Q9HR04 - HALSA - GREMLIN Contacts

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Q9HR04 - Iron-binding protein

UniProt:	Q9HR04	Sequences: MSEESGFRRRTFLAATGAATLSGLAGCSGMLGSNSSTDDRPGIGDFRGSGAIVQERPAPGGESIADLPDLEGELSIYLGGGEGGRYVALIDLINQYYDDFSATQQTQRSSQLANNIVTEYENDTMQADVFWSIDAGSLAYVASNGATRTLSSGTRDPVLSEQFTTEHWVGLAGRSRAVPYNTNQFSESDIPNSVDAFTTADRFQGTLGWAPTYGAFQGFVTAMRQLRGDEATREWLTSMRDQAPTRYRNEYQAVSEGITNGEVGAGLTNHYYPMLVFADRPDAPLDLAFTQNDASSLVNTAGASVLKGADDPELAELYIRHLLSAEAQEFLATRGFAFPMIDGVDPVGPLPSIAELSPPEIDLQSLSDVQPTVKLLKDVGILS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	383 (313)
Sequences:	32694 (25716)
Seq/√Len:	1453.5

ECOLI - YCJN THIB YDCS POTD YNJB MALE POTF UGPB
BACSU - CYCB MDXE YURO MSME ARAN YESO YTCQ LIPO
HALSA - Q9HR04 Q9HNZ3 Q9HMT5 Q9HR87 Q9HHQ8 Q9HP00
SULSO - Q97ZC3 Q97YY1 Q97VC2 Q97UZ1 Q97UF5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
73_E	103_T	3.986	1.00
182_T	286_D	3.504	1.00
75_S	103_T	3.442	1.00
148_R	312_P	3.247	1.00
73_E	101_S	2.930	1.00
198_T	238_S	2.857	1.00
237_T	241_D	2.852	1.00
183_N	284_P	2.786	1.00
200_A	203_F	2.757	1.00
238_S	242_Q	2.540	1.00
94_N	101_S	2.520	1.00
92_L	321_H	2.461	1.00
100_F	314_L	2.442	1.00
87_V	91_D	2.409	1.00
200_A	204_Q	2.379	1.00
324_S	327_A	2.378	1.00
193_S	196_A	2.370	1.00
92_L	95_Q	2.290	1.00
234_E	238_S	2.271	1.00
111_Q	114_N	2.205	1.00
153_G	156_D	2.185	1.00
75_S	105_Q	2.155	1.00
92_L	96_Y	2.147	1.00
329_E	333_T	2.131	1.00
88_A	91_D	2.119	1.00
317_L	320_R	2.109	1.00
182_T	186_S	2.109	1.00
92_L	330_F	2.105	1.00
184_Q	264_G	2.079	1.00
128_D	311_D	2.011	1.00
180_Y	286_D	1.993	1.00
311_D	314_L	1.990	1.00
93_I	317_L	1.972	1.00
183_N	187_E	1.963	1.00
147_T	304_S	1.957	1.00
231_A	234_E	1.939	1.00
72_G	314_L	1.922	1.00
185_F	265_A	1.912	1.00
91_D	95_Q	1.903	1.00
71_E	101_S	1.884	1.00
196_A	199_T	1.838	1.00
325_A	329_E	1.782	1.00
90_I	94_N	1.778	1.00
309_A	312_P	1.772	1.00
168_W	302_G	1.769	1.00
313_E	317_L	1.750	1.00
90_I	318_Y	1.744	1.00
235_W	238_S	1.703	1.00
94_N	98_D	1.701	1.00
257_G	262_E	1.695	1.00
148_R	307_K	1.690	1.00
130_F	306_L	1.659	1.00
312_P	316_E	1.647	1.00
234_E	237_T	1.629	1.00
314_L	317_L	1.629	1.00
327_A	330_F	1.619	1.00
201_D	205_G	1.610	1.00
195_D	198_T	1.600	1.00
235_W	239_M	1.561	1.00
108_R	111_Q	1.552	1.00
348_G	352_S	1.551	1.00
91_D	94_N	1.549	1.00
19_A	22_S	1.548	1.00
189_D	192_N	1.532	1.00
181_N	184_Q	1.531	1.00
192_N	196_A	1.531	1.00
20_T	23_G	1.529	1.00
330_F	334_R	1.517	1.00
250_E	253_A	1.516	1.00
198_T	242_Q	1.511	1.00
88_A	92_L	1.502	1.00
195_D	199_T	1.481	1.00
93_I	318_Y	1.477	1.00
305_V	319_I	1.451	1.00
78_L	104_Q	1.445	1.00
93_I	321_H	1.444	1.00
96_Y	324_S	1.431	1.00
330_F	333_T	1.426	1.00
182_T	284_P	1.419	1.00
180_Y	288_A	1.414	1.00
238_S	241_D	1.402	1.00
72_G	311_D	1.393	1.00
256_E	260_N	1.387	1.00
198_T	239_M	1.372	1.00
142_A	167_H	1.365	1.00
129_V	315_A	1.353	1.00
93_I	100_F	1.352	1.00
107_Q	111_Q	1.322	1.00
132_S	304_S	1.315	1.00
90_I	104_Q	1.314	1.00
198_T	235_W	1.310	1.00
257_G	263_V	1.289	1.00
201_D	204_Q	1.289	1.00
207_L	210_A	1.277	1.00
309_A	315_A	1.273	1.00
17_G	21_L	1.272	1.00
253_A	256_E	1.270	1.00
305_V	315_A	1.267	1.00
154_T	157_P	1.263	1.00
316_E	320_R	1.260	1.00
313_E	316_E	1.249	1.00
177_A	287_L	1.246	1.00
149_T	152_S	1.244	1.00
100_F	317_L	1.240	1.00
178_V	288_A	1.240	1.00
129_V	318_Y	1.237	1.00
84_G	87_V	1.232	1.00
326_E	329_E	1.218	1.00
343_G	346_P	1.212	1.00
203_F	206_T	1.207	1.00
77_Y	120_Y	1.205	1.00
178_V	265_A	1.196	1.00
348_G	351_P	1.194	1.00
325_A	343_G	1.193	1.00
71_E	99_D	1.190	1.00
258_I	285_L	1.187	1.00
90_I	102_A	1.168	1.00
156_D	159_L	1.166	1.00
121_E	126_Q	1.163	1.00
202_R	206_T	1.160	1.00
179_P	268_T	1.159	1.00
217_Q	220_V	1.155	1.00
325_A	341_I	1.152	1.00
305_V	316_E	1.149	1.00
128_D	309_A	1.143	1.00
201_D	242_Q	1.143	1.00
275_L	278_A	1.135	1.00
153_G	157_P	1.135	1.00
129_V	319_I	1.131	1.00
321_H	327_A	1.115	1.00
16_T	20_T	1.114	1.00
160_S	163_F	1.100	1.00
303_A	319_I	1.098	1.00
76_I	303_A	1.097	1.00
96_Y	326_E	1.093	1.00
184_Q	188_S	1.086	1.00
74_L	318_Y	1.081	1.00
20_T	24_L	1.079	1.00
200_A	205_G	1.079	1.00
318_Y	322_L	1.079	1.00
231_A	235_W	1.078	1.00
92_L	326_E	1.064	1.00
145_G	307_K	1.057	1.00
220_V	224_R	1.055	1.00
113_A	137_S	1.055	1.00
156_D	160_S	1.055	1.00
74_L	314_L	1.054	1.00
84_G	88_A	1.048	1.00
206_T	264_G	1.048	1.00
274_M	278_A	1.044	1.00
93_I	314_L	1.043	1.00
352_S	355_E	1.039	1.00
88_A	334_R	1.038	1.00
117_V	144_N	1.037	1.00
157_P	343_G	1.036	1.00
197_F	265_A	1.034	1.00
186_S	190_I	1.030	1.00
115_N	118_T	1.030	1.00
130_F	304_S	1.029	1.00
88_A	330_F	1.027	1.00
115_N	120_Y	1.027	1.00
181_N	284_P	1.025	1.00
181_N	283_A	1.019	1.00
16_T	22_S	1.009	1.00
96_Y	321_H	1.007	1.00
85_R	88_A	1.006	1.00
326_E	330_F	1.005	1.00
221_T	224_R	1.003	1.00
306_L	309_A	1.002	1.00
141_V	147_T	0.999	1.00
240_R	243_A	0.994	1.00
139_A	143_S	0.993	1.00
184_Q	187_E	0.990	1.00
202_R	205_G	0.989	1.00
89_L	92_L	0.989	1.00
225_Q	228_G	0.986	1.00
140_Y	144_N	0.986	1.00
180_Y	190_I	0.982	1.00
189_D	196_A	0.969	1.00
219_F	223_M	0.967	1.00
116_I	130_F	0.964	1.00
305_V	309_A	0.963	1.00
307_K	312_P	0.962	1.00
114_N	118_T	0.962	1.00
155_R	158_V	0.956	1.00
17_G	23_G	0.946	1.00
107_Q	115_N	0.946	1.00
268_T	272_Y	0.946	1.00
329_E	344_V	0.943	1.00
168_W	304_S	0.942	1.00
19_A	23_G	0.940	1.00
183_N	186_S	0.936	1.00
21_L	24_L	0.936	1.00
191_P	196_A	0.933	1.00
341_I	344_V	0.933	1.00
236_L	240_R	0.930	1.00
126_Q	306_L	0.930	1.00
171_L	303_A	0.924	1.00
218_G	221_T	0.923	1.00
214_G	217_Q	0.919	1.00
183_N	283_A	0.913	1.00
318_Y	321_H	0.910	1.00
114_N	117_V	0.910	1.00
148_R	316_E	0.908	1.00
15_A	19_A	0.908	1.00
194_V	198_T	0.906	1.00
92_L	327_A	0.906	1.00
147_T	167_H	0.906	1.00
245_T	248_R	0.903	1.00
159_L	342_D	0.890	1.00
67_L	70_L	0.887	1.00
149_T	167_H	0.883	1.00
72_G	99_D	0.877	1.00
237_T	240_R	0.874	1.00
10_R	22_S	0.869	1.00
102_A	318_Y	0.867	1.00
133_I	136_G	0.863	1.00
256_E	259_T	0.860	1.00
252_Q	255_S	0.859	1.00
77_Y	127_A	0.849	1.00
148_R	309_A	0.848	1.00
18_A	22_S	0.846	1.00
222_A	227_R	0.845	1.00
18_A	21_L	0.844	1.00
148_R	306_L	0.839	1.00
89_L	327_A	0.839	1.00
16_T	19_A	0.837	1.00
150_L	319_I	0.836	1.00
347_V	351_P	0.828	1.00
93_I	98_D	0.826	1.00
203_F	207_L	0.825	1.00
94_N	102_A	0.824	1.00
12_F	19_A	0.818	1.00
69_D	72_G	0.816	1.00
113_A	117_V	0.816	1.00
349_P	352_S	0.815	1.00
27_C	31_L	0.812	1.00
201_D	206_T	0.812	1.00
15_A	21_L	0.812	1.00
148_R	152_S	0.812	1.00
74_L	311_D	0.807	1.00
252_Q	256_E	0.805	1.00
224_R	227_R	0.804	1.00
27_C	30_M	0.801	1.00
215_A	218_G	0.799	1.00
218_G	224_R	0.796	1.00
66_D	69_D	0.796	1.00
12_F	23_G	0.791	1.00
320_R	324_S	0.790	1.00
142_A	147_T	0.785	1.00
10_R	23_G	0.782	1.00
233_R	237_T	0.779	1.00
245_T	249_N	0.778	1.00
12_F	16_T	0.775	1.00
15_A	22_S	0.775	1.00
21_L	25_A	0.772	1.00
254_V	266_G	0.769	1.00
105_Q	115_N	0.768	1.00
86_Y	89_L	0.765	1.00
148_R	305_V	0.762	1.00
99_D	317_L	0.762	1.00
192_N	291_Q	0.762	1.00
18_A	23_G	0.761	1.00
111_Q	115_N	0.760	1.00
154_T	320_R	0.758	1.00
232_T	236_L	0.758	1.00
303_A	322_L	0.753	1.00
154_T	158_V	0.750	1.00
208_G	263_V	0.750	1.00
199_T	202_R	0.749	1.00
200_A	206_T	0.744	1.00
272_Y	275_L	0.739	1.00
179_P	287_L	0.738	1.00
215_A	223_M	0.736	1.00
216_F	219_F	0.735	1.00
17_G	20_T	0.732	1.00
315_A	319_I	0.731	1.00
121_E	124_T	0.729	1.00
353_I	356_L	0.726	1.00
342_D	346_P	0.725	1.00
184_Q	203_F	0.723	1.00
188_S	206_T	0.719	1.00
113_A	140_Y	0.716	1.00
179_P	285_L	0.715	1.00
273_P	277_F	0.715	1.00
246_R	249_N	0.714	1.00
174_R	299_N	0.714	1.00
274_M	277_F	0.714	1.00
16_T	23_G	0.709	1.00
219_F	222_A	0.707	1.00
69_D	99_D	0.703	1.00
121_E	146_A	0.701	1.00
12_F	15_A	0.700	1.00
179_P	273_P	0.697	1.00
255_S	259_T	0.696	1.00
142_A	164_T	0.695	1.00
15_A	18_A	0.694	1.00
130_F	147_T	0.694	1.00
218_G	222_A	0.689	1.00
249_N	253_A	0.688	1.00
98_D	317_L	0.686	1.00
22_S	25_A	0.686	1.00
128_D	315_A	0.682	1.00
131_W	303_A	0.681	1.00
183_N	261_G	0.680	1.00
210_A	263_V	0.679	1.00
10_R	13_L	0.678	1.00
216_F	224_R	0.675	1.00
23_G	26_G	0.673	1.00
117_V	140_Y	0.672	1.00
157_P	341_I	0.671	1.00
74_L	315_A	0.668	1.00
349_P	353_I	0.666	1.00
193_S	292_N	0.665	1.00
244_P	247_Y	0.664	1.00
14_A	18_A	0.659	1.00
142_A	145_G	0.658	1.00
312_P	315_A	0.658	1.00
13_L	17_G	0.658	1.00
101_S	104_Q	0.654	1.00
31_L	34_N	0.652	1.00
216_F	221_T	0.651	1.00
186_S	284_P	0.651	1.00
188_S	203_F	0.645	1.00
148_R	308_G	0.644	1.00
13_L	16_T	0.644	1.00
17_G	22_S	0.643	1.00
150_L	316_E	0.641	1.00
27_C	32_G	0.641	1.00
10_R	21_L	0.639	1.00
278_A	281_P	0.636	1.00
27_C	33_S	0.634	1.00
309_A	313_E	0.633	1.00
198_T	243_A	0.631	1.00
72_G	100_F	0.631	1.00
239_M	243_A	0.631	1.00
77_Y	107_Q	0.630	1.00
30_M	33_S	0.630	1.00
33_S	36_S	0.630	1.00
75_S	128_D	0.630	1.00
317_L	321_H	0.629	1.00
257_G	260_N	0.629	1.00
75_S	78_L	0.629	1.00
214_G	222_A	0.628	1.00
124_T	308_G	0.627	1.00
217_Q	221_T	0.627	1.00
10_R	19_A	0.625	1.00
11_T	22_S	0.625	1.00
216_F	220_V	0.625	1.00
174_R	301_A	0.625	1.00
351_P	355_E	0.622	1.00
328_Q	340_M	0.622	1.00
94_N	100_F	0.622	1.00
180_Y	185_F	0.622	1.00
253_A	257_G	0.621	1.00
68_P	71_E	0.619	1.00
89_L	322_L	0.618	1.00
194_V	235_W	0.617	1.00
137_S	140_Y	0.616	1.00
94_N	99_D	0.615	1.00
233_R	236_L	0.615	1.00
76_I	131_W	0.614	1.00
215_A	219_F	0.613	1.00
152_S	316_E	0.613	1.00
138_L	142_A	0.613	1.00
151_S	316_E	0.612	1.00
150_L	169_V	0.612	1.00
13_L	20_T	0.611	1.00
26_G	29_G	0.610	1.00
76_I	129_V	0.606	1.00
223_M	228_G	0.606	1.00
154_T	159_L	0.604	1.00
129_V	303_A	0.604	1.00
191_P	265_A	0.603	1.00
200_A	207_L	0.603	1.00
90_I	101_S	0.603	1.00
217_Q	224_R	0.601	1.00
185_F	188_S	0.600	1.00
213_Y	217_Q	0.599	1.00
113_A	141_V	0.597	1.00
190_I	288_A	0.596	1.00
215_A	220_V	0.596	1.00
155_R	159_L	0.594	1.00
89_L	321_H	0.594	1.00
32_G	35_S	0.593	1.00
255_S	268_T	0.592	1.00
96_Y	317_L	0.592	1.00
159_L	162_Q	0.592	1.00
98_D	314_L	0.591	1.00
325_A	328_Q	0.589	1.00
169_V	323_L	0.588	1.00
291_Q	294_A	0.588	1.00
76_I	104_Q	0.588	1.00
138_L	168_W	0.587	1.00
12_F	22_S	0.585	1.00
200_A	208_G	0.584	1.00
188_S	264_G	0.582	1.00
214_G	218_G	0.579	1.00
203_F	264_G	0.578	1.00
181_N	261_G	0.573	1.00
216_F	222_A	0.572	1.00
138_L	304_S	0.571	1.00
305_V	312_P	0.569	1.00
77_Y	105_Q	0.569	1.00
157_P	342_D	0.567	1.00
220_V	223_M	0.567	1.00
70_L	317_L	0.564	1.00
291_Q	295_S	0.563	1.00
120_Y	125_M	0.562	1.00
118_T	123_D	0.557	1.00
156_D	162_Q	0.557	1.00
89_L	330_F	0.555	1.00
328_Q	341_I	0.554	1.00
11_T	14_A	0.554	1.00
150_L	305_V	0.554	1.00
218_G	223_M	0.553	1.00
172_A	301_A	0.550	1.00
72_G	75_S	0.549	1.00
24_L	27_C	0.548	1.00
70_L	73_E	0.547	1.00
292_N	295_S	0.546	1.00
222_A	225_Q	0.545	1.00
14_A	21_L	0.544	1.00
160_S	342_D	0.543	1.00
132_S	141_V	0.542	1.00
198_T	201_D	0.541	1.00
178_V	267_L	0.540	1.00
219_F	224_R	0.538	1.00
272_Y	276_V	0.538	1.00
96_Y	99_D	0.535	1.00
217_Q	222_A	0.535	1.00
244_P	248_R	0.533	1.00
14_A	20_T	0.530	1.00
10_R	20_T	0.529	1.00
280_R	283_A	0.529	1.00
93_I	96_Y	0.528	1.00
158_V	162_Q	0.526	1.00
351_P	354_A	0.524	1.00
157_P	160_S	0.524	1.00
182_T	283_A	0.522	1.00
105_Q	127_A	0.520	1.00
149_T	166_E	0.520	1.00
71_E	98_D	0.520	1.00
185_F	264_G	0.519	1.00
145_G	167_H	0.517	1.00
185_F	203_F	0.517	1.00
120_Y	124_T	0.516	1.00
223_M	226_L	0.516	1.00
185_F	191_P	0.515	1.00
316_E	319_I	0.515	1.00
131_W	171_L	0.514	1.00
203_F	265_A	0.514	1.00
78_L	86_Y	0.513	1.00
75_S	127_A	0.513	1.00
204_Q	207_L	0.512	1.00
321_H	324_S	0.511	1.00
308_G	312_P	0.511	1.00
271_Y	337_A	0.510	1.00
128_D	310_D	0.509	1.00
311_D	315_A	0.509	1.00
128_D	312_P	0.509	1.00
264_G	267_L	0.506	1.00
25_A	29_G	0.505	1.00
215_A	222_A	0.505	1.00
212_T	215_A	0.504	1.00
249_N	257_G	0.504	1.00
10_R	14_A	0.503	1.00
74_L	102_A	0.501	1.00
76_I	318_Y	0.501	1.00
169_V	319_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4r2fA	1	0.799	100	0.362	Contact Map
4r9fA	1	0.8094	100	0.363	Contact Map
3waeA	2	0.7911	100	0.37	Contact Map
3uorA	1	0.812	100	0.376	Contact Map
2vozA	3	0.7885	100	0.383	Contact Map
4mfiA	1	0.8094	100	0.391	Contact Map
3c9hA	1	0.8486	100	0.4	Contact Map
2xd3A	1	0.7937	100	0.407	Contact Map
2pt1A	1	0.799	100	0.408	Contact Map
1nnfA	1	0.7885	100	0.41	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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