Q9HR03 - HALSA - GREMLIN Contacts

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Q9HR03 - Uncharacterized protein

UniProt:	Q9HR03	Sequences: MRDLLAAEDVAGAVFDGAAREQWYDDHDIGEYDHLVPAASHAQTSFGLLYMWAHDFEYGVFIDDDTLPHDEWDFFGRHLENLHHEGPVESVSSDERWVNVLYQSDSALYPRGYPYAAMDETTTTGQAETDHVVASQGLWTNVPDLDAVRILMDGDLRGQAQTRTETADFDRDFVAAEGDYLTVCSMNLAFRREVIPAFYQFPMDDNAWDVGRFDDIWSGVVLKRAADVVGGDIYNGAPLCEHNKAPRSTFDDLANEVAGLELNEHFWEEVAAADPATETYAGVAEAVGRRLADGEYDSYNNGAFLNECGEYLLDWVACLDALADREIAAAAGD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	333 (283)
Sequences:	225 (122)
Seq/√Len:	7.3

HALSA - Q9HR03

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
66_T	247_R	3.807	0.95
186_M	244_K	3.707	0.94
137_G	187_N	3.412	0.91
66_T	186_M	3.250	0.89
66_T	244_K	2.964	0.84
144_D	215_D	2.936	0.83
220_V	266_F	2.857	0.81
244_K	247_R	2.518	0.72
215_D	256_E	2.496	0.71
186_M	247_R	2.477	0.71
65_D	147_A	2.407	0.69
186_M	212_R	2.377	0.67
284_A	312_L	2.320	0.66
64_D	252_D	2.294	0.65
147_A	252_D	2.237	0.63
143_P	146_D	2.211	0.62
144_D	256_E	2.115	0.58
20_R	45_S	2.111	0.58
66_T	245_A	2.084	0.57
142_V	242_H	2.075	0.56
65_D	212_R	2.064	0.56
142_V	150_I	2.001	0.54
150_I	252_D	1.983	0.53
20_R	43_Q	1.940	0.51
66_T	242_H	1.899	0.50
110_P	136_Q	1.887	0.49
186_M	242_H	1.860	0.48
68_P	137_G	1.852	0.48
37_P	40_S	1.817	0.46
111_R	144_D	1.816	0.46
44_T	104_S	1.803	0.46
66_T	147_A	1.798	0.46
212_R	252_D	1.798	0.46
44_T	136_Q	1.789	0.45
65_D	216_I	1.766	0.44
184_C	188_L	1.727	0.43
180_Y	190_F	1.719	0.43
218_S	311_Y	1.714	0.42
290_R	293_D	1.690	0.42
63_D	144_D	1.681	0.41
147_A	247_R	1.677	0.41
66_T	142_V	1.672	0.41
181_L	219_G	1.667	0.41
142_V	186_M	1.664	0.41
111_R	215_D	1.658	0.40
139_W	240_C	1.637	0.40
150_I	244_K	1.637	0.40
66_T	150_I	1.632	0.39
142_V	244_K	1.625	0.39
223_K	227_D	1.590	0.38
127_A	130_D	1.584	0.38
142_V	252_D	1.568	0.37
66_T	212_R	1.568	0.37
65_D	151_L	1.561	0.37
163_R	268_E	1.560	0.37
186_M	245_A	1.556	0.37
51_M	55_D	1.545	0.36
17_G	38_A	1.539	0.36
63_D	212_R	1.537	0.36
147_A	212_R	1.514	0.35
64_D	216_I	1.509	0.35
150_I	186_M	1.500	0.35
64_D	150_I	1.499	0.34
146_D	256_E	1.496	0.34
32_Y	39_A	1.486	0.34
101_L	235_N	1.473	0.34
197_A	284_A	1.466	0.33
66_T	252_D	1.463	0.33
51_M	195_I	1.458	0.33
201_F	218_S	1.447	0.33
55_D	312_L	1.431	0.32
65_D	252_D	1.403	0.31
63_D	215_D	1.398	0.31
213_F	217_W	1.393	0.31
221_V	287_V	1.353	0.30
235_N	245_A	1.351	0.29
60_V	189_A	1.351	0.29
146_D	215_D	1.351	0.29
50_Y	180_Y	1.344	0.29
65_D	186_M	1.337	0.29
57_E	64_D	1.334	0.29
151_L	244_K	1.329	0.29
44_T	61_F	1.325	0.29
247_R	252_D	1.321	0.28
134_A	227_D	1.304	0.28
287_V	312_L	1.303	0.28
65_D	111_R	1.298	0.28
100_V	301_N	1.295	0.28
183_V	219_G	1.283	0.27
133_V	183_V	1.270	0.27
33_D	36_V	1.263	0.27
20_R	247_R	1.253	0.26
68_P	187_N	1.251	0.26
186_M	252_D	1.248	0.26
212_R	242_H	1.246	0.26
24_Y	36_V	1.246	0.26
17_G	21_E	1.246	0.26
99_N	110_P	1.241	0.26
43_Q	184_C	1.205	0.25
134_A	222_L	1.201	0.25
44_T	149_R	1.185	0.24
211_G	242_H	1.183	0.24
16_D	19_A	1.181	0.24
101_L	149_R	1.181	0.24
138_L	146_D	1.173	0.24
181_L	262_L	1.171	0.24
209_D	259_G	1.171	0.24
65_D	247_R	1.164	0.24
213_F	259_G	1.160	0.24
113_Y	194_V	1.155	0.24
114_P	215_D	1.154	0.23
225_A	309_G	1.154	0.23
197_A	280_Y	1.136	0.23
61_F	214_D	1.126	0.23
292_A	297_D	1.118	0.22
113_Y	145_L	1.117	0.22
138_L	147_A	1.108	0.22
196_P	221_V	1.106	0.22
70_D	300_N	1.106	0.22
44_T	118_M	1.105	0.22
216_I	252_D	1.096	0.22
162_T	239_L	1.095	0.22
20_R	184_C	1.089	0.22
147_A	242_H	1.088	0.22
41_H	136_Q	1.086	0.22
150_I	245_A	1.077	0.21
55_D	235_N	1.077	0.21
287_V	297_D	1.075	0.21
244_K	252_D	1.074	0.21
143_P	256_E	1.071	0.21
288_G	297_D	1.070	0.21
23_W	30_G	1.060	0.21
291_L	305_L	1.055	0.21
193_E	238_P	1.053	0.21
137_G	185_S	1.052	0.21
210_V	213_F	1.049	0.21
59_G	175_A	1.049	0.21
43_Q	51_M	1.047	0.21
104_S	308_C	1.045	0.21
219_G	236_G	1.044	0.21
184_C	200_Q	1.040	0.20
212_R	215_D	1.040	0.20
186_M	260_L	1.037	0.20
135_S	187_N	1.037	0.20
280_Y	284_A	1.033	0.20
142_V	247_R	1.033	0.20
308_C	312_L	1.031	0.20
42_A	217_W	1.030	0.20
52_W	198_F	1.029	0.20
139_W	239_L	1.029	0.20
71_E	285_E	1.025	0.20
197_A	222_L	1.015	0.20
143_P	244_K	1.012	0.20
211_G	214_D	1.011	0.20
242_H	247_R	1.010	0.20
217_W	263_N	1.009	0.20
63_D	111_R	1.001	0.19
63_D	216_I	0.998	0.19
113_Y	131_H	0.996	0.19
216_I	256_E	0.995	0.19
22_Q	36_V	0.987	0.19
66_T	184_C	0.987	0.19
61_F	218_S	0.980	0.19
97_W	100_V	0.978	0.19
239_L	301_N	0.976	0.19
18_A	251_D	0.975	0.19
138_L	256_E	0.972	0.19
195_I	200_Q	0.968	0.19
65_D	244_K	0.966	0.19
119_D	285_E	0.961	0.19
109_Y	115_Y	0.959	0.18
127_A	174_V	0.958	0.18
44_T	101_L	0.954	0.18
41_H	211_G	0.952	0.18
224_R	227_D	0.950	0.18
272_A	290_R	0.943	0.18
188_L	198_F	0.942	0.18
192_R	196_P	0.932	0.18
197_A	238_P	0.923	0.18
42_A	147_A	0.921	0.18
109_Y	260_L	0.918	0.18
144_D	216_I	0.914	0.17
200_Q	214_D	0.913	0.17
142_V	216_I	0.912	0.17
46_F	235_N	0.912	0.17
273_A	287_V	0.911	0.17
109_Y	118_M	0.910	0.17
106_S	296_Y	0.909	0.17
50_Y	301_N	0.908	0.17
181_L	258_A	0.908	0.17
100_V	291_L	0.907	0.17
195_I	218_S	0.898	0.17
151_L	212_R	0.898	0.17
242_H	245_A	0.896	0.17
248_S	278_E	0.895	0.17
123_T	176_A	0.891	0.17
128_E	272_A	0.890	0.17
51_M	59_G	0.887	0.17
152_M	227_D	0.885	0.17
150_I	247_R	0.885	0.17
151_L	242_H	0.884	0.17
272_A	293_D	0.879	0.17
221_V	284_A	0.874	0.17
54_H	176_A	0.871	0.16
184_C	242_H	0.869	0.16
136_Q	149_R	0.869	0.16
24_Y	141_N	0.866	0.16
54_H	259_G	0.862	0.16
41_H	214_D	0.860	0.16
112_G	216_I	0.859	0.16
194_V	297_D	0.857	0.16
43_Q	247_R	0.855	0.16
200_Q	219_G	0.852	0.16
39_A	220_V	0.849	0.16
44_T	260_L	0.846	0.16
43_Q	186_M	0.843	0.16
220_V	313_L	0.839	0.16
308_C	311_Y	0.838	0.16
109_Y	209_D	0.834	0.16
196_P	259_G	0.832	0.16
134_A	175_A	0.832	0.16
172_D	238_P	0.826	0.16
74_F	226_A	0.826	0.16
196_P	273_A	0.819	0.15
199_Y	283_V	0.818	0.15
99_N	112_G	0.816	0.15
233_I	280_Y	0.814	0.15
24_Y	43_Q	0.809	0.15
195_I	201_F	0.809	0.15
199_Y	305_L	0.807	0.15
35_L	174_V	0.806	0.15
222_L	236_G	0.806	0.15
201_F	308_C	0.804	0.15
98_V	283_V	0.803	0.15
20_R	188_L	0.803	0.15
135_S	227_D	0.796	0.15
136_Q	260_L	0.784	0.15
65_D	217_W	0.784	0.15
244_K	260_L	0.781	0.15
151_L	186_M	0.780	0.15
152_M	259_G	0.780	0.15
41_H	44_T	0.780	0.15
111_R	256_E	0.778	0.15
258_A	262_L	0.773	0.14
212_R	244_K	0.768	0.14
143_P	151_L	0.762	0.14
213_F	267_W	0.762	0.14
292_A	302_G	0.761	0.14
45_S	247_R	0.759	0.14
275_P	283_V	0.758	0.14
147_A	150_I	0.758	0.14
99_N	145_L	0.756	0.14
30_G	198_F	0.753	0.14
64_D	186_M	0.749	0.14
241_E	246_P	0.748	0.14
61_F	301_N	0.743	0.14
225_A	273_A	0.737	0.14
20_R	244_K	0.737	0.14
44_T	218_S	0.736	0.14
139_W	242_H	0.733	0.14
31_E	313_L	0.730	0.14
128_E	268_E	0.728	0.14
118_M	260_L	0.726	0.14
90_S	290_R	0.726	0.14
57_E	141_N	0.718	0.13
125_G	131_H	0.714	0.13
19_A	96_R	0.713	0.13
43_Q	150_I	0.712	0.13
195_I	308_C	0.712	0.13
221_V	231_G	0.710	0.13
268_E	278_E	0.709	0.13
187_N	236_G	0.708	0.13
67_L	241_E	0.708	0.13
43_Q	66_T	0.707	0.13
279_T	282_G	0.707	0.13
43_Q	244_K	0.707	0.13
20_R	240_C	0.702	0.13
65_D	242_H	0.701	0.13
20_R	182_T	0.697	0.13
40_S	139_W	0.696	0.13
62_I	242_H	0.695	0.13
198_F	218_S	0.695	0.13
133_V	181_L	0.694	0.13
135_S	223_K	0.693	0.13
151_L	245_A	0.688	0.13
226_A	231_G	0.685	0.13
132_V	135_S	0.684	0.13
98_V	265_H	0.682	0.13
35_L	213_F	0.680	0.13
180_Y	291_L	0.680	0.13
97_W	199_Y	0.674	0.13
42_A	214_D	0.672	0.13
116_A	264_E	0.666	0.13
221_V	241_E	0.666	0.13
43_Q	145_L	0.663	0.12
53_A	95_E	0.663	0.12
149_R	260_L	0.662	0.12
151_L	252_D	0.662	0.12
56_F	188_L	0.659	0.12
196_P	199_Y	0.659	0.12
17_G	251_D	0.658	0.12
186_M	211_G	0.655	0.12
56_F	311_Y	0.654	0.12
221_V	288_G	0.653	0.12
128_E	309_G	0.651	0.12
112_G	144_D	0.650	0.12
51_M	235_N	0.639	0.12
70_D	233_I	0.637	0.12
221_V	291_L	0.636	0.12
266_F	287_V	0.636	0.12
101_L	226_A	0.632	0.12
30_G	311_Y	0.632	0.12
149_R	253_L	0.631	0.12
45_S	270_V	0.631	0.12
97_W	259_G	0.629	0.12
150_I	188_L	0.629	0.12
285_E	296_Y	0.628	0.12
98_V	275_P	0.628	0.12
189_A	196_P	0.626	0.12
19_A	152_M	0.624	0.12
37_P	143_P	0.623	0.12
224_R	265_H	0.621	0.12
284_A	288_G	0.621	0.12
60_V	213_F	0.619	0.12
128_E	269_E	0.617	0.12
96_R	103_Q	0.616	0.12
182_T	240_C	0.614	0.12
32_Y	274_D	0.614	0.12
109_Y	136_Q	0.613	0.12
142_V	184_C	0.611	0.12
44_T	139_W	0.608	0.12
199_Y	267_W	0.605	0.12
97_W	280_Y	0.604	0.12
115_Y	201_F	0.603	0.11
35_L	68_P	0.603	0.11
187_N	239_L	0.603	0.11
230_G	310_E	0.599	0.11
110_P	147_A	0.599	0.11
104_S	198_F	0.597	0.11
111_R	216_I	0.597	0.11
51_M	223_K	0.597	0.11
184_C	244_K	0.594	0.11
148_V	175_A	0.594	0.11
48_L	198_F	0.593	0.11
22_Q	276_A	0.592	0.11
242_H	252_D	0.592	0.11
224_R	228_V	0.589	0.11
158_G	313_L	0.586	0.11
258_A	296_Y	0.582	0.11
183_V	242_H	0.581	0.11
212_R	247_R	0.580	0.11
32_Y	37_P	0.579	0.11
162_T	283_V	0.577	0.11
188_L	245_A	0.577	0.11
20_R	245_A	0.575	0.11
110_P	252_D	0.574	0.11
115_Y	218_S	0.574	0.11
20_R	111_R	0.573	0.11
175_A	179_D	0.571	0.11
60_V	176_A	0.571	0.11
178_G	296_Y	0.570	0.11
55_D	188_L	0.569	0.11
63_D	256_E	0.568	0.11
20_R	66_T	0.568	0.11
87_P	268_E	0.568	0.11
39_A	53_A	0.567	0.11
97_W	196_P	0.563	0.11
86_G	163_R	0.561	0.11
106_S	175_A	0.561	0.11
61_F	190_F	0.557	0.11
273_A	311_Y	0.556	0.11
211_G	252_D	0.556	0.11
177_E	290_R	0.554	0.11
101_L	308_C	0.551	0.11
48_L	201_F	0.550	0.11
150_I	260_L	0.550	0.11
122_T	224_R	0.549	0.11
41_H	48_L	0.549	0.11
171_R	297_D	0.546	0.11
118_M	280_Y	0.546	0.11
233_I	283_V	0.545	0.11
263_N	267_W	0.544	0.11
184_C	249_T	0.539	0.11
15_F	20_R	0.538	0.10
100_V	219_G	0.538	0.10
143_P	252_D	0.536	0.10
196_P	284_A	0.534	0.10
83_H	272_A	0.534	0.10
137_G	190_F	0.533	0.10
220_V	263_N	0.532	0.10
45_S	267_W	0.532	0.10
96_R	130_D	0.531	0.10
78_H	280_Y	0.531	0.10
19_A	22_Q	0.529	0.10
225_A	267_W	0.529	0.10
53_A	98_V	0.528	0.10
242_H	260_L	0.528	0.10
197_A	229_V	0.527	0.10
101_L	135_S	0.526	0.10
141_N	238_P	0.526	0.10
47_G	216_I	0.524	0.10
51_M	56_F	0.524	0.10
227_D	238_P	0.523	0.10
121_T	126_Q	0.522	0.10
128_E	282_G	0.521	0.10
95_E	313_L	0.520	0.10
39_A	46_F	0.517	0.10
145_L	245_A	0.517	0.10
63_D	252_D	0.517	0.10
183_V	260_L	0.515	0.10
136_Q	209_D	0.510	0.10
171_R	237_A	0.509	0.10
296_Y	308_C	0.508	0.10
60_V	248_S	0.508	0.10
75_F	78_H	0.507	0.10
143_P	215_D	0.506	0.10
201_F	312_L	0.505	0.10
183_V	190_F	0.504	0.10
122_T	287_V	0.504	0.10
13_A	89_E	0.503	0.10
136_Q	145_L	0.503	0.10
221_V	297_D	0.502	0.10
200_Q	240_C	0.502	0.10
171_R	287_V	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2fy7A	1	0.5495	32.1	0.972	Contact Map
4ob0B	1	0.2462	29.8	0.972	Contact Map
1qg8A	1	0.5826	18.9	0.975	Contact Map
2bo4A	4	0.8438	16.5	0.975	Contact Map
2nxvA	4	0.5826	13	0.977	Contact Map
2d0jA	2	0.5465	12	0.977	Contact Map
4irpA	2	0.5435	10.8	0.977	Contact Map
4zgjB	2	0.2462	10.8	0.977	Contact Map
4gr2A	2	0.3183	10.5	0.978	Contact Map
3qyhB	1	0.2462	9.7	0.978	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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