GREMLIN Database
Q9HR22 - Ribose ABC transporter permease
UniProt: Q9HR22 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 407 (310)
Sequences: 9861 (6698)
Seq/√Len: 380.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_V255_A4.1951.00
171_A305_A4.1561.00
140_A173_A3.3711.00
175_G301_G3.1371.00
175_G305_A3.0911.00
187_Y293_K3.0441.00
174_G304_G2.9721.00
282_P296_M2.8171.00
174_G308_G2.7631.00
118_A347_V2.7451.00
275_L299_S2.6521.00
144_A169_A2.6521.00
179_A301_G2.6091.00
181_P199_L2.5631.00
265_L271_F2.5311.00
259_V348_G2.5111.00
271_F298_T2.5081.00
112_F313_M2.4961.00
177_W203_A2.4891.00
85_Q360_G2.3211.00
115_L262_V2.2741.00
283_E286_A2.1931.00
294_R298_T2.1481.00
107_T355_G2.1451.00
231_A234_I2.1421.00
253_L257_A2.1331.00
115_L258_L2.1011.00
291_K294_R2.0901.00
263_A267_A2.0871.00
261_G265_L2.0081.00
92_T95_P1.9721.00
84_E88_F1.8931.00
119_V262_V1.8831.00
122_R276_R1.8821.00
107_T352_L1.8721.00
179_A297_V1.8581.00
125_M300_M1.8521.00
199_L203_A1.8231.00
192_E300_M1.7991.00
121_F337_S1.7951.00
183_A187_Y1.7931.00
260_V264_Y1.7871.00
332_D379_R1.7721.00
278_S295_T1.7621.00
78_G81_G1.7531.00
113_T333_G1.7431.00
125_M192_E1.7321.00
332_D358_K1.7241.00
114_G347_V1.7201.00
141_A170_G1.6991.00
198_M384_L1.6891.00
181_P196_T1.6791.00
186_A293_K1.6511.00
99_R359_S1.6251.00
111_V351_A1.6031.00
274_D295_T1.5991.00
144_A148_A1.5931.00
271_F275_L1.5651.00
167_I312_A1.5621.00
112_F310_S1.5561.00
125_M296_M1.5431.00
270_S274_D1.5371.00
340_A346_G1.5271.00
116_A306_L1.5201.00
226_A229_P1.5171.00
182_G297_V1.5141.00
123_A299_S1.5091.00
230_A233_R1.4911.00
256_V260_V1.4801.00
79_A82_H1.4511.00
290_V295_T1.4211.00
233_R236_N1.4151.00
172_L175_G1.4121.00
264_Y268_R1.3991.00
176_V179_A1.3981.00
74_E81_G1.3911.00
133_Q177_W1.3851.00
226_A231_A1.3831.00
118_A342_N1.3811.00
257_A261_G1.3641.00
139_L207_A1.3501.00
278_S292_E1.3431.00
120_S303_S1.3391.00
113_T134_L1.3361.00
258_L306_L1.3361.00
342_N347_V1.3271.00
282_P286_A1.3161.00
171_A309_I1.3141.00
176_V180_I1.3101.00
286_A293_K1.3071.00
112_F258_L1.2921.00
131_Q328_Q1.2891.00
136_L177_W1.2871.00
111_V348_G1.2801.00
345_L349_F1.2781.00
144_A166_G1.2771.00
304_G308_G1.2771.00
91_G94_T1.2731.00
164_P168_V1.2481.00
298_T301_G1.2471.00
117_V333_G1.2361.00
83_P86_V1.2271.00
199_L202_V1.2231.00
170_G312_A1.2181.00
183_A297_V1.2181.00
143_L210_A1.2171.00
179_A183_A1.2091.00
275_L295_T1.1991.00
153_P165_V1.1991.00
132_G200_N1.1931.00
136_L203_A1.1901.00
89_G92_T1.1891.00
277_T285_A1.1831.00
185_K192_E1.1771.00
374_L377_V1.1721.00
111_V259_V1.1721.00
321_R325_N1.1671.00
119_V299_S1.1561.00
274_D290_V1.1541.00
74_E78_G1.1371.00
226_A230_A1.1321.00
251_G313_M1.1271.00
250_L253_L1.1251.00
185_K300_M1.1231.00
187_Y297_V1.1231.00
204_A330_G1.1191.00
74_E77_L1.1191.00
153_P164_P1.0981.00
166_G316_L1.0941.00
115_L259_V1.0901.00
182_G186_A1.0811.00
145_T166_G1.0781.00
301_G305_A1.0771.00
87_L90_T1.0771.00
209_V374_L1.0721.00
189_D293_K1.0701.00
68_P72_Y1.0621.00
102_S247_F1.0581.00
190_A195_T1.0531.00
322_W325_N1.0511.00
143_L147_Y1.0501.00
119_V266_L1.0471.00
340_A350_A1.0411.00
358_K379_R1.0411.00
184_L190_A1.0361.00
124_G282_P1.0301.00
123_A275_L1.0251.00
152_V165_V1.0241.00
311_G315_V1.0111.00
168_V172_L1.0111.00
258_L309_I1.0081.00
184_L195_T1.0071.00
153_P163_V1.0051.00
339_L350_A0.9951.00
137_G311_G0.9931.00
335_T383_I0.9841.00
180_I199_L0.9811.00
70_A74_E0.9791.00
119_V302_I0.9761.00
138_A315_V0.9761.00
114_G336_V0.9751.00
228_I231_A0.9741.00
267_A276_R0.9721.00
189_D282_P0.9651.00
321_R326_L0.9611.00
152_V169_A0.9521.00
139_L211_V0.9501.00
90_T94_T0.9491.00
103_L356_V0.9481.00
214_W217_P0.9481.00
132_G204_A0.9471.00
82_H86_V0.9471.00
216_T220_S0.9461.00
112_F255_A0.9451.00
297_V301_G0.9381.00
381_L385_F0.9371.00
263_A268_R0.9351.00
260_V263_A0.9341.00
107_T351_A0.9341.00
63_P66_Y0.9321.00
68_P71_V0.9291.00
361_S370_V0.9271.00
89_G93_W0.9251.00
113_T130_V0.9171.00
133_Q307_G0.9121.00
186_A297_V0.9121.00
278_S299_S0.9121.00
178_G304_G0.9111.00
183_A188_A0.9111.00
135_L207_A0.9061.00
142_A321_R0.9061.00
133_Q203_A0.9051.00
72_Y75_L0.9031.00
262_V306_L0.9001.00
314_L329_L0.8991.00
129_G181_P0.8981.00
232_A235_P0.8911.00
229_P232_A0.8911.00
226_A234_I0.8871.00
63_P67_D0.8861.00
244_R247_F0.8841.00
140_A169_A0.8831.00
175_G308_G0.8791.00
303_S307_G0.8791.00
172_L176_V0.8791.00
123_A300_M0.8791.00
360_G364_I0.8761.00
254_F309_I0.8761.00
100_V104_L0.8651.00
298_T302_I0.8611.00
296_M299_S0.8611.00
193_V197_I0.8601.00
144_A147_Y0.8591.00
217_P220_S0.8581.00
224_Q227_T0.8571.00
254_F313_M0.8561.00
75_L78_G0.8541.00
271_F295_T0.8541.00
141_A312_A0.8531.00
255_A259_V0.8511.00
181_P195_T0.8501.00
305_A308_G0.8461.00
314_L318_V0.8461.00
308_G312_A0.8391.00
65_C69_F0.8371.00
136_L206_L0.8361.00
118_A337_S0.8351.00
305_A309_I0.8341.00
262_V302_I0.8341.00
72_Y76_F0.8321.00
89_G94_T0.8311.00
114_G351_A0.8251.00
116_A120_S0.8221.00
64_S68_P0.8211.00
171_A308_G0.8201.00
71_V74_E0.8201.00
102_S359_S0.8201.00
252_L256_V0.8191.00
265_L298_T0.8171.00
359_S363_A0.8171.00
282_P292_E0.8151.00
130_V303_S0.8141.00
336_V350_A0.8121.00
238_P244_R0.8111.00
228_I234_I0.8111.00
67_D70_A0.8101.00
116_A130_V0.8061.00
229_P234_I0.8061.00
231_A235_P0.8031.00
95_P98_F0.8031.00
215_F218_A0.8011.00
80_I83_P0.7961.00
117_V130_V0.7961.00
234_I237_V0.7951.00
140_A144_A0.7941.00
278_S285_A0.7941.00
188_A388_M0.7921.00
62_T66_Y0.7901.00
98_F101_A0.7901.00
126_F191_N0.7831.00
307_G311_G0.7831.00
119_V265_L0.7821.00
134_L310_S0.7801.00
232_A236_N0.7801.00
227_T230_A0.7791.00
70_A79_A0.7751.00
322_W326_L0.7721.00
337_S347_V0.7681.00
70_A73_S0.7621.00
131_Q330_G0.7611.00
225_T229_P0.7601.00
107_T111_V0.7601.00
293_K296_M0.7591.00
133_Q137_G0.7571.00
295_T298_T0.7571.00
128_I331_F0.7551.00
79_A83_P0.7551.00
75_L79_A0.7541.00
80_I84_E0.7531.00
136_L140_A0.7491.00
274_D285_A0.7441.00
78_G82_H0.7421.00
213_T216_T0.7381.00
70_A81_G0.7371.00
76_F80_I0.7361.00
346_G350_A0.7261.00
76_F79_A0.7261.00
135_L204_A0.7241.00
134_L314_L0.7241.00
88_F364_I0.7181.00
228_I233_R0.7181.00
117_V120_S0.7171.00
101_A246_N0.7141.00
337_S342_N0.7131.00
392_F396_G0.7101.00
137_G173_A0.7081.00
67_D71_V0.7041.00
361_S378_L0.7031.00
292_E296_M0.7020.99
121_F126_F0.7020.99
114_G337_S0.7020.99
122_R266_L0.7000.99
320_G323_L0.6950.99
277_T284_A0.6920.99
212_S215_F0.6920.99
109_L310_S0.6910.99
128_I334_I0.6860.99
271_F302_I0.6860.99
103_L355_G0.6830.99
113_T116_A0.6810.99
343_N346_G0.6740.99
171_A312_A0.6720.99
136_L173_A0.6710.99
184_L188_A0.6690.99
117_V303_S0.6690.99
124_G296_M0.6640.99
135_L326_L0.6620.99
212_S216_T0.6580.99
141_A145_T0.6570.99
346_G349_F0.6550.99
137_G170_G0.6540.99
139_L210_A0.6530.99
319_Q322_W0.6530.99
128_I193_V0.6490.99
86_V93_W0.6450.99
121_F342_N0.6440.99
69_F72_Y0.6430.99
230_A234_I0.6420.99
301_G304_G0.6400.99
166_G170_G0.6390.99
169_A173_A0.6360.99
71_V75_L0.6360.99
130_V307_G0.6350.99
77_L80_I0.6330.99
338_I341_G0.6310.99
293_K297_V0.6300.99
340_A348_G0.6300.99
167_I171_A0.6270.99
78_G83_P0.6260.99
165_V168_V0.6260.99
211_V215_F0.6230.99
123_A296_M0.6200.99
376_D379_R0.6190.99
148_A152_V0.6170.99
227_T232_A0.6160.99
183_A186_A0.6160.99
224_Q229_P0.6150.99
233_R320_G0.6150.99
90_T95_P0.6120.99
200_N330_G0.6110.99
137_G307_G0.6080.99
265_L302_I0.6080.99
354_F379_R0.6080.99
140_A143_L0.6060.99
361_S375_V0.6050.99
224_Q230_A0.6040.98
120_S299_S0.6040.98
70_A77_L0.6040.98
131_Q326_L0.6020.98
108_T252_L0.6000.98
232_A237_V0.5990.98
134_L329_L0.5990.98
273_Y276_R0.5980.98
78_G86_V0.5980.98
108_T255_A0.5980.98
229_P233_R0.5900.98
103_L359_S0.5900.98
164_P167_I0.5900.98
148_A153_P0.5880.98
119_V271_F0.5870.98
62_T65_C0.5870.98
211_V214_W0.5870.98
336_V351_A0.5860.98
82_H356_V0.5860.98
331_F335_T0.5820.98
230_A236_N0.5810.98
142_A146_V0.5800.98
74_E82_H0.5790.98
250_L254_F0.5770.98
231_A236_N0.5760.98
227_T231_A0.5760.98
200_N204_A0.5760.98
117_V334_I0.5760.98
330_G334_I0.5740.98
75_L82_H0.5720.98
66_Y70_A0.5700.98
170_G308_G0.5680.98
64_S67_D0.5670.98
127_N303_S0.5670.98
229_P235_P0.5670.98
134_L326_L0.5650.98
204_A208_Y0.5650.98
351_A355_G0.5630.98
99_R363_A0.5610.98
285_A290_V0.5610.98
292_E295_T0.5600.98
388_M392_F0.5590.98
127_N130_V0.5580.97
133_Q304_G0.5580.97
227_T233_R0.5570.97
286_A292_E0.5570.97
373_A376_D0.5560.97
91_G95_P0.5550.97
336_V347_V0.5550.97
226_A236_N0.5550.97
393_R396_G0.5540.97
86_V90_T0.5540.97
178_G181_P0.5520.97
68_P75_L0.5520.97
327_P330_G0.5520.97
338_I353_L0.5520.97
124_G338_I0.5500.97
120_S125_M0.5500.97
319_Q325_N0.5490.97
90_T93_W0.5490.97
77_L85_Q0.5480.97
88_F92_T0.5470.97
206_L209_V0.5450.97
73_S78_G0.5440.97
110_L336_V0.5430.97
104_L107_T0.5420.97
254_F258_L0.5420.97
120_S127_N0.5410.97
226_A232_A0.5400.97
137_G174_G0.5390.97
224_Q228_I0.5390.97
302_I306_L0.5340.97
200_N331_F0.5340.97
391_F395_L0.5340.97
229_P236_N0.5340.97
116_A303_S0.5330.97
171_A175_G0.5330.97
104_L108_T0.5320.97
291_K295_T0.5320.97
144_A149_A0.5310.97
377_V381_L0.5300.97
281_Q284_A0.5300.97
180_I184_L0.5300.97
77_L81_G0.5280.97
101_A252_L0.5270.96
123_A338_I0.5260.96
87_L92_T0.5240.96
238_P245_D0.5190.96
246_N253_L0.5190.96
106_S362_A0.5180.96
149_A153_P0.5180.96
102_S105_R0.5170.96
83_P87_L0.5160.96
226_A233_R0.5160.96
116_A333_G0.5140.96
192_E296_M0.5130.96
70_A82_H0.5120.96
249_L252_L0.5120.96
87_L93_W0.5100.96
379_R382_I0.5090.96
64_S72_Y0.5060.96
81_G84_E0.5050.96
115_L347_V0.5050.96
379_R383_I0.5040.95
259_V344_P0.5040.95
390_E394_L0.5030.95
278_S290_V0.5030.95
117_V337_S0.5020.95
266_L275_L0.5010.95
79_A86_V0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g1uA 2 0.6732 96.3 0.916 Contact Map
2nq2A 2 0.7396 95 0.923 Contact Map
2qi9A 2 0.7273 93.7 0.928 Contact Map
4ezcA 3 0.7322 39 0.957 Contact Map
2gfpA 2 0.4619 37.7 0.957 Contact Map
2onkC 2 0.5921 36.8 0.957 Contact Map
2m20A 2 0.0958 26.4 0.96 Contact Map
2kluA 1 0.113 24.5 0.961 Contact Map
3d31C 2 0.5848 21.2 0.962 Contact Map
2l2tA 2 0.1081 20 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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