GREMLIN Database
Q9HR24 - Cytidine aminohydrolase
UniProt: Q9HR24 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 134 (126)
Sequences: 3323 (2276)
Seq/√Len: 202.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_N88_M3.7701.00
33_A69_D3.1331.00
61_K65_A2.7511.00
34_S67_D2.5961.00
59_V93_L2.3041.00
32_T38_Y2.1931.00
47_N50_N2.1801.00
29_A37_V2.1771.00
61_K64_S2.1321.00
19_V25_K2.1231.00
94_A126_T2.1131.00
31_D72_R1.9801.00
33_A71_Q1.9721.00
77_S83_V1.9141.00
9_A39_T1.9131.00
9_A12_D1.9021.00
36_A67_D1.8241.00
38_Y67_D1.8091.00
52_L60_G1.7921.00
14_T78_S1.7121.00
60_G92_T1.6631.00
52_L57_V1.6541.00
32_T67_D1.6301.00
57_V60_G1.6201.00
97_A101_L1.5911.00
57_V61_K1.5611.00
49_S88_M1.5611.00
104_L116_T1.5561.00
105_C117_Y1.5351.00
63_V96_F1.4841.00
38_Y65_A1.4831.00
84_T105_C1.4791.00
72_R102_T1.4281.00
27_G41_C1.4161.00
72_R104_L1.4071.00
12_D15_A1.4011.00
32_T36_A1.3911.00
102_T116_T1.3841.00
47_N88_M1.3271.00
7_L106_D1.2651.00
94_A128_T1.2531.00
5_D9_A1.2471.00
117_Y121_E1.2361.00
117_Y125_D1.2341.00
24_Y83_V1.2271.00
7_L74_A1.2221.00
31_D71_Q1.2161.00
13_A39_T1.2141.00
109_D113_G1.2011.00
99_D120_G1.1851.00
115_V125_D1.1701.00
59_V92_T1.1361.00
59_V70_F1.1351.00
11_R76_T1.1351.00
107_S113_G1.1301.00
118_T121_E1.1221.00
10_A29_A1.0771.00
59_V96_F1.0561.00
82_A107_S1.0501.00
102_T118_T1.0501.00
52_L56_E1.0481.00
30_L58_A1.0421.00
13_A27_G1.0381.00
30_L73_L1.0371.00
94_A130_S1.0301.00
25_K78_S1.0261.00
32_T70_F1.0161.00
94_A129_A1.0141.00
13_A41_C1.0091.00
98_A101_L0.9971.00
43_I63_V0.9941.00
6_L29_A0.9861.00
76_T106_D0.9801.00
56_E92_T0.9791.00
57_V64_S0.9781.00
9_A37_V0.9731.00
21_Y48_Y0.9731.00
86_C89_C0.9560.99
73_L93_L0.9500.99
119_L122_L0.9460.99
14_T76_T0.9330.99
70_F97_A0.9190.99
30_L70_F0.9100.99
18_H45_N0.9060.99
70_F101_L0.8980.99
11_R14_T0.8810.99
15_A25_K0.8800.99
14_T27_G0.8770.99
4_D8_A0.8460.99
36_A65_A0.8430.99
7_L114_V0.8430.99
7_L11_R0.8420.99
62_A70_F0.8400.99
35_G71_Q0.8290.98
16_A39_T0.8170.98
12_D39_T0.8120.98
105_C125_D0.8040.98
14_T25_K0.7960.98
103_I119_L0.7840.98
103_I122_L0.7820.98
93_L101_L0.7770.98
41_C57_V0.7730.98
87_G123_L0.7670.97
6_L37_V0.7610.97
5_D8_A0.7600.97
8_A12_D0.7510.97
109_D112_A0.7490.97
58_A73_L0.7400.97
93_L97_A0.7360.97
47_N51_S0.7340.97
43_I64_S0.7310.97
11_R106_D0.7310.97
73_L101_L0.7180.96
52_L92_T0.7140.96
100_D120_G0.7130.96
14_T17_A0.7000.96
43_I60_G0.6980.96
93_L119_L0.6910.95
101_L119_L0.6860.95
82_A114_V0.6830.95
12_D16_A0.6810.95
88_M92_T0.6800.95
56_E60_G0.6760.95
63_V70_F0.6730.95
55_E86_C0.6700.94
79_Q82_A0.6680.94
6_L74_A0.6660.94
45_N95_E0.6600.94
41_C64_S0.6530.94
87_G90_R0.6470.93
128_T131_N0.6430.93
8_A11_R0.6390.93
74_A106_D0.6370.93
59_V97_A0.6340.93
18_H21_Y0.6330.93
74_A104_L0.6330.93
21_Y45_N0.6310.92
82_A108_G0.6250.92
13_A64_S0.6200.92
56_E88_M0.6180.92
63_V68_T0.6160.92
10_A74_A0.6150.92
9_A13_A0.6130.91
28_A58_A0.6120.91
81_D84_T0.6120.91
78_S108_G0.6040.91
106_D114_V0.6030.91
24_Y77_S0.6010.91
80_R109_D0.6010.91
84_T90_R0.5990.90
66_G70_F0.5960.90
10_A76_T0.5850.89
31_D37_V0.5790.89
26_V54_A0.5760.89
99_D102_T0.5620.87
87_G91_Q0.5620.87
50_N92_T0.5610.87
6_L10_A0.5580.87
53_H56_E0.5560.87
16_A64_S0.5550.87
45_N49_S0.5490.86
30_L62_A0.5470.86
84_T125_D0.5470.86
82_A105_C0.5430.86
48_Y51_S0.5400.85
123_L127_I0.5400.85
53_H89_C0.5390.85
123_L126_T0.5390.85
14_T77_S0.5380.85
55_E89_C0.5370.85
73_L103_I0.5320.84
53_H86_C0.5290.84
13_A17_A0.5270.84
94_A119_L0.5270.84
11_R108_G0.5250.84
107_S114_V0.5240.84
41_C63_V0.5200.83
84_T131_N0.5160.83
33_A67_D0.5130.82
85_P90_R0.5110.82
90_R122_L0.5110.82
32_T62_A0.5080.82
18_H95_E0.5080.82
56_E62_A0.5080.82
26_V42_N0.5070.82
5_D31_D0.5060.81
4_D114_V0.5060.81
86_C91_Q0.5040.81
16_A68_T0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d30A 4 0.9254 100 0.053 Contact Map
3dmoA 4 0.9552 100 0.081 Contact Map
1cttA 2 0.9104 100 0.172 Contact Map
3b8fA 4 0.9627 100 0.173 Contact Map
1uwzA 4 0.9701 100 0.236 Contact Map
2fr5A 6 0.9776 100 0.244 Contact Map
1r5tA 4 0.9776 100 0.247 Contact Map
3mpzA 4 0.9179 100 0.259 Contact Map
3r2nA 4 0.8806 100 0.279 Contact Map
3oj6A 4 0.9403 100 0.298 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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