GREMLIN Database
Q9HQZ6 - NADH-dependent flavin oxidoreductase
UniProt: Q9HQZ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 366 (327)
Sequences: 11189 (7352)
Seq/√Len: 406.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_T202_E3.5621.00
219_S262_L3.4431.00
99_A177_V3.0851.00
63_E162_A2.9331.00
206_S209_N2.5371.00
20_A328_L2.5011.00
168_R224_E2.4851.00
164_R220_A2.4441.00
149_R155_D2.4401.00
9_E14_T2.4001.00
258_D261_A2.3741.00
91_I98_P2.3601.00
38_D86_P2.3101.00
8_L328_L2.2981.00
293_E325_R2.2921.00
151_L159_V2.2721.00
319_A323_N2.2201.00
232_F266_L2.1371.00
52_A335_F2.1221.00
78_D169_R2.0911.00
260_H302_D2.0791.00
92_S176_E2.0751.00
45_G94_Q2.0621.00
12_D228_D2.0441.00
132_V151_L2.0061.00
338_D344_H2.0031.00
151_L155_D1.9931.00
171_N225_W1.9801.00
306_G330_I1.9421.00
5_F346_A1.9071.00
45_G90_F1.9021.00
161_E165_D1.9021.00
343_L347_R1.9011.00
168_R172_E1.8931.00
188_I214_A1.8731.00
318_D322_R1.8721.00
257_D298_D1.8651.00
60_T100_I1.8571.00
136_A150_K1.8481.00
188_I213_L1.8211.00
165_D169_R1.8091.00
85_A89_E1.7981.00
158_D162_A1.7861.00
3_D6_S1.7661.00
153_T157_E1.7521.00
164_R224_E1.7471.00
157_E216_E1.7031.00
81_G172_E1.6981.00
89_E93_D1.6931.00
111_T146_R1.6911.00
171_N226_P1.6911.00
203_Y216_E1.6771.00
3_D318_D1.6681.00
254_Q258_D1.6651.00
214_A233_V1.6341.00
182_A233_V1.6291.00
209_N212_R1.6271.00
188_I217_V1.5971.00
88_A175_F1.5891.00
153_T203_Y1.5731.00
153_T156_I1.5641.00
152_S155_D1.5621.00
41_R86_P1.5491.00
211_T258_D1.5321.00
161_E220_A1.5221.00
78_D172_E1.5181.00
194_P246_S1.5171.00
349_L352_E1.5161.00
167_A221_V1.5151.00
299_T303_V1.5151.00
65_R158_D1.5141.00
171_N229_K1.5101.00
293_E297_A1.5091.00
84_L175_F1.4961.00
130_D149_R1.4941.00
225_W229_K1.4891.00
296_N327_D1.4631.00
157_E202_E1.4571.00
214_A255_L1.4511.00
38_D42_V1.4421.00
137_D198_H1.4231.00
20_A306_G1.4191.00
341_F345_A1.4181.00
211_T254_Q1.4081.00
42_V45_G1.4071.00
75_I100_I1.3971.00
81_G169_R1.3941.00
19_F342_P1.3871.00
215_R258_D1.3851.00
57_T98_P1.3781.00
30_E33_D1.3781.00
294_R298_D1.3731.00
46_S340_Y1.3711.00
165_D168_R1.3591.00
215_R262_L1.3471.00
24_M332_G1.3421.00
343_L346_A1.3331.00
36_A84_L1.3221.00
16_R97_T1.3181.00
207_F211_T1.3121.00
311_I320_I1.3101.00
218_T259_L1.3001.00
75_I166_A1.2991.00
314_A345_A1.2961.00
21_M47_R1.2911.00
164_R168_R1.2891.00
41_R90_F1.2811.00
220_A223_E1.2721.00
102_L166_A1.2721.00
182_A188_I1.2711.00
137_D148_T1.2701.00
248_T251_E1.2581.00
317_A331_V1.2511.00
160_V220_A1.2441.00
3_D322_R1.2381.00
15_I54_V1.2371.00
132_V149_R1.2231.00
211_T215_R1.2221.00
8_L304_A1.2181.00
157_E203_Y1.2151.00
260_H303_V1.2071.00
220_A224_E1.2071.00
83_A86_P1.2061.00
164_R223_E1.2011.00
294_R297_A1.1911.00
308_V330_I1.1891.00
35_L79_E1.1871.00
45_G93_D1.1771.00
215_R219_S1.1761.00
21_M55_V1.1731.00
13_T97_T1.1731.00
41_R45_G1.1691.00
258_D262_L1.1611.00
30_E37_T1.1591.00
314_A348_E1.1561.00
249_V294_R1.1501.00
150_K200_D1.1421.00
335_F342_P1.1411.00
45_G49_V1.1401.00
100_I170_A1.1361.00
133_A136_A1.1291.00
212_R216_E1.1291.00
155_D158_D1.1231.00
161_E164_R1.1221.00
160_V216_E1.1211.00
97_T176_E1.1191.00
320_I326_A1.1161.00
184_H270_S1.1131.00
88_A98_P1.1061.00
207_F254_Q1.1051.00
306_G328_L1.1001.00
189_H193_S1.0961.00
30_E35_L1.0961.00
307_T326_A1.0961.00
138_P147_D1.0931.00
57_T175_F1.0911.00
89_E92_S1.0911.00
182_A214_A1.0881.00
92_S98_P1.0881.00
68_I105_A1.0851.00
135_S198_H1.0791.00
160_V164_R1.0671.00
78_D82_E1.0631.00
225_W231_V1.0611.00
81_G173_A1.0591.00
34_G67_R1.0501.00
289_L320_I1.0471.00
219_S223_E1.0351.00
314_A318_D1.0341.00
36_A83_A1.0331.00
233_V264_A1.0291.00
134_P196_S1.0281.00
162_A165_D1.0231.00
202_E212_R1.0211.00
254_Q257_D1.0161.00
61_A72_D1.0151.00
37_T40_H1.0081.00
86_P89_E1.0031.00
253_V298_D1.0021.00
9_E12_D1.0001.00
15_I53_G0.9961.00
26_Q39_W0.9931.00
41_R87_V0.9901.00
51_G343_L0.9871.00
88_A173_A0.9871.00
249_V253_V0.9811.00
165_D224_E0.9801.00
73_L84_L0.9751.00
156_I160_V0.9721.00
160_V217_V0.9691.00
21_M335_F0.9591.00
15_I328_L0.9591.00
16_R96_A0.9561.00
267_I303_V0.9551.00
233_V259_L0.9521.00
49_V94_Q0.9511.00
253_V257_D0.9501.00
157_E160_V0.9491.00
15_I20_A0.9491.00
218_T264_A0.9421.00
107_R196_S0.9331.00
11_R265_D0.9311.00
326_A329_A0.9311.00
177_V232_F0.9291.00
136_A147_D0.9271.00
17_N53_G0.9241.00
211_T255_L0.9241.00
74_G80_H0.9221.00
192_L214_A0.9221.00
35_L80_H0.9191.00
4_S317_A0.9161.00
180_I221_V0.9161.00
311_I329_A0.9151.00
253_V294_R0.9111.00
195_V243_D0.9091.00
52_A342_P0.9081.00
19_F341_F0.9071.00
179_E268_D0.9061.00
187_L213_L0.9051.00
36_A73_L0.9041.00
75_I170_A0.8991.00
235_I252_S0.8981.00
22_S268_D0.8951.00
85_A172_E0.8911.00
54_V99_A0.8891.00
299_T302_D0.8871.00
132_V155_D0.8841.00
154_A157_E0.8831.00
98_P175_F0.8801.00
98_P176_E0.8791.00
256_A267_I0.8771.00
203_Y219_S0.8771.00
318_D321_V0.8761.00
3_D321_V0.8751.00
77_S80_H0.8721.00
180_I217_V0.8711.00
221_V231_V0.8701.00
313_S316_Q0.8691.00
157_E220_A0.8671.00
160_V213_L0.8591.00
59_A103_A0.8591.00
82_E85_A0.8561.00
207_F258_D0.8531.00
46_S49_V0.8531.00
211_T214_A0.8461.00
311_I317_A0.8441.00
167_A225_W0.8411.00
218_T262_L0.8411.00
216_E219_S0.8331.00
315_E348_E0.8321.00
160_V203_Y0.8261.00
54_V177_V0.8261.00
13_T99_A0.8241.00
207_F251_E0.8211.00
234_R268_D0.8201.00
222_R265_D0.8181.00
331_V334_E0.8151.00
266_L306_G0.8151.00
22_S330_I0.8121.00
56_M99_A0.8091.00
38_D41_R0.8081.00
21_M24_M0.8071.00
99_A232_F0.8061.00
269_V305_V0.8031.00
22_S332_G0.8011.00
286_N316_Q0.7991.00
153_T160_V0.7991.00
257_D261_A0.7981.00
152_S157_E0.7951.00
237_A269_V0.7951.00
61_A76_W0.7941.00
150_K198_H0.7941.00
247_W255_L0.7901.00
8_L11_R0.7891.00
208_E254_Q0.7851.00
315_E319_A0.7851.00
90_F94_Q0.7841.00
180_I218_T0.7831.00
136_A198_H0.7821.00
61_A67_R0.7791.00
340_Y344_H0.7781.00
189_H252_S0.7761.00
42_V46_S0.7751.00
269_V295_I0.7691.00
202_E209_N0.7671.00
57_T100_I0.7651.00
108_K139_Y0.7641.00
36_A87_V0.7631.00
21_M52_A0.7631.00
159_V162_A0.7631.00
149_R152_S0.7571.00
222_R231_V0.7571.00
213_L217_V0.7561.00
205_G210_R0.7521.00
171_N228_D0.7501.00
77_S81_G0.7461.00
29_C40_H0.7451.00
295_I299_T0.7451.00
12_D229_K0.7431.00
164_R217_V0.7431.00
62_V163_F0.7411.00
56_M177_V0.7401.00
13_T177_V0.7391.00
57_T84_L0.7341.00
232_F306_G0.7331.00
63_E159_V0.7321.00
105_A109_A0.7301.00
222_R226_P0.7301.00
151_L156_I0.7281.00
256_A295_I0.7271.00
76_W80_H0.7261.00
107_R148_T0.7241.00
50_G343_L0.7211.00
271_T288_Q0.7201.00
181_H186_Y0.7191.00
290_Q293_E0.7181.00
247_W250_E0.7181.00
169_R172_E0.7171.00
171_N224_E0.7161.00
331_V335_F0.7151.00
331_V341_F0.7121.00
156_I214_A0.7041.00
90_F93_D0.7041.00
251_E254_Q0.7011.00
62_V217_V0.6961.00
195_V241_I0.6941.00
140_P144_D0.6931.00
208_E258_D0.6911.00
15_I97_T0.6901.00
247_W252_S0.6891.00
250_E253_V0.6871.00
44_L55_V0.6861.00
256_A299_T0.6861.00
85_A88_A0.6861.00
20_A54_V0.6851.00
43_H47_R0.6841.00
14_T97_T0.6831.00
319_A322_R0.6821.00
317_A345_A0.6791.00
133_A196_S0.6780.99
268_D330_I0.6780.99
140_P243_D0.6750.99
63_E158_D0.6750.99
10_L304_A0.6710.99
20_A56_M0.6700.99
66_G104_H0.6680.99
19_F52_A0.6650.99
60_T75_I0.6640.99
218_T233_V0.6630.99
289_L307_T0.6620.99
92_S97_T0.6620.99
320_I325_R0.6610.99
35_L83_A0.6600.99
48_A94_Q0.6580.99
48_A91_I0.6570.99
35_L77_S0.6560.99
205_G209_N0.6530.99
168_R171_N0.6520.99
109_A131_P0.6520.99
108_K242_D0.6520.99
247_W251_E0.6520.99
82_E86_P0.6510.99
62_V103_A0.6510.99
181_H184_H0.6460.99
192_L211_T0.6460.99
23_P234_R0.6440.99
64_E76_W0.6430.99
62_V162_A0.6420.99
164_R221_V0.6410.99
296_N299_T0.6380.99
29_C73_L0.6370.99
5_F342_P0.6340.99
134_P137_D0.6300.99
233_V267_I0.6290.99
91_I96_A0.6260.99
100_I175_F0.6250.99
334_E341_F0.6240.99
192_L255_L0.6210.99
316_Q319_A0.6210.99
107_R190_Q0.6200.99
268_D308_V0.6190.99
136_A148_T0.6190.99
7_P14_T0.6160.99
260_H299_T0.6150.99
16_R346_A0.6110.99
266_L328_L0.6100.99
135_S150_K0.6090.99
218_T231_V0.6040.99
321_V329_A0.6020.99
86_P90_F0.6010.99
343_L349_L0.5970.99
20_A330_I0.5970.99
189_H239_D0.5970.99
81_G85_A0.5960.99
75_I169_R0.5920.99
137_D196_S0.5900.99
291_F294_R0.5890.99
202_E216_E0.5880.99
307_T329_A0.5880.99
217_V220_A0.5840.99
133_A148_T0.5830.98
22_S56_M0.5800.98
54_V97_T0.5780.98
163_F188_I0.5770.98
207_F247_W0.5770.98
289_L292_A0.5760.98
153_T216_E0.5750.98
75_I80_H0.5740.98
331_V345_A0.5730.98
226_P229_K0.5720.98
47_R340_Y0.5720.98
239_D274_I0.5710.98
222_R227_D0.5700.98
65_R159_V0.5700.98
337_R352_E0.5700.98
81_G88_A0.5690.98
188_I221_V0.5680.98
132_V159_V0.5670.98
299_T304_A0.5660.98
72_D105_A0.5660.98
82_E89_E0.5650.98
61_A105_A0.5620.98
232_F268_D0.5620.98
340_Y343_L0.5620.98
49_V340_Y0.5610.98
316_Q320_I0.5590.98
237_A291_F0.5560.98
319_A325_R0.5560.98
255_L258_D0.5550.98
10_L15_I0.5540.98
130_D146_R0.5520.98
259_L264_A0.5520.98
138_P145_E0.5510.98
151_L187_L0.5500.98
295_I298_D0.5490.98
25_C68_I0.5460.98
334_E337_R0.5460.98
52_A55_V0.5450.98
16_R95_G0.5440.98
166_A169_R0.5440.98
104_H159_V0.5440.98
221_V225_W0.5430.98
73_L87_V0.5430.98
134_P190_Q0.5420.98
40_H58_E0.5390.97
157_E161_E0.5380.97
159_V187_L0.5380.97
27_Y69_S0.5380.97
179_E232_F0.5370.97
99_A265_D0.5360.97
235_I269_V0.5360.97
222_R225_W0.5360.97
207_F255_L0.5360.97
88_A100_I0.5340.97
178_A225_W0.5340.97
164_R225_W0.5330.97
159_V163_F0.5330.97
153_T201_D0.5320.97
140_P143_D0.5310.97
204_G210_R0.5290.97
65_R162_A0.5290.97
215_R254_Q0.5290.97
156_I188_I0.5290.97
65_R129_W0.5260.97
140_P145_E0.5250.97
256_A298_D0.5250.97
50_G342_P0.5250.97
23_P268_D0.5230.97
114_I129_W0.5220.97
70_P113_R0.5200.97
221_V224_E0.5180.97
24_M336_L0.5180.97
65_R114_I0.5170.97
180_I231_V0.5150.97
43_H58_E0.5140.97
252_S295_I0.5120.97
36_A40_H0.5100.97
57_T60_T0.5080.96
344_H349_L0.5070.96
133_A137_D0.5070.96
22_S335_F0.5050.96
250_E254_Q0.5040.96
75_I88_A0.5030.96
295_I305_V0.5020.96
321_V326_A0.5020.96
130_D147_D0.5010.96
342_P346_A0.5010.96
222_R262_L0.5010.96
21_M332_G0.5010.96
314_A341_F0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hsaB 2 0.9454 100 0.234 Contact Map
3k30A 2 0.9372 100 0.24 Contact Map
1o94A 2 0.9344 100 0.24 Contact Map
3l5aA 1 0.9536 100 0.244 Contact Map
4qnwA 1 0.9262 100 0.245 Contact Map
3tjlA 2 0.9481 100 0.25 Contact Map
4tmbA 2 0.9563 100 0.251 Contact Map
4e2bA 1 0.9454 100 0.253 Contact Map
4gbuA 2 0.9508 100 0.255 Contact Map
4jicA 1 0.9399 100 0.26 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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