GREMLIN Database
Q9HR06 - Spermidine/putrescine ABC transporter ATP-binding
UniProt: Q9HR06 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 377 (311)
Sequences: 20363 (14336)
Seq/√Len: 812.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
241_G245_G4.1081.00
82_T89_R3.9221.00
56_T226_S3.7781.00
144_A149_P3.7321.00
53_E228_R3.5711.00
28_E48_S3.5561.00
321_G337_V3.5291.00
31_G44_D3.5231.00
30_D82_T3.3871.00
40_T43_R3.0931.00
238_E252_S2.9341.00
136_A140_D2.8321.00
324_V338_E2.7771.00
242_D245_G2.6871.00
43_R236_C2.6531.00
151_M154_R2.5641.00
30_D84_E2.5401.00
33_T40_T2.4981.00
55_L230_A2.4871.00
28_E84_E2.4481.00
50_R53_E2.4411.00
29_L32_V2.3801.00
33_T80_G2.3671.00
35_E40_T2.3621.00
120_A124_A2.3441.00
120_A153_D2.3281.00
120_A136_A2.2031.00
138_R176_E2.1871.00
34_K71_M2.1391.00
31_G46_S2.1381.00
33_T44_D2.1381.00
103_E178_D2.1031.00
253_R299_D2.0991.00
120_A140_D2.0971.00
203_R207_E2.0961.00
147_D196_E2.0541.00
84_E89_R2.0411.00
32_V78_P2.0031.00
86_D178_D2.0001.00
233_N238_E1.9021.00
27_L179_I1.8751.00
230_A237_I1.8711.00
42_V71_M1.8701.00
143_L152_G1.8521.00
137_A141_E1.8451.00
230_A240_V1.8371.00
134_A137_A1.8351.00
71_M78_P1.8101.00
34_K79_T1.7431.00
72_L213_V1.7141.00
138_R141_E1.7071.00
339_L342_G1.6841.00
338_E341_N1.6811.00
223_L244_E1.6751.00
140_D144_A1.6451.00
34_K76_E1.6211.00
88_Q178_D1.6201.00
276_T280_S1.6041.00
120_A139_V1.5981.00
281_Y284_A1.5981.00
89_R92_G1.5911.00
69_L215_V1.5891.00
276_T279_G1.5881.00
124_A139_V1.5751.00
71_M83_I1.5601.00
133_D137_A1.5511.00
322_T338_E1.5311.00
35_E79_T1.5191.00
253_R257_S1.5171.00
45_L68_T1.4891.00
85_L90_V1.4871.00
182_L212_A1.4791.00
29_L47_L1.4771.00
55_L240_V1.4721.00
253_R266_S1.4691.00
134_A138_R1.4671.00
70_R76_E1.4501.00
142_M174_A1.4141.00
257_S266_S1.3971.00
244_E248_E1.3911.00
283_R286_L1.3851.00
141_E144_A1.3771.00
118_S121_E1.3741.00
293_Y296_A1.3741.00
124_A135_T1.3691.00
117_L125_F1.3541.00
33_T43_R1.3531.00
146_V170_A1.3481.00
78_P83_I1.3311.00
140_D152_G1.3241.00
30_D46_S1.3091.00
118_S155_S1.2991.00
141_E176_E1.2971.00
121_E124_A1.2971.00
29_L72_L1.2961.00
49_V55_L1.2951.00
47_L230_A1.2821.00
42_V68_T1.2761.00
55_L228_R1.2431.00
326_R335_Y1.2421.00
245_G249_H1.2331.00
205_L212_A1.2151.00
69_L181_L1.2051.00
280_S283_R1.1821.00
82_T91_A1.1791.00
29_L68_T1.1781.00
121_E128_T1.1771.00
268_R297_M1.1701.00
42_V45_L1.1701.00
262_A301_L1.1701.00
266_S299_D1.1671.00
119_V159_L1.1591.00
35_E80_G1.1581.00
126_G175_P1.1541.00
135_T139_V1.1541.00
279_G283_R1.1511.00
228_R240_V1.1471.00
84_E87_A1.1431.00
132_E136_A1.1331.00
277_A280_S1.1331.00
35_E38_A1.1291.00
205_L210_V1.1221.00
202_R225_I1.1081.00
278_V281_Y1.1041.00
50_R228_R1.0941.00
26_V51_E1.0931.00
202_R206_K1.0921.00
78_P91_A1.0911.00
141_E145_L1.0901.00
51_E86_D1.0791.00
35_E41_A1.0641.00
128_T132_E1.0571.00
120_A152_G1.0511.00
292_G296_A1.0371.00
140_D149_P1.0341.00
63_C232_L1.0311.00
105_G172_S1.0311.00
231_V255_V1.0281.00
51_E178_D1.0131.00
68_T232_L1.0071.00
116_H157_D1.0051.00
153_D156_V0.9961.00
29_L83_I0.9961.00
231_V246_V0.9951.00
32_V71_M0.9941.00
83_I90_V0.9911.00
114_F117_L0.9911.00
26_V48_S0.9901.00
130_R175_P0.9861.00
73_A181_L0.9851.00
147_D150_E0.9831.00
124_A128_T0.9831.00
328_Y333_F0.9751.00
292_G295_G0.9741.00
186_F201_V0.9681.00
145_L207_E0.9601.00
132_E135_T0.9581.00
123_V143_L0.9561.00
248_E328_Y0.9561.00
216_T222_A0.9551.00
125_F129_D0.9521.00
276_T281_Y0.9511.00
123_V170_A0.9501.00
155_S158_Q0.9461.00
142_M173_L0.9431.00
282_D285_L0.9371.00
58_L231_V0.9341.00
303_R307_L0.9291.00
244_E328_Y0.9251.00
279_G284_A0.9241.00
176_E210_V0.9221.00
204_I208_A0.9221.00
28_E87_A0.9221.00
54_L205_L0.9181.00
26_V86_D0.9151.00
53_E227_D0.9151.00
31_G80_G0.9041.00
280_S284_A0.9011.00
195_V199_E0.9001.00
114_F126_G0.8991.00
36_Y41_A0.8991.00
52_G209_G0.8981.00
233_N254_F0.8951.00
47_L240_V0.8951.00
54_L212_A0.8911.00
329_T334_I0.8911.00
287_A291_D0.8901.00
321_G339_L0.8891.00
141_E207_E0.8861.00
142_M145_L0.8851.00
57_L230_A0.8851.00
122_N171_R0.8831.00
105_G177_P0.8821.00
37_G40_T0.8791.00
277_A281_Y0.8781.00
279_G282_D0.8761.00
123_V174_A0.8711.00
154_R158_Q0.8651.00
142_M146_V0.8631.00
32_V83_I0.8631.00
136_A139_V0.8571.00
237_I240_V0.8551.00
180_L210_V0.8551.00
49_V211_T0.8501.00
247_F250_P0.8491.00
52_G211_T0.8451.00
338_E343_D0.8441.00
123_V126_G0.8441.00
176_E207_E0.8421.00
56_T222_A0.8341.00
105_G175_P0.8221.00
290_T293_Y0.8181.00
288_G292_G0.8131.00
54_L225_I0.8061.00
186_F214_S0.8011.00
247_F305_D0.8011.00
60_P63_C0.7951.00
302_V307_L0.7911.00
203_R325_K0.7861.00
299_D303_R0.7821.00
70_R75_L0.7781.00
126_G171_R0.7741.00
204_I209_G0.7731.00
202_R224_S0.7731.00
143_L149_P0.7721.00
34_K67_T0.7641.00
272_D275_D0.7631.00
63_C68_T0.7611.00
113_L156_V0.7601.00
323_I335_Y0.7591.00
66_T70_R0.7591.00
71_M76_E0.7541.00
26_V50_R0.7501.00
220_E224_S0.7491.00
270_G297_M0.7491.00
122_N156_V0.7471.00
194_R218_D0.7461.00
300_V303_R0.7451.00
199_E325_K0.7451.00
291_D295_G0.7431.00
200_E203_R0.7431.00
44_D80_G0.7421.00
214_S226_S0.7411.00
289_L292_G0.7371.00
277_A282_D0.7371.00
178_D210_V0.7351.00
191_V195_V0.7291.00
315_A318_A0.7281.00
111_F188_N0.7271.00
169_V182_L0.7271.00
233_N236_C0.7261.00
55_L213_V0.7221.00
128_T135_T0.7211.00
71_M79_T0.7181.00
135_T138_R0.7171.00
264_F301_L0.7161.00
177_P180_L0.7141.00
104_I179_I0.7131.00
295_G298_V0.7091.00
85_L104_I0.7091.00
287_A290_T0.7081.00
199_E336_H0.7031.00
109_Q188_N0.7021.00
196_E200_E0.7011.00
276_T284_A0.7001.00
340_D343_D0.7001.00
36_Y76_E0.6981.00
325_K328_Y0.6981.00
120_A135_T0.6971.00
57_L68_T0.6971.00
30_D48_S0.6961.00
148_M151_M0.6951.00
197_M200_E0.6951.00
143_L146_V0.6941.00
143_L148_M0.6921.00
138_R142_M0.6911.00
254_F258_F0.6871.00
151_M163_Q0.6861.00
215_V219_Q0.6851.00
35_E43_R0.6821.00
117_L122_N0.6811.00
308_R312_V0.6791.00
45_L237_I0.6781.00
287_A292_G0.6781.00
272_D277_A0.6771.00
220_E329_T0.6771.00
191_V198_R0.6741.00
195_V220_E0.6721.00
126_G130_R0.6721.00
290_T294_Q0.6721.00
326_R329_T0.6711.00
201_V212_A0.6691.00
184_E217_H0.6691.00
118_S153_D0.6681.00
117_L121_E0.6651.00
125_F128_T0.6651.00
321_G324_V0.6621.00
181_L213_V0.6611.00
53_E240_V0.6591.00
182_L214_S0.6591.00
192_R257_S0.6591.00
324_V336_H0.6581.00
255_V258_F0.6581.00
188_N198_R0.6561.00
195_V261_Q0.6551.00
323_I326_R0.6511.00
137_A140_D0.6501.00
295_G303_R0.6471.00
253_R264_F0.6451.00
304_P308_R0.6421.00
43_R234_D0.6411.00
241_G246_V0.6401.00
156_V167_V0.6391.00
187_S191_V0.6391.00
302_V305_D0.6361.00
291_D294_Q0.6341.00
222_A226_S0.6341.00
322_T326_R0.6341.00
302_V306_D0.6331.00
329_T332_S0.6331.00
113_L122_N0.6321.00
323_I329_T0.6321.00
300_V305_D0.6311.00
215_V218_D0.6291.00
323_I337_V0.6281.00
77_R92_G0.6281.00
306_D312_V0.6261.00
278_V282_D0.6251.00
288_G295_G0.6241.00
301_L305_D0.6241.00
317_G320_N0.6221.00
269_V298_V0.6211.00
118_S122_N0.6211.00
318_A321_G0.6211.00
232_L237_I0.6201.00
295_G302_V0.6191.00
205_L208_A0.6191.00
139_V142_M0.6191.00
289_L294_Q0.6191.00
304_P307_L0.6181.00
180_L212_A0.6181.00
309_A312_V0.6171.00
73_A106_I0.6081.00
336_H343_D0.6081.00
275_D278_V0.6071.00
274_V281_Y0.6061.00
288_G291_D0.6051.00
281_Y286_L0.6051.00
161_G166_R0.6031.00
333_F336_H0.6031.00
275_D279_G0.6031.00
322_T325_K0.6011.00
338_E342_G0.6011.00
148_M152_G0.6011.00
295_G299_D0.6001.00
280_S286_L0.6001.00
243_P247_F0.5981.00
268_R299_D0.5981.00
281_Y285_L0.5971.00
137_A144_A0.5971.00
264_F299_D0.5961.00
229_V243_P0.5941.00
120_A123_V0.5931.00
26_V179_I0.5931.00
57_L213_V0.5881.00
206_K325_K0.5881.00
288_G296_A0.5851.00
105_G212_A0.5821.00
319_G322_T0.5801.00
276_T285_L0.5791.00
305_D309_A0.5791.00
302_V309_A0.5781.00
138_R143_L0.5781.00
150_E234_D0.5771.00
29_L45_L0.5771.00
314_D317_G0.5741.00
199_E203_R0.5731.00
308_R311_P0.5721.00
145_L203_R0.5721.00
303_R306_D0.5691.00
140_D150_E0.5691.00
325_K336_H0.5681.00
278_V283_R0.5681.00
255_V259_L0.5661.00
27_L85_L0.5651.00
82_T92_G0.5641.00
49_V213_V0.5641.00
54_L214_S0.5621.00
103_E130_R0.5611.00
254_F257_S0.5591.00
144_A150_E0.5591.00
271_S274_V0.5591.00
202_R328_Y0.5581.00
202_R227_D0.5571.00
57_L232_L0.5561.00
324_V343_D0.5561.00
276_T283_R0.5551.00
127_L174_A0.5551.00
263_A266_S0.5541.00
244_E333_F0.5541.00
312_V315_A0.5491.00
306_D309_A0.5491.00
312_V316_T0.5471.00
147_D200_E0.5471.00
326_R330_G0.5461.00
124_A136_A0.5451.00
339_L343_D0.5441.00
149_P152_G0.5441.00
228_R239_Q0.5431.00
289_L295_G0.5431.00
126_G129_D0.5421.00
283_R287_A0.5421.00
150_E163_Q0.5401.00
36_Y67_T0.5401.00
285_L289_L0.5381.00
40_T44_D0.5381.00
169_V225_I0.5351.00
114_F122_N0.5341.00
142_M170_A0.5341.00
214_S225_I0.5321.00
31_G34_K0.5321.00
134_A176_E0.5321.00
292_G306_D0.5321.00
166_R189_L0.5311.00
47_L237_I0.5311.00
279_G286_L0.5291.00
103_E175_P0.5251.00
272_D294_Q0.5251.00
107_V165_Q0.5251.00
231_V250_P0.5241.00
219_Q258_F0.5241.00
127_L130_R0.5221.00
310_A318_A0.5221.00
289_L293_Y0.5201.00
203_R324_V0.5201.00
328_Y331_P0.5201.00
54_L201_V0.5201.00
205_L227_D0.5191.00
145_L173_L0.5191.00
256_A260_G0.5191.00
34_K42_V0.5181.00
119_V167_V0.5171.00
194_R221_E0.5171.00
316_T322_T0.5171.00
60_P254_F0.5161.00
115_P157_D0.5161.00
121_E153_D0.5151.00
301_L304_P0.5141.00
299_D305_D0.5131.00
317_G321_G0.5121.00
36_Y78_P0.5121.00
330_G333_F0.5111.00
49_V179_I0.5101.00
110_D164_Q0.5091.00
288_G293_Y0.5091.00
139_V146_V0.5081.00
269_V276_T0.5081.00
33_T42_V0.5061.00
280_S285_L0.5051.00
154_R157_D0.5051.00
329_T333_F0.5041.00
292_G298_V0.5021.00
247_F251_E0.5021.00
250_P256_A0.5011.00
199_E327_Q0.5001.00
326_R333_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yyzA 1 0.9204 100 0.232 Contact Map
2it1A 1 0.9204 100 0.237 Contact Map
3fvqA 2 0.9231 100 0.239 Contact Map
1v43A 2 0.9045 100 0.239 Contact Map
1g291 4 0.9363 100 0.241 Contact Map
1oxxK 1 0.9098 100 0.241 Contact Map
3rlfA 2 0.9204 100 0.246 Contact Map
3d31A 2 0.9019 100 0.247 Contact Map
1z47A 2 0.9019 100 0.265 Contact Map
4tquS 2 0.9284 100 0.282 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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