GREMLIN Database
Q9HR11 - Kynureninase
UniProt: Q9HR11 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (333)
Sequences: 35050 (23212)
Seq/√Len: 1272.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
300_Y371_W3.4181.00
304_L374_V3.3121.00
175_T185_V3.2081.00
300_Y367_H3.1581.00
110_T130_V3.1121.00
160_S192_S2.9831.00
170_A173_A2.8341.00
72_R280_D2.7171.00
146_A177_I2.5901.00
110_T128_P2.5411.00
189_L208_G2.5351.00
199_T202_R2.5121.00
146_A180_S2.4891.00
210_W225_G2.4691.00
115_E133_A2.4531.00
110_T150_T2.4011.00
277_G280_D2.3971.00
178_A183_A2.3701.00
144_A147_D2.3571.00
268_D271_A2.2871.00
175_T179_H2.1931.00
300_Y304_L2.1821.00
156_V178_A2.1781.00
304_L371_W2.1641.00
344_R379_T2.1471.00
304_L307_A2.0731.00
34_D38_A2.0231.00
144_A148_A1.9891.00
313_H330_T1.9771.00
296_A367_H1.9761.00
110_T153_T1.9661.00
172_D176_E1.9611.00
78_G199_T1.9421.00
172_D202_R1.8821.00
372_V376_E1.8821.00
358_V373_A1.8761.00
293_H297_L1.8281.00
37_A41_Q1.8121.00
176_E180_S1.8031.00
75_G283_T1.7941.00
158_L174_I1.7841.00
130_V148_A1.7791.00
41_Q45_D1.7711.00
344_R376_E1.7701.00
141_T144_A1.7381.00
88_G92_R1.7291.00
178_A185_V1.7101.00
72_R276_F1.7011.00
94_I120_A1.6931.00
133_A144_A1.6921.00
109_D154_A1.6811.00
110_T152_D1.6761.00
187_F205_V1.6591.00
315_R330_T1.6341.00
173_A176_E1.5991.00
109_D152_D1.5821.00
177_I181_H1.5811.00
313_H332_P1.5761.00
301_V360_P1.5681.00
179_H206_D1.5661.00
135_D139_A1.5621.00
34_D45_D1.5591.00
309_V378_E1.5491.00
339_R343_A1.5331.00
299_W303_G1.5261.00
38_A42_R1.5231.00
340_A380_V1.5181.00
87_A93_T1.5181.00
292_A296_A1.5121.00
97_R207_F1.5101.00
42_R46_Q1.5021.00
142_P177_I1.5001.00
155_V186_G1.4991.00
205_V208_G1.4961.00
142_P173_A1.4801.00
288_T292_A1.4741.00
72_R283_T1.4731.00
179_H204_G1.4601.00
73_V225_G1.4581.00
304_L378_E1.4421.00
158_L185_V1.4281.00
295_V299_W1.4191.00
83_E230_D1.4171.00
71_D75_G1.4131.00
340_A344_R1.4091.00
39_T42_R1.4061.00
149_V177_I1.3841.00
90_S190_A1.3831.00
115_E131_T1.3771.00
367_H371_W1.3731.00
40_L274_P1.3731.00
122_G127_S1.3641.00
212_S275_L1.3631.00
38_A41_Q1.3561.00
146_A181_H1.3511.00
94_I186_G1.3481.00
37_A45_D1.3331.00
175_T204_G1.3241.00
340_A343_A1.3171.00
177_I180_S1.3121.00
298_T302_I1.3121.00
68_L72_R1.3091.00
328_A355_V1.3061.00
291_R295_V1.3051.00
39_T277_G1.3041.00
176_E204_G1.3031.00
33_G281_V1.2951.00
99_V241_T1.2921.00
302_I306_D1.2821.00
303_G307_A1.2801.00
143_A146_A1.2741.00
301_V370_I1.2731.00
171_V187_F1.2721.00
112_V148_A1.2671.00
143_A147_D1.2581.00
68_L276_F1.2491.00
186_G209_V1.2491.00
69_L276_F1.2421.00
161_V323_R1.2371.00
207_F228_V1.2341.00
145_V174_I1.2331.00
306_D318_R1.2311.00
135_D141_T1.2151.00
80_K201_H1.2131.00
47_W61_A1.2131.00
82_S230_D1.2111.00
372_V375_D1.2091.00
146_A173_A1.2081.00
193_A210_W1.2041.00
303_G306_D1.1921.00
113_V131_T1.1851.00
122_G129_V1.1841.00
132_V148_A1.1791.00
215_Y275_L1.1791.00
199_T203_S1.1731.00
280_D284_A1.1731.00
368_E371_W1.1631.00
71_D74_A1.1601.00
293_H296_A1.1531.00
302_I327_V1.1501.00
72_R75_G1.1491.00
156_V183_A1.1451.00
216_L361_S1.1431.00
307_A378_E1.1401.00
122_G125_P1.1371.00
304_L375_D1.1371.00
80_K230_D1.1371.00
108_G154_A1.1351.00
286_G289_E1.1341.00
220_P274_P1.1311.00
101_G184_Y1.1281.00
64_D68_L1.1201.00
375_D379_T1.1151.00
93_T209_V1.1151.00
374_V378_E1.1121.00
128_P150_T1.1071.00
346_V372_V1.1041.00
161_V192_S1.1021.00
366_S369_D1.1011.00
137_A317_P1.0961.00
376_E379_T1.0941.00
142_P146_A1.0931.00
206_D229_H1.0921.00
71_D81_P1.0911.00
112_V153_T1.0881.00
65_Y273_A1.0821.00
289_E292_A1.0721.00
325_G328_A1.0711.00
35_D281_V1.0711.00
297_L370_I1.0681.00
158_L171_V1.0531.00
338_A342_D1.0521.00
348_V356_L1.0491.00
145_V156_V1.0481.00
160_S208_G1.0471.00
207_F232_N1.0401.00
123_E126_A1.0381.00
78_G201_H1.0371.00
76_L193_A1.0311.00
157_Y186_G1.0301.00
336_S340_A1.0221.00
168_L196_V1.0201.00
37_A44_V1.0181.00
333_N336_S1.0141.00
276_F280_D1.0121.00
150_T153_T1.0041.00
130_V150_T1.0041.00
184_Y207_F0.9991.00
323_R326_H0.9891.00
116_G169_L0.9841.00
80_K83_E0.9821.00
371_W375_D0.9811.00
161_V324_G0.9731.00
341_L348_V0.9711.00
302_I314_V0.9701.00
330_T354_D0.9651.00
110_T151_D0.9621.00
200_L227_F0.9601.00
311_D332_P0.9591.00
346_V376_E0.9551.00
122_G126_A0.9541.00
289_E293_H0.9531.00
192_S208_G0.9491.00
277_G281_V0.9381.00
243_W246_P0.9361.00
200_L203_S0.9351.00
179_H185_V0.9341.00
338_A350_V0.9311.00
286_G290_L0.9281.00
335_E339_R0.9271.00
368_E372_V0.9261.00
365_V370_I0.9231.00
42_R45_D0.9161.00
102_F127_S0.9151.00
61_A64_D0.9041.00
84_C227_F0.9031.00
197_D288_T0.9021.00
121_T157_Y0.9021.00
348_V358_V0.9021.00
66_A272_A0.9001.00
339_R342_D0.9001.00
297_L367_H0.8971.00
106_A109_D0.8951.00
178_A182_G0.8921.00
280_D283_T0.8891.00
360_P370_I0.8811.00
74_A79_A0.8811.00
160_S203_S0.8771.00
34_D37_A0.8761.00
142_P145_V0.8751.00
149_V153_T0.8741.00
301_V373_A0.8721.00
76_L279_L0.8711.00
306_D317_P0.8681.00
346_V373_A0.8631.00
298_T327_V0.8591.00
159_P163_P0.8571.00
329_L358_V0.8531.00
175_T203_S0.8441.00
309_V312_C0.8431.00
290_L293_H0.8411.00
101_G207_F0.8401.00
212_S219_G0.8381.00
242_A246_P0.8351.00
229_H232_N0.8331.00
337_V377_L0.8291.00
290_L294_S0.8271.00
212_S223_V0.8271.00
315_R355_V0.8261.00
301_V358_V0.8231.00
67_E71_D0.8231.00
73_V279_L0.8231.00
160_S171_V0.8191.00
149_V181_H0.8151.00
77_I227_F0.8141.00
40_L44_V0.8121.00
305_V329_L0.8111.00
337_V380_V0.8101.00
186_G207_F0.8101.00
77_I210_W0.8091.00
69_L72_R0.8081.00
68_L280_D0.8071.00
204_G229_H0.8071.00
323_R328_A0.8061.00
184_Y232_N0.8051.00
290_L363_Y0.8041.00
338_A348_V0.8031.00
319_A322_R0.8031.00
178_A181_H0.8011.00
198_H202_R0.8001.00
94_I209_V0.7981.00
36_A278_A0.7911.00
95_A99_V0.7841.00
149_V183_A0.7831.00
156_V174_I0.7791.00
48_R51_G0.7791.00
301_V327_V0.7711.00
296_A300_Y0.7701.00
99_V239_A0.7681.00
123_E127_S0.7661.00
285_I289_E0.7651.00
215_Y279_L0.7571.00
223_V271_A0.7531.00
184_Y206_D0.7531.00
223_V272_A0.7511.00
258_H261_E0.7491.00
345_G349_D0.7491.00
33_G36_A0.7471.00
67_E70_G0.7421.00
133_A148_A0.7401.00
300_Y370_I0.7391.00
35_D284_A0.7391.00
336_S339_R0.7391.00
256_A260_A0.7381.00
79_A227_F0.7361.00
60_P63_A0.7331.00
242_A245_T0.7321.00
373_A377_L0.7321.00
172_D203_S0.7301.00
35_D38_A0.7281.00
113_V117_A0.7271.00
301_V374_V0.7261.00
160_S198_H0.7251.00
193_A215_Y0.7251.00
102_F105_A0.7221.00
135_D144_A0.7181.00
151_D181_H0.7121.00
189_L192_S0.7091.00
365_V369_D0.7091.00
69_L272_A0.7051.00
276_F279_L0.7041.00
230_D234_D0.6941.00
174_I185_V0.6941.00
65_Y68_L0.6941.00
189_L193_A0.6931.00
114_P117_A0.6921.00
58_A347_A0.6911.00
77_I200_L0.6891.00
40_L43_A0.6891.00
302_I318_R0.6881.00
173_A177_I0.6851.00
193_A198_H0.6831.00
113_V157_Y0.6811.00
324_G328_A0.6801.00
293_H367_H0.6781.00
85_V96_R0.6771.00
130_V153_T0.6761.00
375_D378_E0.6751.00
139_A169_L0.6741.00
297_L360_P0.6741.00
322_R325_G0.6711.00
39_T43_A0.6711.00
113_V129_V0.6681.00
145_V149_V0.6671.00
237_A241_T0.6631.00
63_A67_E0.6611.00
260_A263_Q0.6601.00
109_D128_P0.6591.00
259_A262_W0.6571.00
323_R327_V0.6561.00
115_E134_A0.6561.00
111_V155_V0.6561.00
278_A282_G0.6541.00
312_C331_H0.6521.00
176_E179_H0.6491.00
172_D204_G0.6481.00
40_L271_A0.6471.00
60_P64_D0.6471.00
371_W374_V0.6471.00
112_V130_V0.6471.00
123_E131_T0.6461.00
90_S94_I0.6441.00
301_V305_V0.6431.00
175_T187_F0.6421.00
305_V377_L0.6411.00
59_E63_A0.6381.00
258_H263_Q0.6371.00
376_E380_V0.6371.00
97_R186_G0.6341.00
37_A42_R0.6331.00
294_S325_G0.6301.00
315_R328_A0.6291.00
35_D277_G0.6281.00
327_V330_T0.6271.00
76_L283_T0.6261.00
143_A173_A0.6261.00
72_R76_L0.6251.00
300_Y303_G0.6251.00
197_D291_R0.6231.00
116_G134_A0.6231.00
258_H262_W0.6221.00
44_V270_Y0.6221.00
288_T291_R0.6211.00
171_V185_V0.6211.00
114_P158_L0.6201.00
34_D41_Q0.6191.00
309_V374_V0.6191.00
142_P174_I0.6171.00
79_A83_E0.6171.00
79_A208_G0.6161.00
192_S196_V0.6151.00
373_A376_E0.6151.00
310_P378_E0.6121.00
72_R279_L0.6121.00
193_A279_L0.6111.00
175_T205_V0.6091.00
148_A151_D0.6091.00
175_T178_A0.6091.00
172_D198_H0.6091.00
83_E201_H0.6071.00
52_D55_W0.6051.00
230_D233_A0.6041.00
49_A52_D0.6031.00
240_R244_L0.6021.00
300_Y374_V0.6011.00
101_G105_A0.6001.00
259_A263_Q0.5991.00
66_A269_V0.5981.00
292_A295_V0.5971.00
160_S187_F0.5951.00
287_I291_R0.5941.00
302_I323_R0.5931.00
296_A299_W0.5911.00
301_V304_L0.5901.00
304_L370_I0.5881.00
117_A121_T0.5881.00
257_S260_A0.5861.00
73_V86_A0.5841.00
74_A81_P0.5811.00
297_L365_V0.5811.00
83_E229_H0.5781.00
132_V144_A0.5781.00
90_S209_V0.5771.00
160_S168_L0.5771.00
97_R226_L0.5761.00
128_P152_D0.5761.00
145_V177_I0.5761.00
322_R326_H0.5751.00
216_L363_Y0.5751.00
307_A310_P0.5741.00
97_R101_G0.5741.00
232_N235_I0.5741.00
75_G78_G0.5731.00
43_A65_Y0.5731.00
68_L71_D0.5721.00
159_P169_L0.5701.00
146_A176_E0.5681.00
239_A242_A0.5661.00
228_V233_A0.5661.00
370_I374_V0.5651.00
33_G37_A0.5651.00
98_L102_F0.5651.00
41_Q44_V0.5641.00
53_G56_T0.5631.00
274_P278_A0.5611.00
159_P162_R0.5601.00
146_A149_V0.5581.00
33_G363_Y0.5581.00
266_P269_V0.5561.00
331_H337_V0.5541.00
47_W51_G0.5531.00
279_L283_T0.5491.00
297_L301_V0.5471.00
241_T244_L0.5461.00
46_Q61_A0.5441.00
37_A40_L0.5431.00
198_H203_S0.5411.00
334_A338_A0.5401.00
190_A211_S0.5391.00
342_D347_A0.5391.00
126_A129_V0.5391.00
240_R246_P0.5381.00
200_L205_V0.5371.00
39_T273_A0.5351.00
91_P95_A0.5341.00
139_A167_Q0.5331.00
116_G120_A0.5321.00
77_I193_A0.5321.00
96_R99_V0.5321.00
240_R243_W0.5301.00
294_S360_P0.5291.00
52_D267_V0.5291.00
158_L187_F0.5291.00
225_G275_L0.5281.00
42_R47_W0.5281.00
212_S225_G0.5271.00
36_A40_L0.5241.00
40_L270_Y0.5241.00
305_V374_V0.5231.00
306_D314_V0.5231.00
112_V132_V0.5211.00
123_E129_V0.5181.00
111_V122_G0.5161.00
80_K229_H0.5161.00
337_V341_L0.5141.00
282_G290_L0.5141.00
179_H183_A0.5131.00
177_I183_A0.5121.00
89_G224_A0.5111.00
38_A45_D0.5111.00
36_A277_G0.5101.00
256_A259_A0.5091.00
344_R380_V0.5091.00
305_V312_C0.5091.00
302_I322_R0.5081.00
214_R357_R0.5081.00
87_A96_R0.5071.00
348_V351_R0.5071.00
98_L121_T0.5071.00
361_S364_Y0.5051.00
309_V381_L0.5051.00
304_L309_V0.5041.00
200_L204_G0.5041.00
328_A331_H0.5041.00
207_F226_L0.5031.00
99_V125_P0.5021.00
126_A131_T0.5011.00
97_R100_A0.5011.00
101_G104_R0.5011.00
111_V157_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e9kA 2 0.9572 100 0.322 Contact Map
1qz9A 2 0.9471 100 0.383 Contact Map
1kmjA 2 0.9421 100 0.4 Contact Map
1t3iA 2 0.9446 100 0.406 Contact Map
4w91A 2 0.9446 100 0.408 Contact Map
4q75A 2 0.9572 100 0.411 Contact Map
1eluA 2 0.9093 100 0.412 Contact Map
4lw2A 2 0.9421 100 0.413 Contact Map
3caiA 2 0.8992 100 0.418 Contact Map
3a9zA 2 0.8791 100 0.44 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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