Q9HQY9 - HALSA - GREMLIN Contacts

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Q9HQY9 - Uncharacterized protein

UniProt:	Q9HQY9	Sequences: MTDTLLVTSTNAGTGKTAVSLALARLAGDRDRTVGYMKPKGTRLQSNVGKTLDADPLLARDLLDLDAEIHDLEPVVYSPTFIQGAVRGREDSANLADRVRDAYDELATDRDVMLVEGAGTPTTGGIVDLTDGDIAALLDARAIVVADYTGPSDVDDVLAAADALGDRCAGVVFNAVADAVYDDVESEVTPFLESQGIPVLGVLPVERDLAGVTVDDLASELGATVLTEDTATTDAIVERFLVGAMSSESALSHFRRTKDAAVITGGDRADIQTAALDAPGVQCLVLTGGHRPSGAVLGKATDAGVPVLSVDADTLTTLERAEELVRDGRVRDEHTVDVMQRLLHDHADTDRLLD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	354 (289)
Sequences:	3214 (2086)
Seq/√Len:	122.7

ECOLI - PTA
HALSA - Q9HQY9 COBQ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
71_D	105_E	4.554	1.00
294_G	297_L	3.711	1.00
185_E	189_T	3.609	1.00
139_D	167_R	3.529	1.00
287_T	291_R	3.195	1.00
27_A	112_V	3.086	1.00
287_T	290_H	2.829	1.00
48_V	67_A	2.822	1.00
182_D	185_E	2.685	1.00
283_C	287_T	2.633	1.00
281_V	285_V	2.619	1.00
29_D	65_L	2.518	1.00
11_N	14_T	2.502	1.00
282_Q	285_V	2.434	1.00
98_R	101_D	2.385	1.00
53_D	58_L	2.326	1.00
136_A	167_R	2.260	1.00
281_V	284_L	2.248	1.00
242_V	264_T	2.227	1.00
4_T	140_A	2.095	1.00
33_T	110_R	2.075	1.00
243_G	275_A	2.073	1.00
28_G	65_L	2.041	1.00
35_G	110_R	2.029	1.00
7_V	145_V	2.020	1.00
103_Y	107_A	2.016	1.00
292_P	297_L	2.008	1.00
281_V	287_T	1.986	1.00
284_L	287_T	1.974	1.00
284_L	288_G	1.971	1.00
283_C	286_L	1.955	1.00
281_V	288_G	1.954	1.00
124_G	190_P	1.935	1.00
22_A	26_L	1.911	1.00
104_D	107_A	1.905	1.00
158_L	194_S	1.894	1.00
87_R	102_A	1.874	1.00
288_G	291_R	1.872	1.00
146_A	153_D	1.870	1.00
32_R	112_V	1.865	1.00
282_Q	288_G	1.853	1.00
143_I	200_L	1.849	1.00
115_V	140_A	1.839	1.00
189_T	193_E	1.831	1.00
19_V	203_L	1.829	1.00
8_T	142_A	1.793	1.00
190_P	194_S	1.786	1.00
115_V	134_I	1.766	1.00
33_T	111_D	1.745	1.00
136_A	164_L	1.736	1.00
134_I	138_L	1.726	1.00
23_L	27_A	1.714	1.00
26_L	30_R	1.703	1.00
146_A	157_V	1.694	1.00
71_D	109_D	1.688	1.00
4_T	103_Y	1.688	1.00
282_Q	287_T	1.655	1.00
285_V	288_G	1.655	1.00
91_D	95_L	1.652	1.00
283_C	291_R	1.603	1.00
100_R	137_L	1.603	1.00
285_V	290_H	1.601	1.00
286_L	291_R	1.598	1.00
284_L	289_G	1.592	1.00
281_V	291_R	1.582	1.00
127_V	162_D	1.570	1.00
51_T	70_H	1.570	1.00
159_A	162_D	1.565	1.00
157_V	171_V	1.544	1.00
281_V	290_H	1.539	1.00
8_T	132_G	1.536	1.00
7_V	23_L	1.522	1.00
159_A	194_S	1.517	1.00
190_P	193_E	1.514	1.00
285_V	289_G	1.511	1.00
274_A	278_A	1.501	1.00
283_C	288_G	1.485	1.00
285_V	291_R	1.483	1.00
24_A	114_L	1.476	1.00
171_V	199_V	1.475	1.00
59_A	211_G	1.470	1.00
281_V	289_G	1.463	1.00
284_L	291_R	1.450	1.00
59_A	212_V	1.450	1.00
181_Y	185_E	1.447	1.00
91_D	94_N	1.442	1.00
275_A	279_P	1.415	1.00
286_L	289_G	1.398	1.00
283_C	289_G	1.390	1.00
5_L	114_L	1.374	1.00
282_Q	290_H	1.359	1.00
284_L	290_H	1.348	1.00
96_A	100_R	1.334	1.00
286_L	290_H	1.324	1.00
276_L	279_P	1.320	1.00
189_T	192_L	1.317	1.00
19_V	145_V	1.316	1.00
69_I	109_D	1.304	1.00
21_L	59_A	1.301	1.00
153_D	173_F	1.283	1.00
69_I	105_E	1.270	1.00
80_T	269_A	1.263	1.00
282_Q	289_G	1.263	1.00
87_R	98_R	1.226	0.99
106_L	113_M	1.223	0.99
218_A	221_L	1.215	0.99
96_A	137_L	1.209	0.99
100_R	104_D	1.205	0.99
184_V	188_V	1.201	0.99
282_Q	286_L	1.199	0.99
283_C	290_H	1.199	0.99
7_V	20_S	1.194	0.99
282_Q	291_R	1.178	0.99
32_R	111_D	1.178	0.99
49_G	69_I	1.173	0.99
179_A	182_D	1.171	0.99
188_V	199_V	1.163	0.99
87_R	101_D	1.159	0.99
273_T	277_D	1.124	0.99
107_A	113_M	1.123	0.99
96_A	133_D	1.123	0.99
4_T	115_V	1.122	0.99
20_S	114_L	1.121	0.99
87_R	105_E	1.101	0.99
277_D	282_Q	1.091	0.99
11_N	156_D	1.081	0.99
239_R	251_L	1.080	0.99
281_V	286_L	1.073	0.98
66_D	110_R	1.071	0.98
46_S	246_S	1.056	0.98
105_E	108_T	1.049	0.98
18_A	209_L	1.049	0.98
188_V	202_V	1.048	0.98
176_V	202_V	1.040	0.98
183_D	186_S	1.030	0.98
240_F	264_T	1.028	0.98
166_D	197_I	1.027	0.98
7_V	172_V	1.025	0.98
4_T	138_L	1.024	0.98
35_G	106_L	1.023	0.98
104_D	137_L	1.021	0.98
83_Q	88_G	1.007	0.98
279_P	282_Q	1.000	0.98
103_Y	113_M	0.998	0.98
92_S	95_L	0.996	0.97
83_Q	86_V	0.994	0.97
266_G	292_P	0.989	0.97
96_A	99_V	0.983	0.97
159_A	165_G	0.983	0.97
262_V	288_G	0.982	0.97
192_L	199_V	0.976	0.97
34_V	111_D	0.974	0.97
212_V	215_D	0.965	0.97
141_R	169_A	0.964	0.97
71_D	87_R	0.964	0.97
84_G	87_R	0.962	0.97
242_V	267_D	0.951	0.97
103_Y	115_V	0.945	0.97
105_E	109_D	0.941	0.96
13_G	213_T	0.934	0.96
70_H	87_R	0.930	0.96
104_D	108_T	0.925	0.96
171_V	197_I	0.924	0.96
81_F	92_S	0.916	0.96
170_G	200_L	0.914	0.96
47_N	50_K	0.902	0.95
237_V	263_I	0.896	0.95
136_A	162_D	0.895	0.95
90_E	93_A	0.895	0.95
39_P	134_I	0.893	0.95
102_A	105_E	0.889	0.95
77_Y	84_G	0.888	0.95
85_A	88_G	0.887	0.95
206_E	209_L	0.882	0.95
163_A	166_D	0.879	0.95
90_E	94_N	0.874	0.95
132_G	142_A	0.869	0.94
89_R	278_A	0.868	0.94
157_V	191_F	0.859	0.94
46_S	212_V	0.853	0.94
7_V	143_I	0.853	0.94
97_D	101_D	0.853	0.94
271_I	274_A	0.853	0.94
244_A	269_A	0.850	0.94
84_G	88_G	0.850	0.94
35_G	66_D	0.849	0.94
133_D	137_L	0.847	0.94
185_E	188_V	0.847	0.94
159_A	164_L	0.847	0.94
154_V	158_L	0.846	0.94
8_T	121_P	0.844	0.94
115_V	138_L	0.842	0.94
100_R	138_L	0.837	0.93
213_T	216_D	0.833	0.93
161_A	164_L	0.829	0.93
267_D	270_D	0.827	0.93
82_I	87_R	0.824	0.93
274_A	277_D	0.822	0.93
38_K	116_E	0.822	0.93
18_A	21_L	0.820	0.93
46_S	249_S	0.818	0.93
212_V	216_D	0.818	0.93
251_L	263_I	0.814	0.92
211_G	215_D	0.813	0.92
240_F	281_V	0.813	0.92
286_L	292_P	0.813	0.92
153_D	157_V	0.811	0.92
98_R	102_A	0.809	0.92
211_G	214_V	0.805	0.92
86_V	98_R	0.801	0.92
7_V	14_T	0.800	0.92
94_N	97_D	0.800	0.92
58_L	68_E	0.799	0.92
158_L	195_Q	0.797	0.92
237_V	261_A	0.793	0.91
82_I	85_A	0.787	0.91
186_S	189_T	0.785	0.91
38_K	74_P	0.774	0.90
39_P	75_V	0.773	0.90
62_L	212_V	0.773	0.90
275_A	278_A	0.773	0.90
15_G	174_N	0.773	0.90
19_V	172_V	0.764	0.90
40_K	118_A	0.757	0.89
251_L	286_L	0.756	0.89
103_Y	134_I	0.752	0.89
71_D	102_A	0.750	0.89
101_D	105_E	0.750	0.89
144_V	168_C	0.750	0.89
247_S	274_A	0.748	0.89
69_I	110_R	0.747	0.89
147_D	150_G	0.743	0.88
211_G	216_D	0.743	0.88
92_S	129_L	0.742	0.88
213_T	248_E	0.742	0.88
124_G	184_V	0.740	0.88
58_L	62_L	0.738	0.88
165_G	197_I	0.737	0.88
278_A	286_L	0.737	0.88
33_T	109_D	0.736	0.88
166_D	278_A	0.735	0.88
138_L	167_R	0.734	0.88
136_A	139_D	0.730	0.88
26_L	203_L	0.730	0.88
242_V	245_M	0.728	0.87
52_L	57_L	0.727	0.87
39_P	96_A	0.726	0.87
6_L	132_G	0.721	0.87
51_T	89_R	0.721	0.87
93_A	97_D	0.719	0.87
94_N	98_R	0.718	0.87
39_P	99_V	0.715	0.86
159_A	163_A	0.714	0.86
243_G	267_D	0.714	0.86
70_H	105_E	0.711	0.86
169_A	200_L	0.709	0.86
18_A	217_L	0.706	0.86
83_Q	268_R	0.705	0.86
70_H	109_D	0.705	0.86
181_Y	188_V	0.705	0.86
219_S	222_G	0.701	0.85
154_V	190_P	0.692	0.85
46_S	80_T	0.691	0.85
68_E	72_L	0.690	0.84
191_F	194_S	0.685	0.84
160_A	164_L	0.684	0.84
27_A	32_R	0.682	0.84
20_S	23_L	0.682	0.84
83_Q	87_R	0.682	0.84
234_D	259_D	0.678	0.83
35_G	113_M	0.673	0.83
185_E	202_V	0.672	0.83
23_L	143_I	0.670	0.83
59_A	99_V	0.670	0.83
143_I	172_V	0.669	0.83
173_F	191_F	0.669	0.83
160_A	163_A	0.669	0.83
42_T	118_A	0.667	0.82
228_E	233_T	0.667	0.82
277_D	280_G	0.666	0.82
57_L	61_D	0.665	0.82
175_A	205_V	0.657	0.81
7_V	18_A	0.655	0.81
95_L	261_A	0.652	0.81
153_D	158_L	0.648	0.81
22_A	96_A	0.648	0.81
22_A	133_D	0.648	0.81
80_T	212_V	0.648	0.81
53_D	68_E	0.644	0.80
169_A	197_I	0.643	0.80
124_G	194_S	0.639	0.80
53_D	69_I	0.639	0.80
75_V	95_L	0.639	0.80
23_L	114_L	0.639	0.80
4_T	107_A	0.635	0.79
169_A	172_V	0.634	0.79
124_G	154_V	0.634	0.79
21_L	212_V	0.633	0.79
242_V	276_L	0.633	0.79
154_V	187_E	0.631	0.79
241_L	255_R	0.627	0.78
107_A	258_K	0.627	0.78
80_T	262_V	0.627	0.78
17_T	54_A	0.625	0.78
193_E	196_G	0.625	0.78
8_T	39_P	0.624	0.78
34_V	112_V	0.622	0.78
149_T	177_A	0.622	0.78
56_P	60_R	0.622	0.78
121_P	132_G	0.620	0.78
144_V	171_V	0.618	0.77
127_V	133_D	0.615	0.77
81_F	86_V	0.615	0.77
59_A	62_L	0.615	0.77
124_G	160_A	0.613	0.77
212_V	275_A	0.611	0.77
187_E	191_F	0.609	0.76
99_V	102_A	0.609	0.76
220_E	223_A	0.608	0.76
181_Y	184_V	0.607	0.76
59_A	256_R	0.604	0.76
132_G	161_A	0.604	0.76
39_P	115_V	0.601	0.75
212_V	249_S	0.601	0.75
86_V	91_D	0.599	0.75
28_G	64_D	0.599	0.75
110_R	114_L	0.593	0.74
7_V	156_D	0.593	0.74
139_D	166_D	0.592	0.74
81_F	129_L	0.591	0.74
23_L	26_L	0.590	0.74
80_T	267_D	0.590	0.74
168_C	197_I	0.584	0.73
13_G	127_V	0.584	0.73
52_L	61_D	0.582	0.73
256_R	259_D	0.582	0.73
30_R	112_V	0.580	0.73
214_V	283_C	0.580	0.73
73_E	79_P	0.575	0.72
171_V	195_Q	0.575	0.72
9_S	16_K	0.575	0.72
83_Q	92_S	0.575	0.72
133_D	142_A	0.574	0.72
184_V	189_T	0.573	0.72
173_F	202_V	0.572	0.72
148_Y	176_V	0.570	0.72
244_A	265_G	0.570	0.72
52_L	78_S	0.560	0.70
54_A	57_L	0.559	0.70
181_Y	202_V	0.559	0.70
95_L	99_V	0.556	0.70
146_A	171_V	0.556	0.70
221_L	225_V	0.555	0.70
158_L	190_P	0.555	0.70
86_V	95_L	0.555	0.70
133_D	141_R	0.555	0.70
252_S	255_R	0.554	0.69
35_G	109_D	0.554	0.69
154_V	157_V	0.553	0.69
133_D	140_A	0.553	0.69
129_L	213_T	0.553	0.69
80_T	271_I	0.553	0.69
137_L	167_R	0.553	0.69
11_N	275_A	0.552	0.69
73_E	76_V	0.552	0.69
87_R	103_Y	0.552	0.69
158_L	191_F	0.551	0.69
66_D	69_I	0.549	0.69
24_A	64_D	0.547	0.68
41_G	44_L	0.546	0.68
247_S	250_A	0.546	0.68
222_G	226_L	0.545	0.68
32_R	114_L	0.544	0.68
252_S	257_T	0.544	0.68
251_L	268_R	0.544	0.68
100_R	103_Y	0.543	0.68
48_V	278_A	0.541	0.68
117_G	131_D	0.540	0.67
8_T	115_V	0.540	0.67
137_L	140_A	0.539	0.67
38_K	41_G	0.538	0.67
171_V	192_L	0.537	0.67
239_R	263_I	0.534	0.67
119_G	151_P	0.534	0.67
128_D	224_T	0.532	0.66
100_R	134_I	0.531	0.66
37_M	103_Y	0.530	0.66
40_K	82_I	0.529	0.66
80_T	249_S	0.529	0.66
27_A	114_L	0.529	0.66
80_T	256_R	0.528	0.66
223_A	226_L	0.528	0.66
81_F	90_E	0.528	0.66
39_P	137_L	0.528	0.66
147_D	152_S	0.528	0.66
76_V	79_P	0.526	0.65
221_L	224_T	0.526	0.65
156_D	195_Q	0.526	0.65
12_A	116_E	0.525	0.65
244_A	271_I	0.523	0.65
154_V	160_A	0.522	0.65
37_M	99_V	0.522	0.65
190_P	199_V	0.521	0.65
39_P	255_R	0.521	0.65
112_V	169_A	0.521	0.65
91_D	207_R	0.520	0.65
35_G	53_D	0.519	0.64
10_T	156_D	0.518	0.64
131_D	265_G	0.516	0.64
94_N	226_L	0.516	0.64
224_T	228_E	0.515	0.64
91_D	96_A	0.515	0.64
79_P	98_R	0.513	0.64
142_A	168_C	0.513	0.64
226_L	278_A	0.512	0.63
103_Y	241_L	0.512	0.63
55_D	212_V	0.512	0.63
276_L	285_V	0.511	0.63
75_V	99_V	0.510	0.63
188_V	191_F	0.509	0.63
108_T	228_E	0.507	0.63
251_L	257_T	0.506	0.62
225_V	228_E	0.506	0.62
97_D	100_R	0.505	0.62
43_R	50_K	0.505	0.62
220_E	225_V	0.505	0.62
7_V	19_V	0.505	0.62
85_A	89_R	0.504	0.62
23_L	112_V	0.503	0.62
4_T	139_D	0.502	0.62
16_K	119_G	0.501	0.62
25_R	63_L	0.501	0.62
127_V	136_A	0.500	0.62
101_D	104_D	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4a0gA	2	0.9661	100	0.648	Contact Map
2iojA	1	0.3333	99.9	0.726	Contact Map
3fgnA	2	0.6243	99.9	0.736	Contact Map
1s1mA	4	0.9746	99.9	0.741	Contact Map
1byiA	2	0.6243	99.9	0.742	Contact Map
3of5A	2	0.6102	99.9	0.745	Contact Map
3qxcA	2	0.5989	99.8	0.77	Contact Map
3zq6A	2	0.5904	99.8	0.774	Contact Map
4zdjA	4	0.9831	99.8	0.781	Contact Map
1vcoA	4	0.9774	99.8	0.784	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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