GREMLIN Database
Q9HR28 - Inosine-5'-monophosphate dehydrogenase
UniProt: Q9HR28 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 177 (170)
Sequences: 134 (88)
Seq/√Len: 6.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_G49_Q3.2810.88
42_G46_N3.1290.85
52_K168_M2.7690.77
135_V162_I2.5980.72
16_A75_E2.4380.67
7_T156_D2.3010.62
38_D156_D2.2090.59
44_I55_Q2.2040.58
32_A151_V2.1270.56
58_E75_E2.1180.55
20_R28_V2.0950.54
41_P59_G2.0550.53
30_G59_G2.0320.52
90_V97_I2.0020.51
21_Y163_L1.9840.50
103_K147_V1.9070.47
6_L10_Q1.8890.47
25_E110_V1.8720.46
21_Y108_T1.8690.46
54_L163_L1.8360.45
26_T32_A1.8310.44
20_R165_I1.8080.44
40_N48_M1.7950.43
18_V169_E1.7370.41
30_G41_P1.7210.40
34_A46_N1.7210.40
150_T166_D1.7000.40
27_A101_N1.6850.39
78_D121_H1.6810.39
39_R48_M1.6440.38
125_S128_D1.6370.37
34_A42_G1.6350.37
90_V137_V1.6050.36
9_S44_I1.5880.36
57_V140_T1.5870.36
18_V147_V1.5350.34
35_D151_V1.5310.34
44_I104_K1.5140.33
92_H130_H1.4830.32
49_Q59_G1.4770.32
39_R47_Q1.4650.31
31_E61_P1.4430.31
162_I170_A1.4320.30
69_P118_A1.4210.30
151_V161_V1.4190.30
74_Y88_V1.4100.30
31_E59_G1.4100.30
141_P145_L1.3640.28
13_V61_P1.3630.28
87_E101_N1.3060.27
36_E147_V1.2880.26
9_S171_P1.2790.26
9_S37_V1.2770.26
91_T135_V1.2650.25
79_I159_G1.2540.25
58_E100_V1.2280.24
58_E68_K1.2230.24
27_A54_L1.2230.24
95_E165_I1.2200.24
44_I120_V1.2180.24
147_V161_V1.2130.24
12_T143_S1.2110.24
44_I48_M1.1680.23
86_A165_I1.1680.23
4_I163_L1.1640.23
74_Y133_D1.1640.23
12_T15_R1.1550.22
94_G107_L1.1530.22
120_V131_D1.1470.22
157_A162_I1.1460.22
81_Q135_V1.1220.21
50_S105_V1.1100.21
122_F161_V1.1080.21
68_K97_I1.1080.21
113_P145_L1.1050.21
129_I135_V1.1020.21
7_T54_L1.0890.21
53_A106_N1.0890.21
20_R94_G1.0870.21
33_I40_N1.0750.20
147_V166_D1.0690.20
55_Q152_D1.0610.20
9_S143_S1.0610.20
16_A53_A1.0510.20
115_L161_V1.0460.20
21_Y118_A1.0400.19
106_N150_T1.0370.19
31_E153_G1.0300.19
5_E89_P1.0270.19
102_V117_R1.0250.19
13_V20_R1.0200.19
7_T137_V1.0190.19
15_R19_D1.0120.19
28_V136_I1.0050.19
94_G127_R1.0050.19
102_V133_D1.0010.19
105_V147_V1.0000.19
7_T10_Q0.9910.18
100_V126_I0.9910.18
30_G83_D0.9900.18
143_S154_K0.9890.18
54_L156_D0.9890.18
31_E49_Q0.9740.18
13_V124_G0.9710.18
106_N171_P0.9550.18
69_P163_L0.9380.17
107_L165_I0.9120.17
47_Q60_V0.9100.17
31_E41_P0.9080.17
59_G109_S0.9070.17
4_I143_S0.9070.17
18_V21_Y0.9070.17
38_D110_V0.9020.16
10_Q133_D0.8950.16
8_A135_V0.8950.16
40_N127_R0.8920.16
8_A157_A0.8890.16
37_V102_V0.8820.16
97_I167_A0.8770.16
18_V92_H0.8730.16
75_E115_L0.8690.16
103_K161_V0.8630.16
39_R116_C0.8620.16
8_A76_A0.8560.15
13_V79_I0.8490.15
16_A167_A0.8490.15
120_V165_I0.8480.15
86_A125_S0.8470.15
36_E121_H0.8450.15
20_R29_K0.8410.15
49_Q116_C0.8380.15
44_I160_V0.8320.15
7_T49_Q0.8310.15
78_D87_E0.8300.15
74_Y92_H0.8280.15
23_Q121_H0.8260.15
76_A150_T0.8210.15
8_A52_K0.8060.15
18_V167_A0.7980.14
91_T96_D0.7950.14
80_Q121_H0.7910.14
126_I132_G0.7890.14
21_Y69_P0.7890.14
13_V33_I0.7730.14
53_A111_H0.7700.14
48_M120_V0.7690.14
150_T164_K0.7680.14
10_Q155_D0.7620.14
33_I48_M0.7580.14
49_Q155_D0.7550.14
93_E163_L0.7540.14
99_D118_A0.7530.14
16_A37_V0.7490.13
19_D22_T0.7420.13
30_G153_G0.7370.13
49_Q61_P0.7360.13
108_T164_K0.7340.13
10_Q145_L0.7330.13
25_E125_S0.7330.13
99_D134_S0.7270.13
28_V173_D0.7260.13
47_Q112_H0.7210.13
94_G124_G0.7200.13
10_Q54_L0.7190.13
129_I167_A0.7190.13
47_Q153_G0.7110.13
64_K77_L0.7100.13
10_Q56_L0.7020.13
16_A76_A0.7010.13
88_V142_L0.6960.13
136_I146_Q0.6950.13
9_S83_D0.6920.13
92_H173_D0.6920.13
58_E117_R0.6870.12
37_V53_A0.6830.12
129_I170_A0.6820.12
37_V44_I0.6790.12
82_L99_D0.6780.12
30_G48_M0.6780.12
106_N129_I0.6750.12
10_Q43_T0.6740.12
82_L97_I0.6740.12
41_P48_M0.6730.12
54_L61_P0.6710.12
97_I134_S0.6710.12
60_V133_D0.6700.12
54_L74_Y0.6620.12
21_Y72_D0.6590.12
12_T162_I0.6580.12
103_K122_F0.6480.12
124_G172_A0.6450.12
4_I111_H0.6410.12
30_G79_I0.6400.12
48_M59_G0.6400.12
38_D128_D0.6370.12
93_E167_A0.6330.12
107_L151_V0.6270.11
34_A69_P0.6270.11
27_A110_V0.6260.11
4_I117_R0.6260.11
25_E152_D0.6260.11
13_V31_E0.6230.11
37_V50_S0.6200.11
89_P124_G0.6170.11
116_C140_T0.6150.11
98_T104_K0.6140.11
97_I147_V0.6070.11
93_E137_V0.6030.11
39_R60_V0.6000.11
47_Q116_C0.6000.11
36_E88_V0.5960.11
79_I153_G0.5930.11
119_E125_S0.5880.11
60_V116_C0.5870.11
82_L115_L0.5790.11
73_A141_P0.5780.11
31_E40_N0.5760.11
64_K131_D0.5750.11
13_V42_G0.5720.11
4_I107_L0.5700.11
75_E158_K0.5680.11
18_V158_K0.5680.11
107_L142_L0.5660.11
69_P111_H0.5650.11
115_L158_K0.5640.11
67_Y70_T0.5620.11
136_I147_V0.5590.10
109_S129_I0.5530.10
48_M116_C0.5490.10
87_E131_D0.5450.10
72_D83_D0.5430.10
111_H171_P0.5380.10
33_I124_G0.5360.10
79_I137_V0.5340.10
61_P144_K0.5330.10
58_E115_L0.5330.10
31_E141_P0.5300.10
78_D122_F0.5290.10
12_T32_A0.5270.10
86_A90_V0.5270.10
80_Q137_V0.5220.10
7_T159_G0.5210.10
61_P76_A0.5200.10
28_V106_N0.5150.10
13_V122_F0.5140.10
99_D129_I0.5140.10
5_E27_A0.5130.10
93_E134_S0.5060.10
107_L164_K0.5040.10
15_R21_Y0.5040.10
23_Q136_I0.5030.10
7_T74_Y0.5020.10
114_E126_I0.5020.10
78_D102_V0.5010.10
148_S167_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k69A 2 0.7966 98.8 0.858 Contact Map
1ylfA 5 0.6893 98.6 0.864 Contact Map
4hf1A 2 0.7797 98.6 0.867 Contact Map
2y75A 5 0.6836 98.5 0.869 Contact Map
4hf0A 3 0.6723 98.5 0.87 Contact Map
3lwfA 5 0.7797 98.5 0.871 Contact Map
3t8rA 2 0.6441 98.4 0.872 Contact Map
4cicA 2 0.7627 98.4 0.873 Contact Map
1stzA 3 0.9548 98.4 0.874 Contact Map
1xmkA 1 0.4237 98.3 0.876 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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