GREMLIN Database
Q9HR08 - Galactosyltransferase homolog
UniProt: Q9HR08 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 229 (199)
Sequences: 50733 (42357)
Seq/√Len: 3002.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_A165_D3.3771.00
20_E91_C3.1361.00
21_A50_R3.0221.00
12_T83_T2.5241.00
17_T51_T2.4251.00
44_V64_E2.3691.00
178_E182_R2.3281.00
102_A195_I2.3141.00
76_A80_A2.3101.00
85_V107_I2.2731.00
52_P56_R2.1451.00
25_D29_T2.0871.00
35_T101_P2.0781.00
50_R53_E2.0631.00
10_D84_P2.0541.00
14_A77_A2.0241.00
111_Y191_I2.0191.00
52_P64_E2.0191.00
43_C77_A1.9881.00
171_Q175_L1.9841.00
74_V90_D1.9741.00
12_T39_A1.9321.00
19_N48_S1.9241.00
163_V188_Y1.8711.00
15_M40_R1.8291.00
44_V47_S1.7931.00
26_T94_T1.7861.00
95_Y99_R1.7011.00
106_R191_I1.6981.00
42_V55_A1.6971.00
70_Y74_V1.6831.00
21_A54_I1.6811.00
25_D54_I1.6671.00
25_D57_E1.6631.00
87_I158_A1.6561.00
106_R193_E1.6421.00
112_D160_R1.6341.00
68_Q72_V1.6241.00
56_R64_E1.6231.00
29_T58_H1.6211.00
103_F158_A1.6151.00
25_D58_H1.6151.00
11_V104_L1.5931.00
99_R103_F1.5661.00
36_D104_L1.5371.00
15_M27_V1.5241.00
202_G205_K1.5211.00
107_I158_A1.5151.00
85_V158_A1.5091.00
39_A83_T1.4681.00
171_Q174_G1.4451.00
52_P62_V1.4451.00
76_A79_D1.4401.00
17_T42_V1.4391.00
98_E102_A1.4211.00
17_T20_E1.4161.00
29_T33_D1.4111.00
18_Y67_P1.4011.00
74_V88_T1.3921.00
102_A105_A1.3861.00
101_P105_A1.3671.00
12_T81_A1.3641.00
78_L164_I1.3601.00
89_T95_Y1.3471.00
87_I100_I1.3471.00
96_P198_A1.3431.00
106_R109_E1.3391.00
112_D188_Y1.3281.00
63_I80_A1.3141.00
45_D67_P1.3131.00
162_P166_A1.3071.00
166_A188_Y1.3011.00
105_A109_E1.2821.00
65_Q68_Q1.2691.00
20_E23_A1.2541.00
166_A186_R1.2381.00
87_I99_R1.2211.00
19_N47_S1.2161.00
30_D95_Y1.2111.00
11_V100_I1.2081.00
172_N175_L1.1961.00
44_V52_P1.1901.00
56_R59_G1.1851.00
26_T200_R1.1761.00
63_I76_A1.1731.00
12_T41_V1.1711.00
54_I57_E1.1701.00
65_Q76_A1.1671.00
28_L58_H1.1641.00
79_D168_D1.1561.00
17_T91_C1.1551.00
157_R180_L1.1461.00
86_V161_A1.1391.00
54_I58_H1.1231.00
81_A161_A1.1201.00
113_V190_V1.1031.00
50_R54_I1.0941.00
104_L108_N1.0901.00
10_D83_T1.0871.00
163_V183_P1.0761.00
43_C73_A1.0731.00
78_L88_T1.0731.00
84_P160_R1.0721.00
10_D82_D1.0701.00
103_F116_G1.0521.00
53_E56_R1.0471.00
162_P165_D1.0411.00
107_I114_V1.0321.00
57_E61_T1.0181.00
87_I95_Y1.0171.00
39_A82_D0.9961.00
78_L86_V0.9901.00
11_V158_A0.9851.00
28_L40_R0.9781.00
53_E57_E0.9771.00
160_R163_V0.9751.00
32_A58_H0.9581.00
98_E101_P0.9501.00
119_L196_G0.9381.00
27_V89_T0.9371.00
55_A62_V0.9341.00
70_Y154_T0.9241.00
35_T98_E0.9231.00
16_G73_A0.9181.00
170_T175_L0.9181.00
13_V31_I0.9091.00
10_D108_N0.9081.00
31_I89_T0.9061.00
102_A193_E0.9011.00
85_V104_L0.9011.00
33_D97_M0.9001.00
117_D192_E0.8961.00
57_E60_A0.8961.00
112_D189_D0.8841.00
72_V76_A0.8841.00
113_V183_P0.8821.00
70_Y90_D0.8821.00
103_F107_I0.8801.00
29_T32_A0.8751.00
28_L42_V0.8701.00
71_G75_A0.8591.00
30_D94_T0.8571.00
106_R114_V0.8391.00
55_A59_G0.8321.00
118_R155_G0.8301.00
107_I160_R0.8301.00
102_A106_R0.8281.00
45_D73_A0.8241.00
45_D68_Q0.8141.00
65_Q72_V0.8131.00
110_G189_D0.8091.00
119_L198_A0.8081.00
26_T29_T0.8001.00
68_Q73_A0.8001.00
164_I179_L0.7941.00
31_I40_R0.7941.00
13_V87_I0.7941.00
96_P99_R0.7911.00
103_F114_V0.7891.00
28_L32_A0.7841.00
99_R116_G0.7751.00
38_R100_I0.7721.00
32_A61_T0.7681.00
17_T55_A0.7601.00
58_H61_T0.7541.00
75_A79_D0.7491.00
24_I54_I0.7381.00
78_L81_A0.7381.00
46_G65_Q0.7371.00
41_V80_A0.7241.00
43_C76_A0.7171.00
73_A90_D0.7121.00
94_T198_A0.7101.00
154_T157_R0.7061.00
104_L158_A0.7011.00
18_Y45_D0.6991.00
105_A108_N0.6961.00
71_G175_L0.6931.00
193_E196_G0.6911.00
27_V30_D0.6891.00
17_T24_I0.6891.00
117_D194_P0.6881.00
35_T38_R0.6881.00
84_P162_P0.6861.00
30_D98_E0.6821.00
130_N133_G0.6821.00
167_I183_P0.6821.00
111_Y115_S0.6751.00
36_D101_P0.6751.00
45_D69_G0.6731.00
41_V77_A0.6701.00
85_V160_R0.6701.00
16_G91_C0.6671.00
24_I91_C0.6611.00
159_Y164_I0.6581.00
170_T174_G0.6571.00
163_V167_I0.6561.00
31_I95_Y0.6561.00
205_K208_P0.6531.00
165_D168_D0.6521.00
202_G207_D0.6521.00
70_Y73_A0.6501.00
99_R156_M0.6421.00
73_A76_A0.6401.00
21_A53_E0.6371.00
52_P55_A0.6331.00
21_A25_D0.6311.00
139_A143_L0.6301.00
46_G67_P0.6291.00
99_R102_A0.6291.00
170_T173_T0.6251.00
29_T61_T0.6251.00
121_W124_D0.6231.00
16_G45_D0.6231.00
13_V100_I0.6211.00
204_T207_D0.6201.00
106_R111_Y0.6201.00
27_V31_I0.6201.00
16_G74_V0.6171.00
125_T128_A0.6171.00
106_R110_G0.6171.00
72_V171_Q0.6141.00
167_I186_R0.6121.00
183_P188_Y0.6121.00
140_I143_L0.6111.00
81_A86_V0.6091.00
56_R60_A0.6061.00
163_V166_A0.6001.00
103_F106_R0.5971.00
24_I55_A0.5971.00
10_D38_R0.5961.00
107_I111_Y0.5931.00
11_V87_I0.5921.00
18_Y46_G0.5911.00
179_L183_P0.5891.00
96_P119_L0.5881.00
10_D36_D0.5871.00
112_D162_P0.5861.00
15_M91_C0.5861.00
68_Q76_A0.5861.00
203_D206_L0.5831.00
41_V81_A0.5801.00
197_Y200_R0.5791.00
112_D163_V0.5771.00
115_S118_R0.5771.00
15_M31_I0.5751.00
59_G62_V0.5751.00
12_T82_D0.5721.00
129_F133_G0.5701.00
35_T97_M0.5701.00
84_P108_N0.5691.00
127_P130_N0.5631.00
159_Y180_L0.5621.00
143_L146_G0.5591.00
87_I156_M0.5581.00
85_V108_N0.5561.00
25_D61_T0.5551.00
128_A132_L0.5541.00
95_Y100_I0.5541.00
86_V164_I0.5531.00
121_W125_T0.5471.00
14_A43_C0.5471.00
202_G206_L0.5451.00
15_M42_V0.5451.00
93_N200_R0.5451.00
36_D100_I0.5441.00
26_T30_D0.5431.00
70_Y88_T0.5431.00
159_Y179_L0.5431.00
88_T159_Y0.5411.00
103_F156_M0.5411.00
126_M129_F0.5391.00
45_D90_D0.5391.00
13_V38_R0.5391.00
21_A49_D0.5381.00
177_A181_I0.5371.00
95_Y197_Y0.5351.00
94_T200_R0.5291.00
48_S51_T0.5281.00
74_V175_L0.5231.00
163_V187_N0.5211.00
111_Y114_V0.5211.00
21_A24_I0.5201.00
47_S51_T0.5191.00
115_S192_E0.5161.00
130_N134_N0.5161.00
32_A40_R0.5141.00
20_E90_D0.5121.00
159_Y183_P0.5111.00
23_A26_T0.5101.00
117_D120_Y0.5091.00
39_A81_A0.5081.00
26_T201_L0.5081.00
10_D39_A0.5041.00
191_I194_P0.5041.00
75_A171_Q0.5041.00
177_A180_L0.5041.00
128_A131_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l7iA 4 0 100 0.312 Contact Map
3bcvA 2 0.7424 100 0.316 Contact Map
1xhbA 1 0.9825 100 0.322 Contact Map
3ckjA 2 0.9345 100 0.33 Contact Map
5ajoA 1 1 100 0.333 Contact Map
1qg8A 1 0.8777 100 0.334 Contact Map
2z86A 2 0.9738 100 0.337 Contact Map
2d7iA 1 0.9956 100 0.339 Contact Map
4fixA 3 0.9956 100 0.344 Contact Map
3f1yA 2 0.9694 100 0.35 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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