Q9HR20 - HALSA - GREMLIN Contacts

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Q9HR20 - Uncharacterized protein

UniProt:	Q9HR20	Sequences: MADFDRREFLKLAGGTVGASLVAGCSSGGGGGDTTKVGTVYGTGGLGDGSFNDQAKQGLERAKKELDITYEESQPENNSEFATDQQQYAQDGSFDLVNCVGYAQKDALATNAADFPDQRWALVDETVDQDNVASYRFREEAGSYLVGELAGLLTQREFSAGSGATNPDAATVGFVGGIETPLIKKFEAGFTAGVNDVSEDIDVLSSYVGSFNDPSAGQSQARSMFNSGADIIYHASAATGDGVFRAAQDIGRFAIGVDRDQSVTKSDFADVVLASMVKRVDTAVYNAINAVANGNFAGGETTRLGLEDDGVVAVYGDQLGAEIPQSVKDAVSKSRTELIAGDIDVPTEP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	349 (316)
Sequences:	3724 (2802)
Seq/√Len:	157.6

BACSU - MED YUFN
HALSA - Q9HR20 Q9HRA0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
337_E	342_D	4.706	1.00
144_Y	196_D	3.762	1.00
325_Q	329_D	3.444	1.00
336_T	340_A	3.415	1.00
99_C	108_L	3.400	1.00
289_N	293_N	3.391	1.00
194_V	201_I	3.348	1.00
333_K	337_E	3.055	1.00
170_A	198_S	3.007	1.00
82_A	110_T	2.734	1.00
225_F	252_R	2.682	1.00
335_R	339_I	2.680	1.00
208_V	239_T	2.678	1.00
148_E	334_S	2.662	1.00
171_T	202_D	2.655	1.00
152_L	330_A	2.634	1.00
172_V	194_V	2.618	1.00
86_Q	114_D	2.584	1.00
65_E	285_Y	2.509	1.00
53_D	57_Q	2.490	1.00
171_T	204_L	2.476	1.00
192_A	346_P	2.453	1.00
154_T	170_A	2.416	1.00
47_G	53_D	2.266	1.00
61_R	285_Y	2.242	1.00
89_A	120_W	2.207	1.00
330_A	333_K	2.175	1.00
305_G	308_D	2.144	1.00
154_T	230_D	2.127	1.00
324_P	327_V	2.123	1.00
179_E	184_K	2.104	1.00
332_S	335_R	1.993	1.00
60_E	63_K	1.968	1.00
328_K	332_S	1.965	1.00
146_V	313_A	1.922	1.00
332_S	336_T	1.914	1.00
153_L	324_P	1.904	1.00
148_E	197_V	1.901	1.00
86_Q	115_F	1.894	1.00
329_D	333_K	1.886	1.00
175_V	243_V	1.872	1.00
286_N	290_A	1.860	1.00
171_T	229_A	1.855	1.00
226_N	250_I	1.830	1.00
142_G	276_M	1.825	1.00
89_A	115_F	1.815	1.00
56_K	60_E	1.767	1.00
312_V	335_R	1.751	1.00
148_E	196_D	1.748	1.00
191_T	195_N	1.721	1.00
149_L	331_V	1.710	1.00
325_Q	328_K	1.696	1.00
60_E	64_K	1.680	1.00
196_D	334_S	1.670	1.00
61_R	65_E	1.669	1.00
139_E	185_K	1.667	1.00
217_G	239_T	1.644	1.00
137_F	283_A	1.636	1.00
336_T	339_I	1.620	1.00
38_G	88_Y	1.617	1.00
210_S	213_D	1.604	1.00
337_E	343_I	1.594	1.00
153_L	327_V	1.588	1.00
97_V	118_Q	1.580	1.00
62_A	288_I	1.551	1.00
46_L	72_E	1.550	1.00
187_E	191_T	1.548	1.00
146_V	255_I	1.539	1.00
138_R	305_G	1.516	1.00
18_G	21_L	1.515	1.00
204_L	229_A	1.509	1.00
218_Q	249_D	1.465	1.00
214_P	239_T	1.457	1.00
73_S	88_Y	1.454	1.00
290_A	295_N	1.450	1.00
218_Q	222_R	1.432	1.00
306_L	339_I	1.423	1.00
151_G	154_T	1.405	1.00
221_A	232_I	1.395	1.00
66_L	289_N	1.373	1.00
38_G	94_F	1.371	1.00
330_A	334_S	1.370	1.00
256_G	261_Q	1.363	1.00
225_F	247_A	1.359	1.00
309_D	312_V	1.353	1.00
151_G	201_I	1.348	1.00
35_T	291_V	1.339	1.00
222_R	250_I	1.333	1.00
85_Q	99_C	1.325	1.00
329_D	332_S	1.322	1.00
62_A	66_L	1.316	1.00
66_L	285_Y	1.313	1.00
222_R	226_N	1.311	1.00
71_E	94_F	1.288	1.00
141_A	307_E	1.277	1.00
138_R	141_A	1.257	1.00
218_Q	245_R	1.240	1.00
127_V	134_S	1.235	1.00
36_K	94_F	1.222	1.00
105_K	125_E	1.219	1.00
145_L	335_R	1.217	1.00
279_R	282_T	1.210	1.00
55_A	284_V	1.207	1.00
337_E	340_A	1.200	1.00
80_E	83_T	1.182	1.00
173_G	229_A	1.181	1.00
86_Q	90_Q	1.180	1.00
142_G	311_V	1.174	1.00
334_S	337_E	1.172	1.00
17_V	20_S	1.172	1.00
90_Q	115_F	1.169	1.00
61_R	281_D	1.166	1.00
65_E	289_N	1.161	1.00
208_V	220_Q	1.156	1.00
63_K	69_T	1.149	1.00
144_Y	334_S	1.148	1.00
21_L	24_G	1.147	1.00
57_Q	60_E	1.140	1.00
34_T	69_T	1.132	1.00
169_A	230_D	1.131	1.00
96_L	288_I	1.131	1.00
146_V	276_M	1.128	1.00
109_A	113_A	1.121	1.00
176_G	183_I	1.114	1.00
145_L	331_V	1.112	1.00
244_F	272_V	1.111	1.00
154_T	169_A	1.107	1.00
152_L	327_V	1.106	1.00
149_L	274_A	1.105	1.00
151_G	197_V	1.098	0.99
154_T	231_I	1.085	0.99
25_C	28_G	1.072	0.99
251_G	271_V	1.071	0.99
36_K	69_T	1.070	0.99
35_T	292_A	1.070	0.99
86_Q	111_N	1.066	0.99
171_T	228_G	1.063	0.99
154_T	194_V	1.057	0.99
133_A	296_F	1.054	0.99
285_Y	289_N	1.052	0.99
44_G	52_N	1.052	0.99
204_L	227_S	1.052	0.99
149_L	323_I	1.041	0.99
222_R	246_A	1.036	0.99
248_Q	270_D	1.035	0.99
279_R	312_V	1.031	0.99
82_A	111_N	1.017	0.99
82_A	86_Q	1.016	0.99
243_V	254_A	1.016	0.99
219_S	222_R	1.014	0.99
59_L	70_Y	1.010	0.99
173_G	224_M	1.003	0.99
274_A	314_V	1.000	0.99
246_A	249_D	0.999	0.99
286_N	289_N	0.997	0.99
100_V	123_V	0.989	0.99
37_V	96_L	0.986	0.99
253_F	273_L	0.986	0.99
208_V	217_G	0.982	0.99
320_G	328_K	0.980	0.99
254_A	271_V	0.978	0.99
41_Y	72_E	0.975	0.99
225_F	232_I	0.974	0.99
274_A	315_Y	0.970	0.99
92_G	118_Q	0.966	0.99
88_Y	94_F	0.963	0.99
244_F	254_A	0.963	0.99
206_S	224_M	0.958	0.99
56_K	72_E	0.958	0.99
213_D	216_A	0.957	0.99
138_R	303_R	0.952	0.99
246_A	250_I	0.950	0.99
85_Q	111_N	0.947	0.98
253_F	322_E	0.945	0.98
46_L	56_K	0.943	0.98
122_L	125_E	0.942	0.98
75_P	84_D	0.940	0.98
105_K	109_A	0.937	0.98
133_A	302_T	0.926	0.98
282_T	286_N	0.924	0.98
231_I	255_I	0.922	0.98
58_G	281_D	0.919	0.98
336_T	342_D	0.917	0.98
109_A	132_V	0.913	0.98
194_V	203_V	0.913	0.98
85_Q	108_L	0.910	0.98
198_S	201_I	0.907	0.98
18_G	22_V	0.902	0.98
277_V	312_V	0.901	0.98
128_D	134_S	0.900	0.98
95_D	118_Q	0.899	0.98
148_E	330_A	0.899	0.98
86_Q	89_A	0.896	0.98
98_N	121_A	0.894	0.98
244_F	271_V	0.889	0.98
89_A	118_Q	0.885	0.98
216_A	219_S	0.880	0.98
191_T	203_V	0.874	0.97
63_K	70_Y	0.873	0.97
143_S	186_F	0.871	0.97
148_E	152_L	0.869	0.97
109_A	129_Q	0.864	0.97
16_T	19_A	0.862	0.97
256_G	275_S	0.861	0.97
77_N	80_E	0.860	0.97
233_Y	276_M	0.850	0.97
121_A	135_Y	0.848	0.97
319_L	322_E	0.846	0.97
334_S	343_I	0.842	0.97
191_T	205_S	0.842	0.97
138_R	308_D	0.841	0.97
333_K	336_T	0.838	0.97
96_L	291_V	0.837	0.97
304_L	308_D	0.836	0.97
119_R	296_F	0.827	0.96
225_F	250_I	0.827	0.96
96_L	121_A	0.827	0.96
326_S	329_D	0.821	0.96
15_G	21_L	0.817	0.96
143_S	276_M	0.817	0.96
85_Q	104_Q	0.817	0.96
37_V	288_I	0.816	0.96
39_T	55_A	0.815	0.96
153_L	273_L	0.815	0.96
224_M	229_A	0.808	0.96
289_N	292_A	0.807	0.96
201_I	205_S	0.806	0.96
290_A	293_N	0.805	0.96
170_A	230_D	0.801	0.96
59_L	63_K	0.800	0.96
262_S	314_V	0.798	0.96
150_A	255_I	0.797	0.96
106_D	109_A	0.796	0.96
89_A	111_N	0.795	0.96
206_S	220_Q	0.792	0.95
309_D	339_I	0.786	0.95
108_L	132_V	0.786	0.95
154_T	201_I	0.786	0.95
254_A	272_V	0.785	0.95
39_T	59_L	0.782	0.95
14_G	17_V	0.780	0.95
151_G	198_S	0.778	0.95
119_R	291_V	0.775	0.95
153_L	231_I	0.775	0.95
41_Y	46_L	0.771	0.95
277_V	314_V	0.771	0.95
186_F	235_A	0.770	0.95
14_G	20_S	0.765	0.95
61_R	282_T	0.762	0.94
41_Y	56_K	0.751	0.94
221_A	225_F	0.749	0.94
258_D	278_K	0.746	0.94
247_A	254_A	0.746	0.94
155_Q	169_A	0.745	0.94
46_L	53_D	0.743	0.94
35_T	95_D	0.742	0.94
170_A	200_D	0.740	0.94
15_G	19_A	0.738	0.93
19_A	22_V	0.737	0.93
105_K	127_V	0.736	0.93
123_V	280_V	0.734	0.93
151_G	170_A	0.731	0.93
62_A	70_Y	0.728	0.93
333_K	342_D	0.727	0.93
137_F	278_K	0.727	0.93
169_A	228_G	0.726	0.93
124_D	278_K	0.725	0.93
56_K	70_Y	0.722	0.93
57_Q	259_R	0.720	0.93
44_G	48_D	0.718	0.92
174_F	235_A	0.717	0.92
62_A	68_I	0.710	0.92
174_F	187_E	0.709	0.92
177_G	237_A	0.709	0.92
14_G	18_G	0.707	0.92
144_Y	193_G	0.706	0.92
192_A	195_N	0.705	0.92
326_S	330_A	0.705	0.92
245_R	248_Q	0.704	0.92
33_D	95_D	0.704	0.92
144_Y	148_E	0.704	0.92
10_L	14_G	0.703	0.92
193_G	196_D	0.703	0.92
133_A	287_A	0.702	0.92
55_A	280_V	0.700	0.92
141_A	305_G	0.699	0.91
149_L	153_L	0.698	0.91
255_I	274_A	0.695	0.91
148_E	194_V	0.694	0.91
149_L	255_I	0.693	0.91
186_F	257_V	0.693	0.91
61_R	64_K	0.691	0.91
49_G	264_T	0.690	0.91
85_Q	89_A	0.689	0.91
152_L	197_V	0.689	0.91
36_K	95_D	0.685	0.91
10_L	17_V	0.682	0.90
257_V	278_K	0.680	0.90
113_A	129_Q	0.678	0.90
182_L	185_K	0.678	0.90
216_A	220_Q	0.677	0.90
187_E	205_S	0.676	0.90
62_A	285_Y	0.676	0.90
219_S	223_S	0.674	0.90
54_Q	281_D	0.674	0.90
87_Q	91_D	0.673	0.90
235_A	257_V	0.673	0.90
43_T	212_N	0.670	0.90
171_T	227_S	0.670	0.90
140_E	185_K	0.669	0.90
215_S	218_Q	0.669	0.90
139_E	276_M	0.669	0.90
196_D	199_E	0.667	0.89
231_I	273_L	0.664	0.89
187_E	207_Y	0.663	0.89
234_H	243_V	0.662	0.89
320_G	323_I	0.662	0.89
306_L	338_L	0.661	0.89
129_Q	132_V	0.659	0.89
135_Y	287_A	0.659	0.89
313_A	331_V	0.658	0.89
248_Q	271_V	0.657	0.89
139_E	278_K	0.652	0.88
175_V	221_A	0.652	0.88
73_S	84_D	0.651	0.88
135_Y	304_L	0.651	0.88
98_N	288_I	0.649	0.88
195_N	199_E	0.646	0.88
58_G	62_A	0.645	0.88
201_I	206_S	0.644	0.88
186_F	258_D	0.644	0.88
145_L	306_L	0.642	0.88
323_I	327_V	0.642	0.88
260_D	315_Y	0.641	0.88
21_L	25_C	0.641	0.88
247_A	252_R	0.641	0.88
91_D	94_F	0.640	0.87
143_S	235_A	0.640	0.87
48_D	53_D	0.640	0.87
140_E	345_V	0.639	0.87
55_A	100_V	0.636	0.87
236_S	242_G	0.636	0.87
66_L	292_A	0.636	0.87
9_F	20_S	0.631	0.87
78_N	103_A	0.627	0.86
22_V	25_C	0.627	0.86
155_Q	200_D	0.626	0.86
179_E	209_G	0.625	0.86
143_S	233_Y	0.625	0.86
297_A	300_E	0.622	0.86
117_D	130_D	0.622	0.86
272_V	275_S	0.620	0.86
133_A	297_A	0.619	0.86
319_L	323_I	0.619	0.86
134_S	300_E	0.617	0.85
291_V	296_F	0.615	0.85
56_K	59_L	0.615	0.85
121_A	287_A	0.615	0.85
90_Q	114_D	0.614	0.85
323_I	328_K	0.614	0.85
176_G	187_E	0.613	0.85
287_A	290_A	0.613	0.85
11_K	18_G	0.610	0.85
270_D	321_A	0.610	0.85
17_V	21_L	0.609	0.85
82_A	107_A	0.608	0.85
110_T	114_D	0.608	0.85
95_D	117_D	0.607	0.85
148_E	331_V	0.606	0.84
105_K	122_L	0.605	0.84
94_F	118_Q	0.604	0.84
122_L	127_V	0.604	0.84
22_V	26_S	0.602	0.84
71_E	88_Y	0.602	0.84
126_T	136_R	0.602	0.84
64_K	117_D	0.601	0.84
153_L	253_F	0.601	0.84
225_F	246_A	0.600	0.84
309_D	335_R	0.599	0.84
146_V	274_A	0.599	0.84
71_E	91_D	0.598	0.84
178_I	211_F	0.597	0.84
43_T	103_A	0.596	0.83
176_G	207_Y	0.595	0.83
220_Q	224_M	0.595	0.83
63_K	68_I	0.592	0.83
184_K	207_Y	0.590	0.83
111_N	114_D	0.590	0.83
240_G	257_V	0.589	0.83
282_T	285_Y	0.589	0.83
236_S	240_G	0.589	0.83
217_G	240_G	0.589	0.83
286_N	308_D	0.588	0.83
290_A	302_T	0.584	0.82
40_V	84_D	0.584	0.82
126_T	134_S	0.584	0.82
338_L	343_I	0.583	0.82
48_D	52_N	0.581	0.82
222_R	249_D	0.580	0.82
15_G	18_G	0.579	0.82
218_Q	246_A	0.577	0.81
242_G	246_A	0.572	0.81
329_D	336_T	0.571	0.81
20_S	23_A	0.571	0.81
149_L	152_L	0.568	0.80
51_F	124_D	0.567	0.80
204_L	224_M	0.567	0.80
319_L	328_K	0.567	0.80
192_A	196_D	0.566	0.80
172_V	190_F	0.565	0.80
153_L	323_I	0.562	0.80
217_G	242_G	0.562	0.80
92_G	95_D	0.557	0.79
119_R	133_A	0.557	0.79
13_A	21_L	0.557	0.79
62_A	292_A	0.554	0.79
143_S	182_L	0.554	0.79
190_F	233_Y	0.549	0.78
262_S	270_D	0.549	0.78
13_A	17_V	0.547	0.78
327_V	331_V	0.546	0.78
319_L	332_S	0.545	0.78
100_V	135_Y	0.545	0.78
111_N	120_W	0.544	0.78
68_I	288_I	0.544	0.78
290_A	297_A	0.544	0.78
265_K	271_V	0.541	0.77
80_E	84_D	0.541	0.77
149_L	327_V	0.540	0.77
54_Q	57_Q	0.539	0.77
145_L	313_A	0.538	0.77
81_F	104_Q	0.538	0.77
133_A	290_A	0.536	0.77
196_D	337_E	0.536	0.77
194_V	197_V	0.535	0.76
244_F	265_K	0.535	0.76
236_S	239_T	0.534	0.76
136_R	185_K	0.534	0.76
338_L	345_V	0.530	0.76
136_R	303_R	0.529	0.76
152_L	326_S	0.529	0.76
175_V	234_H	0.529	0.76
306_L	335_R	0.529	0.76
190_F	193_G	0.528	0.75
260_D	314_V	0.528	0.75
182_L	233_Y	0.527	0.75
172_V	201_I	0.526	0.75
261_Q	264_T	0.525	0.75
15_G	20_S	0.524	0.75
54_Q	259_R	0.524	0.75
313_A	335_R	0.523	0.75
115_F	120_W	0.521	0.75
24_G	27_S	0.518	0.74
57_Q	281_D	0.517	0.74
11_K	21_L	0.517	0.74
245_R	249_D	0.516	0.74
11_K	17_V	0.515	0.74
85_Q	120_W	0.513	0.73
15_G	23_A	0.512	0.73
283_A	310_G	0.510	0.73
174_F	183_I	0.510	0.73
282_T	310_G	0.508	0.73
15_G	22_V	0.508	0.73
212_N	239_T	0.506	0.72
133_A	298_G	0.506	0.72
10_L	16_T	0.504	0.72
188_A	192_A	0.503	0.72
221_A	246_A	0.503	0.72
78_N	107_A	0.503	0.72
99_C	104_Q	0.502	0.72
232_I	243_V	0.502	0.72
12_L	15_G	0.501	0.72
13_A	18_G	0.501	0.72
9_F	23_A	0.500	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pevA	1	0.8797	100	0.411	Contact Map
3s99A	1	0.8338	100	0.428	Contact Map
4iilA	1	0.8711	100	0.431	Contact Map
4p98A	1	0.8367	100	0.44	Contact Map
2fqxA	1	0.8596	100	0.452	Contact Map
2hqbA	1	0.8052	100	0.492	Contact Map
4ycsA	1	0.3467	100	0.636	Contact Map
4wzzA	1	0.808	99.9	0.708	Contact Map
4yv7A	1	0.7822	99.8	0.752	Contact Map
4kzkA	1	0.7794	99.8	0.765	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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