GREMLIN Database
Q9HR04 - Iron-binding protein
UniProt: Q9HR04 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 383 (313)
Sequences: 32694 (25716)
Seq/√Len: 1453.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_E103_T3.9861.00
182_T286_D3.5041.00
75_S103_T3.4421.00
148_R312_P3.2471.00
73_E101_S2.9301.00
198_T238_S2.8571.00
237_T241_D2.8521.00
183_N284_P2.7861.00
200_A203_F2.7571.00
238_S242_Q2.5401.00
94_N101_S2.5201.00
92_L321_H2.4611.00
100_F314_L2.4421.00
87_V91_D2.4091.00
200_A204_Q2.3791.00
324_S327_A2.3781.00
193_S196_A2.3701.00
92_L95_Q2.2901.00
234_E238_S2.2711.00
111_Q114_N2.2051.00
153_G156_D2.1851.00
75_S105_Q2.1551.00
92_L96_Y2.1471.00
329_E333_T2.1311.00
88_A91_D2.1191.00
317_L320_R2.1091.00
182_T186_S2.1091.00
92_L330_F2.1051.00
184_Q264_G2.0791.00
128_D311_D2.0111.00
180_Y286_D1.9931.00
311_D314_L1.9901.00
93_I317_L1.9721.00
183_N187_E1.9631.00
147_T304_S1.9571.00
231_A234_E1.9391.00
72_G314_L1.9221.00
185_F265_A1.9121.00
91_D95_Q1.9031.00
71_E101_S1.8841.00
196_A199_T1.8381.00
325_A329_E1.7821.00
90_I94_N1.7781.00
309_A312_P1.7721.00
168_W302_G1.7691.00
313_E317_L1.7501.00
90_I318_Y1.7441.00
235_W238_S1.7031.00
94_N98_D1.7011.00
257_G262_E1.6951.00
148_R307_K1.6901.00
130_F306_L1.6591.00
312_P316_E1.6471.00
234_E237_T1.6291.00
314_L317_L1.6291.00
327_A330_F1.6191.00
201_D205_G1.6101.00
195_D198_T1.6001.00
235_W239_M1.5611.00
108_R111_Q1.5521.00
348_G352_S1.5511.00
91_D94_N1.5491.00
19_A22_S1.5481.00
189_D192_N1.5321.00
181_N184_Q1.5311.00
192_N196_A1.5311.00
20_T23_G1.5291.00
330_F334_R1.5171.00
250_E253_A1.5161.00
198_T242_Q1.5111.00
88_A92_L1.5021.00
195_D199_T1.4811.00
93_I318_Y1.4771.00
305_V319_I1.4511.00
78_L104_Q1.4451.00
93_I321_H1.4441.00
96_Y324_S1.4311.00
330_F333_T1.4261.00
182_T284_P1.4191.00
180_Y288_A1.4141.00
238_S241_D1.4021.00
72_G311_D1.3931.00
256_E260_N1.3871.00
198_T239_M1.3721.00
142_A167_H1.3651.00
129_V315_A1.3531.00
93_I100_F1.3521.00
107_Q111_Q1.3221.00
132_S304_S1.3151.00
90_I104_Q1.3141.00
198_T235_W1.3101.00
257_G263_V1.2891.00
201_D204_Q1.2891.00
207_L210_A1.2771.00
309_A315_A1.2731.00
17_G21_L1.2721.00
253_A256_E1.2701.00
305_V315_A1.2671.00
154_T157_P1.2631.00
316_E320_R1.2601.00
313_E316_E1.2491.00
177_A287_L1.2461.00
149_T152_S1.2441.00
100_F317_L1.2401.00
178_V288_A1.2401.00
129_V318_Y1.2371.00
84_G87_V1.2321.00
326_E329_E1.2181.00
343_G346_P1.2121.00
203_F206_T1.2071.00
77_Y120_Y1.2051.00
178_V265_A1.1961.00
348_G351_P1.1941.00
325_A343_G1.1931.00
71_E99_D1.1901.00
258_I285_L1.1871.00
90_I102_A1.1681.00
156_D159_L1.1661.00
121_E126_Q1.1631.00
202_R206_T1.1601.00
179_P268_T1.1591.00
217_Q220_V1.1551.00
325_A341_I1.1521.00
305_V316_E1.1491.00
128_D309_A1.1431.00
201_D242_Q1.1431.00
275_L278_A1.1351.00
153_G157_P1.1351.00
129_V319_I1.1311.00
321_H327_A1.1151.00
16_T20_T1.1141.00
160_S163_F1.1001.00
303_A319_I1.0981.00
76_I303_A1.0971.00
96_Y326_E1.0931.00
184_Q188_S1.0861.00
74_L318_Y1.0811.00
20_T24_L1.0791.00
200_A205_G1.0791.00
318_Y322_L1.0791.00
231_A235_W1.0781.00
92_L326_E1.0641.00
145_G307_K1.0571.00
220_V224_R1.0551.00
113_A137_S1.0551.00
156_D160_S1.0551.00
74_L314_L1.0541.00
84_G88_A1.0481.00
206_T264_G1.0481.00
274_M278_A1.0441.00
93_I314_L1.0431.00
352_S355_E1.0391.00
88_A334_R1.0381.00
117_V144_N1.0371.00
157_P343_G1.0361.00
197_F265_A1.0341.00
186_S190_I1.0301.00
115_N118_T1.0301.00
130_F304_S1.0291.00
88_A330_F1.0271.00
115_N120_Y1.0271.00
181_N284_P1.0251.00
181_N283_A1.0191.00
16_T22_S1.0091.00
96_Y321_H1.0071.00
85_R88_A1.0061.00
326_E330_F1.0051.00
221_T224_R1.0031.00
306_L309_A1.0021.00
141_V147_T0.9991.00
240_R243_A0.9941.00
139_A143_S0.9931.00
184_Q187_E0.9901.00
202_R205_G0.9891.00
89_L92_L0.9891.00
225_Q228_G0.9861.00
140_Y144_N0.9861.00
180_Y190_I0.9821.00
189_D196_A0.9691.00
219_F223_M0.9671.00
116_I130_F0.9641.00
305_V309_A0.9631.00
307_K312_P0.9621.00
114_N118_T0.9621.00
155_R158_V0.9561.00
17_G23_G0.9461.00
107_Q115_N0.9461.00
268_T272_Y0.9461.00
329_E344_V0.9431.00
168_W304_S0.9421.00
19_A23_G0.9401.00
183_N186_S0.9361.00
21_L24_L0.9361.00
191_P196_A0.9331.00
341_I344_V0.9331.00
236_L240_R0.9301.00
126_Q306_L0.9301.00
171_L303_A0.9241.00
218_G221_T0.9231.00
214_G217_Q0.9191.00
183_N283_A0.9131.00
318_Y321_H0.9101.00
114_N117_V0.9101.00
148_R316_E0.9081.00
15_A19_A0.9081.00
194_V198_T0.9061.00
92_L327_A0.9061.00
147_T167_H0.9061.00
245_T248_R0.9031.00
159_L342_D0.8901.00
67_L70_L0.8871.00
149_T167_H0.8831.00
72_G99_D0.8771.00
237_T240_R0.8741.00
10_R22_S0.8691.00
102_A318_Y0.8671.00
133_I136_G0.8631.00
256_E259_T0.8601.00
252_Q255_S0.8591.00
77_Y127_A0.8491.00
148_R309_A0.8481.00
18_A22_S0.8461.00
222_A227_R0.8451.00
18_A21_L0.8441.00
148_R306_L0.8391.00
89_L327_A0.8391.00
16_T19_A0.8371.00
150_L319_I0.8361.00
347_V351_P0.8281.00
93_I98_D0.8261.00
203_F207_L0.8251.00
94_N102_A0.8241.00
12_F19_A0.8181.00
69_D72_G0.8161.00
113_A117_V0.8161.00
349_P352_S0.8151.00
27_C31_L0.8121.00
201_D206_T0.8121.00
15_A21_L0.8121.00
148_R152_S0.8121.00
74_L311_D0.8071.00
252_Q256_E0.8051.00
224_R227_R0.8041.00
27_C30_M0.8011.00
215_A218_G0.7991.00
218_G224_R0.7961.00
66_D69_D0.7961.00
12_F23_G0.7911.00
320_R324_S0.7901.00
142_A147_T0.7851.00
10_R23_G0.7821.00
233_R237_T0.7791.00
245_T249_N0.7781.00
12_F16_T0.7751.00
15_A22_S0.7751.00
21_L25_A0.7721.00
254_V266_G0.7691.00
105_Q115_N0.7681.00
86_Y89_L0.7651.00
148_R305_V0.7621.00
99_D317_L0.7621.00
192_N291_Q0.7621.00
18_A23_G0.7611.00
111_Q115_N0.7601.00
154_T320_R0.7581.00
232_T236_L0.7581.00
303_A322_L0.7531.00
154_T158_V0.7501.00
208_G263_V0.7501.00
199_T202_R0.7491.00
200_A206_T0.7441.00
272_Y275_L0.7391.00
179_P287_L0.7381.00
215_A223_M0.7361.00
216_F219_F0.7351.00
17_G20_T0.7321.00
315_A319_I0.7311.00
121_E124_T0.7291.00
353_I356_L0.7261.00
342_D346_P0.7251.00
184_Q203_F0.7231.00
188_S206_T0.7191.00
113_A140_Y0.7161.00
179_P285_L0.7151.00
273_P277_F0.7151.00
246_R249_N0.7141.00
174_R299_N0.7141.00
274_M277_F0.7141.00
16_T23_G0.7091.00
219_F222_A0.7071.00
69_D99_D0.7031.00
121_E146_A0.7011.00
12_F15_A0.7001.00
179_P273_P0.6971.00
255_S259_T0.6961.00
142_A164_T0.6951.00
15_A18_A0.6941.00
130_F147_T0.6941.00
218_G222_A0.6891.00
249_N253_A0.6881.00
98_D317_L0.6861.00
22_S25_A0.6861.00
128_D315_A0.6821.00
131_W303_A0.6811.00
183_N261_G0.6801.00
210_A263_V0.6791.00
10_R13_L0.6781.00
216_F224_R0.6751.00
23_G26_G0.6731.00
117_V140_Y0.6721.00
157_P341_I0.6711.00
74_L315_A0.6681.00
349_P353_I0.6661.00
193_S292_N0.6651.00
244_P247_Y0.6641.00
14_A18_A0.6591.00
142_A145_G0.6581.00
312_P315_A0.6581.00
13_L17_G0.6581.00
101_S104_Q0.6541.00
31_L34_N0.6521.00
216_F221_T0.6511.00
186_S284_P0.6511.00
188_S203_F0.6451.00
148_R308_G0.6441.00
13_L16_T0.6441.00
17_G22_S0.6431.00
150_L316_E0.6411.00
27_C32_G0.6411.00
10_R21_L0.6391.00
278_A281_P0.6361.00
27_C33_S0.6341.00
309_A313_E0.6331.00
198_T243_A0.6311.00
72_G100_F0.6311.00
239_M243_A0.6311.00
77_Y107_Q0.6301.00
30_M33_S0.6301.00
33_S36_S0.6301.00
75_S128_D0.6301.00
317_L321_H0.6291.00
257_G260_N0.6291.00
75_S78_L0.6291.00
214_G222_A0.6281.00
124_T308_G0.6271.00
217_Q221_T0.6271.00
10_R19_A0.6251.00
11_T22_S0.6251.00
216_F220_V0.6251.00
174_R301_A0.6251.00
351_P355_E0.6221.00
328_Q340_M0.6221.00
94_N100_F0.6221.00
180_Y185_F0.6221.00
253_A257_G0.6211.00
68_P71_E0.6191.00
89_L322_L0.6181.00
194_V235_W0.6171.00
137_S140_Y0.6161.00
94_N99_D0.6151.00
233_R236_L0.6151.00
76_I131_W0.6141.00
215_A219_F0.6131.00
152_S316_E0.6131.00
138_L142_A0.6131.00
151_S316_E0.6121.00
150_L169_V0.6121.00
13_L20_T0.6111.00
26_G29_G0.6101.00
76_I129_V0.6061.00
223_M228_G0.6061.00
154_T159_L0.6041.00
129_V303_A0.6041.00
191_P265_A0.6031.00
200_A207_L0.6031.00
90_I101_S0.6031.00
217_Q224_R0.6011.00
185_F188_S0.6001.00
213_Y217_Q0.5991.00
113_A141_V0.5971.00
190_I288_A0.5961.00
215_A220_V0.5961.00
155_R159_L0.5941.00
89_L321_H0.5941.00
32_G35_S0.5931.00
255_S268_T0.5921.00
96_Y317_L0.5921.00
159_L162_Q0.5921.00
98_D314_L0.5911.00
325_A328_Q0.5891.00
169_V323_L0.5881.00
291_Q294_A0.5881.00
76_I104_Q0.5881.00
138_L168_W0.5871.00
12_F22_S0.5851.00
200_A208_G0.5841.00
188_S264_G0.5821.00
214_G218_G0.5791.00
203_F264_G0.5781.00
181_N261_G0.5731.00
216_F222_A0.5721.00
138_L304_S0.5711.00
305_V312_P0.5691.00
77_Y105_Q0.5691.00
157_P342_D0.5671.00
220_V223_M0.5671.00
70_L317_L0.5641.00
291_Q295_S0.5631.00
120_Y125_M0.5621.00
118_T123_D0.5571.00
156_D162_Q0.5571.00
89_L330_F0.5551.00
328_Q341_I0.5541.00
11_T14_A0.5541.00
150_L305_V0.5541.00
218_G223_M0.5531.00
172_A301_A0.5501.00
72_G75_S0.5491.00
24_L27_C0.5481.00
70_L73_E0.5471.00
292_N295_S0.5461.00
222_A225_Q0.5451.00
14_A21_L0.5441.00
160_S342_D0.5431.00
132_S141_V0.5421.00
198_T201_D0.5411.00
178_V267_L0.5401.00
219_F224_R0.5381.00
272_Y276_V0.5381.00
96_Y99_D0.5351.00
217_Q222_A0.5351.00
244_P248_R0.5331.00
14_A20_T0.5301.00
10_R20_T0.5291.00
280_R283_A0.5291.00
93_I96_Y0.5281.00
158_V162_Q0.5261.00
351_P354_A0.5241.00
157_P160_S0.5241.00
182_T283_A0.5221.00
105_Q127_A0.5201.00
149_T166_E0.5201.00
71_E98_D0.5201.00
185_F264_G0.5191.00
145_G167_H0.5171.00
185_F203_F0.5171.00
120_Y124_T0.5161.00
223_M226_L0.5161.00
185_F191_P0.5151.00
316_E319_I0.5151.00
131_W171_L0.5141.00
203_F265_A0.5141.00
78_L86_Y0.5131.00
75_S127_A0.5131.00
204_Q207_L0.5121.00
321_H324_S0.5111.00
308_G312_P0.5111.00
271_Y337_A0.5101.00
128_D310_D0.5091.00
311_D315_A0.5091.00
128_D312_P0.5091.00
264_G267_L0.5061.00
25_A29_G0.5051.00
215_A222_A0.5051.00
212_T215_A0.5041.00
249_N257_G0.5041.00
10_R14_A0.5031.00
74_L102_A0.5011.00
76_I318_Y0.5011.00
169_V319_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r2fA 1 0.799 100 0.362 Contact Map
4r9fA 1 0.8094 100 0.363 Contact Map
3waeA 2 0.7911 100 0.37 Contact Map
3uorA 1 0.812 100 0.376 Contact Map
2vozA 3 0.7885 100 0.383 Contact Map
4mfiA 1 0.8094 100 0.391 Contact Map
3c9hA 1 0.8486 100 0.4 Contact Map
2xd3A 1 0.7937 100 0.407 Contact Map
2pt1A 1 0.799 100 0.408 Contact Map
1nnfA 1 0.7885 100 0.41 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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