Q9HQZ1 - HALSA - GREMLIN Contacts

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Q9HQZ1 - GufA protein

UniProt:	Q9HQZ1	Sequences: MSPSGELLFVVFAGLLTDLATGLGALPFFFVDDIDDRWRVGLWGLASGIMVSASGFGLFREALNYGGPTEIAAGALAGVALVVVAEHVIDDHEFEPRDIAAADVKKLALIAGVLTVHSFPEGVAVGVSFADMGIDGGLSVLGFSIPILAVFMTIAISIHNVPEGLAVSIPLHEHGARRWTLVGVAVFTSIPQPIGAGIAYVFVQIARAALPFGYGFAGGAMVFLVLSEFIPEAREVGGALPHNGRRELATGIAVGVAGMVPMLFVT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	266 (233)
Sequences:	5459 (3680)
Seq/√Len:	241.1

ECOLI - ZUPT
HALSA - Q9HQZ1
SULSO - Q97UE9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
81_L	216_F	4.169	1.00
62_A	215_G	3.551	1.00
41_G	251_G	3.332	1.00
119_F	195_G	3.315	1.00
14_G	196_A	3.006	1.00
22_G	186_V	2.872	1.00
59_F	75_A	2.819	1.00
45_L	258_G	2.711	1.00
123_V	199_A	2.632	1.00
255_G	259_M	2.600	1.00
75_A	222_V	2.545	1.00
79_V	253_A	2.506	1.00
95_E	98_D	2.434	1.00
74_G	212_F	2.426	1.00
183_G	187_F	2.318	1.00
177_R	180_T	2.265	1.00
99_I	103_D	2.260	1.00
94_F	97_R	2.181	1.00
251_G	255_G	2.158	1.00
10_V	14_G	2.038	1.00
91_D	94_F	2.028	1.00
255_G	258_G	2.027	1.00
96_P	99_I	1.977	1.00
179_W	183_G	1.929	1.00
99_I	102_A	1.844	1.00
50_M	221_M	1.739	1.00
52_S	260_V	1.720	1.00
52_S	56_F	1.685	1.00
41_G	247_E	1.666	1.00
47_S	229_F	1.657	1.00
253_A	257_A	1.655	1.00
100_A	103_D	1.617	1.00
55_G	222_V	1.617	1.00
97_R	100_A	1.583	1.00
21_T	24_G	1.550	1.00
83_V	87_H	1.490	1.00
76_L	257_A	1.488	1.00
198_I	201_V	1.487	1.00
13_A	129_F	1.478	1.00
72_A	257_A	1.471	1.00
14_G	18_D	1.469	1.00
79_V	226_L	1.464	1.00
161_V	221_M	1.458	1.00
15_L	19_L	1.448	1.00
20_A	157_S	1.441	1.00
257_A	261_P	1.434	1.00
111_A	184_V	1.425	1.00
12_F	16_L	1.421	1.00
26_L	182_V	1.409	1.00
70_E	212_F	1.391	1.00
17_T	24_G	1.378	1.00
73_A	212_F	1.368	1.00
56_F	260_V	1.365	1.00
51_V	225_V	1.360	1.00
86_E	223_F	1.354	1.00
208_A	212_F	1.345	1.00
27_P	161_V	1.344	1.00
121_E	160_N	1.343	1.00
38_W	42_L	1.342	1.00
115_T	191_P	1.342	1.00
11_V	15_L	1.339	1.00
123_V	202_F	1.337	1.00
91_D	103_D	1.333	1.00
20_A	161_V	1.333	1.00
172_H	178_R	1.327	1.00
74_G	77_A	1.319	1.00
54_S	222_V	1.316	1.00
97_R	101_A	1.306	1.00
37_R	247_E	1.297	1.00
24_G	28_F	1.296	1.00
17_T	20_A	1.292	1.00
117_H	122_G	1.292	1.00
38_W	41_G	1.290	1.00
23_L	161_V	1.287	1.00
57_G	259_M	1.284	1.00
117_H	159_H	1.283	1.00
62_A	71_I	1.280	1.00
74_G	215_G	1.273	1.00
125_V	156_I	1.270	1.00
22_G	189_S	1.268	1.00
98_D	102_A	1.265	1.00
43_W	233_A	1.261	1.00
132_M	146_P	1.259	1.00
61_E	64_N	1.253	1.00
153_T	157_S	1.252	1.00
94_F	100_A	1.246	1.00
197_G	201_V	1.239	1.00
217_A	220_A	1.238	1.00
17_T	21_T	1.235	1.00
132_M	149_A	1.235	1.00
25_A	168_S	1.230	1.00
61_E	65_Y	1.218	1.00
21_T	28_F	1.193	1.00
53_A	57_G	1.191	1.00
26_L	29_F	1.187	1.00
76_L	80_A	1.181	1.00
16_L	153_T	1.177	1.00
167_V	188_T	1.176	1.00
98_D	101_A	1.176	1.00
31_V	34_I	1.171	1.00
150_V	154_I	1.169	1.00
160_N	221_M	1.169	1.00
10_V	28_F	1.152	1.00
63_L	71_I	1.144	1.00
96_P	100_A	1.143	1.00
70_E	77_A	1.136	1.00
118_S	188_T	1.129	1.00
51_V	252_I	1.128	1.00
45_L	254_V	1.123	1.00
78_G	82_V	1.122	1.00
160_N	164_G	1.120	1.00
114_L	121_E	1.119	1.00
164_G	185_A	1.105	1.00
10_V	17_T	1.105	1.00
111_A	167_V	1.104	1.00
62_A	211_P	1.099	1.00
73_A	77_A	1.080	1.00
190_I	194_I	1.075	1.00
74_G	78_G	1.074	1.00
83_V	223_F	1.058	1.00
200_Y	203_V	1.057	1.00
163_E	221_M	1.056	1.00
55_G	59_F	1.050	1.00
226_L	252_I	1.042	1.00
63_L	72_A	1.040	1.00
94_F	98_D	1.034	1.00
53_A	159_H	1.029	1.00
171_L	176_A	1.021	1.00
256_V	260_V	1.015	1.00
114_L	117_H	1.012	1.00
252_I	255_G	0.995	1.00
128_S	152_M	0.987	1.00
96_P	101_A	0.985	1.00
237_G	240_L	0.984	1.00
40_V	233_A	0.984	1.00
14_G	200_Y	0.982	1.00
230_I	234_R	0.981	1.00
160_N	188_T	0.979	1.00
123_V	195_G	0.975	1.00
60_R	64_N	0.969	1.00
95_E	99_I	0.967	1.00
59_F	218_G	0.959	1.00
152_M	163_E	0.959	1.00
97_R	102_A	0.952	1.00
252_I	256_V	0.950	1.00
247_E	251_G	0.949	1.00
115_T	119_F	0.948	1.00
85_A	90_D	0.934	1.00
36_D	236_V	0.933	1.00
18_D	193_P	0.931	1.00
157_S	221_M	0.927	1.00
199_A	202_F	0.917	1.00
257_A	260_V	0.915	1.00
160_N	163_E	0.909	1.00
111_A	171_L	0.907	1.00
72_A	261_P	0.903	1.00
22_G	185_A	0.903	1.00
129_F	149_A	0.894	1.00
55_G	60_R	0.893	1.00
54_S	57_G	0.892	1.00
40_V	238_G	0.887	1.00
25_A	185_A	0.878	0.99
84_V	88_V	0.877	0.99
21_T	25_A	0.865	0.99
70_E	74_G	0.855	0.99
110_I	113_V	0.846	0.99
12_F	15_L	0.846	0.99
57_G	159_H	0.846	0.99
254_V	258_G	0.844	0.99
25_A	28_F	0.839	0.99
54_S	221_M	0.834	0.99
226_L	230_I	0.832	0.99
47_S	113_V	0.828	0.99
29_F	182_V	0.823	0.99
78_G	216_F	0.812	0.99
209_A	212_F	0.810	0.99
95_E	102_A	0.809	0.99
47_S	230_I	0.809	0.99
160_N	167_V	0.806	0.99
183_G	186_V	0.800	0.99
132_M	147_I	0.800	0.99
66_G	71_I	0.797	0.99
49_I	226_L	0.796	0.99
107_L	174_H	0.789	0.99
160_N	220_A	0.785	0.99
44_G	233_A	0.784	0.99
180_T	183_G	0.782	0.99
216_F	220_A	0.781	0.99
25_A	29_F	0.776	0.99
62_A	218_G	0.774	0.99
15_L	193_P	0.770	0.99
118_S	193_P	0.770	0.99
163_E	167_V	0.769	0.99
16_L	20_A	0.761	0.98
125_V	153_T	0.760	0.98
10_V	196_A	0.758	0.98
164_G	221_M	0.755	0.98
190_I	193_P	0.754	0.98
119_F	198_I	0.754	0.98
77_A	212_F	0.753	0.98
112_G	116_V	0.746	0.98
13_A	17_T	0.739	0.98
95_E	100_A	0.730	0.98
234_R	248_L	0.728	0.98
132_M	250_T	0.726	0.98
35_D	38_W	0.724	0.98
166_A	170_P	0.721	0.98
17_T	57_G	0.720	0.98
48_G	55_G	0.720	0.98
112_G	151_F	0.719	0.98
181_L	185_A	0.716	0.98
127_V	131_D	0.716	0.98
11_V	197_G	0.714	0.98
120_P	163_E	0.713	0.98
77_A	81_L	0.710	0.98
54_S	225_V	0.710	0.98
53_A	259_M	0.709	0.98
247_E	255_G	0.708	0.98
19_L	26_L	0.708	0.98
147_I	151_F	0.707	0.98
236_V	239_A	0.698	0.97
85_A	116_V	0.695	0.97
95_E	101_A	0.694	0.97
179_W	254_V	0.694	0.97
49_I	259_M	0.693	0.97
233_A	248_L	0.690	0.97
156_I	163_E	0.687	0.97
24_G	164_G	0.684	0.97
61_E	159_H	0.683	0.97
176_A	180_T	0.679	0.97
18_D	22_G	0.679	0.97
70_E	73_A	0.679	0.97
91_D	95_E	0.675	0.97
158_I	168_S	0.674	0.97
51_V	222_V	0.674	0.97
33_D	36_D	0.672	0.97
80_A	252_I	0.671	0.97
18_D	28_F	0.669	0.97
14_G	17_T	0.668	0.97
211_P	219_G	0.661	0.96
69_T	73_A	0.655	0.96
114_L	167_V	0.654	0.96
43_W	107_L	0.653	0.96
80_A	84_V	0.652	0.96
180_T	184_V	0.648	0.96
149_A	153_T	0.648	0.96
85_A	91_D	0.646	0.96
121_E	163_E	0.644	0.96
71_I	215_G	0.643	0.96
14_G	197_G	0.643	0.96
65_Y	190_I	0.640	0.96
10_V	200_Y	0.639	0.96
47_S	83_V	0.639	0.96
114_L	164_G	0.639	0.96
45_L	53_A	0.635	0.95
95_E	103_D	0.632	0.95
122_G	159_H	0.627	0.95
51_V	55_G	0.626	0.95
167_V	171_L	0.623	0.95
163_E	188_T	0.623	0.95
29_F	179_W	0.621	0.95
39_R	42_L	0.620	0.95
124_A	152_M	0.615	0.95
170_P	228_E	0.614	0.94
37_R	41_G	0.613	0.94
182_V	186_V	0.612	0.94
17_T	28_F	0.610	0.94
47_S	252_I	0.608	0.94
168_S	185_A	0.604	0.94
238_G	247_E	0.603	0.94
114_L	163_E	0.603	0.94
249_A	252_I	0.602	0.94
157_S	160_N	0.602	0.94
16_L	157_S	0.599	0.94
186_V	189_S	0.597	0.94
117_H	121_E	0.597	0.94
50_M	170_P	0.592	0.93
43_W	46_A	0.590	0.93
53_A	220_A	0.589	0.93
160_N	192_Q	0.582	0.93
56_F	61_E	0.581	0.93
10_V	20_A	0.579	0.93
23_L	26_L	0.577	0.92
111_A	115_T	0.576	0.92
202_F	205_I	0.576	0.92
117_H	167_V	0.575	0.92
17_T	22_G	0.575	0.92
124_A	219_G	0.571	0.92
248_L	251_G	0.571	0.92
13_A	203_V	0.569	0.92
240_L	250_T	0.569	0.92
108_A	112_G	0.564	0.92
215_G	219_G	0.564	0.92
19_L	103_D	0.563	0.92
126_G	217_A	0.561	0.91
82_V	113_V	0.560	0.91
110_I	229_F	0.558	0.91
187_F	190_I	0.554	0.91
53_A	152_M	0.553	0.91
249_A	255_G	0.552	0.91
220_A	224_L	0.551	0.91
9_F	12_F	0.550	0.91
68_P	260_V	0.550	0.91
187_F	191_P	0.549	0.91
164_G	167_V	0.548	0.90
220_A	229_F	0.548	0.90
75_A	215_G	0.546	0.90
225_V	229_F	0.546	0.90
48_G	217_A	0.546	0.90
230_I	252_I	0.543	0.90
120_P	124_A	0.543	0.90
15_L	97_R	0.542	0.90
10_V	13_A	0.540	0.90
197_G	200_Y	0.540	0.90
107_L	110_I	0.539	0.90
13_A	196_A	0.539	0.90
18_D	186_V	0.539	0.90
53_A	217_A	0.539	0.90
18_D	24_G	0.535	0.89
54_S	75_A	0.535	0.89
55_G	76_L	0.534	0.89
118_S	164_G	0.532	0.89
88_V	190_I	0.532	0.89
212_F	216_F	0.529	0.89
171_L	181_L	0.528	0.89
127_V	203_V	0.525	0.89
20_A	25_A	0.522	0.88
32_D	37_R	0.521	0.88
163_E	166_A	0.521	0.88
146_P	150_V	0.521	0.88
180_T	190_I	0.519	0.88
118_S	160_N	0.518	0.88
192_Q	221_M	0.518	0.88
14_G	21_T	0.518	0.88
13_A	153_T	0.517	0.88
12_F	153_T	0.515	0.88
110_I	167_V	0.514	0.87
78_G	90_D	0.513	0.87
62_A	65_Y	0.512	0.87
20_A	24_G	0.510	0.87
98_D	103_D	0.510	0.87
234_R	237_G	0.508	0.87
12_F	194_I	0.508	0.87
118_S	192_Q	0.506	0.87
18_D	160_N	0.505	0.87
57_G	61_E	0.504	0.86
195_G	200_Y	0.502	0.86
256_V	259_M	0.501	0.86
42_L	61_E	0.501	0.86
60_R	63_L	0.500	0.86

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4dveA	3	0.4887	54.4	0.931	Contact Map
4g1uA	2	0.4737	33	0.94	Contact Map
4tkrA	2	0.4624	31.2	0.941	Contact Map
3rlbA	1	0.4323	23	0.944	Contact Map
4av3A	2	0.8083	22.2	0.945	Contact Map
4a01A	2	0.8008	16.3	0.948	Contact Map
4tnwA	3	0.3459	12.8	0.95	Contact Map
3dh4A	3	0.312	11.3	0.951	Contact Map
4oo9A	1	0.3008	9.7	0.953	Contact Map
4pypA	1	0.5752	9.5	0.953	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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