GREMLIN Database
Q9HQZ4 - NADH oxidase
UniProt: Q9HQZ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (181)
Sequences: 10787 (8226)
Seq/√Len: 611.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_D30_A4.4711.00
39_E155_R3.6411.00
33_D36_T3.5071.00
34_D62_Q2.9911.00
34_D38_A2.7231.00
30_A190_P2.6861.00
58_F144_A2.5171.00
57_E209_H2.4891.00
158_T191_S2.2591.00
42_R45_T2.2161.00
40_L152_A2.2101.00
19_T153_H2.1811.00
36_T155_R2.1411.00
69_E173_F2.0801.00
157_L190_P2.0291.00
149_L159_A1.9591.00
64_D68_A1.9311.00
44_A148_L1.9181.00
43_D151_S1.8941.00
15_D19_T1.8641.00
27_D192_G1.7961.00
145_A184_V1.7861.00
25_N192_G1.7731.00
171_A182_P1.7361.00
36_T157_L1.7331.00
66_R69_E1.6701.00
13_L17_L1.6501.00
149_L161_P1.6351.00
73_I169_A1.6181.00
12_A15_D1.5891.00
18_R46_L1.5801.00
145_A186_I1.5581.00
202_R206_E1.5291.00
40_L148_L1.5061.00
13_L16_G1.5041.00
14_I18_R1.4841.00
166_D169_A1.4721.00
31_D62_Q1.4671.00
153_H158_T1.4381.00
90_A180_T1.4271.00
58_F87_I1.4241.00
152_A188_V1.4201.00
204_V208_L1.4181.00
139_R142_S1.4181.00
157_L188_V1.4141.00
14_I39_E1.4121.00
169_A172_E1.4091.00
70_L170_A1.3721.00
11_D15_D1.3561.00
41_I208_L1.3491.00
149_L186_I1.3431.00
73_I173_F1.3341.00
40_L157_L1.3191.00
40_L188_V1.3111.00
63_D66_R1.2871.00
68_A72_E1.2791.00
71_A81_V1.2621.00
143_L146_Q1.2561.00
38_A205_D1.2541.00
36_T190_P1.2481.00
26_F187_A1.2461.00
36_T39_E1.2371.00
78_Q82_D1.2341.00
152_A159_A1.2321.00
141_A183_V1.2271.00
66_R173_F1.2181.00
14_I43_D1.2181.00
45_T207_V1.2101.00
43_D155_R1.2011.00
57_E180_T1.1841.00
32_I157_L1.1491.00
64_D67_L1.1451.00
65_D68_A1.1421.00
22_S160_T1.1311.00
38_A204_V1.1141.00
125_A128_E1.1071.00
191_S194_E1.1041.00
18_R42_R1.0891.00
14_I155_R1.0871.00
47_A147_N1.0851.00
69_E72_E1.0831.00
169_A173_F1.0741.00
138_I183_V1.0621.00
151_S155_R1.0501.00
68_A81_V1.0431.00
87_I148_L1.0421.00
50_S136_Y1.0371.00
12_A154_A1.0351.00
98_A101_V1.0351.00
38_A42_R1.0321.00
159_A186_I1.0281.00
159_A188_V1.0211.00
165_F185_L1.0091.00
17_L147_N1.0091.00
35_D38_A1.0081.00
161_P184_V1.0061.00
78_Q81_V1.0061.00
11_D154_A0.9981.00
65_D69_E0.9971.00
60_A208_L0.9851.00
168_E172_E0.9851.00
100_R104_E0.9831.00
145_A161_P0.9791.00
15_D18_R0.9761.00
100_R103_E0.9611.00
41_I44_A0.9571.00
33_D190_P0.9511.00
101_V104_E0.9491.00
99_D103_E0.9441.00
147_N150_L0.9361.00
160_T187_A0.9361.00
39_E43_D0.9251.00
32_I190_P0.9161.00
59_V90_A0.9121.00
148_L188_V0.9111.00
134_R181_V0.8991.00
151_S154_A0.8981.00
58_F89_V0.8931.00
97_T100_R0.8921.00
103_E107_D0.8801.00
59_V180_T0.8791.00
148_L186_I0.8751.00
42_R204_V0.8741.00
104_E107_D0.8721.00
104_E108_A0.8691.00
97_T101_V0.8691.00
91_G137_A0.8601.00
101_V105_W0.8561.00
146_Q150_L0.8541.00
176_L180_T0.8521.00
72_E76_D0.8501.00
162_M187_A0.8481.00
136_Y163_S0.8471.00
13_L150_L0.8411.00
27_D190_P0.8401.00
17_L150_L0.8341.00
143_L147_N0.8321.00
88_L185_L0.8201.00
31_D64_D0.8151.00
60_A85_T0.8121.00
39_E42_R0.8091.00
41_I60_A0.8061.00
102_F107_D0.8011.00
89_V148_L0.8001.00
13_L154_A0.7971.00
171_A181_V0.7951.00
142_S161_P0.7951.00
69_E73_I0.7921.00
203_S206_E0.7901.00
40_L155_R0.7821.00
68_A71_A0.7811.00
139_R163_S0.7751.00
16_G154_A0.7711.00
102_F105_W0.7651.00
25_N193_G0.7581.00
167_F182_P0.7561.00
37_L188_V0.7561.00
99_D106_V0.7481.00
37_L41_I0.7361.00
56_W141_A0.7321.00
140_N163_S0.7311.00
98_A102_F0.7291.00
26_F160_T0.7271.00
135_D138_I0.7261.00
177_P180_T0.7231.00
138_I142_S0.7231.00
14_I154_A0.7231.00
77_Q81_V0.7221.00
105_W108_A0.7211.00
50_S163_S0.7191.00
100_R206_E0.7141.00
49_S56_W0.7141.00
30_A33_D0.7131.00
202_R207_V0.7091.00
79_H83_A0.7081.00
37_L85_T0.7051.00
167_F171_A0.7041.00
35_D39_E0.7021.00
135_D139_R0.6981.00
143_L161_P0.6961.00
59_V174_A0.6851.00
67_L71_A0.6831.00
139_R143_L0.6771.00
101_V106_V0.6761.00
61_V66_R0.6751.00
61_V174_A0.6731.00
103_E106_V0.6721.00
32_I36_T0.6711.00
32_I35_D0.6711.00
170_A173_F0.6711.00
11_D16_G0.6681.00
102_F106_V0.6671.00
79_H82_D0.6661.00
177_P209_H0.6651.00
44_A58_F0.6621.00
27_D193_G0.6591.00
146_Q149_L0.6531.00
83_A86_A0.6471.00
46_L198_R0.6441.00
98_A104_E0.6431.00
171_A176_L0.6411.00
129_S132_A0.6371.00
74_A80_I0.6361.00
89_V93_T0.6281.00
48_P159_A0.6201.00
97_T102_F0.6191.00
89_V145_A0.6161.00
50_S140_N0.6121.00
23_G191_S0.6101.00
167_F181_V0.6101.00
87_I188_V0.6071.00
168_E171_A0.6051.00
17_L43_D0.6031.00
94_D179_D0.6001.00
126_S182_P0.5981.00
92_H95_P0.5951.00
13_L151_S0.5951.00
86_A187_A0.5951.00
66_R174_A0.5941.00
89_V141_A0.5941.00
80_I83_A0.5931.00
36_T40_L0.5911.00
73_I170_A0.5901.00
17_L154_A0.5891.00
71_A75_Y0.5881.00
91_G95_P0.5871.00
14_I151_S0.5821.00
165_F170_A0.5781.00
37_L60_A0.5771.00
16_G150_L0.5741.00
86_A185_L0.5731.00
81_V84_G0.5731.00
98_A105_W0.5731.00
56_W207_V0.5721.00
138_I181_V0.5681.00
150_L154_A0.5681.00
82_D85_T0.5671.00
144_A207_V0.5671.00
72_E173_F0.5651.00
100_R108_A0.5631.00
49_S54_Q0.5631.00
59_V209_H0.5621.00
90_A93_T0.5611.00
24_H160_T0.5581.00
70_L185_L0.5561.00
41_I207_V0.5551.00
27_D31_D0.5541.00
77_Q80_I0.5460.99
74_A185_L0.5410.99
145_A149_L0.5390.99
99_D108_A0.5380.99
62_Q85_T0.5330.99
40_L44_A0.5320.99
56_W144_A0.5280.99
24_H79_H0.5280.99
100_R105_W0.5260.99
25_N194_E0.5250.99
32_I37_L0.5250.99
93_T181_V0.5240.99
71_A77_Q0.5190.99
71_A76_D0.5180.99
142_S146_Q0.5180.99
136_Y140_N0.5140.99
45_T204_V0.5120.99
18_R43_D0.5120.99
144_A148_L0.5120.99
139_R184_V0.5110.99
88_L174_A0.5090.99
139_R183_V0.5060.99
61_V70_L0.5040.99
20_R159_A0.5010.99
170_A185_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qlxA 2 0.9906 100 0.233 Contact Map
3gagA 4 0.9577 100 0.233 Contact Map
3ge6A 2 0.9624 100 0.235 Contact Map
3gbhA 3 0.9718 100 0.241 Contact Map
3of4A 3 0.939 100 0.243 Contact Map
2h0uA 2 0.8638 100 0.248 Contact Map
1noxA 2 0.9202 100 0.254 Contact Map
3bemA 2 0.9671 100 0.254 Contact Map
1icrA 2 0.939 100 0.255 Contact Map
2hayA 2 0.9765 100 0.257 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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