GREMLIN Database
Q9HQZ9 - Alkanal monooxygenase homolog
UniProt: Q9HQZ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (295)
Sequences: 16346 (10481)
Seq/√Len: 610.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
235_D296_T5.3451.00
29_Q65_E3.3601.00
235_D293_S2.8791.00
70_R102_D2.7631.00
132_T182_E2.6361.00
30_Q33_D2.5711.00
32_D68_R2.5521.00
178_A208_S2.5471.00
300_L303_Q2.5341.00
203_D207_E2.5031.00
63_A97_A2.4791.00
235_D239_A2.4741.00
234_T237_A2.4231.00
59_L71_L2.3721.00
293_S296_T2.3341.00
136_K183_L2.2861.00
302_E306_D2.2581.00
149_D154_G2.2471.00
129_G151_A2.2441.00
232_A237_A2.2421.00
177_A204_V2.1721.00
22_A98_P2.1671.00
207_E211_A2.1041.00
202_F206_R2.0941.00
209_F221_P2.0871.00
202_F223_G2.0681.00
28_A62_L2.0581.00
25_V29_Q2.0571.00
29_Q33_D2.0551.00
204_V208_S2.0461.00
143_H164_P1.9501.00
39_F69_I1.9361.00
199_T203_D1.9321.00
94_D99_G1.8921.00
290_I297_L1.8851.00
26_A29_Q1.8811.00
236_A240_R1.8361.00
63_A71_L1.8351.00
40_W72_G1.8291.00
90_F101_V1.8211.00
243_A247_A1.8201.00
54_T89_Q1.8071.00
25_V65_E1.8031.00
181_G208_S1.7831.00
233_D327_R1.7021.00
208_S211_A1.6941.00
139_L164_P1.6481.00
62_L71_L1.6271.00
30_Q34_L1.6221.00
28_A39_F1.6141.00
90_F103_A1.6081.00
126_D151_A1.6051.00
296_T299_G1.6021.00
136_K140_G1.5961.00
231_C297_L1.5821.00
111_S115_D1.5651.00
204_V207_E1.5651.00
129_G152_Y1.5551.00
295_E299_G1.5301.00
16_T19_D1.5081.00
178_A211_A1.4821.00
322_H326_L1.4801.00
200_R203_D1.4771.00
139_L183_L1.4671.00
241_R324_A1.4611.00
298_A302_E1.4561.00
112_P115_D1.4561.00
178_A182_E1.4351.00
225_V310_V1.4301.00
25_V61_H1.4291.00
171_G187_Y1.4211.00
237_A241_R1.3961.00
28_A66_T1.3911.00
33_D67_D1.3871.00
140_G144_D1.3811.00
30_Q326_L1.3771.00
302_E305_A1.3761.00
209_F214_L1.3741.00
32_D66_T1.3731.00
231_C294_P1.3611.00
140_G145_D1.3571.00
61_H64_A1.3461.00
139_L167_P1.3371.00
296_T300_L1.3361.00
132_T183_L1.3081.00
34_L326_L1.3081.00
280_T283_E1.3051.00
299_G303_Q1.3011.00
22_A26_A1.2951.00
61_H96_L1.2911.00
19_D23_N1.2901.00
232_A238_A1.2781.00
321_G324_A1.2721.00
230_V241_R1.2591.00
54_T57_V1.2571.00
303_Q306_D1.2541.00
26_A30_Q1.2541.00
222_T311_E1.2461.00
41_V59_L1.2401.00
81_Y89_Q1.2361.00
181_G212_S1.2341.00
126_D129_G1.2301.00
139_L185_L1.2271.00
168_W224_M1.2171.00
32_D67_D1.2161.00
240_R243_A1.2131.00
59_L73_S1.1821.00
135_V183_L1.1751.00
126_D152_Y1.1731.00
93_L101_V1.1721.00
28_A69_I1.1721.00
182_E212_S1.1711.00
237_A240_R1.1671.00
178_A204_V1.1661.00
174_P204_V1.1641.00
72_G102_D1.1621.00
86_V134_A1.1601.00
138_V142_L1.1571.00
266_A269_E1.1561.00
53_T92_A1.1451.00
132_T136_K1.1421.00
233_D237_A1.1391.00
168_W186_R1.1371.00
118_L121_E1.1361.00
57_V60_G1.1321.00
178_A212_S1.1311.00
197_F200_R1.1241.00
175_S178_A1.1191.00
137_A153_S1.1181.00
105_L135_V1.1151.00
282_P285_D1.1121.00
29_Q67_D1.1081.00
136_K148_E1.1041.00
103_A138_V1.1031.00
41_V62_L1.0981.00
240_R244_S1.0961.00
161_D164_P1.0851.00
23_N26_A1.0831.00
290_I300_L1.0801.00
85_K89_Q1.0781.00
130_D133_D1.0721.00
61_H65_E1.0701.00
56_E89_Q1.0681.00
239_A243_A1.0651.00
242_R246_E1.0591.00
208_S212_S1.0571.00
199_T308_V1.0551.00
251_R254_R1.0491.00
237_A324_A1.0471.00
264_E268_D1.0471.00
195_P303_Q1.0471.00
292_G297_L1.0461.00
260_T263_V1.0421.00
194_R197_F1.0411.00
222_T312_E1.0351.00
229_A315_V1.0341.00
75_A170_L1.0291.00
57_V93_L1.0221.00
137_A140_G1.0181.00
18_A22_A1.0171.00
94_D163_E1.0111.00
26_A326_L1.0111.00
23_N322_H1.0101.00
139_L143_H1.0031.00
209_F218_V1.0001.00
76_V86_V0.9981.00
26_A322_H0.9971.00
200_R204_V0.9951.00
133_D150_H0.9821.00
129_G175_S0.9811.00
179_I183_L0.9761.00
94_D162_D0.9761.00
137_A155_I0.9741.00
265_E268_D0.9671.00
132_T179_I0.9621.00
264_E267_I0.9531.00
242_R291_S0.9511.00
227_V290_I0.9461.00
280_T284_G0.9441.00
180_A187_Y0.9361.00
144_D147_P0.9341.00
30_Q323_D0.9301.00
38_R72_G0.9271.00
232_A241_R0.9201.00
56_E76_V0.9181.00
126_D130_D0.9121.00
75_A106_G0.9041.00
188_C224_M0.9031.00
210_T218_V0.9031.00
133_D151_A0.8981.00
299_G302_E0.8981.00
148_E151_A0.8921.00
21_Y96_L0.8901.00
258_G261_P0.8881.00
279_E282_P0.8861.00
261_P265_E0.8851.00
22_A25_V0.8821.00
177_A208_S0.8811.00
26_A323_D0.8801.00
227_V301_F0.8791.00
195_P199_T0.8781.00
236_A239_A0.8761.00
140_G147_P0.8651.00
26_A33_D0.8651.00
59_L63_A0.8651.00
263_V268_D0.8631.00
244_S247_A0.8631.00
157_V160_G0.8551.00
78_V134_A0.8521.00
130_D134_A0.8501.00
234_T238_A0.8481.00
177_A181_G0.8471.00
60_G64_A0.8471.00
206_R223_G0.8471.00
262_G266_A0.8451.00
137_A148_E0.8411.00
94_D164_P0.8341.00
263_V266_A0.8331.00
157_V161_D0.8321.00
133_D137_A0.8291.00
281_L285_D0.8251.00
158_P161_D0.8241.00
169_L180_A0.8231.00
38_R312_E0.8211.00
142_L165_P0.8211.00
83_P137_A0.8181.00
243_A246_E0.8181.00
63_A101_V0.8161.00
134_A138_V0.8141.00
261_P264_E0.8121.00
108_A113_A0.8101.00
202_F205_Y0.8051.00
209_F212_S0.8021.00
256_T260_T0.7991.00
20_A23_N0.7981.00
262_G265_E0.7961.00
265_E269_E0.7951.00
64_A97_A0.7921.00
121_E125_S0.7871.00
95_G163_E0.7801.00
178_A207_E0.7801.00
244_S248_S0.7771.00
203_D309_G0.7731.00
140_G148_E0.7711.00
206_R210_T0.7691.00
281_L284_G0.7621.00
94_D161_D0.7611.00
169_L176_S0.7541.00
209_F219_D0.7521.00
133_D152_Y0.7511.00
239_A286_W0.7511.00
132_T175_S0.7491.00
102_D168_W0.7461.00
174_P208_S0.7451.00
59_L101_V0.7421.00
78_V86_V0.7391.00
128_D175_S0.7381.00
63_A93_L0.7361.00
252_M255_G0.7301.00
76_V90_F0.7281.00
241_R244_S0.7271.00
90_F142_L0.7261.00
214_L218_V0.7261.00
205_Y209_F0.7261.00
187_Y205_Y0.7251.00
324_A327_R0.7161.00
86_V138_V0.7131.00
40_W74_G0.7111.00
239_A291_S0.7061.00
141_H147_P0.7051.00
77_L108_A0.7041.00
23_N27_A0.7031.00
25_V62_L0.7011.00
133_D136_K0.7011.00
21_Y61_H0.6941.00
45_H88_E0.6931.00
177_A187_Y0.6931.00
22_A64_A0.6931.00
140_G143_H0.6911.00
279_E283_E0.6901.00
83_P134_A0.6851.00
174_P178_A0.6851.00
197_F201_A0.6841.00
17_A20_A0.6841.00
59_L93_L0.6831.00
150_H153_S0.6831.00
202_F308_V0.6821.00
43_E81_Y0.6811.00
169_L184_G0.6791.00
224_M312_E0.6781.00
73_S101_V0.6771.00
82_S85_K0.6771.00
263_V267_I0.6741.00
189_F201_A0.6721.00
323_D326_L0.6711.00
239_A242_R0.6711.00
95_G160_G0.6701.00
81_Y85_K0.6701.00
209_F220_E0.6691.00
169_L179_I0.6681.00
136_K182_E0.6661.00
160_G163_E0.6631.00
37_K68_R0.6581.00
39_F62_L0.6541.00
98_P160_G0.6521.00
41_V58_L0.6511.00
260_T265_E0.6511.00
259_T264_E0.6491.00
182_E211_A0.6491.00
70_R166_Q0.6491.00
196_Q199_T0.6491.00
38_R314_M0.6481.00
182_E208_S0.6471.00
125_S175_S0.6441.00
205_Y221_P0.6411.00
264_E269_E0.6401.00
248_S251_R0.6401.00
25_V28_A0.6381.00
71_L97_A0.6381.00
121_E126_D0.6381.00
25_V64_A0.6361.00
259_T262_G0.6361.00
263_V269_E0.6311.00
130_D153_S0.6311.00
22_A67_D0.6311.00
31_A69_I0.6301.00
107_R131_H0.6301.00
181_G209_F0.6291.00
229_A290_I0.6271.00
107_R127_P0.6261.00
235_D238_A0.6261.00
206_R209_F0.6251.00
223_G310_V0.6241.00
136_K139_L0.6211.00
214_L219_D0.6211.00
84_L141_H0.6191.00
60_G93_L0.6181.00
212_S218_V0.6171.00
251_R255_G0.6171.00
66_T100_R0.6141.00
206_R311_E0.6131.00
323_D327_R0.6121.00
198_A201_A0.6101.00
37_K70_R0.6051.00
233_D294_P0.6031.00
56_E90_F0.6011.00
295_E298_A0.6001.00
32_D69_I0.5981.00
280_T285_D0.5961.00
177_A205_Y0.5961.00
305_A310_V0.5951.00
247_A251_R0.5951.00
21_Y25_V0.5941.00
175_S179_I0.5941.00
322_H325_A0.5931.00
105_L167_P0.5921.00
131_H134_A0.5921.00
72_G168_W0.5911.00
300_L304_L0.5891.00
66_T69_I0.5821.00
60_G97_A0.5821.00
205_Y223_G0.5801.00
58_L92_A0.5791.00
94_D97_A0.5781.00
238_A242_R0.5771.00
171_G176_S0.5761.00
117_A121_E0.5751.00
279_E284_G0.5751.00
288_R300_L0.5751.00
158_P163_E0.5751.00
250_Q254_R0.5741.00
57_V89_Q0.5731.00
119_E122_R0.5731.00
172_S201_A0.5721.00
105_L138_V0.5711.00
81_Y86_V0.5691.00
232_A235_D0.5691.00
168_W222_T0.5681.00
206_R309_G0.5681.00
172_S191_A0.5641.00
262_G269_E0.5641.00
174_P200_R0.5621.00
301_F315_V0.5601.00
61_H97_A0.5601.00
301_F313_V0.5571.00
206_R218_V0.5561.00
226_A314_M0.5551.00
230_V242_R0.5541.00
19_D22_A0.5541.00
203_D206_R0.5531.00
83_P153_S0.5531.00
137_A147_P0.5521.00
207_E210_T0.5510.99
94_D159_G0.5510.99
166_Q222_T0.5510.99
91_G142_L0.5490.99
294_P298_A0.5480.99
259_T268_D0.5470.99
254_R278_P0.5460.99
253_K256_T0.5450.99
158_P162_D0.5440.99
57_V61_H0.5410.99
259_T266_A0.5410.99
234_T240_R0.5400.99
156_A160_G0.5400.99
55_P73_S0.5380.99
133_D148_E0.5380.99
164_P185_L0.5370.99
246_E249_Y0.5350.99
78_V105_L0.5340.99
248_S252_M0.5340.99
231_C293_S0.5340.99
104_G170_L0.5330.99
260_T268_D0.5310.99
202_F310_V0.5310.99
97_A101_V0.5300.99
260_T264_E0.5280.99
74_G188_C0.5260.99
297_L300_L0.5240.99
256_T261_P0.5210.99
135_V169_L0.5210.99
109_N113_A0.5210.99
256_T259_T0.5200.99
206_R220_E0.5190.99
260_T267_I0.5190.99
57_V96_L0.5180.99
122_R125_S0.5160.99
142_L167_P0.5150.99
87_A142_L0.5140.99
56_E60_G0.5140.99
94_D165_P0.5130.99
60_G63_A0.5110.99
156_A161_D0.5110.99
196_Q200_R0.5100.99
91_G160_G0.5080.99
206_R219_D0.5080.99
278_P282_P0.5060.99
168_W312_E0.5040.99
91_G95_G0.5030.99
304_L308_V0.5020.99
156_A159_G0.5020.99
128_D179_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lucA 1 0.926 100 0.194 Contact Map
1lucB 1 0.926 100 0.197 Contact Map
4us5A 3 0.9497 100 0.202 Contact Map
2wgkA 2 0.9704 100 0.211 Contact Map
2i7gA 2 0.9467 100 0.225 Contact Map
1z69A 4 0.932 100 0.238 Contact Map
1f07A 3 0.926 100 0.241 Contact Map
1ezwA 3 0.932 100 0.246 Contact Map
3b9oA 2 0.9704 100 0.251 Contact Map
3raoA 2 0.9497 100 0.261 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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