GREMLIN Database
Q9HR14 - Uncharacterized protein
UniProt: Q9HR14 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 90 (72)
Sequences: 15756 (12973)
Seq/√Len: 1528.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_E46_D3.2141.00
5_Q34_T2.5191.00
8_T37_K2.4371.00
30_A55_D2.3301.00
18_A44_R2.2591.00
22_Y47_D2.1791.00
5_Q59_A1.9671.00
8_T62_D1.9351.00
37_K62_D1.9301.00
34_T59_A1.8531.00
25_R50_R1.7241.00
26_P51_A1.6581.00
18_A26_P1.6441.00
54_Q57_Y1.5941.00
30_A34_T1.5631.00
6_H35_L1.5631.00
3_T6_H1.5461.00
46_D74_V1.4841.00
21_E74_V1.4381.00
44_R51_A1.4361.00
28_P53_F1.4021.00
24_Q49_E1.3921.00
55_D59_A1.3711.00
29_S32_R1.2931.00
18_A24_Q1.2521.00
6_H60_E1.2411.00
29_S54_Q1.2221.00
44_R72_L1.2061.00
22_Y37_K1.1871.00
35_L60_E1.1691.00
27_F52_A1.1231.00
21_E37_K1.1141.00
31_T56_A1.1101.00
28_P32_R1.0761.00
46_D62_D1.0701.00
9_A38_G1.0411.00
32_R35_L1.0201.00
6_H29_S1.0191.00
72_L75_L0.9921.00
27_F50_R0.9891.00
3_T32_R0.9891.00
57_Y60_E0.9801.00
18_A72_L0.9671.00
7_A11_P0.9521.00
5_Q8_T0.9391.00
44_R49_E0.9271.00
53_F57_Y0.8931.00
22_Y75_L0.8891.00
10_V64_L0.8861.00
18_A21_E0.8721.00
34_T37_K0.8691.00
17_A20_C0.8671.00
20_C36_H0.8431.00
3_T57_Y0.8401.00
25_R52_A0.8231.00
47_D62_D0.8121.00
59_A62_D0.7961.00
47_D75_L0.7761.00
32_R57_Y0.7721.00
38_G63_D0.7611.00
15_T41_H0.7531.00
66_S69_L0.7421.00
9_A63_D0.7411.00
6_H9_A0.7391.00
36_H40_D0.7361.00
45_I48_A0.7181.00
10_V39_T0.7121.00
48_A61_E0.7081.00
69_L73_A0.6961.00
31_T35_L0.6861.00
43_Q48_A0.6791.00
17_A36_H0.6651.00
62_D66_S0.6371.00
20_C23_C0.6371.00
23_C36_H0.6321.00
70_R73_A0.6231.00
11_P17_A0.6151.00
43_Q55_D0.6141.00
48_A52_A0.6121.00
71_A75_L0.6101.00
35_L38_G0.6091.00
45_I61_E0.6031.00
17_A43_Q0.6021.00
9_A16_P0.5951.00
29_S33_L0.5901.00
17_A40_D0.5781.00
33_L36_H0.5751.00
9_A14_E0.5701.00
56_A60_E0.5651.00
39_T53_F0.5651.00
44_R47_D0.5631.00
12_A15_T0.5631.00
46_D51_A0.5621.00
30_A37_K0.5621.00
10_V28_P0.5541.00
16_P26_P0.5501.00
13_G28_P0.5431.00
5_Q9_A0.5411.00
23_C40_D0.5341.00
4_A58_L0.5311.00
27_F33_L0.5221.00
45_I65_R0.5151.00
54_Q58_L0.5151.00
35_L39_T0.5101.00
68_R71_A0.5081.00
13_G16_P0.5041.00
12_A16_P0.5041.00
42_P53_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i13A 1 0.9889 99.4 0.28 Contact Map
2n25A 1 0.2889 99.4 0.292 Contact Map
3w5kB 1 0.9556 99.4 0.293 Contact Map
1x6hA 1 0.8778 99.4 0.294 Contact Map
2dmiA 1 0.9889 99.4 0.3 Contact Map
2dlqA 1 0.9889 99.4 0.308 Contact Map
3zmsC 1 0 99.4 0.311 Contact Map
2jp9A 1 0.9889 99.3 0.323 Contact Map
2lt7A 1 0.9889 99.3 0.323 Contact Map
2ctdA 1 0.8333 99.3 0.329 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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