYTLTRGDTTVFWPGASDALASHDAIDCDVLLAPISRRITMGETEAADLADRLDPALAVPIHYNTVERLTGDGRRFACAVASSGVPVALDEQASTARPSQRGARGGRCP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	264 (222)
Sequences:	4817 (3298)
Seq/√Len:	221.3

ECOLI - ULAG
BACSU - YDDR YTKL
HALSA - Q9HR33 Q9HR59 Y1038
SULSO - Y099 Q97W37

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
133_V	155_C	3.563	1.00
18_T	216_I	3.489	1.00
160_T	165_T	3.183	1.00
130_A	160_T	2.970	1.00
134_T	158_T	2.962	1.00
21_E	27_V	2.897	1.00
186_L	210_P	2.872	1.00
89_T	116_R	2.865	1.00
205_A	213_A	2.820	1.00
70_T	168_W	2.743	1.00
123_R	130_A	2.741	1.00
199_T	234_A	2.621	1.00
174_A	207_R	2.600	1.00
158_T	183_C	2.514	1.00
26_T	127_A	2.479	1.00
132_T	160_T	2.344	1.00
28_A	66_L	2.316	1.00
196_M	204_L	2.287	1.00
97_D	117_R	2.244	1.00
9_T	21_E	2.200	1.00
184_D	211_A	2.171	1.00
125_R	130_A	2.155	1.00
187_L	214_V	2.133	1.00
57_A	60_R	2.129	1.00
166_V	187_L	2.087	1.00
192_R	197_G	2.040	1.00
123_R	132_T	2.013	1.00
134_T	156_G	2.002	1.00
169_P	189_P	1.959	1.00
30_T	70_T	1.953	1.00
179_D	207_R	1.889	1.00
18_T	187_L	1.857	1.00
19_R	27_V	1.851	1.00
97_D	101_T	1.843	1.00
68_V	157_Y	1.840	1.00
68_V	159_L	1.826	1.00
10_V	185_V	1.810	1.00
139_A	194_I	1.801	1.00
118_V	133_V	1.723	1.00
229_R	233_C	1.721	1.00
203_D	206_D	1.708	1.00
203_D	207_R	1.694	1.00
169_P	188_A	1.660	1.00
205_A	210_P	1.655	1.00
66_L	89_T	1.611	1.00
230_R	234_A	1.561	1.00
165_T	183_C	1.546	1.00
185_V	214_V	1.533	1.00
35_Y	76_D	1.522	1.00
67_V	90_V	1.518	1.00
22_W	161_R	1.474	1.00
30_T	168_W	1.414	1.00
168_W	216_I	1.410	1.00
187_L	216_I	1.395	1.00
121_G	135_E	1.374	1.00
234_A	237_S	1.357	1.00
125_R	128_G	1.351	1.00
66_L	91_V	1.343	1.00
72_A	99_A	1.315	1.00
77_P	81_A	1.311	1.00
94_D	119_E	1.307	1.00
190_I	201_A	1.304	1.00
206_D	242_V	1.300	1.00
116_R	124_Q	1.285	1.00
66_L	126_A	1.283	1.00
20_I	166_V	1.282	1.00
119_E	139_A	1.267	1.00
131_L	157_Y	1.266	1.00
30_T	159_L	1.251	1.00
11_D	21_E	1.214	1.00
201_A	213_A	1.207	1.00
13_L	55_P	1.203	1.00
238_S	241_P	1.200	1.00
91_V	118_V	1.199	1.00
197_G	200_E	1.195	1.00
133_V	157_Y	1.191	1.00
202_A	238_S	1.185	1.00
10_V	18_T	1.181	1.00
26_T	129_V	1.178	1.00
61_A	64_G	1.178	1.00
233_C	237_S	1.171	1.00
59_Y	82_R	1.143	1.00
10_V	187_L	1.133	1.00
159_L	166_V	1.120	1.00
174_A	203_D	1.120	1.00
68_V	131_L	1.109	1.00
156_G	169_P	1.105	1.00
17_T	30_T	1.084	1.00
91_V	124_Q	1.077	1.00
169_P	186_L	1.077	1.00
78_H	82_R	1.070	1.00
205_A	235_V	1.065	1.00
93_Y	155_C	1.045	1.00
206_D	238_S	1.045	1.00
26_T	65_D	1.045	1.00
234_A	238_S	1.041	1.00
185_V	212_L	1.039	1.00
34_R	58_E	1.039	1.00
149_H	152_G	1.036	1.00
13_L	17_T	1.032	1.00
230_R	233_C	1.030	1.00
176_A	180_A	1.017	1.00
79_G	83_V	1.010	1.00
20_I	30_T	1.007	1.00
188_A	208_L	1.005	1.00
188_A	204_L	1.005	1.00
119_E	122_A	0.989	1.00
79_G	82_R	0.983	1.00
19_R	64_G	0.983	1.00
79_G	84_A	0.980	1.00
94_D	98_A	0.980	1.00
134_T	167_F	0.978	1.00
118_V	122_A	0.963	1.00
28_A	129_V	0.960	1.00
148_L	151_P	0.960	1.00
227_D	230_R	0.959	1.00
33_G	38_L	0.959	1.00
98_A	101_T	0.958	1.00
29_Y	64_G	0.950	1.00
146_T	149_H	0.950	1.00
71_H	171_A	0.947	1.00
186_L	208_L	0.944	1.00
178_H	181_I	0.942	1.00
13_L	34_R	0.942	1.00
66_L	131_L	0.938	1.00
27_V	63_D	0.934	1.00
90_V	105_V	0.932	1.00
8_V	164_T	0.925	0.99
91_V	131_L	0.925	0.99
100_T	103_R	0.920	0.99
92_V	96_I	0.919	0.99
27_V	64_G	0.914	0.99
116_R	193_R	0.912	0.99
92_V	97_D	0.912	0.99
30_T	68_V	0.908	0.99
218_Y	232_A	0.904	0.99
91_V	157_Y	0.902	0.99
12_W	216_I	0.902	0.99
18_T	214_V	0.901	0.99
28_A	131_L	0.897	0.99
75_Y	80_I	0.891	0.99
186_L	205_A	0.880	0.99
169_P	172_S	0.875	0.99
97_D	115_V	0.868	0.99
13_L	19_R	0.864	0.99
136_A	172_S	0.863	0.99
19_R	29_Y	0.857	0.99
34_R	79_G	0.850	0.99
167_F	204_L	0.847	0.99
80_I	105_V	0.847	0.99
118_V	124_Q	0.833	0.99
17_T	34_R	0.831	0.99
164_T	184_D	0.828	0.99
229_R	232_A	0.824	0.99
198_E	226_G	0.821	0.99
212_L	215_P	0.810	0.99
78_H	83_V	0.807	0.99
87_D	106_T	0.807	0.99
226_G	231_F	0.805	0.99
26_T	66_L	0.803	0.99
165_T	184_D	0.802	0.99
175_L	178_H	0.799	0.99
190_I	218_Y	0.797	0.98
71_H	217_H	0.795	0.98
106_T	114_D	0.790	0.98
132_T	158_T	0.787	0.98
131_L	159_L	0.787	0.98
167_F	208_L	0.784	0.98
16_A	189_P	0.784	0.98
147_S	151_P	0.783	0.98
92_V	157_Y	0.783	0.98
147_S	152_G	0.780	0.98
161_R	164_T	0.777	0.98
141_D	150_P	0.777	0.98
27_V	65_D	0.775	0.98
68_V	155_C	0.774	0.98
158_T	181_I	0.772	0.98
24_D	161_R	0.772	0.98
198_E	230_R	0.767	0.98
192_R	226_G	0.766	0.98
188_A	196_M	0.765	0.98
232_A	236_A	0.754	0.98
172_S	178_H	0.750	0.98
197_G	201_A	0.748	0.98
200_E	203_D	0.748	0.98
171_A	217_H	0.741	0.98
89_T	114_D	0.739	0.98
178_H	204_L	0.739	0.98
24_D	163_D	0.737	0.98
10_V	214_V	0.735	0.97
22_W	28_A	0.735	0.97
137_Q	175_L	0.733	0.97
120_Y	173_D	0.727	0.97
20_I	28_A	0.719	0.97
228_G	231_F	0.718	0.97
82_R	86_A	0.718	0.97
13_L	54_P	0.716	0.97
91_V	126_A	0.715	0.97
76_D	79_G	0.710	0.97
81_A	84_A	0.708	0.97
147_S	150_P	0.708	0.97
22_W	159_L	0.707	0.97
161_R	166_V	0.704	0.97
50_A	53_H	0.702	0.97
236_A	241_P	0.700	0.97
37_V	48_E	0.699	0.97
176_A	179_D	0.695	0.96
121_G	134_T	0.694	0.96
182_D	211_A	0.691	0.96
93_Y	96_I	0.687	0.96
238_S	242_V	0.681	0.96
99_A	103_R	0.676	0.96
138_T	217_H	0.673	0.96
165_T	182_D	0.670	0.96
240_V	243_A	0.665	0.95
22_W	162_G	0.664	0.95
136_A	156_G	0.663	0.95
26_T	128_G	0.660	0.95
90_V	100_T	0.659	0.95
99_A	102_S	0.656	0.95
231_F	235_V	0.656	0.95
202_A	235_V	0.655	0.95
37_V	47_F	0.651	0.95
94_D	117_R	0.648	0.95
166_V	185_V	0.642	0.95
36_G	49_G	0.641	0.94
204_L	208_L	0.640	0.94
8_V	22_W	0.638	0.94
237_S	240_V	0.638	0.94
56_G	61_A	0.637	0.94
121_G	181_I	0.636	0.94
182_D	209_D	0.631	0.94
17_T	33_G	0.629	0.94
93_Y	157_Y	0.624	0.94
12_W	219_N	0.622	0.94
69_I	75_Y	0.622	0.94
175_L	181_I	0.621	0.93
210_P	213_A	0.621	0.93
77_P	80_I	0.621	0.93
71_H	138_T	0.621	0.93
188_A	205_A	0.621	0.93
189_P	201_A	0.619	0.93
75_Y	96_I	0.614	0.93
169_P	178_H	0.613	0.93
183_C	186_L	0.613	0.93
177_S	180_A	0.612	0.93
120_Y	153_V	0.607	0.93
190_I	215_P	0.607	0.93
120_Y	155_C	0.605	0.93
138_T	171_A	0.603	0.92
11_D	19_R	0.603	0.92
93_Y	133_V	0.600	0.92
192_R	223_R	0.599	0.92
145_G	148_L	0.598	0.92
24_D	164_T	0.597	0.92
215_P	218_Y	0.597	0.92
56_G	60_R	0.596	0.92
137_Q	173_D	0.595	0.92
148_L	152_G	0.595	0.92
239_G	244_L	0.594	0.92
66_L	127_A	0.593	0.92
156_G	167_F	0.590	0.92
67_V	83_V	0.589	0.92
77_P	82_R	0.589	0.92
146_T	150_P	0.589	0.92
215_P	231_F	0.587	0.91
178_H	207_R	0.584	0.91
105_V	115_V	0.584	0.91
198_E	234_A	0.583	0.91
145_G	149_H	0.581	0.91
126_A	129_V	0.581	0.91
158_T	165_T	0.580	0.91
172_S	196_M	0.579	0.91
83_V	88_A	0.578	0.91
87_D	114_D	0.576	0.91
194_I	224_L	0.575	0.91
146_T	151_P	0.575	0.91
72_A	96_I	0.572	0.90
92_V	117_R	0.570	0.90
168_W	187_L	0.569	0.90
202_A	206_D	0.567	0.90
16_A	216_I	0.566	0.90
80_I	103_R	0.565	0.90
221_V	224_L	0.565	0.90
202_A	234_A	0.562	0.90
173_D	200_E	0.560	0.89
121_G	180_A	0.559	0.89
235_V	244_L	0.557	0.89
12_W	218_Y	0.557	0.89
158_T	167_F	0.557	0.89
160_T	163_D	0.557	0.89
39_T	46_G	0.555	0.89
237_S	241_P	0.554	0.89
140_P	154_G	0.553	0.89
215_P	226_G	0.552	0.89
135_E	153_V	0.549	0.89
77_P	103_R	0.547	0.88
69_I	96_I	0.545	0.88
202_A	239_G	0.545	0.88
72_A	140_P	0.538	0.88
81_A	105_V	0.536	0.87
215_P	228_G	0.535	0.87
18_T	30_T	0.533	0.87
80_I	90_V	0.533	0.87
64_G	67_V	0.533	0.87
58_E	82_R	0.532	0.87
74_H	171_A	0.531	0.87
24_D	162_G	0.529	0.87
71_H	74_H	0.529	0.87
101_T	115_V	0.529	0.87
78_H	84_A	0.528	0.87
47_F	50_A	0.528	0.87
198_E	202_A	0.524	0.86
10_V	20_I	0.522	0.86
87_D	90_V	0.522	0.86
134_T	181_I	0.521	0.86
92_V	115_V	0.520	0.86
63_D	86_A	0.520	0.86
233_C	236_A	0.520	0.86
74_H	79_G	0.520	0.86
29_Y	61_A	0.517	0.85
22_W	129_V	0.515	0.85
141_D	151_P	0.514	0.85
84_A	105_V	0.510	0.85
52_E	220_T	0.509	0.85
94_D	153_V	0.508	0.84
206_D	209_D	0.505	0.84
172_S	189_P	0.504	0.84
51_H	222_E	0.504	0.84
83_V	86_A	0.503	0.84
17_T	54_P	0.502	0.84
35_Y	78_H	0.500	0.83
85_S	88_A	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qn9A	2	0.928	100	0.436	Contact Map
3rpcA	2	0.9053	100	0.484	Contact Map
3bv6A	5	0.9811	100	0.537	Contact Map
2wylA	5	0.9356	100	0.553	Contact Map
4jo0A	2	0.8447	100	0.569	Contact Map
3kl7A	1	0.7917	100	0.59	Contact Map
1zkpA	2	0.8182	99.9	0.634	Contact Map
2cbnA	2	0.8182	99.9	0.646	Contact Map
1vjnA	1	0.6818	99.9	0.661	Contact Map
1y44A	2	0.8295	99.9	0.661	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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