GREMLIN Database
Q9HR27 - NADH dehydrogenase
UniProt: Q9HR27 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 389 (314)
Sequences: 34749 (24697)
Seq/√Len: 1393.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_V237_Y4.1721.00
36_D77_S4.0141.00
4_R30_E3.5101.00
151_N180_D3.2911.00
182_T214_L3.0661.00
86_R276_R3.0371.00
87_S95_D2.9771.00
203_R207_E2.7951.00
180_D212_T2.7351.00
267_S271_Q2.7041.00
223_S228_E2.5681.00
17_A102_V2.5681.00
32_V74_I2.5341.00
221_A228_E2.3991.00
4_R32_V2.3931.00
83_T274_D2.3601.00
110_A247_T2.3421.00
258_D265_Q2.3041.00
4_R99_D2.2761.00
186_A218_P2.2651.00
34_V96_V2.2481.00
89_S95_D2.2471.00
153_V184_V2.2411.00
100_Y276_R2.2051.00
98_Y101_L2.1691.00
82_D85_E2.1591.00
115_E221_A2.1561.00
5_V21_L2.1341.00
108_E249_P2.1301.00
30_E72_E2.1191.00
151_N182_T2.0931.00
228_E234_S2.0631.00
6_V34_V2.0151.00
86_R90_L2.0151.00
151_N238_D1.9831.00
182_T212_T1.9771.00
108_E247_T1.9311.00
188_P216_D1.9281.00
337_E342_H1.8861.00
6_V88_V1.8591.00
87_S97_A1.8581.00
102_V312_V1.8571.00
108_E250_S1.8361.00
13_A280_V1.8261.00
214_L233_D1.7921.00
6_V96_V1.7831.00
217_D231_E1.7731.00
258_D273_D1.7721.00
189_E199_Q1.7241.00
251_E254_D1.7231.00
105_I283_C1.7101.00
278_F311_N1.7021.00
100_Y278_F1.7011.00
128_D131_M1.6851.00
153_V227_I1.6651.00
80_D89_S1.6651.00
196_S340_I1.6431.00
271_Q275_E1.6011.00
83_T277_V1.5951.00
220_T228_E1.5631.00
214_L217_D1.5301.00
218_P230_D1.5281.00
148_D179_I1.5261.00
308_V312_V1.5221.00
152_V168_V1.5081.00
184_V235_L1.5041.00
196_S200_G1.4731.00
6_V32_V1.4651.00
100_Y312_V1.4591.00
77_S91_A1.4481.00
80_D254_D1.4301.00
169_A211_V1.4271.00
157_A185_E1.4261.00
62_P65_D1.4221.00
6_V98_Y1.4131.00
7_V18_I1.4111.00
124_L127_L1.3991.00
10_A35_A1.3931.00
205_R208_D1.3921.00
314_R319_R1.3831.00
150_A238_D1.3831.00
307_V311_N1.3791.00
5_V29_A1.3791.00
264_L279_A1.3621.00
126_S129_D1.3601.00
79_T89_S1.3571.00
162_I183_L1.3561.00
151_N236_D1.3521.00
309_A313_A1.3511.00
90_L96_V1.3481.00
169_A180_D1.3421.00
152_V239_V1.3411.00
152_V179_I1.3351.00
59_I62_P1.3341.00
102_V280_V1.3311.00
185_E215_T1.3231.00
203_R215_T1.3161.00
13_A301_A1.3151.00
223_S234_S1.3101.00
122_L136_Q1.3051.00
79_T91_A1.2911.00
82_D87_S1.2871.00
305_A309_A1.2871.00
217_D230_D1.2761.00
205_R209_A1.2591.00
64_E67_K1.2511.00
63_V66_I1.2501.00
20_G310_R1.2441.00
5_V102_V1.2271.00
189_E196_S1.2111.00
127_L131_M1.2101.00
8_L105_I1.2001.00
8_L78_V1.1951.00
62_P66_I1.1931.00
107_S246_V1.1931.00
204_H207_E1.1881.00
280_V308_V1.1771.00
220_T230_D1.1771.00
170_E209_A1.1751.00
269_T311_N1.1731.00
74_I96_V1.1491.00
131_M134_H1.1471.00
32_V96_V1.1451.00
104_G280_V1.1421.00
214_L235_L1.1401.00
204_H208_D1.1351.00
129_D132_E1.1311.00
270_L308_V1.1281.00
4_R97_A1.1261.00
200_G203_R1.1191.00
8_L103_V1.1041.00
222_A240_F1.1021.00
149_P179_I1.1001.00
125_K128_D1.0981.00
76_D92_D1.0981.00
217_D233_D1.0931.00
229_F235_L1.0921.00
32_V72_E1.0851.00
7_V14_G1.0821.00
271_Q276_R1.0751.00
113_G117_M1.0751.00
20_G306_D1.0721.00
61_I65_D1.0591.00
120_H224_E1.0541.00
153_V235_L1.0541.00
270_L284_S1.0391.00
203_R213_I1.0381.00
17_A280_V1.0341.00
189_E203_R1.0281.00
266_A284_S1.0241.00
190_I215_T1.0081.00
34_V74_I1.0061.00
103_V283_C1.0011.00
151_N179_I0.9941.00
22_E71_T0.9881.00
261_H285_M0.9861.00
21_L309_A0.9861.00
201_A205_R0.9851.00
217_D229_F0.9781.00
250_S254_D0.9721.00
124_L130_A0.9651.00
155_G240_F0.9641.00
237_Y240_F0.9531.00
185_E192_P0.9511.00
223_S226_A0.9491.00
264_L283_C0.9491.00
123_T126_S0.9471.00
124_L128_D0.9471.00
82_D89_S0.9461.00
34_V90_L0.9451.00
74_I94_D0.9431.00
169_A209_A0.9411.00
279_A283_C0.9351.00
250_S253_S0.9331.00
310_R315_A0.9321.00
58_K61_I0.9321.00
162_I328_D0.9311.00
157_A190_I0.9301.00
65_D68_S0.9291.00
14_G18_I0.9281.00
109_T112_Y0.9261.00
17_A305_A0.9241.00
274_D277_V0.9231.00
266_A279_A0.9221.00
34_V78_V0.9191.00
101_L277_V0.9171.00
85_E95_D0.9151.00
17_A308_V0.9141.00
35_A73_F0.9111.00
278_F308_V0.9051.00
60_T64_E0.9031.00
182_T237_Y0.8981.00
130_A133_I0.8981.00
308_V311_N0.8961.00
121_P222_A0.8961.00
134_H138_R0.8921.00
82_D86_R0.8811.00
130_A134_H0.8811.00
20_G23_S0.8801.00
18_I71_T0.8801.00
78_V81_I0.8771.00
128_D132_E0.8731.00
194_G324_W0.8711.00
114_I117_M0.8681.00
155_G242_W0.8651.00
38_D76_D0.8641.00
90_L94_D0.8641.00
125_K129_D0.8631.00
165_A183_L0.8591.00
271_Q311_N0.8501.00
272_A279_A0.8461.00
155_G244_G0.8441.00
61_I64_E0.8421.00
102_V308_V0.8411.00
127_L130_A0.8381.00
279_A284_S0.8371.00
66_I69_R0.8331.00
278_F312_V0.8331.00
265_Q273_D0.8321.00
76_D91_A0.8281.00
271_Q278_F0.8221.00
201_A204_H0.8221.00
184_V214_L0.8211.00
259_A265_Q0.8191.00
338_T341_A0.8181.00
260_E265_Q0.8151.00
184_V217_D0.8131.00
324_W334_S0.8121.00
271_Q274_D0.8121.00
182_T235_L0.8081.00
14_G104_G0.8051.00
55_V58_K0.8041.00
184_V229_F0.8031.00
270_L307_V0.8031.00
10_A33_W0.8011.00
251_E255_V0.7991.00
80_D101_L0.7991.00
200_G204_H0.7981.00
19_A23_S0.7981.00
29_A99_D0.7951.00
132_E135_E0.7941.00
60_T63_V0.7911.00
16_G302_W0.7891.00
49_V52_D0.7881.00
17_A309_A0.7861.00
49_V56_Q0.7861.00
225_D236_D0.7851.00
58_K62_P0.7841.00
115_E118_A0.7791.00
189_E200_G0.7761.00
78_V82_D0.7761.00
187_L192_P0.7741.00
166_G170_E0.7731.00
300_A304_A0.7701.00
7_V17_A0.7701.00
40_H73_F0.7701.00
5_V312_V0.7671.00
21_L29_A0.7671.00
326_Y330_G0.7641.00
125_K133_I0.7641.00
188_P196_S0.7621.00
20_G309_A0.7611.00
303_Q306_D0.7611.00
266_A270_L0.7601.00
19_A69_R0.7591.00
207_E212_T0.7541.00
150_A179_I0.7531.00
16_G20_G0.7521.00
155_G219_I0.7441.00
165_A181_V0.7431.00
98_Y276_R0.7431.00
133_I239_V0.7421.00
37_T47_H0.7391.00
154_I161_G0.7381.00
230_D233_D0.7381.00
134_H171_F0.7371.00
135_E138_R0.7351.00
6_V101_L0.7331.00
337_E341_A0.7321.00
21_L31_L0.7311.00
131_M135_E0.7311.00
110_A113_G0.7291.00
150_A180_D0.7271.00
162_I206_L0.7261.00
13_A104_G0.7261.00
151_N237_Y0.7251.00
154_I165_A0.7241.00
22_E70_T0.7211.00
161_G185_E0.7181.00
64_E75_E0.7161.00
310_R314_R0.7151.00
194_G334_S0.7101.00
154_I241_V0.7091.00
190_I203_R0.7081.00
39_Y60_T0.7071.00
278_F315_A0.7041.00
206_L213_I0.7021.00
125_K131_M0.6991.00
306_D310_R0.6981.00
81_I95_D0.6981.00
301_A305_A0.6971.00
164_S167_E0.6971.00
226_A234_S0.6951.00
129_D133_I0.6941.00
61_I66_I0.6931.00
122_L239_V0.6921.00
4_R29_A0.6911.00
112_Y242_W0.6851.00
116_G221_A0.6841.00
269_T316_M0.6811.00
220_T232_R0.6801.00
72_E75_E0.6791.00
125_K130_A0.6781.00
45_E48_R0.6771.00
29_A313_A0.6761.00
149_P238_D0.6731.00
100_Y315_A0.6721.00
119_E224_E0.6721.00
183_L213_I0.6671.00
16_G19_A0.6671.00
263_R296_P0.6661.00
18_I33_W0.6651.00
77_S80_D0.6611.00
190_I199_Q0.6581.00
117_M242_W0.6581.00
38_D75_E0.6581.00
164_S241_V0.6571.00
36_D249_P0.6571.00
272_A277_V0.6561.00
320_P323_T0.6561.00
44_H49_V0.6541.00
255_V274_D0.6521.00
327_E330_G0.6501.00
83_T98_Y0.6491.00
78_V88_V0.6481.00
132_E136_Q0.6481.00
197_E200_G0.6471.00
4_R96_V0.6471.00
126_S130_A0.6471.00
105_I251_E0.6461.00
260_E263_R0.6441.00
123_T129_D0.6421.00
165_A211_V0.6411.00
111_T242_W0.6401.00
16_G305_A0.6381.00
248_G263_R0.6371.00
58_K63_V0.6341.00
111_T123_T0.6341.00
268_S318_G0.6341.00
58_K66_I0.6341.00
153_V240_F0.6341.00
21_L313_A0.6331.00
156_G161_G0.6311.00
229_F233_D0.6291.00
111_T117_M0.6281.00
22_E31_L0.6281.00
60_T66_I0.6281.00
128_D133_I0.6251.00
110_A244_G0.6221.00
16_G306_D0.6221.00
84_D274_D0.6211.00
315_A318_G0.6181.00
286_I295_P0.6181.00
257_M264_L0.6171.00
49_V131_M0.6161.00
152_V241_V0.6121.00
21_L312_V0.6101.00
264_L272_A0.6101.00
252_L255_V0.6081.00
100_Y316_M0.6061.00
196_S199_Q0.6041.00
14_G33_W0.6041.00
90_L93_G0.6041.00
189_E340_I0.6031.00
323_T327_E0.6031.00
255_V259_A0.6031.00
30_E99_D0.6011.00
113_G116_G0.6011.00
153_V182_T0.5981.00
262_N285_M0.5981.00
323_T330_G0.5971.00
160_S243_T0.5941.00
44_H47_H0.5941.00
84_D87_S0.5931.00
159_L163_Q0.5911.00
270_L311_N0.5901.00
257_M272_A0.5881.00
29_A312_V0.5871.00
253_S259_A0.5851.00
280_V305_A0.5831.00
76_D90_L0.5801.00
190_I213_I0.5761.00
85_E97_A0.5751.00
259_A264_L0.5731.00
199_Q203_R0.5721.00
81_I103_V0.5701.00
219_I227_I0.5681.00
80_D83_T0.5671.00
12_Y16_G0.5641.00
282_D301_A0.5641.00
48_R51_R0.5621.00
17_A21_L0.5621.00
124_L133_I0.5621.00
59_I65_D0.5611.00
117_M121_P0.5611.00
152_V181_V0.5611.00
44_H48_R0.5601.00
56_Q131_M0.5591.00
268_S287_S0.5551.00
111_T118_A0.5531.00
33_W71_T0.5531.00
126_S131_M0.5521.00
12_Y298_A0.5511.00
27_P310_R0.5511.00
83_T276_R0.5501.00
198_I201_A0.5491.00
321_L324_W0.5481.00
259_A263_R0.5481.00
185_E188_P0.5471.00
5_V100_Y0.5461.00
161_G243_T0.5451.00
48_R53_P0.5451.00
50_I54_G0.5451.00
314_R318_G0.5431.00
297_T300_A0.5421.00
261_H265_Q0.5401.00
325_T328_D0.5381.00
35_A75_E0.5361.00
33_W73_F0.5321.00
164_S168_V0.5291.00
123_T127_L0.5281.00
255_V277_V0.5271.00
5_V31_L0.5261.00
79_T82_D0.5251.00
323_T328_D0.5251.00
259_A262_N0.5241.00
298_A301_A0.5241.00
326_Y329_Q0.5231.00
6_V86_R0.5231.00
206_L330_G0.5231.00
299_Q303_Q0.5221.00
15_A33_W0.5211.00
23_S69_R0.5211.00
162_I213_I0.5201.00
59_I63_V0.5201.00
49_V53_P0.5171.00
257_M274_D0.5161.00
162_I190_I0.5151.00
43_L47_H0.5151.00
12_Y302_W0.5141.00
10_A40_H0.5131.00
124_L131_M0.5121.00
331_T334_S0.5111.00
333_V336_G0.5111.00
166_G209_A0.5101.00
321_L330_G0.5101.00
256_E259_A0.5101.00
29_A100_Y0.5101.00
43_L46_A0.5091.00
252_L259_A0.5071.00
284_S304_A0.5051.00
60_T65_D0.5041.00
160_S163_Q0.5041.00
314_R317_E0.5041.00
207_E213_I0.5041.00
324_W329_Q0.5031.00
258_D272_A0.5021.00
295_P300_A0.5021.00
27_P313_A0.5011.00
5_V17_A0.5001.00
52_D56_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nwzA 2 0.9537 100 0.282 Contact Map
3l8kA 3 0.9152 100 0.286 Contact Map
1ojtA 2 0.9177 100 0.29 Contact Map
3icsA 2 0.9614 100 0.296 Contact Map
1lvlA 2 0.9075 100 0.298 Contact Map
3urhA 2 0.9203 100 0.3 Contact Map
1v59A 2 0.9203 100 0.302 Contact Map
4jq9A 3 0.9152 100 0.302 Contact Map
2a8xA 2 0.9152 100 0.304 Contact Map
3ladA 2 0.9203 100 0.306 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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