GREMLIN Database
Q9HR23 - Ribose ABC transporter permease
UniProt: Q9HR23 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 361 (288)
Sequences: 27245 (17490)
Seq/√Len: 1030.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_V251_L4.0861.00
113_V247_L3.5151.00
113_V251_L3.2821.00
228_P242_R3.0241.00
85_T111_A2.9531.00
56_T201_M2.8381.00
63_I297_T2.7461.00
117_G247_L2.7351.00
125_K239_H2.6951.00
89_V107_G2.6611.00
221_V245_S2.5521.00
112_S254_G2.4681.00
237_N240_R2.4401.00
240_R244_V2.4031.00
116_A250_G2.3001.00
211_V217_F2.2931.00
112_S250_G2.2381.00
217_F244_V2.2181.00
209_W213_N2.2071.00
119_F137_V2.1711.00
207_V211_V2.1221.00
220_W241_V2.1001.00
58_A283_A2.0791.00
169_V172_L2.0541.00
117_G243_Y2.0441.00
109_V255_M2.0411.00
86_A108_G2.0361.00
210_Y214_H2.0211.00
59_A297_T1.9921.00
89_V93_L1.9861.00
121_V125_K1.9781.00
282_I308_E1.9621.00
224_S241_V1.9161.00
206_A210_Y1.9021.00
52_A305_S1.8971.00
100_A103_T1.8551.00
64_F208_S1.8461.00
102_W106_A1.8431.00
223_A231_L1.7901.00
105_F258_A1.7731.00
65_A249_S1.7731.00
120_A243_Y1.7451.00
115_L141_A1.7211.00
139_L142_L1.7061.00
282_I331_P1.6301.00
229_N232_D1.6231.00
52_A302_M1.6221.00
86_A258_A1.6221.00
56_T301_A1.6071.00
217_F221_V1.6051.00
216_A220_W1.5701.00
185_S188_G1.5581.00
81_I115_L1.5431.00
205_V298_F1.5341.00
68_S245_S1.5311.00
125_K243_Y1.5301.00
57_L259_A1.5301.00
137_V141_A1.5231.00
88_L148_A1.5031.00
67_K222_E1.5021.00
109_V258_A1.4941.00
88_L92_A1.4901.00
90_A104_G1.4881.00
57_L256_G1.4841.00
79_L260_L1.4671.00
290_G296_G1.4581.00
58_A79_L1.4381.00
60_L208_S1.4351.00
64_F245_S1.4261.00
244_V247_L1.3921.00
70_V242_R1.3891.00
220_W236_V1.3871.00
171_V174_D1.3771.00
44_M309_S1.3751.00
228_P232_D1.3691.00
70_V246_V1.3631.00
236_V241_V1.3581.00
293_N296_G1.3561.00
61_G252_L1.3531.00
80_I145_A1.3321.00
70_V130_Q1.3251.00
243_Y247_L1.3231.00
99_A103_T1.3131.00
124_I239_H1.3121.00
32_A310_L1.3081.00
170_P174_D1.2981.00
78_L115_L1.2751.00
103_T106_A1.2591.00
224_S238_V1.2551.00
110_L113_V1.2541.00
104_G108_G1.2411.00
62_G283_A1.2401.00
192_L195_N1.2391.00
220_W231_L1.2371.00
56_T298_F1.2291.00
75_L253_S1.2181.00
121_V243_Y1.2121.00
93_L99_A1.1961.00
86_A262_V1.1891.00
62_G287_Y1.1891.00
122_V133_A1.1891.00
231_L236_V1.1851.00
232_D239_H1.1771.00
59_A286_T1.1741.00
85_T89_V1.1701.00
247_L251_L1.1601.00
67_K292_Y1.1591.00
250_G254_G1.1501.00
206_A209_W1.1481.00
244_V248_V1.1261.00
108_G112_S1.1241.00
290_G300_A1.1241.00
31_V35_L1.1081.00
224_S231_L1.1071.00
63_I287_Y1.1011.00
309_S312_I1.0991.00
221_V241_V1.0971.00
59_A287_Y1.0941.00
66_E287_Y1.0931.00
94_G100_A1.0921.00
326_L329_V1.0911.00
77_G142_L1.0891.00
84_F145_A1.0821.00
46_E50_R1.0821.00
119_F133_A1.0811.00
113_V254_G1.0771.00
213_N222_E1.0751.00
308_E331_P1.0731.00
108_G258_A1.0731.00
199_Y203_G1.0661.00
106_A110_L1.0641.00
204_A252_L1.0641.00
241_V244_V1.0621.00
127_E228_P1.0601.00
205_V252_L1.0591.00
248_V252_L1.0361.00
170_P173_H1.0351.00
48_A305_S1.0321.00
77_G141_A1.0321.00
29_G33_G1.0271.00
257_G261_S1.0211.00
114_L117_G1.0211.00
217_F241_V1.0171.00
89_V104_G1.0091.00
279_K282_I1.0071.00
295_L299_G1.0031.00
52_A301_A1.0021.00
33_G36_L1.0011.00
68_S221_V1.0011.00
192_L199_Y0.9961.00
203_G207_V0.9951.00
36_L40_S0.9921.00
60_L204_A0.9821.00
76_E280_G0.9811.00
54_P256_G0.9801.00
201_M205_V0.9761.00
209_W214_H0.9751.00
84_F149_S0.9731.00
99_A102_W0.9711.00
121_V126_Y0.9691.00
150_S154_G0.9691.00
148_A151_V0.9661.00
196_P199_Y0.9651.00
208_S248_V0.9571.00
147_F326_L0.9541.00
260_L264_H0.9521.00
89_V92_A0.9491.00
32_A36_L0.9491.00
30_S34_E0.9481.00
169_V173_H0.9471.00
188_G191_L0.9451.00
114_L118_L0.9411.00
142_L146_P0.9391.00
34_E37_G0.9391.00
109_V254_G0.9381.00
58_A256_G0.9371.00
78_L253_S0.9251.00
110_L114_L0.9241.00
72_N75_L0.9241.00
249_S253_S0.9181.00
83_S268_F0.9151.00
328_Q331_P0.9141.00
286_T301_A0.9101.00
310_L314_I0.9091.00
83_S261_S0.9071.00
152_V156_K0.9061.00
26_V29_G0.9041.00
239_H243_Y0.9031.00
219_R222_E0.9031.00
196_P200_L0.8991.00
76_E278_G0.8891.00
198_V202_F0.8851.00
138_W142_L0.8831.00
224_S245_S0.8781.00
64_F248_V0.8771.00
61_G75_L0.8741.00
59_A301_A0.8711.00
85_T88_L0.8701.00
58_A75_L0.8691.00
81_I85_T0.8651.00
82_S108_G0.8611.00
253_S257_G0.8581.00
117_G121_V0.8581.00
47_I51_L0.8571.00
86_A90_A0.8551.00
239_H242_R0.8541.00
187_V190_V0.8521.00
124_I243_Y0.8501.00
185_S189_H0.8481.00
286_T300_A0.8451.00
53_V198_V0.8441.00
202_F206_A0.8431.00
293_N297_T0.8431.00
87_V268_F0.8411.00
240_R243_Y0.8381.00
232_D238_V0.8361.00
99_A107_G0.8341.00
82_S112_S0.8331.00
87_V91_W0.8321.00
56_T205_V0.8311.00
120_A124_I0.8311.00
65_A72_N0.8291.00
130_Q246_V0.8281.00
304_F331_P0.8271.00
197_I259_A0.8271.00
103_T107_G0.8171.00
33_G40_S0.8131.00
238_V242_R0.8121.00
62_G75_L0.8101.00
251_L255_M0.8081.00
60_L297_T0.8081.00
64_F212_L0.8071.00
82_S257_G0.7961.00
61_G253_S0.7961.00
183_I187_V0.7961.00
68_S224_S0.7951.00
251_L254_G0.7951.00
191_L199_Y0.7891.00
43_I46_E0.7831.00
144_L148_A0.7831.00
27_F30_S0.7821.00
33_G37_G0.7821.00
210_Y213_N0.7811.00
51_L55_I0.7801.00
152_V155_G0.7771.00
94_G99_A0.7761.00
77_G138_W0.7731.00
122_V126_Y0.7691.00
78_L82_S0.7681.00
333_V337_V0.7681.00
86_A104_G0.7681.00
48_A306_G0.7671.00
83_S275_M0.7661.00
57_L201_M0.7631.00
174_D183_I0.7601.00
254_G258_A0.7601.00
169_V174_D0.7561.00
84_F270_G0.7531.00
151_V154_G0.7491.00
93_L100_A0.7461.00
67_K212_L0.7431.00
81_I141_A0.7411.00
123_C130_Q0.7371.00
208_S252_L0.7371.00
211_V214_H0.7361.00
309_S313_G0.7311.00
337_V341_L0.7271.00
228_P238_V0.7271.00
66_E284_I0.7271.00
123_C246_V0.7251.00
106_A109_V0.7251.00
78_L141_A0.7201.00
142_L280_G0.7201.00
118_L122_V0.7191.00
205_V209_W0.7191.00
82_S111_A0.7181.00
184_L187_V0.7181.00
57_L204_A0.7161.00
79_L256_G0.7131.00
297_T301_A0.7121.00
140_V144_L0.7111.00
212_L221_V0.7101.00
100_A104_G0.7101.00
116_A247_L0.7081.00
79_L279_K0.7081.00
58_A61_G0.7031.00
112_S116_A0.7021.00
70_V228_P0.7011.00
27_F31_V0.6981.00
220_W237_N0.6921.00
32_A37_G0.6911.00
122_V128_A0.6911.00
79_L276_I0.6901.00
52_A56_T0.6891.00
78_L112_S0.6861.00
224_S242_R0.6851.00
85_T107_G0.6831.00
109_V113_V0.6811.00
64_F211_V0.6811.00
151_V155_G0.6721.00
209_W295_L0.6711.00
278_G282_I0.6701.00
55_I286_T0.6701.00
90_A262_V0.6681.00
42_P45_A0.6681.00
60_L205_V0.6661.00
242_R245_S0.6661.00
301_A305_S0.6651.00
208_S212_L0.6631.00
207_V210_Y0.6601.00
324_S327_I0.6571.00
50_R263_G0.6551.00
217_F248_V0.6531.00
24_G28_P0.6521.00
331_P339_L0.6511.00
302_M306_G0.6511.00
127_E239_H0.6511.00
123_C133_A0.6511.00
63_I294_P0.6471.00
227_N230_A0.6451.00
54_P263_G0.6441.00
119_F134_G0.6391.00
81_I111_A0.6351.00
63_I292_Y0.6341.00
55_I279_K0.6331.00
74_G119_F0.6311.00
55_I282_I0.6311.00
168_T172_L0.6301.00
149_S152_V0.6271.00
168_T171_V0.6271.00
138_W280_G0.6231.00
200_L204_A0.6231.00
153_F156_K0.6201.00
75_L249_S0.6201.00
105_F109_V0.6181.00
68_S242_R0.6161.00
26_V30_S0.6151.00
139_L143_G0.6141.00
81_I112_S0.6111.00
287_Y297_T0.6091.00
113_V116_A0.6091.00
31_V37_G0.6081.00
65_A246_V0.6071.00
285_A335_V0.6041.00
101_L262_V0.6031.00
49_L53_V0.6011.00
189_H192_L0.6011.00
63_I67_K0.5991.00
211_V244_V0.5991.00
311_Q322_V0.5981.00
32_A35_L0.5981.00
47_I309_S0.5981.00
325_Q328_Q0.5971.00
247_L250_G0.5961.00
238_V241_V0.5961.00
248_V251_L0.5911.00
311_Q330_I0.5901.00
86_A89_V0.5891.00
195_N198_V0.5891.00
89_V100_A0.5861.00
29_G32_A0.5851.00
135_L138_W0.5841.00
286_T297_T0.5821.00
230_A234_A0.5821.00
187_V191_L0.5801.00
209_W293_N0.5781.00
223_A230_A0.5731.00
335_V339_L0.5721.00
183_I188_G0.5721.00
55_I301_A0.5681.00
61_G65_A0.5661.00
277_D280_G0.5651.00
184_L188_G0.5641.00
109_V112_S0.5641.00
250_G253_S0.5631.00
222_E292_Y0.5631.00
308_E327_I0.5621.00
124_I134_G0.5601.00
49_L52_A0.5581.00
89_V99_A0.5571.00
43_I47_I0.5541.00
57_L255_M0.5531.00
42_P46_E0.5491.00
173_H183_I0.5481.00
48_A309_S0.5481.00
73_I284_I0.5481.00
44_M313_G0.5481.00
194_A199_Y0.5481.00
168_T173_H0.5461.00
222_E225_G0.5461.00
183_I190_V0.5461.00
339_L342_V0.5451.00
147_F151_V0.5451.00
86_A257_G0.5421.00
260_L279_K0.5421.00
168_T174_D0.5411.00
305_S309_S0.5411.00
37_G40_S0.5381.00
29_G306_G0.5371.00
137_V140_V0.5311.00
185_S191_L0.5311.00
203_G206_A0.5261.00
281_F285_A0.5251.00
34_E38_I0.5231.00
150_S153_F0.5221.00
89_V94_G0.5201.00
56_T60_L0.5201.00
53_V57_L0.5191.00
53_V201_M0.5181.00
31_V34_E0.5171.00
184_L191_L0.5171.00
200_L255_M0.5161.00
78_L116_A0.5131.00
88_L91_W0.5131.00
331_P335_V0.5121.00
60_L209_W0.5121.00
200_L203_G0.5101.00
60_L206_A0.5101.00
47_I50_R0.5051.00
65_A70_V0.5051.00
211_V215_T0.5041.00
35_L38_I0.5041.00
289_F300_A0.5041.00
283_A287_Y0.5041.00
150_S155_G0.5031.00
289_F338_V0.5021.00
61_G249_S0.5021.00
121_V124_I0.5021.00
125_K240_R0.5011.00
229_N233_T0.5011.00
69_G242_R0.5001.00
185_S190_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.7867 96.5 0.895 Contact Map
4g1uA 2 0.7535 96 0.9 Contact Map
2qi9A 2 0.8116 95.9 0.9 Contact Map
2gfpA 2 0.5319 34.2 0.949 Contact Map
2m20A 2 0.1219 15.6 0.957 Contact Map
1u7gA 3 0.5346 14.4 0.957 Contact Map
4m64A 1 0.5679 11.5 0.959 Contact Map
3k3fA 3 0.8283 9.3 0.961 Contact Map
2rddB 1 0.0942 8.4 0.962 Contact Map
4pypA 1 0.5734 7.7 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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