Q9HQZ3 - HALSA - GREMLIN Contacts

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Q9HQZ3 - Uncharacterized protein

UniProt:	Q9HQZ3	Sequences: MWRAAVAPGMSAPTVAACQIAVADLDPAANLATIGERLAAVDSAGVDVAVFPEYALTGFVADDRVYAAALDRDGAILDRLAAAAAEHDVAVLAGYIEDAPDSDAYHNTVVYVTPGGERTHYRKRHLWAGEQDALTPGTEPVIVDTPVGRTGLVTCYDLNFVAVSAAFTRERVDALFVVGAWPGTYSENWRLLLRARALDGVRWVVGCGRTGRRTIPDAPVVEYAGRSAVVRPDGVVCQALNRGQRTLTATLDPDVLAEQRAFIPVLPGEA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	270 (244)
Sequences:	13921 (9736)
Seq/√Len:	623.3

ECOLI - YAFV YBEM YOBB LNT
BACSU - MTNU YHCX
HALSA - Q9HQZ3
SULSO - Q97ZZ7 Q97WN8 Q981B6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
14_T	250_T	3.142	1.00
144_D	149_R	2.982	1.00
26_D	29_A	2.599	1.00
229_V	249_A	2.344	1.00
196_R	199_D	2.316	1.00
95_Y	110_V	2.302	1.00
34_I	55_A	2.287	1.00
33_T	244_Q	2.262	1.00
231_R	235_V	2.252	1.00
97_E	122_R	2.210	1.00
190_R	239_A	2.181	1.00
16_A	248_T	2.179	1.00
241_N	245_R	2.149	1.00
151_G	167_F	2.139	1.00
108_T	122_R	2.128	1.00
153_V	164_S	2.098	1.00
16_A	46_V	2.088	1.00
35_G	79_R	2.081	1.00
35_G	83_A	2.057	1.00
17_A	205_V	2.032	1.00
17_A	207_C	2.010	1.00
39_A	87_H	2.000	1.00
50_V	176_F	1.958	1.00
39_A	86_E	1.919	1.00
173_D	257_A	1.912	1.00
240_L	245_R	1.856	1.00
44_A	248_T	1.838	1.00
240_L	247_L	1.835	1.00
104_A	135_T	1.832	1.00
15_V	205_V	1.825	1.00
90_A	114_P	1.824	1.00
191_L	194_R	1.800	1.00
33_T	36_E	1.787	1.00
49_A	89_V	1.781	1.00
47_D	146_P	1.770	1.00
81_A	112_V	1.753	1.00
35_G	39_A	1.746	1.00
145_T	148_G	1.739	1.00
106_H	122_R	1.709	1.00
175_L	202_R	1.692	1.00
40_A	44_A	1.664	1.00
84_A	91_V	1.662	1.00
90_A	111_Y	1.615	1.00
109_V	152_L	1.614	1.00
149_R	173_D	1.606	1.00
203_W	232_P	1.605	1.00
46_V	248_T	1.580	1.00
80_L	93_A	1.556	1.00
92_L	111_Y	1.552	1.00
230_V	236_V	1.547	1.00
82_A	86_E	1.542	1.00
150_T	174_A	1.531	1.00
113_T	117_E	1.521	1.00
39_A	83_A	1.519	1.00
108_T	120_H	1.515	1.00
111_Y	152_L	1.514	1.00
238_Q	247_L	1.503	1.00
50_V	207_C	1.483	1.00
129_G	132_D	1.483	1.00
18_C	49_A	1.482	1.00
38_L	91_V	1.477	1.00
34_I	51_F	1.470	1.00
36_E	40_A	1.470	1.00
92_L	109_V	1.469	1.00
92_L	176_F	1.464	1.00
193_L	206_G	1.461	1.00
38_L	49_A	1.450	1.00
205_V	229_V	1.421	1.00
255_V	258_E	1.418	1.00
90_A	145_T	1.414	1.00
31_L	79_R	1.406	1.00
190_R	194_R	1.398	1.00
48_V	176_F	1.381	1.00
77_L	110_V	1.375	1.00
153_V	177_V	1.369	1.00
153_V	163_V	1.354	1.00
37_R	40_A	1.348	1.00
128_A	131_Q	1.343	1.00
164_S	175_L	1.336	1.00
203_W	237_C	1.328	1.00
32_A	36_E	1.315	1.00
18_C	51_F	1.301	1.00
114_P	146_P	1.292	1.00
29_A	32_A	1.259	1.00
92_L	152_L	1.253	1.00
95_Y	120_H	1.253	1.00
231_R	237_C	1.251	1.00
109_V	178_V	1.251	1.00
83_A	87_H	1.248	1.00
38_L	83_A	1.233	1.00
150_T	176_F	1.228	1.00
258_E	262_F	1.217	1.00
41_V	246_T	1.214	1.00
23_A	29_A	1.202	1.00
212_R	222_E	1.202	1.00
32_A	79_R	1.197	1.00
226_R	239_A	1.195	1.00
162_A	165_A	1.192	1.00
28_A	32_A	1.190	1.00
18_C	246_T	1.188	1.00
97_E	108_T	1.183	1.00
78_D	82_A	1.162	1.00
166_A	170_E	1.162	1.00
56_L	76_I	1.159	1.00
78_D	81_A	1.154	1.00
119_T	141_V	1.149	1.00
164_S	177_V	1.144	1.00
174_A	205_V	1.141	1.00
29_A	33_T	1.131	1.00
88_D	114_P	1.124	1.00
231_R	255_V	1.121	1.00
191_L	198_L	1.117	1.00
73_D	77_L	1.098	1.00
20_I	37_R	1.093	1.00
77_L	112_V	1.087	1.00
156_Y	160_F	1.087	1.00
38_L	89_V	1.085	1.00
70_L	74_G	1.077	1.00
64_R	67_A	1.074	1.00
35_G	86_E	1.066	1.00
172_V	175_L	1.065	1.00
193_L	230_V	1.058	1.00
37_R	246_T	1.058	1.00
121_Y	141_V	1.052	1.00
33_T	37_R	1.050	1.00
18_C	37_R	1.047	1.00
110_V	120_H	1.046	1.00
46_V	49_A	1.035	1.00
106_H	135_T	1.034	1.00
197_A	204_V	1.034	1.00
90_A	113_T	1.030	1.00
226_R	242_R	1.022	1.00
79_R	82_A	1.013	1.00
190_R	228_A	1.011	1.00
112_V	118_R	1.005	1.00
31_L	35_G	1.000	1.00
209_R	213_R	0.987	1.00
70_L	76_I	0.985	1.00
148_G	173_D	0.974	1.00
81_A	117_E	0.972	1.00
79_R	83_A	0.969	1.00
193_L	228_A	0.968	1.00
168_T	202_R	0.967	1.00
80_L	91_V	0.966	1.00
14_T	248_T	0.963	1.00
34_I	80_L	0.963	1.00
148_G	174_A	0.963	1.00
42_D	89_V	0.959	1.00
257_A	261_A	0.955	1.00
23_A	26_D	0.955	1.00
111_Y	143_V	0.955	1.00
165_A	200_G	0.950	1.00
193_L	204_V	0.944	1.00
90_A	146_P	0.943	1.00
142_I	149_R	0.943	1.00
151_G	172_V	0.937	1.00
20_I	34_I	0.934	1.00
82_A	85_A	0.934	1.00
39_A	43_S	0.925	1.00
144_D	147_V	0.916	1.00
197_A	230_V	0.914	1.00
254_D	257_A	0.912	1.00
119_T	143_V	0.911	1.00
63_D	67_A	0.909	1.00
19_Q	227_S	0.902	1.00
73_D	78_D	0.900	1.00
17_A	247_L	0.898	1.00
187_E	194_R	0.896	1.00
210_T	243_G	0.896	1.00
83_A	86_E	0.895	1.00
74_G	77_L	0.894	1.00
17_A	229_V	0.883	1.00
57_T	73_D	0.882	1.00
237_C	249_A	0.880	1.00
186_S	226_R	0.880	1.00
254_D	258_E	0.879	1.00
31_L	80_L	0.875	1.00
93_A	112_V	0.871	1.00
28_A	75_A	0.870	1.00
145_T	150_T	0.867	1.00
35_G	82_A	0.866	1.00
228_A	236_V	0.865	1.00
121_Y	157_D	0.860	1.00
165_A	169_R	0.854	1.00
191_L	195_A	0.852	1.00
40_A	43_S	0.852	1.00
189_W	206_G	0.849	1.00
187_E	190_R	0.845	1.00
252_D	255_V	0.843	1.00
238_Q	249_A	0.838	1.00
13_P	148_G	0.834	1.00
236_V	239_A	0.834	1.00
173_D	253_P	0.834	1.00
142_I	172_V	0.833	1.00
203_W	256_L	0.825	1.00
74_G	78_D	0.823	1.00
54_Y	134_L	0.818	1.00
77_L	118_R	0.815	1.00
27_P	31_L	0.810	1.00
21_A	244_Q	0.798	1.00
20_I	55_A	0.797	1.00
28_A	79_R	0.795	1.00
47_D	114_P	0.792	1.00
14_T	44_A	0.789	1.00
15_V	251_L	0.781	1.00
42_D	87_H	0.780	1.00
123_K	155_C	0.774	1.00
124_R	163_V	0.769	1.00
36_E	39_A	0.765	1.00
203_W	251_L	0.764	1.00
41_V	46_V	0.761	1.00
101_D	104_A	0.752	1.00
97_E	120_H	0.746	1.00
71_D	98_D	0.745	1.00
21_A	210_T	0.745	1.00
34_I	93_A	0.744	1.00
38_L	87_H	0.743	1.00
255_V	259_Q	0.738	1.00
167_F	172_V	0.735	1.00
158_L	177_V	0.735	1.00
16_A	246_T	0.734	1.00
51_F	55_A	0.730	1.00
54_Y	59_F	0.729	1.00
125_H	157_D	0.728	1.00
177_V	204_V	0.728	1.00
38_L	51_F	0.728	1.00
19_Q	225_G	0.725	1.00
107_N	123_K	0.720	1.00
34_I	38_L	0.718	1.00
17_A	227_S	0.717	1.00
158_L	193_L	0.715	1.00
32_A	35_G	0.714	1.00
81_A	118_R	0.713	1.00
228_A	239_A	0.713	1.00
90_A	147_V	0.713	1.00
65_V	68_A	0.713	1.00
27_P	70_L	0.712	1.00
44_A	246_T	0.710	1.00
13_P	251_L	0.708	1.00
180_A	209_R	0.707	1.00
203_W	255_V	0.702	1.00
72_R	77_L	0.701	1.00
16_A	49_A	0.701	1.00
16_A	41_V	0.697	1.00
175_L	204_V	0.696	1.00
148_G	253_P	0.695	1.00
210_T	244_Q	0.691	1.00
253_P	257_A	0.690	1.00
31_L	76_I	0.688	1.00
153_V	167_F	0.687	1.00
84_A	87_H	0.683	1.00
233_D	259_Q	0.679	1.00
143_V	150_T	0.673	1.00
50_V	92_L	0.671	1.00
124_R	140_P	0.670	1.00
43_S	87_H	0.666	1.00
13_P	147_V	0.666	1.00
125_H	160_F	0.665	1.00
113_T	146_P	0.664	1.00
20_I	33_T	0.663	1.00
48_V	90_A	0.662	1.00
41_V	49_A	0.662	1.00
27_P	76_I	0.661	1.00
48_V	92_L	0.660	1.00
235_V	255_V	0.651	1.00
139_E	142_I	0.650	1.00
140_P	163_V	0.649	1.00
77_L	81_A	0.643	1.00
75_A	78_D	0.643	1.00
50_V	205_V	0.643	1.00
64_R	68_A	0.640	1.00
183_G	222_E	0.638	1.00
54_Y	96_I	0.637	1.00
77_L	93_A	0.631	1.00
101_D	122_R	0.630	1.00
111_Y	150_T	0.624	1.00
168_T	200_G	0.620	1.00
73_D	95_Y	0.620	1.00
26_D	30_N	0.616	1.00
76_I	79_R	0.614	1.00
127_W	156_Y	0.610	1.00
81_A	84_A	0.609	1.00
97_E	110_V	0.604	1.00
190_R	226_R	0.602	1.00
187_E	191_L	0.596	1.00
189_W	193_L	0.595	1.00
59_F	155_C	0.594	1.00
35_G	87_H	0.593	1.00
163_V	167_F	0.592	1.00
40_A	246_T	0.590	1.00
41_V	89_V	0.588	1.00
84_A	116_G	0.586	1.00
47_D	88_D	0.583	1.00
180_A	223_Y	0.583	1.00
39_A	42_D	0.581	1.00
196_R	200_G	0.580	1.00
113_T	119_T	0.579	1.00
209_R	223_Y	0.579	1.00
41_V	45_G	0.578	1.00
66_Y	69_A	0.578	1.00
46_V	89_V	0.577	1.00
98_D	105_Y	0.577	1.00
256_L	260_R	0.577	1.00
48_V	147_V	0.575	1.00
28_A	31_L	0.570	1.00
107_N	155_C	0.570	1.00
182_P	185_Y	0.569	1.00
159_N	181_W	0.569	1.00
186_S	224_A	0.567	1.00
55_A	93_A	0.567	1.00
208_G	227_S	0.561	1.00
47_D	147_V	0.556	1.00
166_A	169_R	0.556	1.00
192_L	195_A	0.556	1.00
159_N	192_L	0.555	1.00
140_P	143_V	0.552	1.00
23_A	30_N	0.549	1.00
65_V	69_A	0.549	1.00
96_I	134_L	0.546	1.00
208_G	224_A	0.545	0.99
13_P	48_V	0.544	0.99
190_R	230_V	0.544	0.99
151_G	175_L	0.543	0.99
56_L	80_L	0.543	0.99
97_E	106_H	0.542	0.99
127_W	159_N	0.541	0.99
123_K	130_E	0.541	0.99
142_I	170_E	0.540	0.99
42_D	88_D	0.539	0.99
181_W	189_W	0.536	0.99
13_P	250_T	0.535	0.99
13_P	47_D	0.534	0.99
21_A	33_T	0.534	0.99
59_F	134_L	0.533	0.99
54_Y	107_N	0.532	0.99
17_A	238_Q	0.530	0.99
40_A	245_R	0.529	0.99
174_A	203_W	0.529	0.99
140_P	167_F	0.527	0.99
164_S	196_R	0.527	0.99
19_Q	240_L	0.526	0.99
57_T	68_A	0.526	0.99
21_A	209_R	0.526	0.99
140_P	166_A	0.525	0.99
190_R	236_V	0.524	0.99
119_T	152_L	0.524	0.99
53_E	155_C	0.522	0.99
95_Y	108_T	0.519	0.99
167_F	175_L	0.518	0.99
84_A	112_V	0.517	0.99
194_R	230_V	0.515	0.99
173_D	256_L	0.514	0.99
149_R	170_E	0.514	0.99
107_N	154_T	0.514	0.99
194_R	236_V	0.512	0.99
31_L	56_L	0.512	0.99
72_R	75_A	0.510	0.99
95_Y	154_T	0.507	0.99
141_V	170_E	0.506	0.99
48_V	111_Y	0.506	0.99
188_N	192_L	0.506	0.99
124_R	166_A	0.506	0.99
90_A	150_T	0.505	0.99
181_W	206_G	0.504	0.99
201_V	259_Q	0.503	0.99
23_A	33_T	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4izuA	2	0.8963	100	0.176	Contact Map
3p8kA	2	0.9556	100	0.18	Contact Map
2vhhA	5	1	100	0.181	Contact Map
3ivzA	2	0.9185	100	0.19	Contact Map
2w1vA	2	0.937	100	0.19	Contact Map
2e11A	2	0.9333	100	0.191	Contact Map
1f89A	2	0.9667	100	0.197	Contact Map
1uf5A	4	0.9444	100	0.199	Contact Map
1emsA	3	0.9481	100	0.203	Contact Map
3wuyA	2	0.9556	100	0.208	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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