GREMLIN Database
Q9HR16 - Proline permease
UniProt: Q9HR16 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 522 (441)
Sequences: 11530 (7107)
Seq/√Len: 338.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
404_T450_V5.9551.00
333_T336_Q4.2301.00
393_V451_L3.9511.00
237_R240_N3.9501.00
329_N336_Q3.5411.00
404_T446_V3.3271.00
143_V349_G3.3051.00
452_V456_L3.2711.00
174_I178_A3.1601.00
324_Y332_A3.1451.00
401_S451_L3.1301.00
394_T458_T3.0691.00
185_A188_A3.0501.00
176_A265_Y2.9841.00
450_V454_V2.9831.00
454_V458_T2.9821.00
335_A339_R2.9581.00
400_A454_V2.9551.00
408_T446_V2.9061.00
71_K238_V2.8481.00
396_A458_T2.8391.00
386_A451_L2.7821.00
397_G455_S2.7521.00
130_D133_V2.7281.00
339_R343_Y2.6481.00
139_G353_I2.5081.00
266_A279_A2.4391.00
151_Y234_G2.3431.00
236_D240_N2.2981.00
5_G12_R2.2951.00
195_S198_S2.2901.00
14_V155_A2.2681.00
194_A197_T2.2611.00
86_A97_K2.2511.00
343_Y347_A2.2321.00
194_A198_S2.2231.00
400_A450_V2.1631.00
394_T397_G2.1441.00
84_F387_V2.1421.00
390_W393_V2.1201.00
193_G197_T2.1101.00
185_A189_A2.1051.00
396_A400_A2.1041.00
6_D11_G2.1031.00
38_G277_D2.0671.00
332_A336_Q2.0591.00
136_V140_V2.0541.00
383_L398_A2.0431.00
89_L393_V1.9731.00
9_I12_R1.9601.00
394_T455_S1.9571.00
30_G118_A1.9391.00
168_A299_A1.9261.00
397_G454_V1.9191.00
170_A174_I1.9161.00
329_N332_A1.9011.00
350_F354_G1.8971.00
407_A411_L1.8641.00
78_A87_T1.8351.00
198_S201_G1.8181.00
240_N243_T1.8161.00
184_F188_A1.8131.00
321_E325_H1.8011.00
270_F286_E1.8001.00
386_A448_A1.7981.00
282_L286_E1.7961.00
239_R243_T1.7931.00
294_G298_A1.7781.00
149_G153_A1.7771.00
390_W456_L1.7661.00
392_R456_L1.7621.00
239_R242_R1.7621.00
449_V453_V1.7541.00
18_V159_Y1.7501.00
325_H337_L1.7431.00
339_R342_R1.7421.00
324_Y340_Y1.7411.00
142_V308_A1.7311.00
397_G401_S1.6671.00
319_V344_V1.6661.00
390_W452_V1.6551.00
208_A211_G1.6531.00
153_A158_D1.6531.00
16_P240_N1.6501.00
188_A192_N1.5881.00
180_W186_D1.5791.00
188_A191_D1.5601.00
140_V144_G1.5521.00
392_R459_T1.5491.00
404_T408_T1.5431.00
324_Y329_N1.5331.00
121_T275_N1.5251.00
319_V323_V1.5131.00
83_T322_D1.5121.00
336_Q339_R1.5061.00
132_W357_Y1.5041.00
400_A404_T1.4721.00
445_V449_V1.4601.00
19_T235_I1.4541.00
120_G135_I1.4411.00
193_G198_S1.4371.00
312_L349_G1.4361.00
158_D231_R1.4341.00
21_F159_Y1.4341.00
90_N395_A1.4081.00
83_T321_E1.3841.00
195_S199_I1.3831.00
135_I353_I1.3801.00
196_L201_G1.3781.00
315_A348_I1.3741.00
324_Y336_Q1.3671.00
133_V136_V1.3661.00
88_R387_V1.3661.00
133_V137_A1.3541.00
394_T459_T1.3531.00
328_L332_A1.3431.00
196_L199_I1.3391.00
103_V406_T1.3361.00
139_G349_G1.3321.00
65_L385_I1.3231.00
155_A158_D1.3071.00
207_A211_G1.3011.00
338_V342_R1.2891.00
142_V305_M1.2861.00
8_V341_S1.2851.00
319_V324_Y1.2671.00
189_A192_N1.2491.00
10_G14_V1.2431.00
197_T200_T1.2431.00
84_F88_R1.2401.00
40_A47_A1.2341.00
189_A268_T1.2311.00
392_R460_P1.2201.00
86_A91_D1.2171.00
119_A138_G1.2131.00
332_A337_L1.2121.00
67_K71_K1.2091.00
157_S309_D1.1941.00
86_A326_G1.1871.00
153_A157_S1.1781.00
411_L415_W1.1741.00
446_V450_V1.1741.00
432_S435_L1.1731.00
20_G247_V1.1701.00
124_R131_M1.1691.00
10_G151_Y1.1641.00
96_V399_V1.1621.00
393_V397_G1.1621.00
26_S310_S1.1561.00
102_F106_V1.1501.00
205_G208_A1.1501.00
163_A167_A1.1481.00
394_T454_V1.1411.00
442_P445_V1.1351.00
116_I139_G1.1341.00
129_V134_G1.1301.00
161_Q309_D1.1281.00
336_Q340_Y1.1271.00
136_V353_I1.1251.00
158_D309_D1.1211.00
80_T317_S1.1181.00
97_K322_D1.1181.00
22_S310_S1.1131.00
340_Y344_V1.1121.00
320_V340_Y1.1121.00
184_F187_L1.1111.00
183_P187_L1.1071.00
320_V341_S1.1021.00
396_A454_V1.1011.00
344_V347_A1.0991.00
354_G358_V1.0931.00
179_T269_Q1.0911.00
363_P366_E1.0911.00
68_R71_K1.0901.00
145_Y305_M1.0891.00
196_L200_T1.0891.00
334_E337_L1.0861.00
67_K242_R1.0821.00
445_V448_A1.0751.00
395_A399_V1.0751.00
383_L402_M1.0721.00
100_S402_M1.0691.00
99_V399_V1.0681.00
450_V453_V1.0651.00
379_A447_S1.0641.00
448_A452_V1.0631.00
401_S405_G1.0631.00
136_V357_Y1.0631.00
66_A70_R1.0611.00
332_A340_Y1.0581.00
207_A210_F1.0531.00
396_A457_L1.0521.00
112_V352_S1.0301.00
96_V398_A1.0281.00
194_A200_T1.0281.00
48_F52_V1.0251.00
99_V402_M1.0231.00
386_A393_V1.0211.00
16_P20_G1.0191.00
116_I135_I1.0161.00
193_G200_T1.0161.00
440_L444_F1.0151.00
167_A171_I1.0111.00
181_G185_A1.0101.00
324_Y328_L1.0101.00
85_F100_S1.0101.00
145_Y309_D1.0081.00
408_T450_V1.0051.00
284_T296_V1.0051.00
132_W136_V1.0031.00
142_V309_D1.0031.00
387_V398_A1.0001.00
55_I253_F0.9971.00
171_I292_V0.9961.00
60_A64_G0.9931.00
8_V317_S0.9901.00
401_S447_S0.9891.00
102_F323_V0.9881.00
24_R251_F0.9881.00
158_D310_S0.9841.00
5_G77_R0.9831.00
393_V455_S0.9821.00
3_S6_D0.9811.00
105_I319_V0.9781.00
147_M346_L0.9781.00
193_G199_I0.9751.00
129_V137_A0.9741.00
171_I175_I0.9691.00
98_A327_F0.9671.00
16_P243_T0.9661.00
195_S200_T0.9651.00
275_N278_N0.9641.00
316_T320_V0.9611.00
405_G409_M0.9591.00
173_P258_G0.9571.00
282_L285_L0.9551.00
365_Y370_N0.9521.00
187_L190_M0.9441.00
386_A452_V0.9431.00
186_D265_Y0.9421.00
195_S202_G0.9421.00
113_G355_F0.9391.00
42_T276_T0.9371.00
39_D43_T0.9251.00
66_A69_L0.9221.00
22_S25_A0.9221.00
246_V250_L0.9191.00
306_S309_D0.9141.00
221_G226_P0.9141.00
180_W268_T0.9131.00
193_G196_L0.9131.00
154_V157_S0.9121.00
89_L387_V0.9071.00
187_L191_D0.9061.00
85_F96_V0.9041.00
265_Y269_Q0.8921.00
26_S158_D0.8891.00
175_I179_T0.8891.00
319_V348_I0.8881.00
347_A351_A0.8851.00
205_G209_L0.8841.00
403_V407_A0.8821.00
284_T293_A0.8821.00
235_I241_V0.8811.00
172_L280_M0.8811.00
30_G304_M0.8811.00
364_I368_V0.8771.00
383_L447_S0.8761.00
262_V283_V0.8741.00
350_F353_I0.8721.00
103_V402_M0.8711.00
201_G204_T0.8711.00
434_M442_P0.8691.00
364_I367_L0.8681.00
178_A183_P0.8671.00
145_Y161_Q0.8651.00
453_V457_L0.8631.00
161_Q302_A0.8611.00
22_S155_A0.8601.00
22_S26_S0.8581.00
448_A451_L0.8581.00
392_R461_P0.8561.00
29_S111_Y0.8521.00
40_A264_L0.8491.00
324_Y327_F0.8471.00
22_S231_R0.8461.00
88_R390_W0.8451.00
91_D395_A0.8451.00
135_I356_A0.8451.00
206_W211_G0.8441.00
145_Y306_S0.8441.00
186_D190_M0.8421.00
179_T287_L0.8411.00
64_G67_K0.8391.00
157_S161_Q0.8381.00
281_P284_T0.8381.00
459_T462_D0.8351.00
53_G57_A0.8311.00
325_H330_E0.8301.00
25_A231_R0.8291.00
396_A459_T0.8291.00
313_L316_T0.8271.00
390_W397_G0.8271.00
194_A199_I0.8271.00
202_G205_G0.8261.00
341_S345_T0.8251.00
21_F162_G0.8211.00
176_A179_T0.8211.00
197_T201_G0.8191.00
449_V452_V0.8161.00
50_N62_W0.8161.00
203_A206_W0.8161.00
446_V449_V0.8141.00
191_D194_A0.8131.00
370_N374_G0.8111.00
156_W159_Y0.8101.00
291_A295_V0.8081.00
394_T460_P0.8081.00
288_L292_V0.8071.00
405_G447_S0.8041.00
404_T454_V0.8041.00
206_W210_F0.8041.00
266_A283_V0.8031.00
10_G234_G0.8021.00
367_L372_A0.8021.00
371_Y413_T0.8021.00
278_N282_L0.8001.00
70_R238_V0.7991.00
328_L331_Q0.7961.00
411_L414_Q0.7961.00
390_W455_S0.7941.00
405_G408_T0.7931.00
45_I264_L0.7891.00
169_F259_A0.7871.00
124_R128_G0.7851.00
16_P247_V0.7841.00
55_I249_Q0.7841.00
18_V155_A0.7821.00
218_V222_I0.7811.00
172_L176_A0.7811.00
316_T345_T0.7791.00
111_Y226_P0.7761.00
67_K70_R0.7761.00
203_A207_A0.7761.00
399_V403_V0.7741.00
58_D62_W0.7721.00
123_L134_G0.7721.00
382_P448_A0.7701.00
120_G131_M0.7691.00
198_S202_G0.7691.00
105_I315_A0.7691.00
354_G357_Y0.7691.00
7_Y345_T0.7681.00
452_V455_S0.7671.00
161_Q306_S0.7621.00
161_Q307_S0.7611.00
365_Y368_V0.7591.00
50_N54_M0.7591.00
343_Y346_L0.7581.00
198_S205_G0.7571.00
161_Q305_M0.7561.00
15_G240_N0.7551.00
89_L451_L0.7551.00
406_T410_I0.7541.00
170_A173_P0.7471.00
204_T207_A0.7461.00
408_T412_W0.7461.00
131_M135_I0.7461.00
206_W209_L0.7440.99
121_T124_R0.7420.99
151_Y155_A0.7410.99
145_Y153_A0.7410.99
186_D189_A0.7370.99
453_V456_L0.7360.99
397_G400_A0.7340.99
180_W185_A0.7280.99
67_K238_V0.7280.99
90_N462_D0.7270.99
83_T87_T0.7250.99
398_A405_G0.7240.99
250_L254_V0.7240.99
63_A246_V0.7230.99
412_W442_P0.7220.99
51_G58_D0.7210.99
134_G138_G0.7200.99
82_P100_S0.7190.99
33_T169_F0.7180.99
50_N53_G0.7170.99
5_G334_E0.7170.99
432_S436_T0.7160.99
166_L170_A0.7150.99
408_T411_L0.7130.99
119_A304_M0.7130.99
17_V21_F0.7110.99
146_T309_D0.7080.99
362_T367_L0.7080.99
32_L256_Y0.7050.99
59_L63_A0.7050.99
115_Q308_A0.7040.99
438_Y442_P0.7040.99
386_A390_W0.7040.99
47_A50_N0.7030.99
41_Y272_G0.7020.99
434_M437_V0.7000.99
186_D268_T0.6950.99
14_V19_T0.6940.99
319_V340_Y0.6930.99
27_E54_M0.6930.99
345_T349_G0.6930.99
143_V346_L0.6930.99
235_I240_N0.6910.99
121_T277_D0.6910.99
402_M405_G0.6890.99
305_M309_D0.6880.99
390_W394_T0.6880.99
457_L460_P0.6870.99
222_I226_P0.6870.99
205_G211_G0.6870.99
117_V121_T0.6850.99
167_A170_A0.6840.99
324_Y330_E0.6840.99
171_I174_I0.6810.99
454_V457_L0.6800.99
392_R395_A0.6800.99
185_A268_T0.6800.99
218_V225_N0.6790.99
92_D399_V0.6790.99
97_K101_S0.6780.99
460_P463_Q0.6780.99
439_G443_A0.6770.99
85_F383_L0.6740.99
200_T203_A0.6740.99
98_A101_S0.6730.99
316_T344_V0.6720.99
430_A434_M0.6710.99
33_T296_V0.6690.99
99_V403_V0.6670.99
444_F447_S0.6620.99
50_N57_A0.6610.99
80_T322_D0.6610.99
392_R396_A0.6590.99
107_F376_L0.6570.99
458_T461_P0.6550.99
124_R130_D0.6550.99
433_G436_T0.6550.99
7_Y342_R0.6540.99
249_Q253_F0.6540.99
175_I178_A0.6530.99
152_F156_W0.6530.99
447_S451_L0.6510.99
283_V287_L0.6510.99
267_L279_A0.6510.99
177_Y183_P0.6500.99
79_V83_T0.6490.99
154_V310_S0.6480.99
41_Y279_A0.6450.99
381_G385_I0.6450.99
368_V373_W0.6440.99
182_L185_A0.6430.99
22_S158_D0.6420.99
270_F282_L0.6420.99
204_T208_A0.6410.98
353_I357_Y0.6400.98
115_Q307_S0.6390.98
14_V234_G0.6390.98
431_V435_L0.6380.98
400_A403_V0.6380.98
100_S104_L0.6360.98
96_V100_S0.6360.98
64_G68_R0.6350.98
25_A161_Q0.6350.98
15_G18_V0.6320.98
18_V156_W0.6310.98
57_A62_W0.6310.98
311_Q314_V0.6310.98
393_V401_S0.6290.98
53_G62_W0.6280.98
393_V398_A0.6280.98
17_V159_Y0.6270.98
269_Q283_V0.6260.98
39_D42_T0.6250.98
154_V231_R0.6250.98
90_N96_V0.6250.98
25_A162_G0.6240.98
6_D152_F0.6230.98
312_L345_T0.6220.98
29_S33_T0.6210.98
182_L189_A0.6200.98
331_Q336_Q0.6170.98
220_L381_G0.6170.98
267_L271_G0.6160.98
227_H230_V0.6160.98
330_E333_T0.6160.98
316_T341_S0.6160.98
66_A241_V0.6150.98
82_P104_L0.6140.98
177_Y261_L0.6130.98
180_W269_Q0.6120.98
262_V280_M0.6110.98
26_S231_R0.6100.98
4_V8_V0.6090.98
177_Y181_G0.6070.98
243_T247_V0.6070.98
57_A219_G0.6040.98
278_N281_P0.6030.98
441_F445_V0.6030.98
203_A208_A0.6030.98
158_D306_S0.6020.98
177_Y182_L0.6010.98
433_G437_V0.6010.98
408_T443_A0.6000.98
320_V337_L0.6000.98
103_V379_A0.5990.98
430_A433_G0.5970.98
288_L296_V0.5960.98
136_V350_F0.5950.98
195_S201_G0.5940.98
307_S311_Q0.5930.98
72_Y77_R0.5900.97
15_G19_T0.5900.97
397_G450_V0.5890.97
62_W67_K0.5890.97
370_N373_W0.5890.97
260_A264_L0.5880.97
443_A447_S0.5870.97
437_V440_L0.5840.97
89_L386_A0.5840.97
172_L296_V0.5840.97
154_V158_D0.5820.97
252_M256_Y0.5820.97
202_G208_A0.5810.97
180_W189_A0.5810.97
111_Y311_Q0.5800.97
456_L459_T0.5790.97
410_I414_Q0.5790.97
407_A410_I0.5790.97
382_P451_L0.5770.97
435_L438_Y0.5760.97
437_V441_F0.5730.97
68_R389_W0.5730.97
353_I356_A0.5730.97
320_V344_V0.5710.97
112_V308_A0.5700.97
49_Y53_G0.5700.97
196_L202_G0.5700.97
38_G276_T0.5670.97
15_G156_W0.5660.97
397_G447_S0.5640.97
394_T398_A0.5640.97
27_E252_M0.5630.97
435_L442_P0.5630.97
325_H334_E0.5630.97
145_Y149_G0.5620.97
20_G24_R0.5620.97
26_S227_H0.5620.97
401_S404_T0.5610.97
320_V324_Y0.5600.96
139_G356_A0.5600.96
143_V147_M0.5590.96
121_T125_V0.5580.96
164_I298_A0.5570.96
392_R455_S0.5570.96
398_A401_S0.5550.96
24_R162_G0.5520.96
161_Q303_A0.5520.96
89_L398_A0.5520.96
68_R72_Y0.5500.96
78_A84_F0.5500.96
35_G111_Y0.5500.96
438_Y441_F0.5490.96
24_R255_A0.5490.96
232_F245_A0.5480.96
25_A157_S0.5480.96
219_G226_P0.5470.96
26_S146_T0.5470.96
285_L293_A0.5470.96
177_Y186_D0.5470.96
55_I58_D0.5460.96
362_T366_E0.5460.96
281_P300_A0.5450.96
125_V278_N0.5440.96
436_T440_L0.5440.96
325_H331_Q0.5440.96
19_T22_S0.5430.96
49_Y57_A0.5430.96
98_A102_F0.5430.96
337_L341_S0.5420.96
81_L384_L0.5420.96
136_V139_G0.5400.96
355_F358_V0.5400.96
62_W241_V0.5400.96
333_T339_R0.5390.96
104_L380_L0.5390.96
55_I59_L0.5390.96
204_T211_G0.5370.96
412_W416_P0.5370.96
173_P265_Y0.5370.96
117_V131_M0.5360.96
120_G134_G0.5360.96
173_P261_L0.5360.96
394_T452_V0.5350.95
181_G184_F0.5350.95
289_P292_V0.5350.95
109_G351_A0.5340.95
254_V258_G0.5330.95
218_V226_P0.5330.95
243_T246_V0.5320.95
27_E373_W0.5300.95
269_Q287_L0.5300.95
298_A302_A0.5290.95
104_L318_A0.5280.95
125_V281_P0.5270.95
78_A83_T0.5270.95
29_S115_Q0.5270.95
4_V337_L0.5270.95
444_F448_A0.5270.95
217_A226_P0.5260.95
218_V224_G0.5260.95
66_A238_V0.5250.95
31_W373_W0.5240.95
199_I203_A0.5230.95
290_S293_A0.5220.95
190_M267_L0.5220.95
115_Q118_A0.5210.95
68_R388_L0.5210.95
147_M339_R0.5210.95
116_I153_A0.5200.95
169_F258_G0.5200.95
303_A306_S0.5180.95
129_V133_V0.5170.95
19_T244_A0.5160.95
284_T288_L0.5150.94
185_A190_M0.5150.94
231_R310_S0.5140.94
190_M264_L0.5140.94
62_W66_A0.5130.94
91_D97_K0.5120.94
53_G56_P0.5120.94
271_G274_E0.5110.94
96_V395_A0.5110.94
396_A399_V0.5100.94
199_I202_G0.5100.94
363_P367_L0.5090.94
430_A435_L0.5070.94
110_S372_A0.5070.94
290_S294_G0.5060.94
87_T391_R0.5060.94
3_S11_G0.5060.94
253_F256_Y0.5050.94
36_V40_A0.5050.94
447_S450_V0.5050.94
91_D326_G0.5050.94
311_Q380_L0.5040.94
98_A323_V0.5040.94
430_A445_V0.5030.94
364_I370_N0.5030.94
169_F255_A0.5020.94
157_S231_R0.5020.94
404_T407_A0.5020.94
51_G54_M0.5010.94
24_R248_A0.5010.94
79_V321_E0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dh4A 3 0.8563 100 0.315 Contact Map
2xq2A 2 0.8755 100 0.317 Contact Map
3l1lA 2 0.7797 99.4 0.857 Contact Map
3giaA 1 0.8084 99.4 0.862 Contact Map
4djkA 2 0.7969 99.1 0.879 Contact Map
2jlnA 1 0.7835 99.1 0.88 Contact Map
4wgvA 2 0.7088 98.9 0.889 Contact Map
4c7rA 3 0.7778 97.7 0.921 Contact Map
3wdoA 1 0.8295 94.3 0.943 Contact Map
2wswA 3 0.7088 93.9 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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