GREMLIN Database
TOP6A - Type 2 DNA topoisomerase 6 subunit A
UniProt: Q9HR32 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 366 (341)
Sequences: 510 (342)
Seq/√Len: 18.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_M341_Q6.0081.00
148_V234_L3.9461.00
310_L332_L3.6971.00
246_V282_A3.6511.00
237_R241_E3.5741.00
254_P302_L3.4931.00
223_L263_V3.3471.00
151_P191_D3.2921.00
290_Q327_Q3.0850.99
222_H228_A2.8930.99
222_H263_V2.8550.99
356_L360_L2.8420.99
206_R210_N2.7190.98
197_C282_A2.6860.98
302_L335_D2.6450.98
195_V246_V2.5250.97
26_Q31_D2.5040.97
236_K240_D2.4900.96
200_T222_H2.4700.96
192_A219_I2.4100.96
17_L95_T2.3620.95
201_G205_D2.3370.95
260_Y284_F2.3150.95
96_L120_D2.2190.93
258_R309_A2.1630.92
116_Q120_D2.1150.92
232_R266_G2.0870.91
223_L228_A2.0800.91
204_R222_H2.0630.90
88_L130_S2.0590.90
221_V231_T2.0580.90
17_L85_A2.0570.90
98_E202_G2.0080.89
194_F218_A1.9920.89
224_G228_A1.9810.89
96_L124_E1.9510.88
288_R359_R1.9240.87
144_S228_A1.9060.86
77_S235_T1.8820.86
220_V227_P1.8790.86
161_G195_V1.8770.86
258_R316_D1.8720.85
228_A340_Q1.8610.85
84_L139_M1.8090.83
228_A231_T1.8050.83
142_E201_G1.7870.83
253_D259_I1.7830.82
308_N312_S1.7720.82
249_F340_Q1.7650.82
197_C248_V1.7590.82
145_G263_V1.7330.81
147_K201_G1.7190.80
116_Q253_D1.7180.80
331_Q341_Q1.6900.79
291_D359_R1.6640.78
144_S200_T1.6580.77
198_V220_V1.6470.77
190_T242_L1.6430.77
206_R324_W1.6130.75
340_Q351_V1.6020.75
220_V285_I1.6010.75
261_G324_W1.5890.74
35_M42_K1.5870.74
200_T341_Q1.5580.73
137_F218_A1.5570.73
178_I244_L1.5450.72
327_Q337_K1.5290.71
96_L253_D1.5150.71
197_C200_T1.4970.70
223_L252_G1.4960.70
178_I231_T1.4900.69
194_F212_F1.4780.69
198_V204_R1.4710.68
342_A347_G1.4580.68
12_A16_L1.4310.66
226_Q258_R1.4160.65
147_K228_A1.4080.65
203_M356_L1.4030.65
215_D221_V1.4000.64
226_Q255_W1.3960.64
200_T204_R1.3950.64
40_R206_R1.3950.64
86_Q90_E1.3920.64
99_L175_G1.3830.63
14_D18_A1.3710.63
310_L328_I1.3500.61
15_Q18_A1.3440.61
197_C210_N1.3390.61
220_V294_D1.3390.61
197_C235_T1.3390.61
260_Y264_A1.3230.60
84_L257_Y1.3210.60
154_L302_L1.3190.60
248_V260_Y1.3170.60
161_G232_R1.3010.59
11_E14_D1.3000.58
279_T282_A1.2980.58
79_Y103_S1.2880.58
207_L220_V1.2860.58
200_T340_Q1.2830.57
228_A263_V1.2760.57
204_R228_A1.2660.56
224_G231_T1.2640.56
219_I238_L1.2550.56
112_Q257_Y1.2540.56
144_S231_T1.2510.55
221_V235_T1.2510.55
352_T356_L1.2490.55
113_F134_R1.2440.55
149_M208_V1.2280.54
341_Q344_A1.2190.54
162_D198_V1.2160.53
229_R346_R1.2110.53
190_T234_L1.2070.53
188_L238_L1.2040.53
234_L347_G1.2030.53
307_V335_D1.1970.52
284_F288_R1.1910.52
138_H210_N1.1660.50
9_E12_A1.1640.50
156_E206_R1.1630.50
81_V204_R1.1540.49
192_A244_L1.1530.49
219_I285_I1.1420.49
289_P331_Q1.1320.48
256_S263_V1.1300.48
249_F341_Q1.1280.48
206_R209_E1.1230.48
307_V332_L1.1230.48
137_F267_S1.1230.48
175_G292_I1.1180.47
200_T337_K1.1170.47
192_A342_A1.1160.47
73_K236_K1.1160.47
10_T23_F1.1140.47
95_T341_Q1.1100.47
227_P254_P1.1090.47
21_E25_D1.1090.47
39_T51_A1.1020.46
11_E15_Q1.1010.46
252_G335_D1.1000.46
288_R327_Q1.0990.46
179_P182_P1.0980.46
141_P310_L1.0970.46
15_Q29_D1.0930.46
352_T357_P1.0750.45
145_G228_A1.0750.45
180_N253_D1.0660.44
126_L332_L1.0640.44
252_G277_L1.0620.44
15_Q130_S1.0620.44
306_D337_K1.0560.43
303_S306_D1.0490.43
144_S201_G1.0490.43
145_G223_L1.0490.43
129_V194_F1.0490.43
231_T328_I1.0440.43
129_V218_A1.0420.43
12_A27_F1.0370.42
249_F351_V1.0370.42
79_Y224_G1.0360.42
207_L217_N1.0360.42
57_G118_E1.0340.42
310_L316_D1.0330.42
27_F325_T1.0320.42
96_L103_S1.0300.42
87_Q210_N1.0250.42
202_G338_A1.0240.41
49_E285_I1.0180.41
81_V189_D1.0180.41
222_H256_S1.0150.41
22_Q29_D1.0050.40
224_G338_A1.0020.40
167_C192_A1.0000.40
31_D36_S0.9970.40
141_P144_S0.9960.40
139_M244_L0.9880.39
91_G238_L0.9830.39
22_Q26_Q0.9830.39
330_L333_D0.9770.39
126_L300_D0.9720.38
97_R101_Y0.9710.38
329_G354_T0.9690.38
88_L288_R0.9680.38
95_T230_A0.9680.38
200_T256_S0.9640.38
154_L281_Q0.9630.38
144_S263_V0.9620.38
18_A41_S0.9580.38
10_T25_D0.9560.37
127_E284_F0.9560.37
286_G341_Q0.9560.37
212_F216_Y0.9540.37
292_I334_I0.9540.37
207_L344_A0.9530.37
175_G278_A0.9510.37
152_L167_C0.9490.37
100_Y278_A0.9420.37
102_L230_A0.9410.37
144_S223_L0.9390.36
200_T223_L0.9360.36
144_S147_K0.9360.36
195_V235_T0.9330.36
228_A328_I0.9320.36
100_Y336_K0.9270.36
11_E29_D0.9270.36
155_R198_V0.9250.36
99_L271_A0.9160.35
97_R199_E0.9150.35
23_F31_D0.9100.35
58_D220_V0.9090.35
9_E91_G0.9080.35
200_T203_M0.8980.34
96_L127_E0.8930.34
49_E62_T0.8930.34
103_S253_D0.8920.34
264_A309_A0.8900.34
206_R343_L0.8900.34
18_A21_E0.8780.33
138_H265_Y0.8770.33
221_V313_E0.8760.33
63_R77_S0.8750.33
355_Y359_R0.8720.33
223_L235_T0.8700.33
84_L87_Q0.8700.33
230_A269_K0.8700.33
18_A25_D0.8660.32
114_N309_A0.8560.32
200_T228_A0.8520.32
255_W308_N0.8500.31
141_P221_V0.8490.31
154_L218_A0.8430.31
285_I303_S0.8420.31
274_S278_A0.8400.31
195_V201_G0.8380.31
98_E324_W0.8370.31
351_V360_L0.8350.31
144_S306_D0.8340.31
327_Q343_L0.8340.31
137_F256_S0.8320.30
39_T55_V0.8320.30
13_R89_D0.8300.30
122_L129_V0.8300.30
100_Y220_V0.8270.30
72_R76_K0.8250.30
98_E349_D0.8250.30
23_F35_M0.8240.30
119_S265_Y0.8220.30
144_S224_G0.8170.30
197_C222_H0.8160.30
47_Y123_V0.8120.29
262_S267_S0.8100.29
155_R164_E0.8070.29
190_T219_I0.8050.29
35_M74_L0.8050.29
120_D124_E0.8030.29
152_L244_L0.8000.29
96_L228_A0.7950.29
179_P277_L0.7950.29
125_D207_L0.7920.28
120_D196_L0.7900.28
250_T303_S0.7900.28
225_G251_D0.7870.28
228_A256_S0.7870.28
28_A36_S0.7850.28
314_L325_T0.7840.28
144_S337_K0.7820.28
84_L126_L0.7800.28
219_I248_V0.7780.28
195_V252_G0.7770.28
95_T202_G0.7750.28
21_E130_S0.7720.27
79_Y96_L0.7710.27
252_G289_P0.7700.27
201_G253_D0.7690.27
78_V126_L0.7680.27
98_E313_E0.7660.27
288_R323_F0.7650.27
99_L139_M0.7650.27
100_Y214_D0.7620.27
98_E203_M0.7600.27
12_A84_L0.7590.27
133_K220_V0.7550.27
40_R44_N0.7480.26
180_N343_L0.7470.26
84_L235_T0.7450.26
62_T325_T0.7450.26
26_Q33_P0.7440.26
68_V173_Q0.7440.26
254_P306_D0.7410.26
14_D29_D0.7390.26
66_N120_D0.7370.26
40_R125_D0.7360.26
143_E340_Q0.7340.26
46_E238_L0.7320.25
74_L236_K0.7320.25
29_D52_D0.7310.25
70_G234_L0.7260.25
134_R232_R0.7250.25
124_E341_Q0.7240.25
60_Q343_L0.7230.25
191_D236_K0.7230.25
47_Y67_S0.7230.25
226_Q312_S0.7220.25
227_P343_L0.7220.25
354_T358_E0.7210.25
138_H194_F0.7210.25
115_D287_I0.7180.25
165_I234_L0.7160.25
302_L307_V0.7160.25
198_V289_P0.7160.25
55_V220_V0.7150.25
131_G360_L0.7130.25
124_E141_P0.7130.25
227_P263_V0.7100.24
154_L178_I0.7050.24
71_A125_D0.7050.24
273_L276_Y0.7040.24
249_F284_F0.7030.24
11_E21_E0.7020.24
257_Y331_Q0.7020.24
179_P183_D0.6980.24
86_Q269_K0.6970.24
20_A34_R0.6960.24
219_I308_N0.6930.24
13_R37_L0.6890.23
51_A59_S0.6890.23
253_D277_L0.6890.23
199_E251_D0.6880.23
149_M288_R0.6880.23
20_A28_A0.6850.23
11_E17_L0.6830.23
87_Q149_M0.6830.23
198_V287_I0.6830.23
124_E255_W0.6720.23
85_A249_F0.6720.23
83_F99_L0.6710.23
237_R248_V0.6690.23
151_P275_E0.6680.23
19_I216_Y0.6640.22
254_P286_G0.6610.22
42_K49_E0.6600.22
235_T288_R0.6590.22
25_D29_D0.6570.22
80_T341_Q0.6570.22
148_V207_L0.6550.22
75_L112_Q0.6540.22
96_L112_Q0.6530.22
35_M47_Y0.6520.22
10_T22_Q0.6510.22
9_E24_Y0.6500.22
152_L164_E0.6480.22
84_L268_I0.6470.22
101_Y251_D0.6460.22
16_L20_A0.6460.22
223_L341_Q0.6450.22
111_A202_G0.6430.21
150_G341_Q0.6430.21
202_G261_G0.6430.21
49_E89_D0.6430.21
15_Q27_F0.6430.21
97_R251_D0.6420.21
84_L123_V0.6400.21
311_E332_L0.6390.21
263_V340_Q0.6390.21
195_V234_L0.6390.21
82_D85_A0.6380.21
36_S49_E0.6360.21
10_T36_S0.6350.21
97_R256_S0.6350.21
201_G263_V0.6350.21
98_E344_A0.6340.21
14_D22_Q0.6320.21
96_L277_L0.6300.21
22_Q50_D0.6290.21
21_E38_P0.6280.21
221_V311_E0.6260.21
68_V186_D0.6240.21
127_E217_N0.6240.21
95_T228_A0.6220.21
81_V338_A0.6220.21
338_A341_Q0.6200.21
200_T249_F0.6170.20
32_I95_T0.6160.20
16_L232_R0.6130.20
309_A316_D0.6110.20
130_S256_S0.6110.20
351_V357_P0.6110.20
10_T14_D0.6090.20
194_F216_Y0.6070.20
13_R50_D0.6060.20
97_R116_Q0.6060.20
99_L322_D0.6050.20
43_S49_E0.6050.20
264_A279_T0.6040.20
102_L206_R0.6020.20
21_E28_A0.6010.20
47_Y52_D0.5980.20
100_Y292_I0.5980.20
10_T34_R0.5960.20
125_D343_L0.5950.20
200_T263_V0.5940.19
207_L223_L0.5910.19
272_H277_L0.5880.19
103_S114_N0.5870.19
302_L310_L0.5830.19
15_Q28_A0.5810.19
231_T347_G0.5810.19
23_F78_V0.5800.19
14_D39_T0.5800.19
134_R324_W0.5780.19
74_L196_L0.5770.19
135_E229_R0.5760.19
132_V204_R0.5740.19
117_S120_D0.5740.19
10_T325_T0.5740.19
326_E334_I0.5740.19
71_A134_R0.5730.19
112_Q258_R0.5730.19
310_L349_D0.5710.19
112_Q253_D0.5670.18
22_Q25_D0.5640.18
133_K234_L0.5630.18
225_G259_I0.5620.18
67_S265_Y0.5610.18
13_R236_K0.5610.18
277_L324_W0.5600.18
97_R259_I0.5580.18
157_Q162_D0.5580.18
11_E18_A0.5570.18
151_P166_H0.5560.18
125_D271_A0.5560.18
15_Q31_D0.5550.18
120_D138_H0.5550.18
104_E201_G0.5540.18
85_A201_G0.5540.18
18_A28_A0.5530.18
168_Q267_S0.5530.18
302_L306_D0.5530.18
66_N77_S0.5530.18
14_D34_R0.5520.18
15_Q19_I0.5510.18
223_L258_R0.5500.18
96_L309_A0.5490.18
119_S126_L0.5490.18
122_L262_S0.5490.18
204_R207_L0.5490.18
193_D208_V0.5490.18
284_F327_Q0.5480.18
288_R343_L0.5480.18
142_E224_G0.5470.18
234_L273_L0.5470.18
103_S144_S0.5470.18
202_G222_H0.5470.18
201_G222_H0.5470.18
183_D195_V0.5460.18
277_L355_Y0.5450.18
93_S181_N0.5440.18
31_D43_S0.5420.18
24_Y39_T0.5410.17
30_G43_S0.5400.17
10_T86_Q0.5380.17
260_Y343_L0.5380.17
115_D343_L0.5380.17
68_V71_A0.5380.17
135_E309_A0.5380.17
100_Y332_L0.5370.17
193_D276_Y0.5360.17
49_E269_K0.5360.17
76_K104_E0.5350.17
9_E15_Q0.5350.17
36_S46_E0.5350.17
208_V235_T0.5350.17
77_S84_L0.5330.17
251_D256_S0.5320.17
253_D256_S0.5320.17
103_S197_C0.5300.17
326_E356_L0.5290.17
62_T287_I0.5280.17
150_G175_G0.5280.17
30_G34_R0.5270.17
257_Y285_I0.5270.17
66_N70_G0.5260.17
14_D48_D0.5260.17
195_V217_N0.5250.17
22_Q46_E0.5240.17
220_V240_D0.5230.17
33_P44_N0.5230.17
274_S301_P0.5230.17
81_V84_L0.5220.17
227_P273_L0.5210.17
314_L351_V0.5200.17
87_Q129_V0.5190.17
248_V282_A0.5150.17
9_E42_K0.5150.17
95_T223_L0.5150.17
98_E112_Q0.5120.16
63_R100_Y0.5120.16
127_E226_Q0.5110.16
243_D322_D0.5090.16
113_F341_Q0.5070.16
137_F249_F0.5070.16
123_V296_D0.5060.16
263_V303_S0.5060.16
145_G231_T0.5050.16
19_I28_A0.5040.16
14_D50_D0.5040.16
95_T101_Y0.5010.16
203_M344_A0.5010.16
76_K252_G0.5010.16
141_P352_T0.5000.16
85_A303_S0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zbkA 2 0.8962 100 0.15 Contact Map
2q2eA 2 0.8579 100 0.154 Contact Map
1d3yA 2 0.7814 100 0.242 Contact Map
3mm4A 1 0.3251 31.7 0.969 Contact Map
1t6t1 2 0.3005 29 0.97 Contact Map
2j48A 1 0.3169 19.3 0.972 Contact Map
4myrA 1 0.3251 18.6 0.972 Contact Map
3f6pA 1 0.3197 18 0.972 Contact Map
4nicA 2 0.3115 13.4 0.974 Contact Map
4hyeA 2 0.4262 13.4 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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