GREMLIN Database
Q9HQY9 - Uncharacterized protein
UniProt: Q9HQY9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 354 (289)
Sequences: 3214 (2086)
Seq/√Len: 122.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_D105_E4.5541.00
294_G297_L3.7111.00
185_E189_T3.6091.00
139_D167_R3.5291.00
287_T291_R3.1951.00
27_A112_V3.0861.00
287_T290_H2.8291.00
48_V67_A2.8221.00
182_D185_E2.6851.00
283_C287_T2.6331.00
281_V285_V2.6191.00
29_D65_L2.5181.00
11_N14_T2.5021.00
282_Q285_V2.4341.00
98_R101_D2.3851.00
53_D58_L2.3261.00
136_A167_R2.2601.00
281_V284_L2.2481.00
242_V264_T2.2271.00
4_T140_A2.0951.00
33_T110_R2.0751.00
243_G275_A2.0731.00
28_G65_L2.0411.00
35_G110_R2.0291.00
7_V145_V2.0201.00
103_Y107_A2.0161.00
292_P297_L2.0081.00
281_V287_T1.9861.00
284_L287_T1.9741.00
284_L288_G1.9711.00
283_C286_L1.9551.00
281_V288_G1.9541.00
124_G190_P1.9351.00
22_A26_L1.9111.00
104_D107_A1.9051.00
158_L194_S1.8941.00
87_R102_A1.8741.00
288_G291_R1.8721.00
146_A153_D1.8701.00
32_R112_V1.8651.00
282_Q288_G1.8531.00
143_I200_L1.8491.00
115_V140_A1.8391.00
189_T193_E1.8311.00
19_V203_L1.8291.00
8_T142_A1.7931.00
190_P194_S1.7861.00
115_V134_I1.7661.00
33_T111_D1.7451.00
136_A164_L1.7361.00
134_I138_L1.7261.00
23_L27_A1.7141.00
26_L30_R1.7031.00
146_A157_V1.6941.00
71_D109_D1.6881.00
4_T103_Y1.6881.00
282_Q287_T1.6551.00
285_V288_G1.6551.00
91_D95_L1.6521.00
283_C291_R1.6031.00
100_R137_L1.6031.00
285_V290_H1.6011.00
286_L291_R1.5981.00
284_L289_G1.5921.00
281_V291_R1.5821.00
127_V162_D1.5701.00
51_T70_H1.5701.00
159_A162_D1.5651.00
157_V171_V1.5441.00
281_V290_H1.5391.00
8_T132_G1.5361.00
7_V23_L1.5221.00
159_A194_S1.5171.00
190_P193_E1.5141.00
285_V289_G1.5111.00
274_A278_A1.5011.00
283_C288_G1.4851.00
285_V291_R1.4831.00
24_A114_L1.4761.00
171_V199_V1.4751.00
59_A211_G1.4701.00
281_V289_G1.4631.00
284_L291_R1.4501.00
59_A212_V1.4501.00
181_Y185_E1.4471.00
91_D94_N1.4421.00
275_A279_P1.4151.00
286_L289_G1.3981.00
283_C289_G1.3901.00
5_L114_L1.3741.00
282_Q290_H1.3591.00
284_L290_H1.3481.00
96_A100_R1.3341.00
286_L290_H1.3241.00
276_L279_P1.3201.00
189_T192_L1.3171.00
19_V145_V1.3161.00
69_I109_D1.3041.00
21_L59_A1.3011.00
153_D173_F1.2831.00
69_I105_E1.2701.00
80_T269_A1.2631.00
282_Q289_G1.2631.00
87_R98_R1.2260.99
106_L113_M1.2230.99
218_A221_L1.2150.99
96_A137_L1.2090.99
100_R104_D1.2050.99
184_V188_V1.2010.99
282_Q286_L1.1990.99
283_C290_H1.1990.99
7_V20_S1.1940.99
282_Q291_R1.1780.99
32_R111_D1.1780.99
49_G69_I1.1730.99
179_A182_D1.1710.99
188_V199_V1.1630.99
87_R101_D1.1590.99
273_T277_D1.1240.99
107_A113_M1.1230.99
96_A133_D1.1230.99
4_T115_V1.1220.99
20_S114_L1.1210.99
87_R105_E1.1010.99
277_D282_Q1.0910.99
11_N156_D1.0810.99
239_R251_L1.0800.99
281_V286_L1.0730.98
66_D110_R1.0710.98
46_S246_S1.0560.98
105_E108_T1.0490.98
18_A209_L1.0490.98
188_V202_V1.0480.98
176_V202_V1.0400.98
183_D186_S1.0300.98
240_F264_T1.0280.98
166_D197_I1.0270.98
7_V172_V1.0250.98
4_T138_L1.0240.98
35_G106_L1.0230.98
104_D137_L1.0210.98
83_Q88_G1.0070.98
279_P282_Q1.0000.98
103_Y113_M0.9980.98
92_S95_L0.9960.97
83_Q86_V0.9940.97
266_G292_P0.9890.97
96_A99_V0.9830.97
159_A165_G0.9830.97
262_V288_G0.9820.97
192_L199_V0.9760.97
34_V111_D0.9740.97
212_V215_D0.9650.97
141_R169_A0.9640.97
71_D87_R0.9640.97
84_G87_R0.9620.97
242_V267_D0.9510.97
103_Y115_V0.9450.97
105_E109_D0.9410.96
13_G213_T0.9340.96
70_H87_R0.9300.96
104_D108_T0.9250.96
171_V197_I0.9240.96
81_F92_S0.9160.96
170_G200_L0.9140.96
47_N50_K0.9020.95
237_V263_I0.8960.95
136_A162_D0.8950.95
90_E93_A0.8950.95
39_P134_I0.8930.95
102_A105_E0.8890.95
77_Y84_G0.8880.95
85_A88_G0.8870.95
206_E209_L0.8820.95
163_A166_D0.8790.95
90_E94_N0.8740.95
132_G142_A0.8690.94
89_R278_A0.8680.94
157_V191_F0.8590.94
46_S212_V0.8530.94
7_V143_I0.8530.94
97_D101_D0.8530.94
271_I274_A0.8530.94
244_A269_A0.8500.94
84_G88_G0.8500.94
35_G66_D0.8490.94
133_D137_L0.8470.94
185_E188_V0.8470.94
159_A164_L0.8470.94
154_V158_L0.8460.94
8_T121_P0.8440.94
115_V138_L0.8420.94
100_R138_L0.8370.93
213_T216_D0.8330.93
161_A164_L0.8290.93
267_D270_D0.8270.93
82_I87_R0.8240.93
274_A277_D0.8220.93
38_K116_E0.8220.93
18_A21_L0.8200.93
46_S249_S0.8180.93
212_V216_D0.8180.93
251_L263_I0.8140.92
211_G215_D0.8130.92
240_F281_V0.8130.92
286_L292_P0.8130.92
153_D157_V0.8110.92
98_R102_A0.8090.92
211_G214_V0.8050.92
86_V98_R0.8010.92
7_V14_T0.8000.92
94_N97_D0.8000.92
58_L68_E0.7990.92
158_L195_Q0.7970.92
237_V261_A0.7930.91
82_I85_A0.7870.91
186_S189_T0.7850.91
38_K74_P0.7740.90
39_P75_V0.7730.90
62_L212_V0.7730.90
275_A278_A0.7730.90
15_G174_N0.7730.90
19_V172_V0.7640.90
40_K118_A0.7570.89
251_L286_L0.7560.89
103_Y134_I0.7520.89
71_D102_A0.7500.89
101_D105_E0.7500.89
144_V168_C0.7500.89
247_S274_A0.7480.89
69_I110_R0.7470.89
147_D150_G0.7430.88
211_G216_D0.7430.88
92_S129_L0.7420.88
213_T248_E0.7420.88
124_G184_V0.7400.88
58_L62_L0.7380.88
165_G197_I0.7370.88
278_A286_L0.7370.88
33_T109_D0.7360.88
166_D278_A0.7350.88
138_L167_R0.7340.88
136_A139_D0.7300.88
26_L203_L0.7300.88
242_V245_M0.7280.87
52_L57_L0.7270.87
39_P96_A0.7260.87
6_L132_G0.7210.87
51_T89_R0.7210.87
93_A97_D0.7190.87
94_N98_R0.7180.87
39_P99_V0.7150.86
159_A163_A0.7140.86
243_G267_D0.7140.86
70_H105_E0.7110.86
169_A200_L0.7090.86
18_A217_L0.7060.86
83_Q268_R0.7050.86
70_H109_D0.7050.86
181_Y188_V0.7050.86
219_S222_G0.7010.85
154_V190_P0.6920.85
46_S80_T0.6910.85
68_E72_L0.6900.84
191_F194_S0.6850.84
160_A164_L0.6840.84
27_A32_R0.6820.84
20_S23_L0.6820.84
83_Q87_R0.6820.84
234_D259_D0.6780.83
35_G113_M0.6730.83
185_E202_V0.6720.83
23_L143_I0.6700.83
59_A99_V0.6700.83
143_I172_V0.6690.83
173_F191_F0.6690.83
160_A163_A0.6690.83
42_T118_A0.6670.82
228_E233_T0.6670.82
277_D280_G0.6660.82
57_L61_D0.6650.82
175_A205_V0.6570.81
7_V18_A0.6550.81
95_L261_A0.6520.81
153_D158_L0.6480.81
22_A96_A0.6480.81
22_A133_D0.6480.81
80_T212_V0.6480.81
53_D68_E0.6440.80
169_A197_I0.6430.80
124_G194_S0.6390.80
53_D69_I0.6390.80
75_V95_L0.6390.80
23_L114_L0.6390.80
4_T107_A0.6350.79
169_A172_V0.6340.79
124_G154_V0.6340.79
21_L212_V0.6330.79
242_V276_L0.6330.79
154_V187_E0.6310.79
241_L255_R0.6270.78
107_A258_K0.6270.78
80_T262_V0.6270.78
17_T54_A0.6250.78
193_E196_G0.6250.78
8_T39_P0.6240.78
34_V112_V0.6220.78
149_T177_A0.6220.78
56_P60_R0.6220.78
121_P132_G0.6200.78
144_V171_V0.6180.77
127_V133_D0.6150.77
81_F86_V0.6150.77
59_A62_L0.6150.77
124_G160_A0.6130.77
212_V275_A0.6110.77
187_E191_F0.6090.76
99_V102_A0.6090.76
220_E223_A0.6080.76
181_Y184_V0.6070.76
59_A256_R0.6040.76
132_G161_A0.6040.76
39_P115_V0.6010.75
212_V249_S0.6010.75
86_V91_D0.5990.75
28_G64_D0.5990.75
110_R114_L0.5930.74
7_V156_D0.5930.74
139_D166_D0.5920.74
81_F129_L0.5910.74
23_L26_L0.5900.74
80_T267_D0.5900.74
168_C197_I0.5840.73
13_G127_V0.5840.73
52_L61_D0.5820.73
256_R259_D0.5820.73
30_R112_V0.5800.73
214_V283_C0.5800.73
73_E79_P0.5750.72
171_V195_Q0.5750.72
9_S16_K0.5750.72
83_Q92_S0.5750.72
133_D142_A0.5740.72
184_V189_T0.5730.72
173_F202_V0.5720.72
148_Y176_V0.5700.72
244_A265_G0.5700.72
52_L78_S0.5600.70
54_A57_L0.5590.70
181_Y202_V0.5590.70
95_L99_V0.5560.70
146_A171_V0.5560.70
221_L225_V0.5550.70
158_L190_P0.5550.70
86_V95_L0.5550.70
133_D141_R0.5550.70
252_S255_R0.5540.69
35_G109_D0.5540.69
154_V157_V0.5530.69
133_D140_A0.5530.69
129_L213_T0.5530.69
80_T271_I0.5530.69
137_L167_R0.5530.69
11_N275_A0.5520.69
73_E76_V0.5520.69
87_R103_Y0.5520.69
158_L191_F0.5510.69
66_D69_I0.5490.69
24_A64_D0.5470.68
41_G44_L0.5460.68
247_S250_A0.5460.68
222_G226_L0.5450.68
32_R114_L0.5440.68
252_S257_T0.5440.68
251_L268_R0.5440.68
100_R103_Y0.5430.68
48_V278_A0.5410.68
117_G131_D0.5400.67
8_T115_V0.5400.67
137_L140_A0.5390.67
38_K41_G0.5380.67
171_V192_L0.5370.67
239_R263_I0.5340.67
119_G151_P0.5340.67
128_D224_T0.5320.66
100_R134_I0.5310.66
37_M103_Y0.5300.66
40_K82_I0.5290.66
80_T249_S0.5290.66
27_A114_L0.5290.66
80_T256_R0.5280.66
223_A226_L0.5280.66
81_F90_E0.5280.66
39_P137_L0.5280.66
147_D152_S0.5280.66
76_V79_P0.5260.65
221_L224_T0.5260.65
156_D195_Q0.5260.65
12_A116_E0.5250.65
244_A271_I0.5230.65
154_V160_A0.5220.65
37_M99_V0.5220.65
190_P199_V0.5210.65
39_P255_R0.5210.65
112_V169_A0.5210.65
91_D207_R0.5200.65
35_G53_D0.5190.64
10_T156_D0.5180.64
131_D265_G0.5160.64
94_N226_L0.5160.64
224_T228_E0.5150.64
91_D96_A0.5150.64
79_P98_R0.5130.64
142_A168_C0.5130.64
226_L278_A0.5120.63
103_Y241_L0.5120.63
55_D212_V0.5120.63
276_L285_V0.5110.63
75_V99_V0.5100.63
188_V191_F0.5090.63
108_T228_E0.5070.63
251_L257_T0.5060.62
225_V228_E0.5060.62
97_D100_R0.5050.62
43_R50_K0.5050.62
220_E225_V0.5050.62
7_V19_V0.5050.62
85_A89_R0.5040.62
23_L112_V0.5030.62
4_T139_D0.5020.62
16_K119_G0.5010.62
25_R63_L0.5010.62
127_V136_A0.5000.62
101_D104_D0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a0gA 2 0.9661 100 0.648 Contact Map
2iojA 1 0.3333 99.9 0.726 Contact Map
3fgnA 2 0.6243 99.9 0.736 Contact Map
1s1mA 4 0.9746 99.9 0.741 Contact Map
1byiA 2 0.6243 99.9 0.742 Contact Map
3of5A 2 0.6102 99.9 0.745 Contact Map
3qxcA 2 0.5989 99.8 0.77 Contact Map
3zq6A 2 0.5904 99.8 0.774 Contact Map
4zdjA 4 0.9831 99.8 0.781 Contact Map
1vcoA 4 0.9774 99.8 0.784 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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