Q9HR08 - HALSA - GREMLIN Contacts

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Q9HR08 - Galactosyltransferase homolog

UniProt:	Q9HR08	Sequences: MHDRSYTLDDVTVAMGTYNEAAAIDTVLTDIADATDDRARVVCVDGSSDRTPEIAREHGATVIEQEPQGYGVAVAAALDAADTPVVITTDCDNTYPMERIPAFLARINEGYDVVSGDRLYWGADTMPAFNRLGNAAFAAITSLLVGERVHDTTTGMRAYRAPVIDAIDWTQNTGLSAELLIRPLCRNYDVIEEPIGYADRLGDTKLDPLEGGAEILGSILKVCAEERLP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	229 (199)
Sequences:	50733 (42357)
Seq/√Len:	3002.6

ECOLI - ARNC YAIP GTRB YIBD WCAA WCAE PGAC WBBL
BACSU - CSBB YKCC GGAA EPSH YKOT CGED GGAB EPSJ EPSE YDAM YFNE TUAG SPSA YWDF TAGF
HALSA - Q9HR08 Q9HQQ6 Q9HNK3 Q9HQP4 Q9HQP8 Q9HSC8 Q9HSB1 Q9HQP3
SULSO - Q97TZ0 Q7LXF7 Q97X05 Q97TY0 Q97YM4 Q97YG5 Q97UK7 Q97WK7 Q7LXY2 Q97W52 Q7LXG6 Q97YN4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
161_A	165_D	3.377	1.00
20_E	91_C	3.136	1.00
21_A	50_R	3.022	1.00
12_T	83_T	2.524	1.00
17_T	51_T	2.425	1.00
44_V	64_E	2.369	1.00
178_E	182_R	2.328	1.00
102_A	195_I	2.314	1.00
76_A	80_A	2.310	1.00
85_V	107_I	2.273	1.00
52_P	56_R	2.145	1.00
25_D	29_T	2.087	1.00
35_T	101_P	2.078	1.00
50_R	53_E	2.063	1.00
10_D	84_P	2.054	1.00
14_A	77_A	2.024	1.00
111_Y	191_I	2.019	1.00
52_P	64_E	2.019	1.00
43_C	77_A	1.988	1.00
171_Q	175_L	1.984	1.00
74_V	90_D	1.974	1.00
12_T	39_A	1.932	1.00
19_N	48_S	1.924	1.00
163_V	188_Y	1.871	1.00
15_M	40_R	1.829	1.00
44_V	47_S	1.793	1.00
26_T	94_T	1.786	1.00
95_Y	99_R	1.701	1.00
106_R	191_I	1.698	1.00
42_V	55_A	1.697	1.00
70_Y	74_V	1.683	1.00
21_A	54_I	1.681	1.00
25_D	54_I	1.667	1.00
25_D	57_E	1.663	1.00
87_I	158_A	1.656	1.00
106_R	193_E	1.642	1.00
112_D	160_R	1.634	1.00
68_Q	72_V	1.624	1.00
56_R	64_E	1.623	1.00
29_T	58_H	1.621	1.00
103_F	158_A	1.615	1.00
25_D	58_H	1.615	1.00
11_V	104_L	1.593	1.00
99_R	103_F	1.566	1.00
36_D	104_L	1.537	1.00
15_M	27_V	1.524	1.00
202_G	205_K	1.521	1.00
107_I	158_A	1.515	1.00
85_V	158_A	1.509	1.00
39_A	83_T	1.468	1.00
171_Q	174_G	1.445	1.00
52_P	62_V	1.445	1.00
76_A	79_D	1.440	1.00
17_T	42_V	1.439	1.00
98_E	102_A	1.421	1.00
17_T	20_E	1.416	1.00
29_T	33_D	1.411	1.00
18_Y	67_P	1.401	1.00
74_V	88_T	1.392	1.00
102_A	105_A	1.386	1.00
101_P	105_A	1.367	1.00
12_T	81_A	1.364	1.00
78_L	164_I	1.360	1.00
89_T	95_Y	1.347	1.00
87_I	100_I	1.347	1.00
96_P	198_A	1.343	1.00
106_R	109_E	1.339	1.00
112_D	188_Y	1.328	1.00
63_I	80_A	1.314	1.00
45_D	67_P	1.313	1.00
162_P	166_A	1.307	1.00
166_A	188_Y	1.301	1.00
105_A	109_E	1.282	1.00
65_Q	68_Q	1.269	1.00
20_E	23_A	1.254	1.00
166_A	186_R	1.238	1.00
87_I	99_R	1.221	1.00
19_N	47_S	1.216	1.00
30_D	95_Y	1.211	1.00
11_V	100_I	1.208	1.00
172_N	175_L	1.196	1.00
44_V	52_P	1.190	1.00
56_R	59_G	1.185	1.00
26_T	200_R	1.176	1.00
63_I	76_A	1.173	1.00
12_T	41_V	1.171	1.00
54_I	57_E	1.170	1.00
65_Q	76_A	1.167	1.00
28_L	58_H	1.164	1.00
79_D	168_D	1.156	1.00
17_T	91_C	1.155	1.00
157_R	180_L	1.146	1.00
86_V	161_A	1.139	1.00
54_I	58_H	1.123	1.00
81_A	161_A	1.120	1.00
113_V	190_V	1.103	1.00
50_R	54_I	1.094	1.00
104_L	108_N	1.090	1.00
10_D	83_T	1.087	1.00
163_V	183_P	1.076	1.00
43_C	73_A	1.073	1.00
78_L	88_T	1.073	1.00
84_P	160_R	1.072	1.00
10_D	82_D	1.070	1.00
103_F	116_G	1.052	1.00
53_E	56_R	1.047	1.00
162_P	165_D	1.041	1.00
107_I	114_V	1.032	1.00
57_E	61_T	1.018	1.00
87_I	95_Y	1.017	1.00
39_A	82_D	0.996	1.00
78_L	86_V	0.990	1.00
11_V	158_A	0.985	1.00
28_L	40_R	0.978	1.00
53_E	57_E	0.977	1.00
160_R	163_V	0.975	1.00
32_A	58_H	0.958	1.00
98_E	101_P	0.950	1.00
119_L	196_G	0.938	1.00
27_V	89_T	0.937	1.00
55_A	62_V	0.934	1.00
70_Y	154_T	0.924	1.00
35_T	98_E	0.923	1.00
16_G	73_A	0.918	1.00
170_T	175_L	0.918	1.00
13_V	31_I	0.909	1.00
10_D	108_N	0.908	1.00
31_I	89_T	0.906	1.00
102_A	193_E	0.901	1.00
85_V	104_L	0.901	1.00
33_D	97_M	0.900	1.00
117_D	192_E	0.896	1.00
57_E	60_A	0.896	1.00
112_D	189_D	0.884	1.00
72_V	76_A	0.884	1.00
113_V	183_P	0.882	1.00
70_Y	90_D	0.882	1.00
103_F	107_I	0.880	1.00
29_T	32_A	0.875	1.00
28_L	42_V	0.870	1.00
71_G	75_A	0.859	1.00
30_D	94_T	0.857	1.00
106_R	114_V	0.839	1.00
55_A	59_G	0.832	1.00
118_R	155_G	0.830	1.00
107_I	160_R	0.830	1.00
102_A	106_R	0.828	1.00
45_D	73_A	0.824	1.00
45_D	68_Q	0.814	1.00
65_Q	72_V	0.813	1.00
110_G	189_D	0.809	1.00
119_L	198_A	0.808	1.00
26_T	29_T	0.800	1.00
68_Q	73_A	0.800	1.00
164_I	179_L	0.794	1.00
31_I	40_R	0.794	1.00
13_V	87_I	0.794	1.00
96_P	99_R	0.791	1.00
103_F	114_V	0.789	1.00
28_L	32_A	0.784	1.00
99_R	116_G	0.775	1.00
38_R	100_I	0.772	1.00
32_A	61_T	0.768	1.00
17_T	55_A	0.760	1.00
58_H	61_T	0.754	1.00
75_A	79_D	0.749	1.00
24_I	54_I	0.738	1.00
78_L	81_A	0.738	1.00
46_G	65_Q	0.737	1.00
41_V	80_A	0.724	1.00
43_C	76_A	0.717	1.00
73_A	90_D	0.712	1.00
94_T	198_A	0.710	1.00
154_T	157_R	0.706	1.00
104_L	158_A	0.701	1.00
18_Y	45_D	0.699	1.00
105_A	108_N	0.696	1.00
71_G	175_L	0.693	1.00
193_E	196_G	0.691	1.00
27_V	30_D	0.689	1.00
17_T	24_I	0.689	1.00
117_D	194_P	0.688	1.00
35_T	38_R	0.688	1.00
84_P	162_P	0.686	1.00
30_D	98_E	0.682	1.00
130_N	133_G	0.682	1.00
167_I	183_P	0.682	1.00
111_Y	115_S	0.675	1.00
36_D	101_P	0.675	1.00
45_D	69_G	0.673	1.00
41_V	77_A	0.670	1.00
85_V	160_R	0.670	1.00
16_G	91_C	0.667	1.00
24_I	91_C	0.661	1.00
159_Y	164_I	0.658	1.00
170_T	174_G	0.657	1.00
163_V	167_I	0.656	1.00
31_I	95_Y	0.656	1.00
205_K	208_P	0.653	1.00
165_D	168_D	0.652	1.00
202_G	207_D	0.652	1.00
70_Y	73_A	0.650	1.00
99_R	156_M	0.642	1.00
73_A	76_A	0.640	1.00
21_A	53_E	0.637	1.00
52_P	55_A	0.633	1.00
21_A	25_D	0.631	1.00
139_A	143_L	0.630	1.00
46_G	67_P	0.629	1.00
99_R	102_A	0.629	1.00
170_T	173_T	0.625	1.00
29_T	61_T	0.625	1.00
121_W	124_D	0.623	1.00
16_G	45_D	0.623	1.00
13_V	100_I	0.621	1.00
204_T	207_D	0.620	1.00
106_R	111_Y	0.620	1.00
27_V	31_I	0.620	1.00
16_G	74_V	0.617	1.00
125_T	128_A	0.617	1.00
106_R	110_G	0.617	1.00
72_V	171_Q	0.614	1.00
167_I	186_R	0.612	1.00
183_P	188_Y	0.612	1.00
140_I	143_L	0.611	1.00
81_A	86_V	0.609	1.00
56_R	60_A	0.606	1.00
163_V	166_A	0.600	1.00
103_F	106_R	0.597	1.00
24_I	55_A	0.597	1.00
10_D	38_R	0.596	1.00
107_I	111_Y	0.593	1.00
11_V	87_I	0.592	1.00
18_Y	46_G	0.591	1.00
179_L	183_P	0.589	1.00
96_P	119_L	0.588	1.00
10_D	36_D	0.587	1.00
112_D	162_P	0.586	1.00
15_M	91_C	0.586	1.00
68_Q	76_A	0.586	1.00
203_D	206_L	0.583	1.00
41_V	81_A	0.580	1.00
197_Y	200_R	0.579	1.00
112_D	163_V	0.577	1.00
115_S	118_R	0.577	1.00
15_M	31_I	0.575	1.00
59_G	62_V	0.575	1.00
12_T	82_D	0.572	1.00
129_F	133_G	0.570	1.00
35_T	97_M	0.570	1.00
84_P	108_N	0.569	1.00
127_P	130_N	0.563	1.00
159_Y	180_L	0.562	1.00
143_L	146_G	0.559	1.00
87_I	156_M	0.558	1.00
85_V	108_N	0.556	1.00
25_D	61_T	0.555	1.00
128_A	132_L	0.554	1.00
95_Y	100_I	0.554	1.00
86_V	164_I	0.553	1.00
121_W	125_T	0.547	1.00
14_A	43_C	0.547	1.00
202_G	206_L	0.545	1.00
15_M	42_V	0.545	1.00
93_N	200_R	0.545	1.00
36_D	100_I	0.544	1.00
26_T	30_D	0.543	1.00
70_Y	88_T	0.543	1.00
159_Y	179_L	0.543	1.00
88_T	159_Y	0.541	1.00
103_F	156_M	0.541	1.00
126_M	129_F	0.539	1.00
45_D	90_D	0.539	1.00
13_V	38_R	0.539	1.00
21_A	49_D	0.538	1.00
177_A	181_I	0.537	1.00
95_Y	197_Y	0.535	1.00
94_T	200_R	0.529	1.00
48_S	51_T	0.528	1.00
74_V	175_L	0.523	1.00
163_V	187_N	0.521	1.00
111_Y	114_V	0.521	1.00
21_A	24_I	0.520	1.00
47_S	51_T	0.519	1.00
115_S	192_E	0.516	1.00
130_N	134_N	0.516	1.00
32_A	40_R	0.514	1.00
20_E	90_D	0.512	1.00
159_Y	183_P	0.511	1.00
23_A	26_T	0.510	1.00
117_D	120_Y	0.509	1.00
39_A	81_A	0.508	1.00
26_T	201_L	0.508	1.00
10_D	39_A	0.504	1.00
191_I	194_P	0.504	1.00
75_A	171_Q	0.504	1.00
177_A	180_L	0.504	1.00
128_A	131_R	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3l7iA	4	0	100	0.312	Contact Map
3bcvA	2	0.7424	100	0.316	Contact Map
1xhbA	1	0.9825	100	0.322	Contact Map
3ckjA	2	0.9345	100	0.33	Contact Map
5ajoA	1	1	100	0.333	Contact Map
1qg8A	1	0.8777	100	0.334	Contact Map
2z86A	2	0.9738	100	0.337	Contact Map
2d7iA	1	0.9956	100	0.339	Contact Map
4fixA	3	0.9956	100	0.344	Contact Map
3f1yA	2	0.9694	100	0.35	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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