Q9HR25 - HALSA - GREMLIN Contacts

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Q9HR25 - Uridine phosphorylase

UniProt:	Q9HR25	Sequences: MPGTSEDPNDEVQYHLEVAAEDIADAVLLPGNPERVDTITPLWDDHEEMAHHREYRTATGAYDGTPISVTSTGIGSPSAAIAVEELARAGADTFIRVGSCGALQADMEPGDLVITRGAVRQEGTTDEYVREDYPAVADHEVVAALIAAAERLGHDYHVGLTMSADSFYAGQGRDGFEGFRAPGADAMLDELRDANVKNIEMEAAAICTLANVYGLRAGAVCSVFANRETGEFLTEGESTASETASLAVHLLAKMDQRKAAAGVDQWHAGMSLD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	273 (226)
Sequences:	3419 (2225)
Seq/√Len:	148.0

ECOLI - UDP DEOD
BACSU - DEOD
HALSA - Q9HR25 Q9HP14
SULSO - PNPH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
100_C	223_V	4.344	1.00
210_A	217_A	4.144	1.00
93_T	216_R	3.398	1.00
138_D	216_R	3.311	1.00
25_D	92_D	3.058	1.00
203_A	219_A	3.007	1.00
45_D	61_A	2.764	1.00
87_A	215_L	2.738	1.00
117_G	136_V	2.611	1.00
115_T	161_T	2.549	1.00
143_A	147_A	2.493	1.00
37_D	41_P	2.460	1.00
19_A	22_D	2.251	1.00
26_A	93_T	2.244	1.00
22_D	47_E	2.178	1.00
116_R	158_V	2.141	1.00
146_I	150_E	2.125	1.00
55_Y	71_S	2.120	1.00
76_S	205_A	2.116	1.00
146_I	158_V	2.078	1.00
61_A	66_P	2.056	1.00
92_D	215_L	2.024	1.00
48_E	51_H	1.997	1.00
145_L	218_G	1.985	1.00
29_L	72_T	1.980	1.00
108_E	111_D	1.932	1.00
141_V	218_G	1.901	1.00
38_T	241_S	1.894	1.00
76_S	163_S	1.842	1.00
100_C	198_N	1.822	1.00
114_I	142_V	1.804	1.00
114_I	156_Y	1.797	1.00
29_L	94_F	1.796	1.00
83_V	209_L	1.767	1.00
117_G	160_L	1.754	1.00
47_E	66_P	1.745	1.00
161_T	221_C	1.680	1.00
113_V	198_N	1.662	1.00
106_D	157_H	1.642	1.00
88_R	213_Y	1.641	1.00
234_T	237_E	1.637	1.00
27_V	91_A	1.612	1.00
104_Q	197_K	1.604	1.00
49_M	70_T	1.595	1.00
51_H	56_R	1.573	1.00
241_S	245_S	1.557	1.00
63_D	249_H	1.538	1.00
118_A	203_A	1.523	1.00
140_E	216_R	1.519	1.00
26_A	65_T	1.517	1.00
44_D	61_A	1.516	1.00
94_F	215_L	1.506	1.00
159_G	197_K	1.503	1.00
143_A	150_E	1.501	1.00
84_E	213_Y	1.455	1.00
20_A	90_G	1.424	1.00
39_I	69_V	1.419	1.00
31_G	35_R	1.416	1.00
114_I	146_I	1.413	1.00
162_M	196_V	1.409	1.00
79_A	83_V	1.396	1.00
57_T	70_T	1.383	1.00
148_A	151_R	1.380	1.00
142_V	218_G	1.379	1.00
161_T	198_N	1.366	1.00
108_E	231_E	1.366	1.00
111_D	157_H	1.363	1.00
242_E	245_S	1.341	1.00
107_M	157_H	1.339	1.00
124_T	128_Y	1.325	1.00
84_E	88_R	1.323	1.00
110_G	233_L	1.303	1.00
79_A	206_I	1.290	1.00
241_S	244_A	1.260	1.00
189_D	192_R	1.260	1.00
63_D	252_A	1.242	1.00
187_M	190_E	1.242	1.00
59_T	68_S	1.237	1.00
152_L	245_S	1.227	1.00
23_I	49_M	1.206	1.00
243_T	247_A	1.193	1.00
83_V	94_F	1.191	1.00
139_H	143_A	1.186	1.00
148_A	250_L	1.185	1.00
143_A	146_I	1.183	1.00
149_A	156_Y	1.167	1.00
108_E	229_T	1.151	1.00
198_N	223_V	1.150	1.00
233_L	237_E	1.149	1.00
87_A	94_F	1.144	1.00
124_T	209_L	1.139	1.00
148_A	152_L	1.111	0.99
189_D	193_D	1.107	0.99
102_A	107_M	1.089	0.99
119_V	134_P	1.086	0.99
200_E	203_A	1.075	0.99
147_A	150_E	1.073	0.99
137_A	207_C	1.072	0.99
226_N	229_T	1.067	0.99
24_A	68_S	1.053	0.99
142_V	158_V	1.045	0.99
34_E	51_H	1.045	0.99
113_V	197_K	1.042	0.99
115_T	221_C	1.035	0.99
116_R	136_V	1.033	0.99
152_L	249_H	1.027	0.99
113_V	223_V	1.020	0.99
146_I	156_Y	1.008	0.99
170_G	212_V	1.007	0.99
102_A	226_N	0.996	0.99
147_A	151_R	0.991	0.99
40_T	58_A	0.987	0.99
17_E	51_H	0.985	0.99
246_L	250_L	0.981	0.99
55_Y	74_I	0.978	0.98
125_T	208_T	0.969	0.98
126_D	132_D	0.964	0.98
121_Q	162_M	0.963	0.98
79_A	205_A	0.961	0.98
26_A	251_L	0.961	0.98
186_A	189_D	0.961	0.98
80_A	84_E	0.955	0.98
245_S	249_H	0.940	0.98
163_S	203_A	0.939	0.98
117_G	134_P	0.937	0.98
144_A	148_A	0.936	0.98
51_H	54_E	0.934	0.98
171_Q	186_A	0.924	0.98
104_Q	107_M	0.921	0.98
72_T	94_F	0.916	0.98
103_L	227_R	0.908	0.98
84_E	209_L	0.903	0.97
24_A	59_T	0.902	0.97
57_T	68_S	0.901	0.97
199_I	227_R	0.897	0.97
112_L	246_L	0.896	0.97
188_L	227_R	0.895	0.97
76_S	124_T	0.893	0.97
103_L	199_I	0.892	0.97
119_V	196_V	0.884	0.97
47_E	59_T	0.879	0.97
125_T	128_Y	0.876	0.97
240_A	248_V	0.875	0.97
242_E	246_L	0.873	0.97
18_V	21_E	0.872	0.97
39_I	97_V	0.867	0.97
120_R	208_T	0.862	0.97
72_T	83_V	0.858	0.97
154_H	246_L	0.856	0.96
90_G	215_L	0.854	0.96
93_T	141_V	0.846	0.96
123_G	128_Y	0.844	0.96
114_I	218_G	0.839	0.96
34_E	37_D	0.836	0.96
23_I	68_S	0.836	0.96
243_T	246_L	0.834	0.96
207_C	218_G	0.832	0.96
100_C	113_V	0.830	0.96
44_D	63_D	0.825	0.96
38_T	244_A	0.825	0.96
139_H	146_I	0.825	0.96
148_A	249_H	0.822	0.96
53_R	85_E	0.818	0.95
25_D	65_T	0.817	0.95
137_A	142_V	0.812	0.95
240_A	246_L	0.806	0.95
141_V	145_L	0.802	0.95
80_A	209_L	0.800	0.95
139_H	142_V	0.799	0.95
114_I	149_A	0.797	0.95
135_A	208_T	0.794	0.95
43_W	60_G	0.790	0.95
33_P	71_S	0.786	0.94
249_H	252_A	0.786	0.94
114_I	158_V	0.783	0.94
76_S	204_A	0.780	0.94
186_A	190_E	0.778	0.94
171_Q	227_R	0.777	0.94
74_I	81_I	0.776	0.94
50_A	57_T	0.776	0.94
99_S	224_F	0.775	0.94
114_I	220_V	0.773	0.94
127_E	130_R	0.766	0.94
205_A	209_L	0.753	0.93
116_R	160_L	0.749	0.93
192_R	228_E	0.746	0.93
35_R	96_R	0.744	0.93
24_A	66_P	0.743	0.93
25_D	66_P	0.738	0.92
80_A	205_A	0.738	0.92
136_V	160_L	0.737	0.92
46_H	58_A	0.732	0.92
138_D	141_V	0.728	0.92
236_G	239_T	0.727	0.92
30_P	72_T	0.726	0.92
18_V	89_A	0.725	0.92
30_P	97_V	0.722	0.91
78_S	81_I	0.720	0.91
18_V	22_D	0.718	0.91
34_E	54_E	0.718	0.91
235_E	238_S	0.717	0.91
220_V	247_A	0.716	0.91
140_E	144_A	0.714	0.91
81_I	85_E	0.714	0.91
243_T	248_V	0.713	0.91
134_P	160_L	0.709	0.91
37_D	56_R	0.706	0.91
105_A	228_E	0.699	0.90
36_V	58_A	0.699	0.90
30_P	36_V	0.693	0.90
121_Q	164_A	0.693	0.90
224_F	240_A	0.688	0.89
115_T	198_N	0.688	0.89
70_T	82_A	0.687	0.89
123_G	127_E	0.680	0.89
203_A	207_C	0.680	0.89
31_G	96_R	0.677	0.89
144_A	250_L	0.676	0.89
41_P	46_H	0.675	0.88
48_E	58_A	0.674	0.88
49_M	68_S	0.668	0.88
34_E	52_H	0.667	0.88
163_S	219_A	0.665	0.88
133_Y	208_T	0.664	0.88
157_H	197_K	0.664	0.88
188_L	191_L	0.662	0.87
119_V	136_V	0.659	0.87
87_A	213_Y	0.658	0.87
77_P	165_D	0.657	0.87
87_A	91_A	0.656	0.87
42_L	241_S	0.655	0.87
234_T	238_S	0.653	0.87
123_G	126_D	0.653	0.87
145_L	148_A	0.652	0.87
104_Q	157_H	0.652	0.87
115_T	207_C	0.650	0.87
108_E	155_D	0.650	0.87
124_T	205_A	0.644	0.86
121_Q	166_S	0.643	0.86
116_R	142_V	0.640	0.86
65_T	252_A	0.634	0.85
164_A	199_I	0.634	0.85
61_A	64_G	0.632	0.85
129_V	194_A	0.631	0.85
95_I	141_V	0.631	0.85
44_D	64_G	0.631	0.85
37_D	51_H	0.629	0.85
203_A	221_C	0.629	0.85
105_A	192_R	0.627	0.85
247_A	251_L	0.624	0.84
50_A	59_T	0.624	0.84
27_V	68_S	0.622	0.84
32_N	35_R	0.621	0.84
33_P	40_T	0.618	0.84
235_E	239_T	0.615	0.83
240_A	243_T	0.609	0.83
62_Y	248_V	0.609	0.83
106_D	195_N	0.608	0.83
119_V	162_M	0.608	0.83
36_V	69_V	0.607	0.83
22_D	50_A	0.607	0.83
125_T	132_D	0.606	0.82
142_V	145_L	0.605	0.82
140_E	143_A	0.604	0.82
48_E	56_R	0.603	0.82
124_T	127_E	0.602	0.82
49_M	57_T	0.601	0.82
240_A	247_A	0.596	0.81
118_A	163_S	0.594	0.81
14_Y	17_E	0.592	0.81
101_G	200_E	0.592	0.81
142_V	146_I	0.591	0.81
124_T	129_V	0.590	0.81
120_R	204_A	0.590	0.81
102_A	223_V	0.588	0.81
30_P	39_I	0.587	0.80
145_L	246_L	0.585	0.80
110_G	237_E	0.585	0.80
103_L	196_V	0.579	0.80
38_T	41_P	0.578	0.79
21_E	68_S	0.576	0.79
38_T	42_L	0.574	0.79
107_M	113_V	0.574	0.79
74_I	82_A	0.573	0.79
139_H	158_V	0.568	0.78
125_T	129_V	0.567	0.78
118_A	207_C	0.564	0.78
96_R	99_S	0.563	0.78
246_L	249_H	0.561	0.77
100_C	221_C	0.560	0.77
42_L	245_S	0.559	0.77
200_E	219_A	0.558	0.77
189_D	228_E	0.556	0.77
35_R	99_S	0.554	0.77
55_Y	82_A	0.553	0.76
171_Q	187_M	0.551	0.76
102_A	109_P	0.551	0.76
41_P	241_S	0.551	0.76
97_V	220_V	0.550	0.76
119_V	131_E	0.549	0.76
150_E	156_Y	0.548	0.76
103_L	192_R	0.548	0.76
50_A	89_A	0.548	0.76
199_I	225_A	0.546	0.76
112_L	154_H	0.544	0.75
105_A	229_T	0.543	0.75
62_Y	67_I	0.542	0.75
143_A	158_V	0.542	0.75
50_A	54_E	0.540	0.75
79_A	84_E	0.540	0.75
14_Y	224_F	0.538	0.74
126_D	131_E	0.533	0.74
171_Q	190_E	0.533	0.74
244_A	248_V	0.533	0.74
17_E	22_D	0.533	0.74
187_M	191_L	0.532	0.74
166_S	170_G	0.530	0.73
96_R	206_I	0.528	0.73
190_E	193_D	0.525	0.73
161_T	203_A	0.525	0.73
29_L	83_V	0.525	0.73
106_D	229_T	0.523	0.72
136_V	211_N	0.523	0.72
131_E	191_L	0.523	0.72
87_A	92_D	0.522	0.72
99_S	240_A	0.518	0.72
162_M	191_L	0.517	0.72
144_A	147_A	0.517	0.72
52_H	55_Y	0.516	0.71
37_D	58_A	0.516	0.71
145_L	250_L	0.516	0.71
240_A	251_L	0.514	0.71
76_S	122_E	0.511	0.71
15_H	81_I	0.510	0.71
138_D	144_A	0.506	0.70
155_D	214_G	0.503	0.69
119_V	133_Y	0.501	0.69
199_I	224_F	0.500	0.69
137_A	218_G	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bjeA	2	0.9194	100	0.27	Contact Map
3eufA	2	0.9414	100	0.312	Contact Map
3phcA	5	0.8645	100	0.326	Contact Map
3mb8A	4	0.8718	100	0.33	Contact Map
2b94A	4	0.8462	100	0.332	Contact Map
3qpbA	6	0.9121	100	0.34	Contact Map
3p0fA	2	0.9341	100	0.341	Contact Map
4tymA	5	0.8388	100	0.353	Contact Map
4m3nA	3	0.8278	100	0.357	Contact Map
4r31A	5	0.9304	100	0.36	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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