GREMLIN Database
Q9HR25 - Uridine phosphorylase
UniProt: Q9HR25 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 273 (226)
Sequences: 3419 (2225)
Seq/√Len: 148.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_C223_V4.3441.00
210_A217_A4.1441.00
93_T216_R3.3981.00
138_D216_R3.3111.00
25_D92_D3.0581.00
203_A219_A3.0071.00
45_D61_A2.7641.00
87_A215_L2.7381.00
117_G136_V2.6111.00
115_T161_T2.5491.00
143_A147_A2.4931.00
37_D41_P2.4601.00
19_A22_D2.2511.00
26_A93_T2.2441.00
22_D47_E2.1781.00
116_R158_V2.1411.00
146_I150_E2.1251.00
55_Y71_S2.1201.00
76_S205_A2.1161.00
146_I158_V2.0781.00
61_A66_P2.0561.00
92_D215_L2.0241.00
48_E51_H1.9971.00
145_L218_G1.9851.00
29_L72_T1.9801.00
108_E111_D1.9321.00
141_V218_G1.9011.00
38_T241_S1.8941.00
76_S163_S1.8421.00
100_C198_N1.8221.00
114_I142_V1.8041.00
114_I156_Y1.7971.00
29_L94_F1.7961.00
83_V209_L1.7671.00
117_G160_L1.7541.00
47_E66_P1.7451.00
161_T221_C1.6801.00
113_V198_N1.6621.00
106_D157_H1.6421.00
88_R213_Y1.6411.00
234_T237_E1.6371.00
27_V91_A1.6121.00
104_Q197_K1.6041.00
49_M70_T1.5951.00
51_H56_R1.5731.00
241_S245_S1.5571.00
63_D249_H1.5381.00
118_A203_A1.5231.00
140_E216_R1.5191.00
26_A65_T1.5171.00
44_D61_A1.5161.00
94_F215_L1.5061.00
159_G197_K1.5031.00
143_A150_E1.5011.00
84_E213_Y1.4551.00
20_A90_G1.4241.00
39_I69_V1.4191.00
31_G35_R1.4161.00
114_I146_I1.4131.00
162_M196_V1.4091.00
79_A83_V1.3961.00
57_T70_T1.3831.00
148_A151_R1.3801.00
142_V218_G1.3791.00
161_T198_N1.3661.00
108_E231_E1.3661.00
111_D157_H1.3631.00
242_E245_S1.3411.00
107_M157_H1.3391.00
124_T128_Y1.3251.00
84_E88_R1.3231.00
110_G233_L1.3031.00
79_A206_I1.2901.00
241_S244_A1.2601.00
189_D192_R1.2601.00
63_D252_A1.2421.00
187_M190_E1.2421.00
59_T68_S1.2371.00
152_L245_S1.2271.00
23_I49_M1.2061.00
243_T247_A1.1931.00
83_V94_F1.1911.00
139_H143_A1.1861.00
148_A250_L1.1851.00
143_A146_I1.1831.00
149_A156_Y1.1671.00
108_E229_T1.1511.00
198_N223_V1.1501.00
233_L237_E1.1491.00
87_A94_F1.1441.00
124_T209_L1.1391.00
148_A152_L1.1110.99
189_D193_D1.1070.99
102_A107_M1.0890.99
119_V134_P1.0860.99
200_E203_A1.0750.99
147_A150_E1.0730.99
137_A207_C1.0720.99
226_N229_T1.0670.99
24_A68_S1.0530.99
142_V158_V1.0450.99
34_E51_H1.0450.99
113_V197_K1.0420.99
115_T221_C1.0350.99
116_R136_V1.0330.99
152_L249_H1.0270.99
113_V223_V1.0200.99
146_I156_Y1.0080.99
170_G212_V1.0070.99
102_A226_N0.9960.99
147_A151_R0.9910.99
40_T58_A0.9870.99
17_E51_H0.9850.99
246_L250_L0.9810.99
55_Y74_I0.9780.98
125_T208_T0.9690.98
126_D132_D0.9640.98
121_Q162_M0.9630.98
79_A205_A0.9610.98
26_A251_L0.9610.98
186_A189_D0.9610.98
80_A84_E0.9550.98
245_S249_H0.9400.98
163_S203_A0.9390.98
117_G134_P0.9370.98
144_A148_A0.9360.98
51_H54_E0.9340.98
171_Q186_A0.9240.98
104_Q107_M0.9210.98
72_T94_F0.9160.98
103_L227_R0.9080.98
84_E209_L0.9030.97
24_A59_T0.9020.97
57_T68_S0.9010.97
199_I227_R0.8970.97
112_L246_L0.8960.97
188_L227_R0.8950.97
76_S124_T0.8930.97
103_L199_I0.8920.97
119_V196_V0.8840.97
47_E59_T0.8790.97
125_T128_Y0.8760.97
240_A248_V0.8750.97
242_E246_L0.8730.97
18_V21_E0.8720.97
39_I97_V0.8670.97
120_R208_T0.8620.97
72_T83_V0.8580.97
154_H246_L0.8560.96
90_G215_L0.8540.96
93_T141_V0.8460.96
123_G128_Y0.8440.96
114_I218_G0.8390.96
34_E37_D0.8360.96
23_I68_S0.8360.96
243_T246_L0.8340.96
207_C218_G0.8320.96
100_C113_V0.8300.96
44_D63_D0.8250.96
38_T244_A0.8250.96
139_H146_I0.8250.96
148_A249_H0.8220.96
53_R85_E0.8180.95
25_D65_T0.8170.95
137_A142_V0.8120.95
240_A246_L0.8060.95
141_V145_L0.8020.95
80_A209_L0.8000.95
139_H142_V0.7990.95
114_I149_A0.7970.95
135_A208_T0.7940.95
43_W60_G0.7900.95
33_P71_S0.7860.94
249_H252_A0.7860.94
114_I158_V0.7830.94
76_S204_A0.7800.94
186_A190_E0.7780.94
171_Q227_R0.7770.94
74_I81_I0.7760.94
50_A57_T0.7760.94
99_S224_F0.7750.94
114_I220_V0.7730.94
127_E130_R0.7660.94
205_A209_L0.7530.93
116_R160_L0.7490.93
192_R228_E0.7460.93
35_R96_R0.7440.93
24_A66_P0.7430.93
25_D66_P0.7380.92
80_A205_A0.7380.92
136_V160_L0.7370.92
46_H58_A0.7320.92
138_D141_V0.7280.92
236_G239_T0.7270.92
30_P72_T0.7260.92
18_V89_A0.7250.92
30_P97_V0.7220.91
78_S81_I0.7200.91
18_V22_D0.7180.91
34_E54_E0.7180.91
235_E238_S0.7170.91
220_V247_A0.7160.91
140_E144_A0.7140.91
81_I85_E0.7140.91
243_T248_V0.7130.91
134_P160_L0.7090.91
37_D56_R0.7060.91
105_A228_E0.6990.90
36_V58_A0.6990.90
30_P36_V0.6930.90
121_Q164_A0.6930.90
224_F240_A0.6880.89
115_T198_N0.6880.89
70_T82_A0.6870.89
123_G127_E0.6800.89
203_A207_C0.6800.89
31_G96_R0.6770.89
144_A250_L0.6760.89
41_P46_H0.6750.88
48_E58_A0.6740.88
49_M68_S0.6680.88
34_E52_H0.6670.88
163_S219_A0.6650.88
133_Y208_T0.6640.88
157_H197_K0.6640.88
188_L191_L0.6620.87
119_V136_V0.6590.87
87_A213_Y0.6580.87
77_P165_D0.6570.87
87_A91_A0.6560.87
42_L241_S0.6550.87
234_T238_S0.6530.87
123_G126_D0.6530.87
145_L148_A0.6520.87
104_Q157_H0.6520.87
115_T207_C0.6500.87
108_E155_D0.6500.87
124_T205_A0.6440.86
121_Q166_S0.6430.86
116_R142_V0.6400.86
65_T252_A0.6340.85
164_A199_I0.6340.85
61_A64_G0.6320.85
129_V194_A0.6310.85
95_I141_V0.6310.85
44_D64_G0.6310.85
37_D51_H0.6290.85
203_A221_C0.6290.85
105_A192_R0.6270.85
247_A251_L0.6240.84
50_A59_T0.6240.84
27_V68_S0.6220.84
32_N35_R0.6210.84
33_P40_T0.6180.84
235_E239_T0.6150.83
240_A243_T0.6090.83
62_Y248_V0.6090.83
106_D195_N0.6080.83
119_V162_M0.6080.83
36_V69_V0.6070.83
22_D50_A0.6070.83
125_T132_D0.6060.82
142_V145_L0.6050.82
140_E143_A0.6040.82
48_E56_R0.6030.82
124_T127_E0.6020.82
49_M57_T0.6010.82
240_A247_A0.5960.81
118_A163_S0.5940.81
14_Y17_E0.5920.81
101_G200_E0.5920.81
142_V146_I0.5910.81
124_T129_V0.5900.81
120_R204_A0.5900.81
102_A223_V0.5880.81
30_P39_I0.5870.80
145_L246_L0.5850.80
110_G237_E0.5850.80
103_L196_V0.5790.80
38_T41_P0.5780.79
21_E68_S0.5760.79
38_T42_L0.5740.79
107_M113_V0.5740.79
74_I82_A0.5730.79
139_H158_V0.5680.78
125_T129_V0.5670.78
118_A207_C0.5640.78
96_R99_S0.5630.78
246_L249_H0.5610.77
100_C221_C0.5600.77
42_L245_S0.5590.77
200_E219_A0.5580.77
189_D228_E0.5560.77
35_R99_S0.5540.77
55_Y82_A0.5530.76
171_Q187_M0.5510.76
102_A109_P0.5510.76
41_P241_S0.5510.76
97_V220_V0.5500.76
119_V131_E0.5490.76
150_E156_Y0.5480.76
103_L192_R0.5480.76
50_A89_A0.5480.76
199_I225_A0.5460.76
112_L154_H0.5440.75
105_A229_T0.5430.75
62_Y67_I0.5420.75
143_A158_V0.5420.75
50_A54_E0.5400.75
79_A84_E0.5400.75
14_Y224_F0.5380.74
126_D131_E0.5330.74
171_Q190_E0.5330.74
244_A248_V0.5330.74
17_E22_D0.5330.74
187_M191_L0.5320.74
166_S170_G0.5300.73
96_R206_I0.5280.73
190_E193_D0.5250.73
161_T203_A0.5250.73
29_L83_V0.5250.73
106_D229_T0.5230.72
136_V211_N0.5230.72
131_E191_L0.5230.72
87_A92_D0.5220.72
99_S240_A0.5180.72
162_M191_L0.5170.72
144_A147_A0.5170.72
52_H55_Y0.5160.71
37_D58_A0.5160.71
145_L250_L0.5160.71
240_A251_L0.5140.71
76_S122_E0.5110.71
15_H81_I0.5100.71
138_D144_A0.5060.70
155_D214_G0.5030.69
119_V133_Y0.5010.69
199_I224_F0.5000.69
137_A218_G0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bjeA 2 0.9194 100 0.27 Contact Map
3eufA 2 0.9414 100 0.312 Contact Map
3phcA 5 0.8645 100 0.326 Contact Map
3mb8A 4 0.8718 100 0.33 Contact Map
2b94A 4 0.8462 100 0.332 Contact Map
3qpbA 6 0.9121 100 0.34 Contact Map
3p0fA 2 0.9341 100 0.341 Contact Map
4tymA 5 0.8388 100 0.353 Contact Map
4m3nA 3 0.8278 100 0.357 Contact Map
4r31A 5 0.9304 100 0.36 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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