GREMLIN Database
Q9HR20 - Uncharacterized protein
UniProt: Q9HR20 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 349 (316)
Sequences: 3724 (2802)
Seq/√Len: 157.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
337_E342_D4.7061.00
144_Y196_D3.7621.00
325_Q329_D3.4441.00
336_T340_A3.4151.00
99_C108_L3.4001.00
289_N293_N3.3911.00
194_V201_I3.3481.00
333_K337_E3.0551.00
170_A198_S3.0071.00
82_A110_T2.7341.00
225_F252_R2.6821.00
335_R339_I2.6801.00
208_V239_T2.6781.00
148_E334_S2.6621.00
171_T202_D2.6551.00
152_L330_A2.6341.00
172_V194_V2.6181.00
86_Q114_D2.5841.00
65_E285_Y2.5091.00
53_D57_Q2.4901.00
171_T204_L2.4761.00
192_A346_P2.4531.00
154_T170_A2.4161.00
47_G53_D2.2661.00
61_R285_Y2.2421.00
89_A120_W2.2071.00
330_A333_K2.1751.00
305_G308_D2.1441.00
154_T230_D2.1271.00
324_P327_V2.1231.00
179_E184_K2.1041.00
332_S335_R1.9931.00
60_E63_K1.9681.00
328_K332_S1.9651.00
146_V313_A1.9221.00
332_S336_T1.9141.00
153_L324_P1.9041.00
148_E197_V1.9011.00
86_Q115_F1.8941.00
329_D333_K1.8861.00
175_V243_V1.8721.00
286_N290_A1.8601.00
171_T229_A1.8551.00
226_N250_I1.8301.00
142_G276_M1.8251.00
89_A115_F1.8151.00
56_K60_E1.7671.00
312_V335_R1.7511.00
148_E196_D1.7481.00
191_T195_N1.7211.00
149_L331_V1.7101.00
325_Q328_K1.6961.00
60_E64_K1.6801.00
196_D334_S1.6701.00
61_R65_E1.6691.00
139_E185_K1.6671.00
217_G239_T1.6441.00
137_F283_A1.6361.00
336_T339_I1.6201.00
38_G88_Y1.6171.00
210_S213_D1.6041.00
337_E343_I1.5941.00
153_L327_V1.5881.00
97_V118_Q1.5801.00
62_A288_I1.5511.00
46_L72_E1.5501.00
187_E191_T1.5481.00
146_V255_I1.5391.00
138_R305_G1.5161.00
18_G21_L1.5151.00
204_L229_A1.5091.00
218_Q249_D1.4651.00
214_P239_T1.4571.00
73_S88_Y1.4541.00
290_A295_N1.4501.00
218_Q222_R1.4321.00
306_L339_I1.4231.00
151_G154_T1.4051.00
221_A232_I1.3951.00
66_L289_N1.3731.00
38_G94_F1.3711.00
330_A334_S1.3701.00
256_G261_Q1.3631.00
225_F247_A1.3591.00
309_D312_V1.3531.00
151_G201_I1.3481.00
35_T291_V1.3391.00
222_R250_I1.3331.00
85_Q99_C1.3251.00
329_D332_S1.3221.00
62_A66_L1.3161.00
66_L285_Y1.3131.00
222_R226_N1.3111.00
71_E94_F1.2881.00
141_A307_E1.2771.00
138_R141_A1.2571.00
218_Q245_R1.2401.00
127_V134_S1.2351.00
36_K94_F1.2221.00
105_K125_E1.2191.00
145_L335_R1.2171.00
279_R282_T1.2101.00
55_A284_V1.2071.00
337_E340_A1.2001.00
80_E83_T1.1821.00
173_G229_A1.1811.00
86_Q90_Q1.1801.00
142_G311_V1.1741.00
334_S337_E1.1721.00
17_V20_S1.1721.00
90_Q115_F1.1691.00
61_R281_D1.1661.00
65_E289_N1.1611.00
208_V220_Q1.1561.00
63_K69_T1.1491.00
144_Y334_S1.1481.00
21_L24_G1.1471.00
57_Q60_E1.1401.00
34_T69_T1.1321.00
169_A230_D1.1311.00
96_L288_I1.1311.00
146_V276_M1.1281.00
109_A113_A1.1211.00
176_G183_I1.1141.00
145_L331_V1.1121.00
244_F272_V1.1111.00
154_T169_A1.1071.00
152_L327_V1.1061.00
149_L274_A1.1051.00
151_G197_V1.0980.99
154_T231_I1.0850.99
25_C28_G1.0720.99
251_G271_V1.0710.99
36_K69_T1.0700.99
35_T292_A1.0700.99
86_Q111_N1.0660.99
171_T228_G1.0630.99
154_T194_V1.0570.99
133_A296_F1.0540.99
285_Y289_N1.0520.99
44_G52_N1.0520.99
204_L227_S1.0520.99
149_L323_I1.0410.99
222_R246_A1.0360.99
248_Q270_D1.0350.99
279_R312_V1.0310.99
82_A111_N1.0170.99
82_A86_Q1.0160.99
243_V254_A1.0160.99
219_S222_R1.0140.99
59_L70_Y1.0100.99
173_G224_M1.0030.99
274_A314_V1.0000.99
246_A249_D0.9990.99
286_N289_N0.9970.99
100_V123_V0.9890.99
37_V96_L0.9860.99
253_F273_L0.9860.99
208_V217_G0.9820.99
320_G328_K0.9800.99
254_A271_V0.9780.99
41_Y72_E0.9750.99
225_F232_I0.9740.99
274_A315_Y0.9700.99
92_G118_Q0.9660.99
88_Y94_F0.9630.99
244_F254_A0.9630.99
206_S224_M0.9580.99
56_K72_E0.9580.99
213_D216_A0.9570.99
138_R303_R0.9520.99
246_A250_I0.9500.99
85_Q111_N0.9470.98
253_F322_E0.9450.98
46_L56_K0.9430.98
122_L125_E0.9420.98
75_P84_D0.9400.98
105_K109_A0.9370.98
133_A302_T0.9260.98
282_T286_N0.9240.98
231_I255_I0.9220.98
58_G281_D0.9190.98
336_T342_D0.9170.98
109_A132_V0.9130.98
194_V203_V0.9130.98
85_Q108_L0.9100.98
198_S201_I0.9070.98
18_G22_V0.9020.98
277_V312_V0.9010.98
128_D134_S0.9000.98
95_D118_Q0.8990.98
148_E330_A0.8990.98
86_Q89_A0.8960.98
98_N121_A0.8940.98
244_F271_V0.8890.98
89_A118_Q0.8850.98
216_A219_S0.8800.98
191_T203_V0.8740.97
63_K70_Y0.8730.97
143_S186_F0.8710.97
148_E152_L0.8690.97
109_A129_Q0.8640.97
16_T19_A0.8620.97
256_G275_S0.8610.97
77_N80_E0.8600.97
233_Y276_M0.8500.97
121_A135_Y0.8480.97
319_L322_E0.8460.97
334_S343_I0.8420.97
191_T205_S0.8420.97
138_R308_D0.8410.97
333_K336_T0.8380.97
96_L291_V0.8370.97
304_L308_D0.8360.97
119_R296_F0.8270.96
225_F250_I0.8270.96
96_L121_A0.8270.96
326_S329_D0.8210.96
15_G21_L0.8170.96
143_S276_M0.8170.96
85_Q104_Q0.8170.96
37_V288_I0.8160.96
39_T55_A0.8150.96
153_L273_L0.8150.96
224_M229_A0.8080.96
289_N292_A0.8070.96
201_I205_S0.8060.96
290_A293_N0.8050.96
170_A230_D0.8010.96
59_L63_K0.8000.96
262_S314_V0.7980.96
150_A255_I0.7970.96
106_D109_A0.7960.96
89_A111_N0.7950.96
206_S220_Q0.7920.95
309_D339_I0.7860.95
108_L132_V0.7860.95
154_T201_I0.7860.95
254_A272_V0.7850.95
39_T59_L0.7820.95
14_G17_V0.7800.95
151_G198_S0.7780.95
119_R291_V0.7750.95
153_L231_I0.7750.95
41_Y46_L0.7710.95
277_V314_V0.7710.95
186_F235_A0.7700.95
14_G20_S0.7650.95
61_R282_T0.7620.94
41_Y56_K0.7510.94
221_A225_F0.7490.94
258_D278_K0.7460.94
247_A254_A0.7460.94
155_Q169_A0.7450.94
46_L53_D0.7430.94
35_T95_D0.7420.94
170_A200_D0.7400.94
15_G19_A0.7380.93
19_A22_V0.7370.93
105_K127_V0.7360.93
123_V280_V0.7340.93
151_G170_A0.7310.93
62_A70_Y0.7280.93
333_K342_D0.7270.93
137_F278_K0.7270.93
169_A228_G0.7260.93
124_D278_K0.7250.93
56_K70_Y0.7220.93
57_Q259_R0.7200.93
44_G48_D0.7180.92
174_F235_A0.7170.92
62_A68_I0.7100.92
174_F187_E0.7090.92
177_G237_A0.7090.92
14_G18_G0.7070.92
144_Y193_G0.7060.92
192_A195_N0.7050.92
326_S330_A0.7050.92
245_R248_Q0.7040.92
33_D95_D0.7040.92
144_Y148_E0.7040.92
10_L14_G0.7030.92
193_G196_D0.7030.92
133_A287_A0.7020.92
55_A280_V0.7000.92
141_A305_G0.6990.91
149_L153_L0.6980.91
255_I274_A0.6950.91
148_E194_V0.6940.91
149_L255_I0.6930.91
186_F257_V0.6930.91
61_R64_K0.6910.91
49_G264_T0.6900.91
85_Q89_A0.6890.91
152_L197_V0.6890.91
36_K95_D0.6850.91
10_L17_V0.6820.90
257_V278_K0.6800.90
113_A129_Q0.6780.90
182_L185_K0.6780.90
216_A220_Q0.6770.90
187_E205_S0.6760.90
62_A285_Y0.6760.90
219_S223_S0.6740.90
54_Q281_D0.6740.90
87_Q91_D0.6730.90
235_A257_V0.6730.90
43_T212_N0.6700.90
171_T227_S0.6700.90
140_E185_K0.6690.90
215_S218_Q0.6690.90
139_E276_M0.6690.90
196_D199_E0.6670.89
231_I273_L0.6640.89
187_E207_Y0.6630.89
234_H243_V0.6620.89
320_G323_I0.6620.89
306_L338_L0.6610.89
129_Q132_V0.6590.89
135_Y287_A0.6590.89
313_A331_V0.6580.89
248_Q271_V0.6570.89
139_E278_K0.6520.88
175_V221_A0.6520.88
73_S84_D0.6510.88
135_Y304_L0.6510.88
98_N288_I0.6490.88
195_N199_E0.6460.88
58_G62_A0.6450.88
201_I206_S0.6440.88
186_F258_D0.6440.88
145_L306_L0.6420.88
323_I327_V0.6420.88
260_D315_Y0.6410.88
21_L25_C0.6410.88
247_A252_R0.6410.88
91_D94_F0.6400.87
143_S235_A0.6400.87
48_D53_D0.6400.87
140_E345_V0.6390.87
55_A100_V0.6360.87
236_S242_G0.6360.87
66_L292_A0.6360.87
9_F20_S0.6310.87
78_N103_A0.6270.86
22_V25_C0.6270.86
155_Q200_D0.6260.86
179_E209_G0.6250.86
143_S233_Y0.6250.86
297_A300_E0.6220.86
117_D130_D0.6220.86
272_V275_S0.6200.86
133_A297_A0.6190.86
319_L323_I0.6190.86
134_S300_E0.6170.85
291_V296_F0.6150.85
56_K59_L0.6150.85
121_A287_A0.6150.85
90_Q114_D0.6140.85
323_I328_K0.6140.85
176_G187_E0.6130.85
287_A290_A0.6130.85
11_K18_G0.6100.85
270_D321_A0.6100.85
17_V21_L0.6090.85
82_A107_A0.6080.85
110_T114_D0.6080.85
95_D117_D0.6070.85
148_E331_V0.6060.84
105_K122_L0.6050.84
94_F118_Q0.6040.84
122_L127_V0.6040.84
22_V26_S0.6020.84
71_E88_Y0.6020.84
126_T136_R0.6020.84
64_K117_D0.6010.84
153_L253_F0.6010.84
225_F246_A0.6000.84
309_D335_R0.5990.84
146_V274_A0.5990.84
71_E91_D0.5980.84
178_I211_F0.5970.84
43_T103_A0.5960.83
176_G207_Y0.5950.83
220_Q224_M0.5950.83
63_K68_I0.5920.83
184_K207_Y0.5900.83
111_N114_D0.5900.83
240_G257_V0.5890.83
282_T285_Y0.5890.83
236_S240_G0.5890.83
217_G240_G0.5890.83
286_N308_D0.5880.83
290_A302_T0.5840.82
40_V84_D0.5840.82
126_T134_S0.5840.82
338_L343_I0.5830.82
48_D52_N0.5810.82
222_R249_D0.5800.82
15_G18_G0.5790.82
218_Q246_A0.5770.81
242_G246_A0.5720.81
329_D336_T0.5710.81
20_S23_A0.5710.81
149_L152_L0.5680.80
51_F124_D0.5670.80
204_L224_M0.5670.80
319_L328_K0.5670.80
192_A196_D0.5660.80
172_V190_F0.5650.80
153_L323_I0.5620.80
217_G242_G0.5620.80
92_G95_D0.5570.79
119_R133_A0.5570.79
13_A21_L0.5570.79
62_A292_A0.5540.79
143_S182_L0.5540.79
190_F233_Y0.5490.78
262_S270_D0.5490.78
13_A17_V0.5470.78
327_V331_V0.5460.78
319_L332_S0.5450.78
100_V135_Y0.5450.78
111_N120_W0.5440.78
68_I288_I0.5440.78
290_A297_A0.5440.78
265_K271_V0.5410.77
80_E84_D0.5410.77
149_L327_V0.5400.77
54_Q57_Q0.5390.77
145_L313_A0.5380.77
81_F104_Q0.5380.77
133_A290_A0.5360.77
196_D337_E0.5360.77
194_V197_V0.5350.76
244_F265_K0.5350.76
236_S239_T0.5340.76
136_R185_K0.5340.76
338_L345_V0.5300.76
136_R303_R0.5290.76
152_L326_S0.5290.76
175_V234_H0.5290.76
306_L335_R0.5290.76
190_F193_G0.5280.75
260_D314_V0.5280.75
182_L233_Y0.5270.75
172_V201_I0.5260.75
261_Q264_T0.5250.75
15_G20_S0.5240.75
54_Q259_R0.5240.75
313_A335_R0.5230.75
115_F120_W0.5210.75
24_G27_S0.5180.74
57_Q281_D0.5170.74
11_K21_L0.5170.74
245_R249_D0.5160.74
11_K17_V0.5150.74
85_Q120_W0.5130.73
15_G23_A0.5120.73
283_A310_G0.5100.73
174_F183_I0.5100.73
282_T310_G0.5080.73
15_G22_V0.5080.73
212_N239_T0.5060.72
133_A298_G0.5060.72
10_L16_T0.5040.72
188_A192_A0.5030.72
221_A246_A0.5030.72
78_N107_A0.5030.72
99_C104_Q0.5020.72
232_I243_V0.5020.72
12_L15_G0.5010.72
13_A18_G0.5010.72
9_F23_A0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pevA 1 0.8797 100 0.411 Contact Map
3s99A 1 0.8338 100 0.428 Contact Map
4iilA 1 0.8711 100 0.431 Contact Map
4p98A 1 0.8367 100 0.44 Contact Map
2fqxA 1 0.8596 100 0.452 Contact Map
2hqbA 1 0.8052 100 0.492 Contact Map
4ycsA 1 0.3467 100 0.636 Contact Map
4wzzA 1 0.808 99.9 0.708 Contact Map
4yv7A 1 0.7822 99.8 0.752 Contact Map
4kzkA 1 0.7794 99.8 0.765 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0107 seconds.