GREMLIN Database
Q9HR03 - Uncharacterized protein
UniProt: Q9HR03 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 333 (283)
Sequences: 225 (122)
Seq/√Len: 7.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_T247_R3.8070.95
186_M244_K3.7070.94
137_G187_N3.4120.91
66_T186_M3.2500.89
66_T244_K2.9640.84
144_D215_D2.9360.83
220_V266_F2.8570.81
244_K247_R2.5180.72
215_D256_E2.4960.71
186_M247_R2.4770.71
65_D147_A2.4070.69
186_M212_R2.3770.67
284_A312_L2.3200.66
64_D252_D2.2940.65
147_A252_D2.2370.63
143_P146_D2.2110.62
144_D256_E2.1150.58
20_R45_S2.1110.58
66_T245_A2.0840.57
142_V242_H2.0750.56
65_D212_R2.0640.56
142_V150_I2.0010.54
150_I252_D1.9830.53
20_R43_Q1.9400.51
66_T242_H1.8990.50
110_P136_Q1.8870.49
186_M242_H1.8600.48
68_P137_G1.8520.48
37_P40_S1.8170.46
111_R144_D1.8160.46
44_T104_S1.8030.46
66_T147_A1.7980.46
212_R252_D1.7980.46
44_T136_Q1.7890.45
65_D216_I1.7660.44
184_C188_L1.7270.43
180_Y190_F1.7190.43
218_S311_Y1.7140.42
290_R293_D1.6900.42
63_D144_D1.6810.41
147_A247_R1.6770.41
66_T142_V1.6720.41
181_L219_G1.6670.41
142_V186_M1.6640.41
111_R215_D1.6580.40
139_W240_C1.6370.40
150_I244_K1.6370.40
66_T150_I1.6320.39
142_V244_K1.6250.39
223_K227_D1.5900.38
127_A130_D1.5840.38
142_V252_D1.5680.37
66_T212_R1.5680.37
65_D151_L1.5610.37
163_R268_E1.5600.37
186_M245_A1.5560.37
51_M55_D1.5450.36
17_G38_A1.5390.36
63_D212_R1.5370.36
147_A212_R1.5140.35
64_D216_I1.5090.35
150_I186_M1.5000.35
64_D150_I1.4990.34
146_D256_E1.4960.34
32_Y39_A1.4860.34
101_L235_N1.4730.34
197_A284_A1.4660.33
66_T252_D1.4630.33
51_M195_I1.4580.33
201_F218_S1.4470.33
55_D312_L1.4310.32
65_D252_D1.4030.31
63_D215_D1.3980.31
213_F217_W1.3930.31
221_V287_V1.3530.30
235_N245_A1.3510.29
60_V189_A1.3510.29
146_D215_D1.3510.29
50_Y180_Y1.3440.29
65_D186_M1.3370.29
57_E64_D1.3340.29
151_L244_K1.3290.29
44_T61_F1.3250.29
247_R252_D1.3210.28
134_A227_D1.3040.28
287_V312_L1.3030.28
65_D111_R1.2980.28
100_V301_N1.2950.28
183_V219_G1.2830.27
133_V183_V1.2700.27
33_D36_V1.2630.27
20_R247_R1.2530.26
68_P187_N1.2510.26
186_M252_D1.2480.26
212_R242_H1.2460.26
24_Y36_V1.2460.26
17_G21_E1.2460.26
99_N110_P1.2410.26
43_Q184_C1.2050.25
134_A222_L1.2010.25
44_T149_R1.1850.24
211_G242_H1.1830.24
16_D19_A1.1810.24
101_L149_R1.1810.24
138_L146_D1.1730.24
181_L262_L1.1710.24
209_D259_G1.1710.24
65_D247_R1.1640.24
213_F259_G1.1600.24
113_Y194_V1.1550.24
114_P215_D1.1540.23
225_A309_G1.1540.23
197_A280_Y1.1360.23
61_F214_D1.1260.23
292_A297_D1.1180.22
113_Y145_L1.1170.22
138_L147_A1.1080.22
196_P221_V1.1060.22
70_D300_N1.1060.22
44_T118_M1.1050.22
216_I252_D1.0960.22
162_T239_L1.0950.22
20_R184_C1.0890.22
147_A242_H1.0880.22
41_H136_Q1.0860.22
150_I245_A1.0770.21
55_D235_N1.0770.21
287_V297_D1.0750.21
244_K252_D1.0740.21
143_P256_E1.0710.21
288_G297_D1.0700.21
23_W30_G1.0600.21
291_L305_L1.0550.21
193_E238_P1.0530.21
137_G185_S1.0520.21
210_V213_F1.0490.21
59_G175_A1.0490.21
43_Q51_M1.0470.21
104_S308_C1.0450.21
219_G236_G1.0440.21
184_C200_Q1.0400.20
212_R215_D1.0400.20
186_M260_L1.0370.20
135_S187_N1.0370.20
280_Y284_A1.0330.20
142_V247_R1.0330.20
308_C312_L1.0310.20
42_A217_W1.0300.20
52_W198_F1.0290.20
139_W239_L1.0290.20
71_E285_E1.0250.20
197_A222_L1.0150.20
143_P244_K1.0120.20
211_G214_D1.0110.20
242_H247_R1.0100.20
217_W263_N1.0090.20
63_D111_R1.0010.19
63_D216_I0.9980.19
113_Y131_H0.9960.19
216_I256_E0.9950.19
22_Q36_V0.9870.19
66_T184_C0.9870.19
61_F218_S0.9800.19
97_W100_V0.9780.19
239_L301_N0.9760.19
18_A251_D0.9750.19
138_L256_E0.9720.19
195_I200_Q0.9680.19
65_D244_K0.9660.19
119_D285_E0.9610.19
109_Y115_Y0.9590.18
127_A174_V0.9580.18
44_T101_L0.9540.18
41_H211_G0.9520.18
224_R227_D0.9500.18
272_A290_R0.9430.18
188_L198_F0.9420.18
192_R196_P0.9320.18
197_A238_P0.9230.18
42_A147_A0.9210.18
109_Y260_L0.9180.18
144_D216_I0.9140.17
200_Q214_D0.9130.17
142_V216_I0.9120.17
46_F235_N0.9120.17
273_A287_V0.9110.17
109_Y118_M0.9100.17
106_S296_Y0.9090.17
50_Y301_N0.9080.17
181_L258_A0.9080.17
100_V291_L0.9070.17
195_I218_S0.8980.17
151_L212_R0.8980.17
242_H245_A0.8960.17
248_S278_E0.8950.17
123_T176_A0.8910.17
128_E272_A0.8900.17
51_M59_G0.8870.17
152_M227_D0.8850.17
150_I247_R0.8850.17
151_L242_H0.8840.17
272_A293_D0.8790.17
221_V284_A0.8740.17
54_H176_A0.8710.16
184_C242_H0.8690.16
136_Q149_R0.8690.16
24_Y141_N0.8660.16
54_H259_G0.8620.16
41_H214_D0.8600.16
112_G216_I0.8590.16
194_V297_D0.8570.16
43_Q247_R0.8550.16
200_Q219_G0.8520.16
39_A220_V0.8490.16
44_T260_L0.8460.16
43_Q186_M0.8430.16
220_V313_L0.8390.16
308_C311_Y0.8380.16
109_Y209_D0.8340.16
196_P259_G0.8320.16
134_A175_A0.8320.16
172_D238_P0.8260.16
74_F226_A0.8260.16
196_P273_A0.8190.15
199_Y283_V0.8180.15
99_N112_G0.8160.15
233_I280_Y0.8140.15
24_Y43_Q0.8090.15
195_I201_F0.8090.15
199_Y305_L0.8070.15
35_L174_V0.8060.15
222_L236_G0.8060.15
201_F308_C0.8040.15
98_V283_V0.8030.15
20_R188_L0.8030.15
135_S227_D0.7960.15
136_Q260_L0.7840.15
65_D217_W0.7840.15
244_K260_L0.7810.15
151_L186_M0.7800.15
152_M259_G0.7800.15
41_H44_T0.7800.15
111_R256_E0.7780.15
258_A262_L0.7730.14
212_R244_K0.7680.14
143_P151_L0.7620.14
213_F267_W0.7620.14
292_A302_G0.7610.14
45_S247_R0.7590.14
275_P283_V0.7580.14
147_A150_I0.7580.14
99_N145_L0.7560.14
30_G198_F0.7530.14
64_D186_M0.7490.14
241_E246_P0.7480.14
61_F301_N0.7430.14
225_A273_A0.7370.14
20_R244_K0.7370.14
44_T218_S0.7360.14
139_W242_H0.7330.14
31_E313_L0.7300.14
128_E268_E0.7280.14
118_M260_L0.7260.14
90_S290_R0.7260.14
57_E141_N0.7180.13
125_G131_H0.7140.13
19_A96_R0.7130.13
43_Q150_I0.7120.13
195_I308_C0.7120.13
221_V231_G0.7100.13
268_E278_E0.7090.13
187_N236_G0.7080.13
67_L241_E0.7080.13
43_Q66_T0.7070.13
279_T282_G0.7070.13
43_Q244_K0.7070.13
20_R240_C0.7020.13
65_D242_H0.7010.13
20_R182_T0.6970.13
40_S139_W0.6960.13
62_I242_H0.6950.13
198_F218_S0.6950.13
133_V181_L0.6940.13
135_S223_K0.6930.13
151_L245_A0.6880.13
226_A231_G0.6850.13
132_V135_S0.6840.13
98_V265_H0.6820.13
35_L213_F0.6800.13
180_Y291_L0.6800.13
97_W199_Y0.6740.13
42_A214_D0.6720.13
116_A264_E0.6660.13
221_V241_E0.6660.13
43_Q145_L0.6630.12
53_A95_E0.6630.12
149_R260_L0.6620.12
151_L252_D0.6620.12
56_F188_L0.6590.12
196_P199_Y0.6590.12
17_G251_D0.6580.12
186_M211_G0.6550.12
56_F311_Y0.6540.12
221_V288_G0.6530.12
128_E309_G0.6510.12
112_G144_D0.6500.12
51_M235_N0.6390.12
70_D233_I0.6370.12
221_V291_L0.6360.12
266_F287_V0.6360.12
101_L226_A0.6320.12
30_G311_Y0.6320.12
149_R253_L0.6310.12
45_S270_V0.6310.12
97_W259_G0.6290.12
150_I188_L0.6290.12
285_E296_Y0.6280.12
98_V275_P0.6280.12
189_A196_P0.6260.12
19_A152_M0.6240.12
37_P143_P0.6230.12
224_R265_H0.6210.12
284_A288_G0.6210.12
60_V213_F0.6190.12
128_E269_E0.6170.12
96_R103_Q0.6160.12
182_T240_C0.6140.12
32_Y274_D0.6140.12
109_Y136_Q0.6130.12
142_V184_C0.6110.12
44_T139_W0.6080.12
199_Y267_W0.6050.12
97_W280_Y0.6040.12
115_Y201_F0.6030.11
35_L68_P0.6030.11
187_N239_L0.6030.11
230_G310_E0.5990.11
110_P147_A0.5990.11
104_S198_F0.5970.11
111_R216_I0.5970.11
51_M223_K0.5970.11
184_C244_K0.5940.11
148_V175_A0.5940.11
48_L198_F0.5930.11
22_Q276_A0.5920.11
242_H252_D0.5920.11
224_R228_V0.5890.11
158_G313_L0.5860.11
258_A296_Y0.5820.11
183_V242_H0.5810.11
212_R247_R0.5800.11
32_Y37_P0.5790.11
162_T283_V0.5770.11
188_L245_A0.5770.11
20_R245_A0.5750.11
110_P252_D0.5740.11
115_Y218_S0.5740.11
20_R111_R0.5730.11
175_A179_D0.5710.11
60_V176_A0.5710.11
178_G296_Y0.5700.11
55_D188_L0.5690.11
63_D256_E0.5680.11
20_R66_T0.5680.11
87_P268_E0.5680.11
39_A53_A0.5670.11
97_W196_P0.5630.11
86_G163_R0.5610.11
106_S175_A0.5610.11
61_F190_F0.5570.11
273_A311_Y0.5560.11
211_G252_D0.5560.11
177_E290_R0.5540.11
101_L308_C0.5510.11
48_L201_F0.5500.11
150_I260_L0.5500.11
122_T224_R0.5490.11
41_H48_L0.5490.11
171_R297_D0.5460.11
118_M280_Y0.5460.11
233_I283_V0.5450.11
263_N267_W0.5440.11
184_C249_T0.5390.11
15_F20_R0.5380.10
100_V219_G0.5380.10
143_P252_D0.5360.10
196_P284_A0.5340.10
83_H272_A0.5340.10
137_G190_F0.5330.10
220_V263_N0.5320.10
45_S267_W0.5320.10
96_R130_D0.5310.10
78_H280_Y0.5310.10
19_A22_Q0.5290.10
225_A267_W0.5290.10
53_A98_V0.5280.10
242_H260_L0.5280.10
197_A229_V0.5270.10
101_L135_S0.5260.10
141_N238_P0.5260.10
47_G216_I0.5240.10
51_M56_F0.5240.10
227_D238_P0.5230.10
121_T126_Q0.5220.10
128_E282_G0.5210.10
95_E313_L0.5200.10
39_A46_F0.5170.10
145_L245_A0.5170.10
63_D252_D0.5170.10
183_V260_L0.5150.10
136_Q209_D0.5100.10
171_R237_A0.5090.10
296_Y308_C0.5080.10
60_V248_S0.5080.10
75_F78_H0.5070.10
143_P215_D0.5060.10
201_F312_L0.5050.10
183_V190_F0.5040.10
122_T287_V0.5040.10
13_A89_E0.5030.10
136_Q145_L0.5030.10
221_V297_D0.5020.10
200_Q240_C0.5020.10
171_R287_V0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fy7A 1 0.5495 32.1 0.972 Contact Map
4ob0B 1 0.2462 29.8 0.972 Contact Map
1qg8A 1 0.5826 18.9 0.975 Contact Map
2bo4A 4 0.8438 16.5 0.975 Contact Map
2nxvA 4 0.5826 13 0.977 Contact Map
2d0jA 2 0.5465 12 0.977 Contact Map
4irpA 2 0.5435 10.8 0.977 Contact Map
4zgjB 2 0.2462 10.8 0.977 Contact Map
4gr2A 2 0.3183 10.5 0.978 Contact Map
3qyhB 1 0.2462 9.7 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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