GREMLIN Database
Q9HR00 - MAPK-activated protein kinase
UniProt: Q9HR00 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 521 (441)
Sequences: 382 (325)
Seq/√Len: 15.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
371_A405_V5.9031.00
386_H423_P4.3491.00
342_R404_V4.1631.00
384_G389_A3.7891.00
387_P426_F3.6501.00
271_T407_D3.5400.99
454_Y463_R3.4180.99
383_G440_F3.3900.99
279_A290_L3.2070.99
384_G407_D3.1800.99
383_G423_P3.1420.99
446_V489_S3.1170.99
489_S498_F3.0880.98
374_Y405_V2.9490.98
271_T384_G2.8510.97
383_G422_I2.8160.97
271_T276_D2.7750.97
386_H422_I2.7700.97
279_A288_H2.6580.96
485_L503_D2.6430.96
358_L479_P2.5690.95
386_H389_A2.5510.95
390_V403_P2.4950.94
384_G423_P2.4820.94
271_T274_T2.4630.94
315_A384_G2.4290.93
271_T409_G2.4030.93
276_D389_A2.3880.93
387_P454_Y2.3070.91
325_Y374_Y2.2990.91
343_Y449_L2.2910.91
386_H407_D2.2700.91
187_L190_T2.1700.88
269_R384_G2.1550.88
389_A407_D2.0870.86
167_A170_E2.0830.86
440_F444_T2.0730.86
271_T389_A2.0510.85
262_L463_R2.0120.84
471_A490_L1.9870.83
446_V498_F1.9720.83
368_V390_V1.9570.82
350_A388_G1.9510.82
432_H441_D1.9410.82
431_H440_F1.9350.82
389_A445_D1.9330.82
375_A498_F1.9040.81
262_L333_G1.8970.80
454_Y490_L1.8940.80
168_V176_A1.8610.79
484_S506_A1.8540.79
58_V61_A1.8450.78
383_G421_P1.8250.78
315_A407_D1.8200.77
457_V489_S1.7900.76
271_T386_H1.7880.76
327_H382_H1.7690.75
274_T341_T1.7100.73
325_Y405_V1.6970.72
274_T383_G1.6850.72
358_L462_P1.6560.70
348_T446_V1.6550.70
407_D430_E1.6510.70
391_R406_A1.6490.70
479_P485_L1.6480.70
403_P447_F1.6390.69
384_G422_I1.6320.69
365_V453_A1.6290.69
506_A509_D1.6060.68
472_A475_N1.5790.66
228_V231_D1.5780.66
346_A462_P1.5720.66
173_A176_A1.5720.66
407_D422_I1.5700.66
204_V209_D1.5620.66
149_L153_T1.5510.65
385_L405_V1.5470.65
362_Q508_F1.5450.65
493_S496_A1.5310.64
296_L343_Y1.5250.64
382_H452_L1.5070.63
269_R342_R1.5070.63
426_F471_A1.5050.63
235_R238_E1.4780.61
408_W462_P1.4730.61
210_S214_P1.4690.61
388_G489_S1.4650.60
371_A489_S1.4550.60
368_V385_L1.4530.60
276_D407_D1.4490.60
312_F440_F1.4330.59
426_F463_R1.4330.59
387_P423_P1.4260.58
409_G445_D1.4090.57
322_V498_F1.3920.56
389_A409_G1.3910.56
319_W410_F1.3830.56
47_A50_R1.3750.55
269_R431_H1.3740.55
328_I473_Q1.3710.55
410_F462_P1.3700.55
455_F475_N1.3680.55
265_G333_G1.3650.55
204_V208_D1.3590.55
423_P427_A1.3530.54
207_T210_S1.3500.54
486_F490_L1.3490.54
312_F438_G1.3440.54
273_L374_Y1.3400.53
374_Y411_A1.3390.53
274_T371_A1.3350.53
55_W63_T1.3280.53
423_P426_F1.3260.53
53_A59_E1.3260.53
358_L361_A1.3160.52
274_T420_P1.3160.52
271_T294_R1.3160.52
268_L405_V1.3030.51
429_P447_F1.3000.51
339_V468_V1.2930.51
387_P463_R1.2910.51
177_A183_G1.2910.51
499_E504_F1.2780.50
276_D294_R1.2770.50
407_D429_P1.2760.50
198_L201_D1.2730.50
384_G445_D1.2710.50
250_P253_P1.2630.49
273_L371_A1.2570.49
347_E391_R1.2560.49
448_G489_S1.2550.49
333_G454_Y1.2510.48
211_E215_R1.2500.48
117_D128_A1.2460.48
173_A177_A1.2410.48
74_A77_A1.2410.48
375_A455_F1.2380.48
55_W60_A1.2340.47
93_V127_G1.2320.47
342_R347_E1.2310.47
457_V482_V1.2290.47
333_G489_S1.2220.47
465_G468_V1.2140.46
269_R407_D1.2130.46
274_T409_G1.2120.46
294_R315_A1.2110.46
201_D205_V1.2080.46
403_P408_W1.2020.46
428_A455_F1.1990.45
385_L452_L1.1820.45
327_H499_E1.1800.44
426_F490_L1.1790.44
412_H426_F1.1780.44
166_D176_A1.1730.44
112_L120_D1.1730.44
121_E127_G1.1710.44
387_P425_G1.1690.44
289_G375_A1.1690.44
331_V344_D1.1650.44
390_V416_G1.1640.43
294_R389_A1.1610.43
485_L506_A1.1590.43
409_G450_G1.1580.43
427_A457_V1.1530.43
430_E497_R1.1520.43
385_L411_A1.1450.42
166_D169_A1.1410.42
428_A506_A1.1400.42
424_A449_L1.1400.42
320_A340_A1.1330.42
335_G340_A1.1330.42
376_H386_H1.1330.42
463_R490_L1.1270.41
425_G490_L1.1240.41
268_L308_V1.1240.41
53_A57_L1.1200.41
262_L352_R1.1150.41
46_D57_L1.1140.41
206_T209_D1.1110.41
372_V449_L1.1080.40
352_R494_K1.1070.40
380_V422_I1.1070.40
268_L335_G1.1060.40
78_R81_D1.0990.40
166_D177_A1.0970.40
364_V425_G1.0960.40
388_G463_R1.0960.40
210_S213_G1.0960.40
381_V392_F1.0950.40
361_A451_A1.0910.39
453_A494_K1.0860.39
364_V392_F1.0790.39
328_I331_V1.0770.39
343_Y455_F1.0750.39
93_V149_L1.0730.38
152_L159_L1.0730.38
190_T197_L1.0730.38
273_L325_Y1.0690.38
274_T407_D1.0680.38
281_I333_G1.0670.38
315_A389_A1.0630.38
247_A252_A1.0620.38
44_S47_A1.0610.38
236_G240_A1.0560.38
261_D369_T1.0520.37
56_R59_E1.0360.36
315_A391_R1.0350.36
262_L288_H1.0350.36
445_D450_G1.0320.36
428_A440_F1.0290.36
273_L384_G1.0220.36
407_D445_D1.0220.36
274_T375_A1.0200.36
410_F427_A1.0180.36
368_V411_A1.0170.35
369_T503_D1.0170.35
327_H446_V1.0130.35
235_R240_A1.0130.35
243_G249_V1.0050.35
318_R422_I1.0010.35
371_A391_R1.0000.35
276_D386_H1.0000.35
358_L447_F0.9980.35
421_P440_F0.9970.34
422_I427_A0.9960.34
367_R504_F0.9950.34
431_H444_T0.9920.34
75_I87_R0.9840.34
348_T498_F0.9820.34
427_A503_D0.9750.33
421_P444_T0.9720.33
430_E445_D0.9700.33
90_V108_K0.9640.33
272_V388_G0.9630.33
324_E381_V0.9610.33
389_A423_P0.9590.33
431_H456_L0.9560.32
335_G358_L0.9560.32
268_L495_Q0.9550.32
407_D428_A0.9540.32
175_I184_Y0.9540.32
239_S242_P0.9520.32
425_G447_F0.9490.32
236_G244_H0.9480.32
342_R391_R0.9470.32
176_A181_D0.9460.32
55_W61_A0.9410.32
451_A457_V0.9410.32
331_V391_R0.9390.32
91_T124_R0.9380.31
385_L410_F0.9380.31
388_G426_F0.9380.31
353_G449_L0.9350.31
429_P497_R0.9310.31
191_T198_L0.9300.31
471_A486_F0.9270.31
369_T504_F0.9260.31
272_V421_P0.9220.31
320_A440_F0.9150.30
93_V97_L0.9130.30
485_L509_D0.9100.30
482_V485_L0.9090.30
331_V457_V0.9090.30
290_L368_V0.9090.30
231_D234_D0.9060.30
381_V493_S0.9040.30
187_L200_D0.9030.30
407_D423_P0.8980.30
45_A51_S0.8970.30
472_A479_P0.8960.29
120_D123_V0.8960.29
172_A184_Y0.8920.29
210_S215_R0.8910.29
54_A61_A0.8910.29
344_D434_P0.8890.29
387_P421_P0.8860.29
288_H448_G0.8830.29
62_G66_T0.8820.29
295_R298_A0.8820.29
276_D289_G0.8800.29
276_D384_G0.8780.29
432_H485_L0.8770.29
274_T294_R0.8760.29
404_V424_A0.8750.28
409_G428_A0.8740.28
390_V452_L0.8740.28
186_M190_T0.8720.28
325_Y367_R0.8700.28
87_R92_W0.8680.28
334_T337_T0.8670.28
203_T210_S0.8650.28
112_L168_V0.8630.28
408_W473_Q0.8630.28
335_G425_G0.8630.28
387_P455_F0.8620.28
361_A454_Y0.8610.28
337_T468_V0.8610.28
267_E270_E0.8610.28
316_L452_L0.8610.28
446_V471_A0.8610.28
348_T454_Y0.8570.28
65_P69_R0.8560.28
285_T423_P0.8550.28
75_I78_R0.8550.28
388_G421_P0.8530.27
369_T500_T0.8520.27
271_T383_G0.8510.27
47_A52_G0.8500.27
446_V503_D0.8490.27
234_D238_E0.8480.27
72_L76_V0.8440.27
321_A406_A0.8400.27
195_A198_L0.8360.27
190_T196_A0.8340.27
421_P451_A0.8330.27
463_R472_A0.8330.27
333_G475_N0.8320.27
376_H442_Q0.8260.26
316_L406_A0.8260.26
350_A451_A0.8230.26
229_A232_A0.8230.26
192_A196_A0.8220.26
404_V448_G0.8210.26
84_V87_R0.8210.26
332_L341_T0.8210.26
426_F455_F0.8200.26
273_L389_A0.8170.26
445_D497_R0.8140.26
441_D444_T0.8140.26
277_F371_A0.8110.26
262_L340_A0.8100.26
454_Y489_S0.8090.26
231_D235_R0.8070.25
94_I97_L0.8070.25
348_T489_S0.8070.25
341_T444_T0.8040.25
371_A428_A0.8030.25
124_R146_L0.8000.25
149_L164_A0.7990.25
47_A51_S0.7970.25
272_V461_S0.7970.25
262_L335_G0.7960.25
335_G463_R0.7960.25
371_A456_L0.7950.25
447_F490_L0.7910.25
404_V459_G0.7890.25
123_V328_I0.7840.24
333_G347_E0.7840.24
230_V233_A0.7830.24
165_E183_G0.7830.24
156_A160_L0.7820.24
54_A73_E0.7790.24
379_G406_A0.7780.24
272_V423_P0.7770.24
130_A133_G0.7770.24
141_R155_D0.7750.24
388_G423_P0.7740.24
276_D391_R0.7740.24
466_D489_S0.7740.24
290_L367_R0.7730.24
237_D244_H0.7730.24
116_T131_V0.7720.24
201_D204_V0.7710.24
62_G65_P0.7690.24
314_R410_F0.7690.24
269_R374_Y0.7680.24
450_G497_R0.7650.24
288_H340_A0.7640.24
53_A56_R0.7620.24
315_A383_G0.7610.23
168_V196_A0.7610.23
202_L221_S0.7600.23
180_E186_M0.7600.23
279_A359_S0.7600.23
86_V89_G0.7580.23
53_A58_V0.7580.23
269_R346_A0.7560.23
337_T421_P0.7560.23
243_G246_P0.7540.23
409_G422_I0.7500.23
427_A482_V0.7490.23
342_R447_F0.7490.23
104_A110_S0.7480.23
245_P251_D0.7480.23
388_G424_A0.7480.23
375_A489_S0.7460.23
239_S247_A0.7460.23
186_M201_D0.7460.23
137_R146_L0.7460.23
319_W371_A0.7460.23
48_D51_S0.7430.23
48_D52_G0.7410.23
458_T504_F0.7410.23
374_Y379_G0.7410.23
171_V174_E0.7400.23
421_P426_F0.7390.23
428_A459_G0.7390.23
278_R390_V0.7380.23
236_G239_S0.7380.23
122_L133_G0.7350.22
392_F431_H0.7290.22
306_S319_W0.7290.22
335_G427_A0.7270.22
242_P250_P0.7240.22
56_R79_A0.7220.22
375_A380_V0.7210.22
174_E177_A0.7210.22
330_R408_W0.7200.22
328_I334_T0.7190.22
325_Y383_G0.7160.22
463_R478_L0.7140.22
463_R503_D0.7140.22
168_V182_A0.7110.21
375_A450_G0.7100.21
333_G455_F0.7100.21
325_Y328_I0.7100.21
335_G447_F0.7090.21
232_A235_R0.7080.21
48_D55_W0.7070.21
347_E383_G0.7070.21
71_H130_A0.7060.21
116_T120_D0.7060.21
372_V385_L0.7030.21
243_G251_D0.7020.21
242_P252_A0.7020.21
248_E252_A0.7010.21
71_H77_A0.6960.21
307_R390_V0.6960.21
47_A58_V0.6950.21
324_E330_R0.6930.21
164_A181_D0.6910.21
271_T289_G0.6910.21
105_L131_V0.6880.21
196_A201_D0.6880.21
52_G62_G0.6880.21
95_A98_A0.6870.21
410_F452_L0.6840.20
51_S55_W0.6830.20
191_T194_Y0.6810.20
131_V199_P0.6800.20
388_G425_G0.6790.20
268_L374_Y0.6790.20
133_G142_A0.6780.20
171_V201_D0.6760.20
48_D65_P0.6760.20
448_G475_N0.6760.20
59_E64_E0.6750.20
327_H509_D0.6750.20
273_L405_V0.6740.20
47_A55_W0.6740.20
367_R447_F0.6740.20
67_A71_H0.6730.20
278_R379_G0.6730.20
175_I181_D0.6730.20
239_S243_G0.6720.20
209_D214_P0.6710.20
271_T375_A0.6700.20
463_R466_D0.6700.20
276_D409_G0.6700.20
76_V80_D0.6690.20
228_V233_A0.6690.20
384_G409_G0.6690.20
274_T337_T0.6690.20
315_A422_I0.6670.20
63_T68_V0.6630.20
90_V94_I0.6620.20
271_T315_A0.6600.20
388_G478_L0.6600.20
103_D109_F0.6590.20
312_F316_L0.6580.20
171_V183_G0.6550.19
82_E85_W0.6540.19
383_G424_A0.6540.19
401_D458_T0.6510.19
343_Y503_D0.6510.19
343_Y419_S0.6490.19
110_S131_V0.6480.19
386_H428_A0.6480.19
431_H458_T0.6450.19
47_A54_A0.6440.19
312_F451_A0.6440.19
271_T422_I0.6430.19
141_R145_G0.6430.19
50_R59_E0.6430.19
246_P249_V0.6420.19
382_H445_D0.6420.19
207_T212_D0.6420.19
262_L426_F0.6420.19
383_G427_A0.6410.19
54_A63_T0.6400.19
51_S67_A0.6390.19
491_A496_A0.6380.19
308_V385_L0.6370.19
166_D174_E0.6350.19
370_R499_E0.6350.19
335_G454_Y0.6310.19
72_L80_D0.6310.19
400_W486_F0.6300.19
233_A237_D0.6300.19
335_G361_A0.6290.19
404_V509_D0.6280.18
274_T412_H0.6270.18
176_A182_A0.6260.18
172_A177_A0.6260.18
171_V198_L0.6260.18
312_F479_P0.6240.18
275_T448_G0.6230.18
89_G96_E0.6160.18
173_A185_P0.6160.18
208_D212_D0.6150.18
315_A404_V0.6150.18
426_F454_Y0.6150.18
247_A253_P0.6150.18
240_A243_G0.6140.18
372_V490_L0.6130.18
70_A90_V0.6130.18
52_G61_A0.6130.18
58_V83_D0.6120.18
199_P372_V0.6120.18
386_H434_P0.6100.18
165_E170_E0.6090.18
414_A452_L0.6090.18
387_P451_A0.6080.18
459_G497_R0.6060.18
103_D114_A0.6060.18
49_E63_T0.6060.18
411_A476_P0.6040.18
108_K114_A0.6040.18
382_H421_P0.6040.18
274_T331_V0.6020.18
331_V451_A0.6020.18
288_H463_R0.6010.18
247_A251_D0.5960.17
49_E54_A0.5960.17
212_D216_D0.5950.17
405_V410_F0.5950.17
76_V84_V0.5940.17
229_A238_E0.5940.17
194_Y201_D0.5930.17
61_A64_E0.5930.17
386_H401_D0.5920.17
118_A121_E0.5890.17
408_W455_F0.5890.17
177_A180_E0.5880.17
463_R486_F0.5880.17
288_H356_A0.5880.17
185_P188_V0.5870.17
344_D374_Y0.5860.17
343_Y427_A0.5860.17
94_I486_F0.5850.17
45_A48_D0.5850.17
72_L87_R0.5850.17
64_E67_A0.5840.17
56_R63_T0.5830.17
358_L431_H0.5830.17
52_G64_E0.5820.17
272_V322_V0.5810.17
369_T508_F0.5810.17
346_A374_Y0.5810.17
367_R402_A0.5770.17
228_V240_A0.5770.17
181_D202_L0.5760.17
77_A81_D0.5750.17
54_A57_L0.5750.17
446_V504_F0.5740.17
187_L195_A0.5730.17
319_W331_V0.5720.17
45_A53_A0.5710.17
343_Y398_G0.5700.17
336_D455_F0.5680.17
107_M112_L0.5680.17
364_V456_L0.5670.16
170_E181_D0.5670.16
59_E73_E0.5670.16
235_R243_G0.5670.16
258_S261_D0.5630.16
384_G411_A0.5580.16
289_G389_A0.5580.16
83_D86_V0.5580.16
380_V385_L0.5580.16
388_G475_N0.5560.16
52_G55_W0.5560.16
387_P458_T0.5550.16
172_A193_E0.5550.16
319_W338_W0.5530.16
189_R203_T0.5510.16
322_V453_A0.5500.16
197_L201_D0.5490.16
279_A502_L0.5480.16
386_H490_L0.5470.16
53_A70_A0.5460.16
262_L387_P0.5460.16
180_E195_A0.5450.16
427_A463_R0.5450.16
59_E62_G0.5440.16
200_D217_P0.5440.16
155_D160_L0.5440.16
262_L447_F0.5440.16
477_A481_R0.5430.16
279_A368_V0.5430.16
348_T508_F0.5420.16
386_H426_F0.5410.16
171_V179_A0.5380.16
109_F115_L0.5380.16
276_D428_A0.5380.16
458_T473_Q0.5360.16
55_W58_V0.5360.16
163_Y405_V0.5340.15
289_G386_H0.5340.15
68_V75_I0.5340.15
388_G472_A0.5330.15
361_A457_V0.5330.15
277_F489_S0.5320.15
290_L371_A0.5310.15
228_V232_A0.5310.15
260_A480_E0.5310.15
370_R406_A0.5310.15
169_A172_A0.5300.15
383_G407_D0.5300.15
380_V386_H0.5290.15
276_D430_E0.5290.15
325_Y344_D0.5280.15
372_V426_F0.5270.15
319_W448_G0.5270.15
345_G428_A0.5260.15
269_R440_F0.5260.15
333_G463_R0.5240.15
454_Y457_V0.5230.15
51_S54_A0.5230.15
430_E450_G0.5200.15
385_L409_G0.5200.15
171_V177_A0.5200.15
361_A489_S0.5190.15
315_A341_T0.5190.15
206_T214_P0.5180.15
398_G412_H0.5180.15
489_S499_E0.5180.15
74_A88_R0.5180.15
482_V489_S0.5170.15
49_E56_R0.5170.15
257_V296_L0.5160.15
172_A175_I0.5160.15
261_D479_P0.5160.15
265_G288_H0.5150.15
77_A92_W0.5150.15
56_R61_A0.5140.15
206_T210_S0.5130.15
344_D406_A0.5130.15
198_L206_T0.5120.15
48_D56_R0.5100.15
164_A180_E0.5090.15
494_K497_R0.5090.15
483_D507_A0.5080.15
334_T451_A0.5080.15
205_V215_R0.5080.15
229_A235_R0.5060.15
182_A214_P0.5040.15
361_A421_P0.5040.15
192_A199_P0.5030.15
246_P253_P0.5010.15
386_H424_A0.5010.15
275_T322_V0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lqsA 1 0.5528 100 0.425 Contact Map
4ic7A 1 0.4875 100 0.43 Contact Map
4fr4A 1 0.4952 100 0.432 Contact Map
4gv1A 1 0.4856 100 0.432 Contact Map
4kikA 2 0.4952 100 0.435 Contact Map
4dc2A 1 0.476 100 0.436 Contact Map
2yabA 2 0.4952 100 0.441 Contact Map
4aw2A 2 0.62 100 0.442 Contact Map
3rp9A 1 0.4491 100 0.443 Contact Map
2bdwA 2 0.4894 100 0.443 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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