GREMLIN Database
Q9HR09 - Transcriptional regulatory protein
UniProt: Q9HR09 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (174)
Sequences: 72620 (51726)
Seq/√Len: 3921.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_A51_T3.7211.00
36_A53_Y3.3081.00
40_T51_T3.1911.00
29_V58_A2.7051.00
59_I86_E2.6261.00
56_T77_D2.5391.00
55_G78_V2.3831.00
78_V86_E2.3731.00
50_K66_I2.3481.00
54_S77_D2.2991.00
25_T48_D2.1691.00
25_T50_K2.1101.00
42_W123_R2.0901.00
52_A61_A1.9861.00
178_A181_R1.9771.00
152_K155_L1.9551.00
40_T44_E1.9481.00
74_Q102_V1.8981.00
53_Y57_E1.8411.00
71_L83_V1.8411.00
84_L96_V1.8361.00
98_M113_F1.7751.00
88_R114_D1.7251.00
98_M108_I1.6911.00
27_L52_A1.6851.00
54_S57_E1.6581.00
61_A64_P1.5971.00
50_K61_A1.5801.00
50_K64_P1.5781.00
24_T134_Q1.5721.00
78_V82_D1.5691.00
55_G83_V1.5671.00
86_E90_R1.5621.00
158_E162_P1.5561.00
115_D129_T1.5151.00
170_F181_R1.4921.00
79_S82_D1.4511.00
43_L130_V1.4231.00
159_S163_T1.4131.00
62_I87_L1.4071.00
164_I168_A1.4051.00
86_E89_E1.3891.00
56_T78_V1.3731.00
69_A94_C1.3651.00
84_L98_M1.3571.00
82_D85_D1.3451.00
97_A133_L1.3441.00
183_D186_D1.3311.00
59_I83_V1.3201.00
68_V130_V1.3201.00
30_D36_A1.2941.00
85_D111_L1.2911.00
33_R53_Y1.2741.00
73_R81_D1.2611.00
136_R140_D1.2541.00
29_V75_M1.2461.00
25_T64_P1.2321.00
61_A66_I1.2301.00
59_I78_V1.2161.00
47_Y131_G1.2141.00
73_R98_M1.1951.00
91_G94_C1.1891.00
163_T166_D1.1741.00
71_L84_L1.1601.00
57_E61_A1.1601.00
127_L131_G1.1531.00
27_L66_I1.1481.00
46_D131_G1.1471.00
57_E60_D1.1311.00
27_L58_A1.1181.00
56_T60_D1.1161.00
60_D63_D1.1121.00
26_V47_Y1.1011.00
31_D72_D1.0981.00
27_L61_A1.0931.00
114_D133_L1.0851.00
52_A58_A1.0771.00
164_I172_A1.0721.00
81_D108_I1.0711.00
81_D107_D1.0561.00
154_A158_E1.0531.00
125_T128_E1.0461.00
110_G131_G1.0321.00
153_Q190_D1.0311.00
182_D185_D1.0311.00
167_S170_F1.0271.00
165_T168_A1.0181.00
58_A62_I1.0081.00
81_D111_L1.0071.00
151_R155_L1.0001.00
39_Y99_V0.9951.00
85_D107_D0.9901.00
192_D195_D0.9891.00
37_D51_T0.9791.00
58_A83_V0.9781.00
128_E132_R0.9741.00
164_I170_F0.9581.00
107_D111_L0.9411.00
106_L110_G0.9391.00
168_A172_A0.9391.00
27_L62_I0.9361.00
95_R114_D0.9361.00
33_R37_D0.9341.00
68_V134_Q0.9291.00
24_T47_Y0.9261.00
29_V69_A0.9231.00
184_L196_Y0.9171.00
69_A87_L0.9171.00
149_A153_Q0.9161.00
105_E125_T0.9141.00
169_E172_A0.9091.00
40_T49_V0.9061.00
34_G38_L0.9051.00
155_L158_E0.8961.00
136_R139_Y0.8931.00
52_A57_E0.8891.00
114_D136_R0.8801.00
84_L113_F0.8791.00
29_V52_A0.8781.00
25_T67_D0.8771.00
71_L98_M0.8701.00
107_D110_G0.8691.00
69_A96_V0.8681.00
37_D40_T0.8681.00
84_L111_L0.8651.00
47_Y127_L0.8631.00
28_V39_Y0.8621.00
179_S183_D0.8621.00
136_R144_A0.8551.00
41_I45_D0.8541.00
164_I167_S0.8521.00
159_S172_A0.8461.00
164_I169_E0.8451.00
73_R79_S0.8401.00
178_A185_D0.8371.00
178_A182_D0.8351.00
75_M83_V0.8221.00
82_D86_E0.8221.00
25_T66_I0.8211.00
33_R36_A0.8181.00
62_I91_G0.8161.00
74_Q101_A0.8141.00
85_D89_E0.8131.00
125_T129_T0.8021.00
144_A147_F0.8011.00
71_L96_V0.7971.00
70_L126_L0.7921.00
109_I129_T0.7901.00
184_L188_V0.7871.00
97_A129_T0.7831.00
123_R127_L0.7801.00
28_V49_V0.7791.00
106_L124_D0.7741.00
37_D41_I0.7721.00
24_T138_T0.7691.00
165_T169_E0.7681.00
153_Q156_L0.7611.00
70_L99_V0.7601.00
185_D189_A0.7591.00
62_I66_I0.7541.00
175_S180_L0.7461.00
186_D189_A0.7401.00
73_R102_V0.7351.00
159_S168_A0.7291.00
188_V193_D0.7261.00
39_Y126_L0.7241.00
62_I94_C0.7241.00
87_L96_V0.7231.00
115_D132_R0.7231.00
165_T170_F0.7231.00
29_V83_V0.7231.00
182_D186_D0.7221.00
121_V126_L0.7201.00
140_D144_A0.7141.00
181_R184_L0.7021.00
28_V40_T0.7011.00
159_S173_L0.6991.00
59_I62_I0.6931.00
55_G77_D0.6921.00
108_I113_F0.6881.00
78_V83_V0.6871.00
105_E118_Q0.6861.00
83_V87_L0.6851.00
110_G128_E0.6831.00
36_A40_T0.6821.00
99_V121_V0.6781.00
177_L181_R0.6751.00
55_G59_I0.6701.00
97_A115_D0.6661.00
122_D125_T0.6601.00
137_S140_D0.6591.00
132_R135_R0.6561.00
142_T145_E0.6541.00
139_Y144_A0.6541.00
30_D75_M0.6511.00
129_T133_L0.6471.00
124_D128_E0.6421.00
87_L92_I0.6411.00
141_D144_A0.6401.00
38_L42_W0.6361.00
150_A153_Q0.6341.00
105_E122_D0.6341.00
65_T91_G0.6331.00
158_E161_D0.6331.00
28_V51_T0.6301.00
140_D145_E0.6281.00
95_R134_Q0.6261.00
143_V147_F0.6261.00
103_E107_D0.6241.00
160_D184_L0.6181.00
35_L121_V0.6171.00
121_V125_T0.6161.00
26_V68_V0.6141.00
84_L88_R0.6141.00
137_S141_D0.6131.00
32_E101_A0.6131.00
70_L97_A0.6111.00
101_A120_P0.6081.00
150_A190_D0.6061.00
152_K183_D0.6051.00
62_I69_A0.6051.00
44_E49_V0.6041.00
167_S177_L0.6031.00
166_D172_A0.6011.00
73_R108_I0.6011.00
24_T67_D0.6011.00
149_A152_K0.5921.00
160_D163_T0.5901.00
167_S171_S0.5891.00
139_Y142_T0.5871.00
88_R94_C0.5841.00
71_L75_M0.5791.00
26_V43_L0.5781.00
88_R95_R0.5761.00
100_T116_Y0.5731.00
32_E35_L0.5731.00
70_L130_V0.5721.00
43_L47_Y0.5681.00
159_S162_P0.5651.00
159_S164_I0.5631.00
42_W127_L0.5621.00
35_L38_L0.5561.00
153_Q157_S0.5541.00
161_D164_I0.5541.00
44_E48_D0.5491.00
176_D179_S0.5461.00
175_S179_S0.5441.00
59_I90_R0.5401.00
72_D119_K0.5351.00
115_D133_L0.5321.00
140_D143_V0.5251.00
38_L41_I0.5231.00
31_D100_T0.5201.00
170_F173_L0.5151.00
27_L64_P0.5091.00
128_E131_G0.5081.00
55_G75_M0.5061.00
155_L159_S0.5041.00
106_L109_I0.5031.00
28_V36_A0.5011.00
65_T92_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c3wA 2 0.8826 100 0.328 Contact Map
1yioA 1 0.8685 100 0.334 Contact Map
4gvpA 1 0.8826 100 0.335 Contact Map
1a04A 1 0.8826 100 0.347 Contact Map
4ldzA 2 0.8638 100 0.356 Contact Map
3kloA 2 0.892 100 0.361 Contact Map
4hyeA 2 0.8779 100 0.368 Contact Map
1ys7A 2 0.892 100 0.37 Contact Map
4b09A 2 0.8498 100 0.374 Contact Map
3q9sA 1 0.8451 100 0.377 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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