Q9HQZ6 - HALSA - GREMLIN Contacts

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Q9HQZ6 - NADH-dependent flavin oxidoreductase

UniProt:	Q9HQZ6	Sequences: MADSFSPLELRDTTIRNRFAMSPMCQYSCEDRDGLATDWHRVHLGSRAVGGAGVVMTEATAVEERGRISPEDLGIWSDEHGEALAPVAEFISDQGATPAIQLAHAGRKAGTARIWGDDSGPVPLDEGGWDPVAPSADPYPYEDDERDTRKLSTADIEDVVEAFRDAARRANEAGFEVAEIHAAHGYLIHQFLSPVSNHRDDEYGGSFENRTRLAREVTSAVREEWPDDKPVFVRISATDWIDDRDSWTVEESVQLADDLHALGADLIDVSTAGIHPDQDIQSGGPNYQLQFAERINADTERDVAVGTVGGIQSAEQADAIVRNDRADLAIVGREFLRDPYFPLHAARELGREDAADVPPQYRRGFQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	366 (327)
Sequences:	11189 (7352)
Seq/√Len:	406.6

ECOLI - FADH NEMA
BACSU - NAMA YQIG
HALSA - Q9HQZ6
SULSO - Q97WT9 Q97X55

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
153_T	202_E	3.562	1.00
219_S	262_L	3.443	1.00
99_A	177_V	3.085	1.00
63_E	162_A	2.933	1.00
206_S	209_N	2.537	1.00
20_A	328_L	2.501	1.00
168_R	224_E	2.485	1.00
164_R	220_A	2.444	1.00
149_R	155_D	2.440	1.00
9_E	14_T	2.400	1.00
258_D	261_A	2.374	1.00
91_I	98_P	2.360	1.00
38_D	86_P	2.310	1.00
8_L	328_L	2.298	1.00
293_E	325_R	2.292	1.00
151_L	159_V	2.272	1.00
319_A	323_N	2.220	1.00
232_F	266_L	2.137	1.00
52_A	335_F	2.122	1.00
78_D	169_R	2.091	1.00
260_H	302_D	2.079	1.00
92_S	176_E	2.075	1.00
45_G	94_Q	2.062	1.00
12_D	228_D	2.044	1.00
132_V	151_L	2.006	1.00
338_D	344_H	2.003	1.00
151_L	155_D	1.993	1.00
171_N	225_W	1.980	1.00
306_G	330_I	1.942	1.00
5_F	346_A	1.907	1.00
45_G	90_F	1.902	1.00
161_E	165_D	1.902	1.00
343_L	347_R	1.901	1.00
168_R	172_E	1.893	1.00
188_I	214_A	1.873	1.00
318_D	322_R	1.872	1.00
257_D	298_D	1.865	1.00
60_T	100_I	1.857	1.00
136_A	150_K	1.848	1.00
188_I	213_L	1.821	1.00
165_D	169_R	1.809	1.00
85_A	89_E	1.798	1.00
158_D	162_A	1.786	1.00
3_D	6_S	1.766	1.00
153_T	157_E	1.752	1.00
164_R	224_E	1.747	1.00
157_E	216_E	1.703	1.00
81_G	172_E	1.698	1.00
89_E	93_D	1.693	1.00
111_T	146_R	1.691	1.00
171_N	226_P	1.691	1.00
203_Y	216_E	1.677	1.00
3_D	318_D	1.668	1.00
254_Q	258_D	1.665	1.00
214_A	233_V	1.634	1.00
182_A	233_V	1.629	1.00
209_N	212_R	1.627	1.00
188_I	217_V	1.597	1.00
88_A	175_F	1.589	1.00
153_T	203_Y	1.573	1.00
153_T	156_I	1.564	1.00
152_S	155_D	1.562	1.00
41_R	86_P	1.549	1.00
211_T	258_D	1.532	1.00
161_E	220_A	1.522	1.00
78_D	172_E	1.518	1.00
194_P	246_S	1.517	1.00
349_L	352_E	1.516	1.00
167_A	221_V	1.515	1.00
299_T	303_V	1.515	1.00
65_R	158_D	1.514	1.00
171_N	229_K	1.510	1.00
293_E	297_A	1.509	1.00
84_L	175_F	1.496	1.00
130_D	149_R	1.494	1.00
225_W	229_K	1.489	1.00
296_N	327_D	1.463	1.00
157_E	202_E	1.457	1.00
214_A	255_L	1.451	1.00
38_D	42_V	1.442	1.00
137_D	198_H	1.423	1.00
20_A	306_G	1.419	1.00
341_F	345_A	1.418	1.00
211_T	254_Q	1.408	1.00
42_V	45_G	1.407	1.00
75_I	100_I	1.397	1.00
81_G	169_R	1.394	1.00
19_F	342_P	1.387	1.00
215_R	258_D	1.385	1.00
57_T	98_P	1.378	1.00
30_E	33_D	1.378	1.00
294_R	298_D	1.373	1.00
46_S	340_Y	1.371	1.00
165_D	168_R	1.359	1.00
215_R	262_L	1.347	1.00
24_M	332_G	1.342	1.00
343_L	346_A	1.333	1.00
36_A	84_L	1.322	1.00
16_R	97_T	1.318	1.00
207_F	211_T	1.312	1.00
311_I	320_I	1.310	1.00
218_T	259_L	1.300	1.00
75_I	166_A	1.299	1.00
314_A	345_A	1.296	1.00
21_M	47_R	1.291	1.00
164_R	168_R	1.289	1.00
41_R	90_F	1.281	1.00
220_A	223_E	1.272	1.00
102_L	166_A	1.272	1.00
182_A	188_I	1.271	1.00
137_D	148_T	1.270	1.00
248_T	251_E	1.258	1.00
317_A	331_V	1.251	1.00
160_V	220_A	1.244	1.00
3_D	322_R	1.238	1.00
15_I	54_V	1.237	1.00
132_V	149_R	1.223	1.00
211_T	215_R	1.222	1.00
8_L	304_A	1.218	1.00
157_E	203_Y	1.215	1.00
260_H	303_V	1.207	1.00
220_A	224_E	1.207	1.00
83_A	86_P	1.206	1.00
164_R	223_E	1.201	1.00
294_R	297_A	1.191	1.00
308_V	330_I	1.189	1.00
35_L	79_E	1.187	1.00
45_G	93_D	1.177	1.00
215_R	219_S	1.176	1.00
21_M	55_V	1.173	1.00
13_T	97_T	1.173	1.00
41_R	45_G	1.169	1.00
258_D	262_L	1.161	1.00
30_E	37_T	1.159	1.00
314_A	348_E	1.156	1.00
249_V	294_R	1.150	1.00
150_K	200_D	1.142	1.00
335_F	342_P	1.141	1.00
45_G	49_V	1.140	1.00
100_I	170_A	1.136	1.00
133_A	136_A	1.129	1.00
212_R	216_E	1.129	1.00
155_D	158_D	1.123	1.00
161_E	164_R	1.122	1.00
160_V	216_E	1.121	1.00
97_T	176_E	1.119	1.00
320_I	326_A	1.116	1.00
184_H	270_S	1.113	1.00
88_A	98_P	1.106	1.00
207_F	254_Q	1.105	1.00
306_G	328_L	1.100	1.00
189_H	193_S	1.096	1.00
30_E	35_L	1.096	1.00
307_T	326_A	1.096	1.00
138_P	147_D	1.093	1.00
57_T	175_F	1.091	1.00
89_E	92_S	1.091	1.00
182_A	214_A	1.088	1.00
92_S	98_P	1.088	1.00
68_I	105_A	1.085	1.00
135_S	198_H	1.079	1.00
160_V	164_R	1.067	1.00
78_D	82_E	1.063	1.00
225_W	231_V	1.061	1.00
81_G	173_A	1.059	1.00
34_G	67_R	1.050	1.00
289_L	320_I	1.047	1.00
219_S	223_E	1.035	1.00
314_A	318_D	1.034	1.00
36_A	83_A	1.033	1.00
233_V	264_A	1.029	1.00
134_P	196_S	1.028	1.00
162_A	165_D	1.023	1.00
202_E	212_R	1.021	1.00
254_Q	257_D	1.016	1.00
61_A	72_D	1.015	1.00
37_T	40_H	1.008	1.00
86_P	89_E	1.003	1.00
253_V	298_D	1.002	1.00
9_E	12_D	1.000	1.00
15_I	53_G	0.996	1.00
26_Q	39_W	0.993	1.00
41_R	87_V	0.990	1.00
51_G	343_L	0.987	1.00
88_A	173_A	0.987	1.00
249_V	253_V	0.981	1.00
165_D	224_E	0.980	1.00
73_L	84_L	0.975	1.00
156_I	160_V	0.972	1.00
160_V	217_V	0.969	1.00
21_M	335_F	0.959	1.00
15_I	328_L	0.959	1.00
16_R	96_A	0.956	1.00
267_I	303_V	0.955	1.00
233_V	259_L	0.952	1.00
49_V	94_Q	0.951	1.00
253_V	257_D	0.950	1.00
157_E	160_V	0.949	1.00
15_I	20_A	0.949	1.00
218_T	264_A	0.942	1.00
107_R	196_S	0.933	1.00
11_R	265_D	0.931	1.00
326_A	329_A	0.931	1.00
177_V	232_F	0.929	1.00
136_A	147_D	0.927	1.00
17_N	53_G	0.924	1.00
211_T	255_L	0.924	1.00
74_G	80_H	0.922	1.00
192_L	214_A	0.922	1.00
35_L	80_H	0.919	1.00
4_S	317_A	0.916	1.00
180_I	221_V	0.916	1.00
311_I	329_A	0.915	1.00
253_V	294_R	0.911	1.00
195_V	243_D	0.909	1.00
52_A	342_P	0.908	1.00
19_F	341_F	0.907	1.00
179_E	268_D	0.906	1.00
187_L	213_L	0.905	1.00
36_A	73_L	0.904	1.00
75_I	170_A	0.899	1.00
235_I	252_S	0.898	1.00
22_S	268_D	0.895	1.00
85_A	172_E	0.891	1.00
54_V	99_A	0.889	1.00
299_T	302_D	0.887	1.00
132_V	155_D	0.884	1.00
154_A	157_E	0.883	1.00
98_P	175_F	0.880	1.00
98_P	176_E	0.879	1.00
256_A	267_I	0.877	1.00
203_Y	219_S	0.877	1.00
318_D	321_V	0.876	1.00
3_D	321_V	0.875	1.00
77_S	80_H	0.872	1.00
180_I	217_V	0.871	1.00
221_V	231_V	0.870	1.00
313_S	316_Q	0.869	1.00
157_E	220_A	0.867	1.00
160_V	213_L	0.859	1.00
59_A	103_A	0.859	1.00
82_E	85_A	0.856	1.00
207_F	258_D	0.853	1.00
46_S	49_V	0.853	1.00
211_T	214_A	0.846	1.00
311_I	317_A	0.844	1.00
167_A	225_W	0.841	1.00
218_T	262_L	0.841	1.00
216_E	219_S	0.833	1.00
315_E	348_E	0.832	1.00
160_V	203_Y	0.826	1.00
54_V	177_V	0.826	1.00
13_T	99_A	0.824	1.00
207_F	251_E	0.821	1.00
234_R	268_D	0.820	1.00
222_R	265_D	0.818	1.00
331_V	334_E	0.815	1.00
266_L	306_G	0.815	1.00
22_S	330_I	0.812	1.00
56_M	99_A	0.809	1.00
38_D	41_R	0.808	1.00
21_M	24_M	0.807	1.00
99_A	232_F	0.806	1.00
269_V	305_V	0.803	1.00
22_S	332_G	0.801	1.00
286_N	316_Q	0.799	1.00
153_T	160_V	0.799	1.00
257_D	261_A	0.798	1.00
152_S	157_E	0.795	1.00
237_A	269_V	0.795	1.00
61_A	76_W	0.794	1.00
150_K	198_H	0.794	1.00
247_W	255_L	0.790	1.00
8_L	11_R	0.789	1.00
208_E	254_Q	0.785	1.00
315_E	319_A	0.785	1.00
90_F	94_Q	0.784	1.00
180_I	218_T	0.783	1.00
136_A	198_H	0.782	1.00
61_A	67_R	0.779	1.00
340_Y	344_H	0.778	1.00
189_H	252_S	0.776	1.00
42_V	46_S	0.775	1.00
269_V	295_I	0.769	1.00
202_E	209_N	0.767	1.00
57_T	100_I	0.765	1.00
108_K	139_Y	0.764	1.00
36_A	87_V	0.763	1.00
21_M	52_A	0.763	1.00
159_V	162_A	0.763	1.00
149_R	152_S	0.757	1.00
222_R	231_V	0.757	1.00
213_L	217_V	0.756	1.00
205_G	210_R	0.752	1.00
171_N	228_D	0.750	1.00
77_S	81_G	0.746	1.00
29_C	40_H	0.745	1.00
295_I	299_T	0.745	1.00
12_D	229_K	0.743	1.00
164_R	217_V	0.743	1.00
62_V	163_F	0.741	1.00
56_M	177_V	0.740	1.00
13_T	177_V	0.739	1.00
57_T	84_L	0.734	1.00
232_F	306_G	0.733	1.00
63_E	159_V	0.732	1.00
105_A	109_A	0.730	1.00
222_R	226_P	0.730	1.00
151_L	156_I	0.728	1.00
256_A	295_I	0.727	1.00
76_W	80_H	0.726	1.00
107_R	148_T	0.724	1.00
50_G	343_L	0.721	1.00
271_T	288_Q	0.720	1.00
181_H	186_Y	0.719	1.00
290_Q	293_E	0.718	1.00
247_W	250_E	0.718	1.00
169_R	172_E	0.717	1.00
171_N	224_E	0.716	1.00
331_V	335_F	0.715	1.00
331_V	341_F	0.712	1.00
156_I	214_A	0.704	1.00
90_F	93_D	0.704	1.00
251_E	254_Q	0.701	1.00
62_V	217_V	0.696	1.00
195_V	241_I	0.694	1.00
140_P	144_D	0.693	1.00
208_E	258_D	0.691	1.00
15_I	97_T	0.690	1.00
247_W	252_S	0.689	1.00
250_E	253_V	0.687	1.00
44_L	55_V	0.686	1.00
256_A	299_T	0.686	1.00
85_A	88_A	0.686	1.00
20_A	54_V	0.685	1.00
43_H	47_R	0.684	1.00
14_T	97_T	0.683	1.00
319_A	322_R	0.682	1.00
317_A	345_A	0.679	1.00
133_A	196_S	0.678	0.99
268_D	330_I	0.678	0.99
140_P	243_D	0.675	0.99
63_E	158_D	0.675	0.99
10_L	304_A	0.671	0.99
20_A	56_M	0.670	0.99
66_G	104_H	0.668	0.99
19_F	52_A	0.665	0.99
60_T	75_I	0.664	0.99
218_T	233_V	0.663	0.99
289_L	307_T	0.662	0.99
92_S	97_T	0.662	0.99
320_I	325_R	0.661	0.99
35_L	83_A	0.660	0.99
48_A	94_Q	0.658	0.99
48_A	91_I	0.657	0.99
35_L	77_S	0.656	0.99
205_G	209_N	0.653	0.99
168_R	171_N	0.652	0.99
109_A	131_P	0.652	0.99
108_K	242_D	0.652	0.99
247_W	251_E	0.652	0.99
82_E	86_P	0.651	0.99
62_V	103_A	0.651	0.99
181_H	184_H	0.646	0.99
192_L	211_T	0.646	0.99
23_P	234_R	0.644	0.99
64_E	76_W	0.643	0.99
62_V	162_A	0.642	0.99
164_R	221_V	0.641	0.99
296_N	299_T	0.638	0.99
29_C	73_L	0.637	0.99
5_F	342_P	0.634	0.99
134_P	137_D	0.630	0.99
233_V	267_I	0.629	0.99
91_I	96_A	0.626	0.99
100_I	175_F	0.625	0.99
334_E	341_F	0.624	0.99
192_L	255_L	0.621	0.99
316_Q	319_A	0.621	0.99
107_R	190_Q	0.620	0.99
268_D	308_V	0.619	0.99
136_A	148_T	0.619	0.99
7_P	14_T	0.616	0.99
260_H	299_T	0.615	0.99
16_R	346_A	0.611	0.99
266_L	328_L	0.610	0.99
135_S	150_K	0.609	0.99
218_T	231_V	0.604	0.99
321_V	329_A	0.602	0.99
86_P	90_F	0.601	0.99
343_L	349_L	0.597	0.99
20_A	330_I	0.597	0.99
189_H	239_D	0.597	0.99
81_G	85_A	0.596	0.99
75_I	169_R	0.592	0.99
137_D	196_S	0.590	0.99
291_F	294_R	0.589	0.99
202_E	216_E	0.588	0.99
307_T	329_A	0.588	0.99
217_V	220_A	0.584	0.99
133_A	148_T	0.583	0.98
22_S	56_M	0.580	0.98
54_V	97_T	0.578	0.98
163_F	188_I	0.577	0.98
207_F	247_W	0.577	0.98
289_L	292_A	0.576	0.98
153_T	216_E	0.575	0.98
75_I	80_H	0.574	0.98
331_V	345_A	0.573	0.98
226_P	229_K	0.572	0.98
47_R	340_Y	0.572	0.98
239_D	274_I	0.571	0.98
222_R	227_D	0.570	0.98
65_R	159_V	0.570	0.98
337_R	352_E	0.570	0.98
81_G	88_A	0.569	0.98
188_I	221_V	0.568	0.98
132_V	159_V	0.567	0.98
299_T	304_A	0.566	0.98
72_D	105_A	0.566	0.98
82_E	89_E	0.565	0.98
61_A	105_A	0.562	0.98
232_F	268_D	0.562	0.98
340_Y	343_L	0.562	0.98
49_V	340_Y	0.561	0.98
316_Q	320_I	0.559	0.98
237_A	291_F	0.556	0.98
319_A	325_R	0.556	0.98
255_L	258_D	0.555	0.98
10_L	15_I	0.554	0.98
130_D	146_R	0.552	0.98
259_L	264_A	0.552	0.98
138_P	145_E	0.551	0.98
151_L	187_L	0.550	0.98
295_I	298_D	0.549	0.98
25_C	68_I	0.546	0.98
334_E	337_R	0.546	0.98
52_A	55_V	0.545	0.98
16_R	95_G	0.544	0.98
166_A	169_R	0.544	0.98
104_H	159_V	0.544	0.98
221_V	225_W	0.543	0.98
73_L	87_V	0.543	0.98
134_P	190_Q	0.542	0.98
40_H	58_E	0.539	0.97
157_E	161_E	0.538	0.97
159_V	187_L	0.538	0.97
27_Y	69_S	0.538	0.97
179_E	232_F	0.537	0.97
99_A	265_D	0.536	0.97
235_I	269_V	0.536	0.97
222_R	225_W	0.536	0.97
207_F	255_L	0.536	0.97
88_A	100_I	0.534	0.97
178_A	225_W	0.534	0.97
164_R	225_W	0.533	0.97
159_V	163_F	0.533	0.97
153_T	201_D	0.532	0.97
140_P	143_D	0.531	0.97
204_G	210_R	0.529	0.97
65_R	162_A	0.529	0.97
215_R	254_Q	0.529	0.97
156_I	188_I	0.529	0.97
65_R	129_W	0.526	0.97
140_P	145_E	0.525	0.97
256_A	298_D	0.525	0.97
50_G	342_P	0.525	0.97
23_P	268_D	0.523	0.97
114_I	129_W	0.522	0.97
70_P	113_R	0.520	0.97
221_V	224_E	0.518	0.97
24_M	336_L	0.518	0.97
65_R	114_I	0.517	0.97
180_I	231_V	0.515	0.97
43_H	58_E	0.514	0.97
252_S	295_I	0.512	0.97
36_A	40_H	0.510	0.97
57_T	60_T	0.508	0.96
344_H	349_L	0.507	0.96
133_A	137_D	0.507	0.96
22_S	335_F	0.505	0.96
250_E	254_Q	0.504	0.96
75_I	88_A	0.503	0.96
295_I	305_V	0.502	0.96
321_V	326_A	0.502	0.96
130_D	147_D	0.501	0.96
342_P	346_A	0.501	0.96
222_R	262_L	0.501	0.96
21_M	332_G	0.501	0.96
314_A	341_F	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2hsaB	2	0.9454	100	0.234	Contact Map
3k30A	2	0.9372	100	0.24	Contact Map
1o94A	2	0.9344	100	0.24	Contact Map
3l5aA	1	0.9536	100	0.244	Contact Map
4qnwA	1	0.9262	100	0.245	Contact Map
3tjlA	2	0.9481	100	0.25	Contact Map
4tmbA	2	0.9563	100	0.251	Contact Map
4e2bA	1	0.9454	100	0.253	Contact Map
4gbuA	2	0.9508	100	0.255	Contact Map
4jicA	1	0.9399	100	0.26	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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