GREMLIN Database
Q9HQZ3 - Uncharacterized protein
UniProt: Q9HQZ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (244)
Sequences: 13921 (9736)
Seq/√Len: 623.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_T250_T3.1421.00
144_D149_R2.9821.00
26_D29_A2.5991.00
229_V249_A2.3441.00
196_R199_D2.3161.00
95_Y110_V2.3021.00
34_I55_A2.2871.00
33_T244_Q2.2621.00
231_R235_V2.2521.00
97_E122_R2.2101.00
190_R239_A2.1811.00
16_A248_T2.1791.00
241_N245_R2.1491.00
151_G167_F2.1391.00
108_T122_R2.1281.00
153_V164_S2.0981.00
16_A46_V2.0881.00
35_G79_R2.0811.00
35_G83_A2.0571.00
17_A205_V2.0321.00
17_A207_C2.0101.00
39_A87_H2.0001.00
50_V176_F1.9581.00
39_A86_E1.9191.00
173_D257_A1.9121.00
240_L245_R1.8561.00
44_A248_T1.8381.00
240_L247_L1.8351.00
104_A135_T1.8321.00
15_V205_V1.8251.00
90_A114_P1.8241.00
191_L194_R1.8001.00
33_T36_E1.7871.00
49_A89_V1.7811.00
47_D146_P1.7701.00
81_A112_V1.7531.00
35_G39_A1.7461.00
145_T148_G1.7391.00
106_H122_R1.7091.00
175_L202_R1.6921.00
40_A44_A1.6641.00
84_A91_V1.6621.00
90_A111_Y1.6151.00
109_V152_L1.6141.00
149_R173_D1.6061.00
203_W232_P1.6051.00
46_V248_T1.5801.00
80_L93_A1.5561.00
92_L111_Y1.5521.00
230_V236_V1.5471.00
82_A86_E1.5421.00
150_T174_A1.5311.00
113_T117_E1.5211.00
39_A83_A1.5191.00
108_T120_H1.5151.00
111_Y152_L1.5141.00
238_Q247_L1.5031.00
50_V207_C1.4831.00
129_G132_D1.4831.00
18_C49_A1.4821.00
38_L91_V1.4771.00
34_I51_F1.4701.00
36_E40_A1.4701.00
92_L109_V1.4691.00
92_L176_F1.4641.00
193_L206_G1.4611.00
38_L49_A1.4501.00
205_V229_V1.4211.00
255_V258_E1.4181.00
90_A145_T1.4141.00
31_L79_R1.4061.00
190_R194_R1.3981.00
48_V176_F1.3811.00
77_L110_V1.3751.00
153_V177_V1.3691.00
153_V163_V1.3541.00
37_R40_A1.3481.00
128_A131_Q1.3431.00
164_S175_L1.3361.00
203_W237_C1.3281.00
32_A36_E1.3151.00
18_C51_F1.3011.00
114_P146_P1.2921.00
29_A32_A1.2591.00
92_L152_L1.2531.00
95_Y120_H1.2531.00
231_R237_C1.2511.00
109_V178_V1.2511.00
83_A87_H1.2481.00
38_L83_A1.2331.00
150_T176_F1.2281.00
258_E262_F1.2171.00
41_V246_T1.2141.00
23_A29_A1.2021.00
212_R222_E1.2021.00
32_A79_R1.1971.00
226_R239_A1.1951.00
162_A165_A1.1921.00
28_A32_A1.1901.00
18_C246_T1.1881.00
97_E108_T1.1831.00
78_D82_A1.1621.00
166_A170_E1.1621.00
56_L76_I1.1591.00
78_D81_A1.1541.00
119_T141_V1.1491.00
164_S177_V1.1441.00
174_A205_V1.1411.00
29_A33_T1.1311.00
88_D114_P1.1241.00
231_R255_V1.1211.00
191_L198_L1.1171.00
73_D77_L1.0981.00
20_I37_R1.0931.00
77_L112_V1.0871.00
156_Y160_F1.0871.00
38_L89_V1.0851.00
70_L74_G1.0771.00
64_R67_A1.0741.00
35_G86_E1.0661.00
172_V175_L1.0651.00
193_L230_V1.0581.00
37_R246_T1.0581.00
121_Y141_V1.0521.00
33_T37_R1.0501.00
18_C37_R1.0471.00
110_V120_H1.0461.00
46_V49_A1.0351.00
106_H135_T1.0341.00
197_A204_V1.0341.00
90_A113_T1.0301.00
226_R242_R1.0221.00
79_R82_A1.0131.00
190_R228_A1.0111.00
112_V118_R1.0051.00
31_L35_G1.0001.00
209_R213_R0.9871.00
70_L76_I0.9851.00
148_G173_D0.9741.00
81_A117_E0.9721.00
79_R83_A0.9691.00
193_L228_A0.9681.00
168_T202_R0.9671.00
80_L91_V0.9661.00
14_T248_T0.9631.00
34_I80_L0.9631.00
148_G174_A0.9631.00
42_D89_V0.9591.00
257_A261_A0.9551.00
23_A26_D0.9551.00
111_Y143_V0.9551.00
165_A200_G0.9501.00
193_L204_V0.9441.00
90_A146_P0.9431.00
142_I149_R0.9431.00
151_G172_V0.9371.00
20_I34_I0.9341.00
82_A85_A0.9341.00
39_A43_S0.9251.00
144_D147_V0.9161.00
197_A230_V0.9141.00
254_D257_A0.9121.00
119_T143_V0.9111.00
63_D67_A0.9091.00
19_Q227_S0.9021.00
73_D78_D0.9001.00
17_A247_L0.8981.00
187_E194_R0.8961.00
210_T243_G0.8961.00
83_A86_E0.8951.00
74_G77_L0.8941.00
17_A229_V0.8831.00
57_T73_D0.8821.00
237_C249_A0.8801.00
186_S226_R0.8801.00
254_D258_E0.8791.00
31_L80_L0.8751.00
93_A112_V0.8711.00
28_A75_A0.8701.00
145_T150_T0.8671.00
35_G82_A0.8661.00
228_A236_V0.8651.00
121_Y157_D0.8601.00
165_A169_R0.8541.00
191_L195_A0.8521.00
40_A43_S0.8521.00
189_W206_G0.8491.00
187_E190_R0.8451.00
252_D255_V0.8431.00
238_Q249_A0.8381.00
13_P148_G0.8341.00
236_V239_A0.8341.00
173_D253_P0.8341.00
142_I172_V0.8331.00
203_W256_L0.8251.00
74_G78_D0.8231.00
54_Y134_L0.8181.00
77_L118_R0.8151.00
27_P31_L0.8101.00
21_A244_Q0.7981.00
20_I55_A0.7971.00
28_A79_R0.7951.00
47_D114_P0.7921.00
14_T44_A0.7891.00
15_V251_L0.7811.00
42_D87_H0.7801.00
123_K155_C0.7741.00
124_R163_V0.7691.00
36_E39_A0.7651.00
203_W251_L0.7641.00
41_V46_V0.7611.00
101_D104_A0.7521.00
97_E120_H0.7461.00
71_D98_D0.7451.00
21_A210_T0.7451.00
34_I93_A0.7441.00
38_L87_H0.7431.00
255_V259_Q0.7381.00
167_F172_V0.7351.00
158_L177_V0.7351.00
16_A246_T0.7341.00
51_F55_A0.7301.00
54_Y59_F0.7291.00
125_H157_D0.7281.00
177_V204_V0.7281.00
38_L51_F0.7281.00
19_Q225_G0.7251.00
107_N123_K0.7201.00
34_I38_L0.7181.00
17_A227_S0.7171.00
158_L193_L0.7151.00
32_A35_G0.7141.00
81_A118_R0.7131.00
228_A239_A0.7131.00
90_A147_V0.7131.00
65_V68_A0.7131.00
27_P70_L0.7121.00
44_A246_T0.7101.00
13_P251_L0.7081.00
180_A209_R0.7071.00
203_W255_V0.7021.00
72_R77_L0.7011.00
16_A49_A0.7011.00
16_A41_V0.6971.00
175_L204_V0.6961.00
148_G253_P0.6951.00
210_T244_Q0.6911.00
253_P257_A0.6901.00
31_L76_I0.6881.00
153_V167_F0.6871.00
84_A87_H0.6831.00
233_D259_Q0.6791.00
143_V150_T0.6731.00
50_V92_L0.6711.00
124_R140_P0.6701.00
43_S87_H0.6661.00
13_P147_V0.6661.00
125_H160_F0.6651.00
113_T146_P0.6641.00
20_I33_T0.6631.00
48_V90_A0.6621.00
41_V49_A0.6621.00
27_P76_I0.6611.00
48_V92_L0.6601.00
235_V255_V0.6511.00
139_E142_I0.6501.00
140_P163_V0.6491.00
77_L81_A0.6431.00
75_A78_D0.6431.00
50_V205_V0.6431.00
64_R68_A0.6401.00
183_G222_E0.6381.00
54_Y96_I0.6371.00
77_L93_A0.6311.00
101_D122_R0.6301.00
111_Y150_T0.6241.00
168_T200_G0.6201.00
73_D95_Y0.6201.00
26_D30_N0.6161.00
76_I79_R0.6141.00
127_W156_Y0.6101.00
81_A84_A0.6091.00
97_E110_V0.6041.00
190_R226_R0.6021.00
187_E191_L0.5961.00
189_W193_L0.5951.00
59_F155_C0.5941.00
35_G87_H0.5931.00
163_V167_F0.5921.00
40_A246_T0.5901.00
41_V89_V0.5881.00
84_A116_G0.5861.00
47_D88_D0.5831.00
180_A223_Y0.5831.00
39_A42_D0.5811.00
196_R200_G0.5801.00
113_T119_T0.5791.00
209_R223_Y0.5791.00
41_V45_G0.5781.00
66_Y69_A0.5781.00
46_V89_V0.5771.00
98_D105_Y0.5771.00
256_L260_R0.5771.00
48_V147_V0.5751.00
28_A31_L0.5701.00
107_N155_C0.5701.00
182_P185_Y0.5691.00
159_N181_W0.5691.00
186_S224_A0.5671.00
55_A93_A0.5671.00
208_G227_S0.5611.00
47_D147_V0.5561.00
166_A169_R0.5561.00
192_L195_A0.5561.00
159_N192_L0.5551.00
140_P143_V0.5521.00
23_A30_N0.5491.00
65_V69_A0.5491.00
96_I134_L0.5461.00
208_G224_A0.5450.99
13_P48_V0.5440.99
190_R230_V0.5440.99
151_G175_L0.5430.99
56_L80_L0.5430.99
97_E106_H0.5420.99
127_W159_N0.5410.99
123_K130_E0.5410.99
142_I170_E0.5400.99
42_D88_D0.5390.99
181_W189_W0.5360.99
13_P250_T0.5350.99
13_P47_D0.5340.99
21_A33_T0.5340.99
59_F134_L0.5330.99
54_Y107_N0.5320.99
17_A238_Q0.5300.99
40_A245_R0.5290.99
174_A203_W0.5290.99
140_P167_F0.5270.99
164_S196_R0.5270.99
19_Q240_L0.5260.99
57_T68_A0.5260.99
21_A209_R0.5260.99
140_P166_A0.5250.99
190_R236_V0.5240.99
119_T152_L0.5240.99
53_E155_C0.5220.99
95_Y108_T0.5190.99
167_F175_L0.5180.99
84_A112_V0.5170.99
194_R230_V0.5150.99
173_D256_L0.5140.99
149_R170_E0.5140.99
107_N154_T0.5140.99
194_R236_V0.5120.99
31_L56_L0.5120.99
72_R75_A0.5100.99
95_Y154_T0.5070.99
141_V170_E0.5060.99
48_V111_Y0.5060.99
188_N192_L0.5060.99
124_R166_A0.5060.99
90_A150_T0.5050.99
181_W206_G0.5040.99
201_V259_Q0.5030.99
23_A33_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4izuA 2 0.8963 100 0.176 Contact Map
3p8kA 2 0.9556 100 0.18 Contact Map
2vhhA 5 1 100 0.181 Contact Map
3ivzA 2 0.9185 100 0.19 Contact Map
2w1vA 2 0.937 100 0.19 Contact Map
2e11A 2 0.9333 100 0.191 Contact Map
1f89A 2 0.9667 100 0.197 Contact Map
1uf5A 4 0.9444 100 0.199 Contact Map
1emsA 3 0.9481 100 0.203 Contact Map
3wuyA 2 0.9556 100 0.208 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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