GREMLIN Database
Q9HQY5 - Cell division inhibitor
UniProt: Q9HQY5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (245)
Sequences: 1040 (835)
Seq/√Len: 53.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_T119_L7.8621.00
202_P229_A6.7731.00
85_T115_H6.2031.00
12_A137_A4.8651.00
26_T42_L4.5811.00
41_A115_H4.1851.00
32_A234_A4.0841.00
33_L117_V3.9691.00
216_P219_D3.8031.00
175_R203_H3.6111.00
27_A52_L3.4721.00
25_T230_Y3.2271.00
224_S227_A2.8421.00
13_V29_L2.8241.00
30_G119_L2.6801.00
201_V226_A2.6071.00
23_S55_L2.4441.00
9_Y139_G2.3341.00
38_F117_V2.2431.00
23_S52_L2.2371.00
39_E116_D2.2211.00
22_K124_A1.9871.00
35_D231_D1.9030.99
15_S143_V1.9010.99
36_E235_A1.8920.99
12_A134_M1.8690.99
45_V120_L1.8610.99
13_V26_T1.8560.99
23_S27_A1.8390.99
51_N149_N1.8070.99
143_V174_T1.7990.99
29_L234_A1.7910.99
30_G52_L1.7800.99
43_V118_V1.7790.99
17_K20_V1.7760.99
40_V116_D1.7750.99
12_A122_A1.7250.99
25_T174_T1.6970.99
22_K46_D1.6830.99
42_L119_L1.6610.99
207_V226_A1.6390.98
25_T172_V1.6330.98
25_T201_V1.6280.98
174_T230_Y1.6240.98
41_A78_A1.5850.98
11_F117_V1.5760.98
206_A209_L1.5620.98
32_A218_V1.5570.98
103_S107_V1.5080.97
15_S125_G1.4960.97
141_L172_V1.4700.97
89_G123_G1.4550.97
43_V108_V1.4320.96
199_V233_L1.4060.96
17_K22_K1.3750.95
139_G170_G1.3680.95
237_L249_P1.3540.95
49_M153_D1.3260.94
24_T211_V1.3140.94
52_L86_V1.2940.94
76_D181_F1.2930.93
8_G112_R1.2810.93
34_A84_V1.2780.93
185_E189_A1.2610.93
80_D85_T1.2590.93
50_A89_G1.2460.92
34_A83_G1.2360.92
51_N153_D1.2360.92
33_L119_L1.2290.92
41_A118_V1.2120.91
152_T214_G1.2110.91
217_V237_L1.2010.91
11_F67_V1.1900.90
58_L86_V1.1820.90
63_T66_D1.1670.89
16_G143_V1.1510.89
182_D186_G1.1470.89
42_L56_F1.1420.88
142_L158_G1.1380.88
45_V129_D1.1230.88
172_V233_L1.1210.87
16_G199_V1.1120.87
240_S243_M1.1090.87
49_M124_A1.1050.87
9_Y138_D1.0940.86
231_D235_A1.0790.85
21_G30_G1.0780.85
78_A109_T1.0780.85
67_V70_G1.0780.85
191_L210_A1.0720.85
134_M140_V1.0580.84
155_T159_Q1.0480.84
46_D124_A1.0450.83
182_D190_A1.0390.83
23_S174_T1.0260.82
15_S49_M1.0140.82
13_V141_L1.0130.81
36_E234_A1.0080.81
199_V204_D0.9880.80
20_V51_N0.9870.80
18_G46_D0.9830.79
249_P252_S0.9790.79
145_T175_R0.9720.79
9_Y181_F0.9660.78
48_G51_N0.9630.78
33_L125_G0.9570.78
27_A55_L0.9470.77
15_S22_K0.9470.77
186_G190_A0.9450.77
235_A239_D0.9380.76
16_G154_A0.9320.76
13_V119_L0.9320.76
67_V77_A0.9290.75
183_D190_A0.9260.75
107_V111_L0.9250.75
19_G22_K0.9240.75
15_S90_S0.9200.75
78_A196_A0.9190.75
119_L137_A0.9160.74
21_G174_T0.9060.74
78_A115_H0.8990.73
56_F84_V0.8960.73
111_L114_D0.8910.72
125_G145_T0.8880.72
16_G125_G0.8870.72
26_T228_R0.8810.72
16_G153_D0.8740.71
201_V246_P0.8690.70
186_G214_G0.8640.70
182_D187_I0.8550.69
165_D243_M0.8540.69
24_T122_A0.8510.69
51_N152_T0.8510.69
38_F116_D0.8490.69
14_A122_A0.8450.68
118_V126_L0.8440.68
75_A114_D0.8440.68
122_A133_A0.8410.68
28_N31_V0.8400.68
48_G124_A0.8350.67
156_K187_I0.8350.67
171_A247_Q0.8320.67
51_N124_A0.8300.67
47_L129_D0.8280.67
38_F238_A0.8270.67
32_A118_V0.8250.66
55_L149_N0.8210.66
223_E250_A0.8210.66
148_L212_R0.8170.66
129_D237_L0.8160.66
199_V236_S0.8160.66
11_F28_N0.8130.65
78_A244_T0.8110.65
38_F82_H0.8080.65
204_D224_S0.8060.65
101_A171_A0.8020.64
12_A133_A0.8000.64
85_T88_P0.7980.64
64_L226_A0.7980.64
46_D125_G0.7970.64
23_S144_T0.7970.64
150_S154_A0.7950.64
29_L237_L0.7930.63
27_A149_N0.7890.63
11_F200_S0.7890.63
49_M93_L0.7860.63
91_T199_V0.7820.62
204_D210_A0.7800.62
188_A196_A0.7800.62
114_D235_A0.7790.62
30_G42_L0.7780.62
55_L207_V0.7760.62
43_V120_L0.7750.62
49_M53_A0.7700.61
66_D71_D0.7660.61
16_G57_G0.7590.60
17_K51_N0.7550.60
23_S86_V0.7550.60
40_V84_V0.7520.59
50_A90_S0.7510.59
80_D86_V0.7500.59
110_R185_E0.7500.59
134_M138_D0.7460.59
30_G120_L0.7450.59
50_A156_K0.7430.58
235_A238_A0.7410.58
104_L107_V0.7390.58
248_P252_S0.7390.58
30_G56_F0.7380.58
124_A153_D0.7360.58
52_L157_T0.7360.58
231_D239_D0.7350.58
28_N42_L0.7320.57
105_H111_L0.7320.57
53_A132_M0.7230.56
183_D186_G0.7220.56
36_E231_D0.7210.56
93_L107_V0.7210.56
79_Y158_G0.7210.56
152_T159_Q0.7150.55
64_L107_V0.7140.55
49_M126_L0.7140.55
56_F67_V0.7070.55
151_L220_L0.7030.54
192_G248_P0.7020.54
76_D251_D0.7010.54
196_A236_S0.7010.54
173_F176_T0.6980.54
14_A161_V0.6950.53
43_V87_V0.6950.53
49_M143_V0.6930.53
217_V226_A0.6920.53
47_L153_D0.6870.52
235_A247_Q0.6860.52
42_L52_L0.6830.52
22_K51_N0.6810.52
151_L187_I0.6810.52
32_A231_D0.6790.52
73_S219_D0.6740.51
28_N216_P0.6710.51
46_D147_E0.6710.51
123_G211_V0.6670.50
30_G88_P0.6630.50
38_F80_D0.6610.50
23_S88_P0.6580.49
87_V99_A0.6520.49
16_G150_S0.6470.48
46_D127_S0.6440.48
23_S93_L0.6430.48
13_V76_D0.6370.47
63_T71_D0.6360.47
147_E211_V0.6340.47
246_P249_P0.6340.47
229_A246_P0.6330.47
7_E141_L0.6330.47
90_S127_S0.6310.47
11_F112_R0.6290.46
131_A172_V0.6220.46
203_H207_V0.6210.46
78_A111_L0.6170.45
184_V189_A0.6160.45
45_V50_A0.6150.45
42_L171_A0.6140.45
17_K145_T0.6100.44
147_E183_D0.6070.44
68_L103_S0.6060.44
125_G153_D0.6060.44
123_G214_G0.6060.44
32_A119_L0.6050.44
33_L141_L0.6050.44
247_Q252_S0.6030.44
31_V84_V0.6030.44
142_L206_A0.6030.44
100_D103_S0.6020.44
187_I191_L0.6020.44
26_T87_V0.6010.43
26_T209_L0.6010.43
109_T114_D0.5980.43
108_V228_R0.5980.43
17_K121_D0.5960.43
16_G147_E0.5940.43
232_R240_S0.5890.42
45_V133_A0.5880.42
9_Y241_I0.5880.42
39_E119_L0.5870.42
34_A64_L0.5870.42
108_V136_V0.5870.42
25_T143_V0.5830.42
222_P227_A0.5820.41
16_G124_A0.5810.41
7_E247_Q0.5810.41
50_A117_V0.5750.41
46_D57_G0.5700.40
11_F169_V0.5700.40
108_V164_L0.5700.40
93_L160_L0.5680.40
16_G22_K0.5670.40
14_A45_V0.5660.40
238_A249_P0.5660.40
15_S153_D0.5630.40
112_R171_A0.5630.40
22_K150_S0.5630.40
88_P133_A0.5620.39
112_R138_D0.5620.39
49_M125_G0.5610.39
141_L205_D0.5600.39
144_T208_K0.5590.39
200_S246_P0.5580.39
66_D83_G0.5580.39
71_D112_R0.5580.39
97_A127_S0.5580.39
183_D187_I0.5570.39
83_G232_R0.5570.39
52_L96_F0.5550.39
133_A155_T0.5530.39
23_S167_P0.5530.39
40_V100_D0.5530.39
33_L218_V0.5520.38
51_N155_T0.5520.38
15_S27_A0.5510.38
31_V35_D0.5490.38
70_G137_A0.5490.38
17_K201_V0.5480.38
10_V168_V0.5480.38
213_K223_E0.5480.38
134_M173_F0.5480.38
69_S72_A0.5480.38
201_V229_A0.5460.38
127_S157_T0.5460.38
204_D226_A0.5450.38
74_P87_V0.5450.38
171_A239_D0.5420.37
127_S130_I0.5380.37
26_T30_G0.5370.37
39_E112_R0.5360.37
39_E114_D0.5360.37
173_F184_V0.5350.37
22_K149_N0.5340.37
197_V201_V0.5330.37
218_V227_A0.5320.36
238_A245_P0.5320.36
239_D242_G0.5320.36
15_S174_T0.5300.36
55_L147_E0.5280.36
16_G145_T0.5280.36
23_S85_T0.5260.36
47_L122_A0.5260.36
51_N150_S0.5260.36
78_A85_T0.5250.36
86_V232_R0.5240.36
36_E243_M0.5230.36
64_L157_T0.5230.36
12_A210_A0.5210.35
106_R110_R0.5210.35
39_E214_G0.5200.35
8_G135_S0.5200.35
104_L167_P0.5200.35
23_S42_L0.5200.35
227_A231_D0.5190.35
12_A86_V0.5190.35
7_E215_H0.5180.35
120_L167_P0.5170.35
52_L145_T0.5170.35
70_G73_S0.5150.35
154_A239_D0.5140.35
7_E109_T0.5130.35
53_A124_A0.5120.34
189_A243_M0.5120.34
51_N123_G0.5110.34
74_P142_L0.5110.34
56_F214_G0.5110.34
11_F75_A0.5090.34
93_L96_F0.5070.34
14_A19_G0.5070.34
115_H118_V0.5070.34
158_G193_T0.5060.34
43_V119_L0.5050.34
197_V200_S0.5040.34
45_V64_L0.5040.34
51_N125_G0.5040.34
8_G118_V0.5040.34
89_G186_G0.5030.34
155_T190_A0.5030.34
249_P253_E0.5030.34
50_A202_P0.5020.34
209_L213_K0.5020.34
74_P109_T0.5000.33
235_A242_G0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g3qA 1 0.7214 100 0.378 Contact Map
4rz3A 2 0.7214 100 0.382 Contact Map
3ea0A 2 0.7183 100 0.382 Contact Map
1hyqA 1 0.709 100 0.393 Contact Map
4pfsA 1 0.7028 100 0.397 Contact Map
4v03A 2 0.6966 100 0.402 Contact Map
1wcv1 2 0.7152 100 0.403 Contact Map
3q9lA 2 0.7368 100 0.407 Contact Map
3pg5A 2 0.6502 100 0.408 Contact Map
3ez9A 2 0.6378 100 0.424 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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