GREMLIN Database
Q9HR13 - Uncharacterized protein
UniProt: Q9HR13 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 483 (406)
Sequences: 507 (400)
Seq/√Len: 19.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_V229_L5.8731.00
400_S405_P5.2441.00
401_P405_P5.1331.00
226_G239_A4.3421.00
341_G345_Y3.6781.00
156_V159_V3.6741.00
155_V221_V3.3741.00
145_G160_W3.1560.99
400_S406_P3.1430.99
125_G213_A3.1050.99
377_G428_G2.8960.99
401_P407_N2.8820.99
131_L134_A2.8440.99
128_G135_S2.7380.98
93_S97_P2.6910.98
401_P406_P2.6300.98
60_W64_A2.5870.98
65_T69_T2.5770.98
400_S407_N2.5560.98
65_T71_G2.4570.97
59_R63_L2.4370.97
146_R304_G2.4370.97
164_N223_T2.4080.97
69_T73_S2.3200.96
127_T152_L2.2630.95
372_L408_P2.2350.95
297_G382_H2.1720.94
265_V270_R2.1590.94
250_G424_F2.1180.93
370_P436_A2.1010.93
123_Y127_T2.0940.93
377_G381_A2.0820.92
198_W329_T2.0720.92
161_P164_N2.0550.92
164_N236_F2.0270.91
197_V292_E2.0050.91
444_F453_S1.9910.90
262_V333_L1.9510.90
336_Y339_F1.9480.89
293_L378_Y1.9440.89
67_G70_I1.9410.89
271_L435_A1.9310.89
249_Y376_A1.9220.89
123_Y402_L1.8850.88
213_A432_A1.8620.87
197_V428_G1.8560.87
129_P235_W1.8390.86
158_N161_P1.8230.86
178_V230_V1.8060.85
115_V172_V1.7870.85
235_W259_P1.7630.84
399_A405_P1.7480.83
59_R66_G1.7220.83
342_A464_Y1.7160.82
145_G242_V1.7060.82
250_G380_L1.6910.81
67_G75_L1.6890.81
298_F435_A1.6810.81
271_L380_L1.6790.81
326_V330_A1.6110.78
430_L446_R1.5640.76
180_Y184_L1.5620.76
190_V193_L1.5570.76
192_G241_P1.5550.75
164_N240_D1.5450.75
148_A391_A1.5410.75
190_V281_S1.5350.74
417_F421_S1.5350.74
349_W352_R1.5290.74
468_S472_L1.5230.74
227_A236_F1.5110.73
60_W63_L1.5060.73
387_A391_A1.5060.73
187_W271_L1.5000.73
189_A244_V1.4840.72
249_Y379_H1.4840.72
420_A462_I1.4830.72
75_L78_S1.4620.71
200_E383_Y1.4580.70
183_S337_A1.4510.70
152_L159_V1.4360.69
161_P240_D1.4340.69
112_T225_A1.4340.69
342_A459_L1.4270.69
117_V459_L1.4260.69
225_A427_A1.4140.68
81_T438_T1.4140.68
189_A196_L1.4050.68
228_V440_A1.4050.68
183_S191_C1.3980.67
122_V213_A1.3960.67
153_S158_N1.3940.67
251_A286_V1.3730.66
122_V151_I1.3600.65
338_V341_G1.3600.65
57_V60_W1.3550.65
348_R463_G1.3490.64
170_A253_G1.3450.64
117_V361_R1.3420.64
210_S327_V1.3400.64
379_H394_M1.3360.64
378_Y465_T1.3230.63
124_L401_P1.3160.62
111_R168_A1.3060.62
63_L372_L1.2990.61
97_P258_Y1.2970.61
128_G421_S1.2920.61
122_V361_R1.2790.60
136_F377_G1.2790.60
161_P236_F1.2750.60
353_L456_P1.2740.60
304_G331_V1.2710.60
429_H437_H1.2630.59
423_A427_A1.2630.59
145_G282_D1.2610.59
330_A346_A1.2560.59
115_V168_A1.2520.58
157_G165_P1.2520.58
112_T116_V1.2510.58
218_V222_V1.2500.58
389_S417_F1.2410.58
288_G371_L1.2330.57
95_P98_S1.2270.57
255_V262_V1.2240.57
351_R442_D1.2200.56
440_A459_L1.2160.56
77_A86_I1.2130.56
248_C397_V1.2100.56
63_L66_G1.2090.56
149_L195_A1.1950.55
157_G382_H1.1910.55
200_E293_L1.1870.54
222_V267_P1.1870.54
125_G137_T1.1840.54
59_R70_I1.1790.54
236_F240_D1.1740.53
149_L152_L1.1720.53
139_L394_M1.1710.53
162_I337_A1.1660.53
77_A431_L1.1620.53
190_V289_L1.1610.53
136_F243_S1.1610.53
330_A340_L1.1600.53
121_A140_I1.1590.52
339_F351_R1.1590.52
161_P237_H1.1560.52
225_A306_T1.1520.52
429_H465_T1.1510.52
155_V360_S1.1510.52
118_L216_L1.1490.52
57_V62_Y1.1480.52
152_L262_V1.1480.52
262_V353_L1.1480.52
429_H461_M1.1470.52
337_A341_G1.1450.52
146_R296_S1.1370.51
231_G235_W1.1360.51
325_I332_F1.1320.51
166_W220_S1.1300.51
217_V380_L1.1230.50
60_W68_A1.1230.50
208_V211_V1.1220.50
78_S151_I1.1150.50
298_F432_A1.1120.49
242_V282_D1.1080.49
444_F450_A1.1000.49
339_F345_Y1.1000.49
209_P470_W1.0980.49
295_Y429_H1.0970.48
108_W186_R1.0970.48
146_R202_V1.0960.48
214_T221_V1.0910.48
74_A293_L1.0910.48
350_S354_S1.0870.48
67_G71_G1.0860.48
224_V228_V1.0850.48
118_L158_N1.0830.48
382_H461_M1.0820.47
402_L406_P1.0710.47
290_V456_P1.0710.47
152_L427_A1.0670.47
236_F282_D1.0640.46
162_I221_V1.0620.46
193_L293_L1.0560.46
209_P379_H1.0480.45
461_M471_L1.0440.45
146_R291_W1.0420.45
242_V249_Y1.0360.45
135_S421_S1.0300.44
113_L450_A1.0280.44
390_L393_A1.0260.44
337_A349_W1.0250.44
70_I238_N1.0250.44
61_L64_A1.0250.44
293_L377_G1.0240.44
253_G326_V1.0200.44
164_N215_V1.0200.44
225_A395_V1.0200.44
120_L250_G1.0180.43
209_P213_A1.0080.43
75_L459_L1.0000.42
468_S471_L0.9990.42
145_G239_A0.9980.42
90_D104_R0.9970.42
128_G428_G0.9930.42
241_P408_P0.9890.42
152_L417_F0.9880.41
188_P461_M0.9870.41
230_V286_V0.9870.41
123_Y334_A0.9860.41
187_W381_A0.9830.41
78_S343_Y0.9790.41
64_A70_I0.9760.41
256_Q260_D0.9760.41
420_A423_A0.9760.41
97_P102_L0.9730.41
94_Y97_P0.9730.41
62_Y380_L0.9710.40
462_I466_V0.9710.40
354_S357_Y0.9690.40
368_A387_A0.9690.40
298_F335_G0.9650.40
204_P304_G0.9640.40
201_V383_Y0.9590.40
148_A398_S0.9550.39
231_G296_S0.9500.39
429_H454_Q0.9490.39
434_W463_G0.9490.39
345_Y349_W0.9490.39
377_G424_F0.9480.39
297_G375_A0.9470.39
238_N284_A0.9420.39
179_T304_G0.9370.38
120_L124_L0.9360.38
122_V430_L0.9330.38
237_H376_A0.9330.38
469_L472_L0.9320.38
250_G317_A0.9320.38
425_V460_V0.9290.38
125_G212_L0.9280.38
109_G326_V0.9250.38
420_A424_F0.9200.37
388_V402_L0.9190.37
66_G464_Y0.9190.37
151_I377_G0.9170.37
368_A375_A0.9170.37
248_C421_S0.9080.37
197_V377_G0.9040.36
345_Y466_V0.9040.36
293_L296_S0.9020.36
348_R360_S0.8980.36
142_F145_G0.8970.36
283_I367_F0.8910.36
245_M249_Y0.8880.35
419_A423_A0.8860.35
223_T236_F0.8830.35
291_W471_L0.8770.35
64_A68_A0.8740.35
251_A435_A0.8740.35
150_P171_T0.8730.35
71_G75_L0.8730.35
212_L379_H0.8720.34
66_G439_A0.8700.34
62_Y69_T0.8680.34
109_G217_V0.8680.34
132_P372_L0.8670.34
99_A163_L0.8670.34
210_S299_I0.8610.34
346_A430_L0.8600.34
156_V244_V0.8580.34
387_A396_A0.8570.34
60_W170_A0.8520.33
219_Y231_G0.8500.33
346_A460_V0.8500.33
66_G73_S0.8490.33
126_F217_V0.8470.33
325_I330_A0.8450.33
255_V372_L0.8440.33
266_L269_S0.8430.33
117_V202_V0.8420.33
399_A406_P0.8410.33
432_A461_M0.8380.33
138_I331_V0.8350.32
209_P215_V0.8340.32
99_A255_V0.8320.32
114_G168_A0.8320.32
91_D97_P0.8310.32
380_L424_F0.8310.32
146_R331_V0.8280.32
81_T84_A0.8280.32
103_R106_A0.8270.32
155_V227_A0.8270.32
338_V361_R0.8220.32
130_A415_G0.8210.32
290_V433_V0.8190.31
172_V398_S0.8170.31
375_A444_F0.8160.31
111_R171_T0.8150.31
97_P101_R0.8150.31
235_W290_V0.8130.31
116_V432_A0.8120.31
267_P284_A0.8100.31
326_V335_G0.8080.31
262_V427_A0.8070.31
281_S465_T0.8060.31
145_G241_P0.8040.31
63_L70_I0.8040.31
351_R362_A0.8020.30
333_L423_A0.8000.30
297_G374_V0.8000.30
180_Y214_T0.7990.30
117_V229_L0.7990.30
415_G420_A0.7990.30
64_A75_L0.7980.30
135_S295_Y0.7940.30
179_T356_T0.7920.30
137_T213_A0.7920.30
105_L225_A0.7920.30
188_P231_G0.7910.30
148_A152_L0.7910.30
400_S403_V0.7880.30
330_A341_G0.7860.30
297_G301_T0.7850.30
250_G285_F0.7850.30
212_L247_R0.7850.30
117_V423_A0.7840.30
118_L193_L0.7840.30
243_S246_L0.7810.29
296_S382_H0.7780.29
169_I259_P0.7760.29
147_A196_L0.7740.29
343_Y433_V0.7740.29
81_T142_F0.7730.29
79_F82_D0.7730.29
195_A259_P0.7680.29
220_S236_F0.7660.29
112_T191_C0.7660.29
167_R243_S0.7620.28
367_F444_F0.7620.28
70_I472_L0.7610.28
104_R108_W0.7610.28
224_V459_L0.7610.28
191_C426_L0.7570.28
115_V430_L0.7560.28
123_Y261_R0.7550.28
160_W206_S0.7540.28
286_V386_L0.7530.28
135_S428_G0.7520.28
59_R72_A0.7510.28
218_V365_V0.7480.28
139_L209_P0.7460.28
86_I268_G0.7450.27
363_L462_I0.7430.27
132_P212_L0.7430.27
158_N233_E0.7420.27
63_L71_G0.7420.27
220_S235_W0.7420.27
58_P61_L0.7400.27
332_F336_Y0.7390.27
160_W228_V0.7390.27
255_V352_R0.7390.27
197_V390_L0.7370.27
305_D309_R0.7340.27
328_Y339_F0.7320.27
58_P63_L0.7300.27
116_V310_T0.7300.27
162_I262_V0.7290.27
109_G337_A0.7290.27
143_A193_L0.7290.27
141_A242_V0.7260.27
403_V464_Y0.7250.26
346_A350_S0.7240.26
152_L362_A0.7230.26
121_A319_S0.7210.26
144_G387_A0.7210.26
268_G431_L0.7190.26
96_L341_G0.7180.26
190_V268_G0.7160.26
293_L304_G0.7160.26
300_T386_L0.7150.26
57_V65_T0.7140.26
439_A442_D0.7140.26
333_L427_A0.7110.26
146_R160_W0.7100.26
118_L247_R0.7100.26
79_F163_L0.7090.26
200_E235_W0.7090.26
289_L347_G0.7060.26
124_L400_S0.7040.25
245_M379_H0.7030.25
79_F447_R0.7020.25
296_S437_H0.7000.25
149_L304_G0.6990.25
338_V440_A0.6990.25
454_Q465_T0.6980.25
112_T341_G0.6960.25
146_R185_K0.6960.25
235_W283_I0.6940.25
288_G316_P0.6930.25
126_F169_I0.6910.25
132_P141_A0.6900.25
79_F451_I0.6870.25
201_V472_L0.6870.25
274_P462_I0.6870.25
64_A78_S0.6860.25
65_T70_I0.6860.25
236_F270_R0.6850.24
206_S293_L0.6840.24
196_L383_Y0.6830.24
103_R107_V0.6830.24
243_S256_Q0.6830.24
105_L301_T0.6820.24
306_T354_S0.6820.24
142_F285_F0.6810.24
150_P198_W0.6800.24
98_S179_T0.6800.24
365_V372_L0.6800.24
276_V427_A0.6790.24
163_L342_A0.6750.24
122_V217_V0.6740.24
211_V221_V0.6730.24
372_L439_A0.6730.24
61_L417_F0.6720.24
150_P238_N0.6710.24
145_G293_L0.6710.24
325_I329_T0.6700.24
87_A261_R0.6700.24
122_V446_R0.6690.24
178_V458_V0.6680.24
395_V417_F0.6670.24
352_R355_G0.6670.24
378_Y382_H0.6660.24
271_L453_S0.6650.24
73_S453_S0.6650.24
173_L274_P0.6650.24
63_L76_L0.6640.24
166_W243_S0.6630.23
302_T310_T0.6630.23
156_V327_V0.6610.23
362_A366_R0.6610.23
219_Y235_W0.6600.23
147_A392_P0.6600.23
217_V460_V0.6600.23
182_A402_L0.6590.23
104_R217_V0.6590.23
69_T76_L0.6580.23
247_R463_G0.6570.23
243_S467_V0.6570.23
184_L253_G0.6570.23
158_N297_G0.6550.23
337_A352_R0.6510.23
228_V334_A0.6500.23
235_W267_P0.6490.23
206_S389_S0.6490.23
113_L443_V0.6480.23
160_W233_E0.6450.23
219_Y222_V0.6430.23
428_G456_P0.6420.22
161_P288_G0.6420.22
250_G376_A0.6420.22
345_Y352_R0.6390.22
389_S460_V0.6390.22
310_T467_V0.6380.22
325_I328_Y0.6370.22
242_V383_Y0.6350.22
180_Y403_V0.6350.22
241_P289_L0.6340.22
419_A471_L0.6330.22
413_P460_V0.6330.22
142_F438_T0.6320.22
145_G193_L0.6300.22
100_G330_A0.6290.22
81_T85_F0.6290.22
246_L390_L0.6260.22
184_L234_A0.6260.22
142_F205_I0.6250.22
188_P219_Y0.6240.22
164_N180_Y0.6230.22
82_D345_Y0.6220.22
112_T182_A0.6210.22
60_W75_L0.6200.22
437_H454_Q0.6200.22
61_L68_A0.6180.21
332_F344_L0.6180.21
140_I228_V0.6170.21
141_A203_F0.6160.21
164_N386_L0.6150.21
399_A451_I0.6130.21
235_W375_A0.6120.21
146_R203_F0.6120.21
113_L122_V0.6110.21
171_T233_E0.6080.21
241_P397_V0.6080.21
399_A407_N0.6070.21
202_V309_R0.6050.21
398_S405_P0.6050.21
119_V191_C0.6040.21
325_I347_G0.6040.21
59_R62_Y0.6020.21
166_W382_H0.6010.21
134_A304_G0.5960.20
126_F213_A0.5940.20
169_I464_Y0.5910.20
156_V337_A0.5900.20
74_A146_R0.5890.20
223_T240_D0.5880.20
66_G387_A0.5880.20
210_S337_A0.5880.20
65_T330_A0.5870.20
450_A453_S0.5870.20
218_V338_V0.5870.20
83_R334_A0.5840.20
227_A372_L0.5840.20
161_P241_P0.5840.20
393_A397_V0.5820.20
215_V247_R0.5800.20
58_P62_Y0.5790.20
80_V84_A0.5770.20
200_E375_A0.5770.20
347_G457_F0.5760.20
116_V463_G0.5750.20
304_G392_P0.5750.20
196_L245_M0.5720.19
132_P205_I0.5710.19
153_S243_S0.5700.19
316_P320_T0.5690.19
461_M465_T0.5680.19
228_V254_I0.5670.19
387_A463_G0.5670.19
119_V173_L0.5670.19
383_Y461_M0.5660.19
186_R430_L0.5650.19
119_V427_A0.5640.19
290_V304_G0.5640.19
213_A298_F0.5640.19
147_A291_W0.5630.19
262_V352_R0.5630.19
220_S224_V0.5630.19
332_F335_G0.5610.19
113_L228_V0.5600.19
161_P167_R0.5600.19
378_Y461_M0.5600.19
155_V287_I0.5590.19
249_Y380_L0.5590.19
117_V366_R0.5590.19
113_L237_H0.5590.19
345_Y356_T0.5580.19
73_S264_A0.5570.19
248_C286_V0.5540.19
136_F173_L0.5530.19
198_W271_L0.5510.19
181_P184_L0.5480.19
213_A288_G0.5470.19
91_D184_L0.5460.18
173_L254_I0.5450.18
203_F390_L0.5450.18
142_F161_P0.5450.18
429_H432_A0.5430.18
142_F379_H0.5430.18
325_I339_F0.5410.18
70_I75_L0.5400.18
287_I425_V0.5380.18
378_Y429_H0.5370.18
107_V298_F0.5350.18
440_A458_V0.5350.18
116_V333_L0.5350.18
170_A227_A0.5350.18
280_R337_A0.5350.18
126_F243_S0.5350.18
141_A212_L0.5340.18
74_A201_V0.5330.18
241_P416_W0.5290.18
72_A230_V0.5290.18
454_Q461_M0.5290.18
148_A378_Y0.5290.18
450_A461_M0.5290.18
136_F374_V0.5270.18
242_V288_G0.5270.18
290_V296_S0.5270.18
204_P395_V0.5270.18
330_A342_A0.5260.18
296_S378_Y0.5260.18
191_C218_V0.5250.18
189_A281_S0.5220.18
191_C425_V0.5200.17
154_Y467_V0.5200.17
61_L79_F0.5200.17
216_L416_W0.5190.17
163_L173_L0.5190.17
292_E383_Y0.5180.17
158_N240_D0.5180.17
365_V427_A0.5180.17
90_D173_L0.5160.17
253_G449_V0.5150.17
160_W227_A0.5140.17
248_C377_G0.5140.17
350_S471_L0.5120.17
437_H461_M0.5110.17
367_F469_L0.5090.17
63_L125_G0.5080.17
96_L345_Y0.5060.17
377_G382_H0.5050.17
144_G253_G0.5050.17
273_D362_A0.5050.17
208_V350_S0.5050.17
382_H418_N0.5020.17
125_G209_P0.5000.17
107_V118_L0.5000.17
349_W433_V0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.2588 5.8 0.982 Contact Map
2k1aA 1 0.087 5 0.982 Contact Map
4humA 1 0.2547 4.8 0.982 Contact Map
4httA 1 0.2484 4.4 0.983 Contact Map
4b4aA 1 0.2484 4.2 0.983 Contact Map
1sghB 1 0.0331 3.8 0.983 Contact Map
2d10E 1 0.0331 3.5 0.984 Contact Map
2lk9A 1 0.0497 3.3 0.984 Contact Map
2d11E 1 0.0331 3.3 0.984 Contact Map
2ls4A 1 0.0497 3.2 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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