Q9HQY5 - HALSA - GREMLIN Contacts

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Q9HQY5 - Cell division inhibitor

UniProt:	Q9HQY5	Sequences: MSEAGREGYVFAVASGKGGVGKSTTTANLGVALADEGFEVALVDVDLGMANLAGLFGLTEDVTLHDVLSGDASPADAAYDAHGVTVVPGSTDLEQFAEADAKSLHRVVTRLRADHDVVLLDAGAGLSYDIAMAMSVADGVLLVTTAELNSLTDATKTGQLVSKLDKPVVGAVFTRTGDGGFDDVEGIAAALGTTDAVTVSVPHDDAVKLAVRKGHPVVDLTPESPAARAYDRLAASLADSIGMTPPQPPADSEDTSTDDGDAFEWVDPDTGESQPDDDDEADAEGPVYEISIEEMLAEAGVDADEETAERRVKLFDRVKSRLS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	323 (245)
Sequences:	1040 (835)
Seq/√Len:	53.3

ECOLI - MRP MIND BCSQ
BACSU - YLXH SALA SOJ MIND YWQD YVEL
HALSA - Q9HQY5 Q9HNF1 Q9HHZ7 Q9HHU2 Q9HQJ7 Q9HHL5 O54573 O51991 O51969
SULSO - Q97ZW4 Q981B3 Q97VX7 Q97WA2 Q97YM8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
26_T	119_L	7.862	1.00
202_P	229_A	6.773	1.00
85_T	115_H	6.203	1.00
12_A	137_A	4.865	1.00
26_T	42_L	4.581	1.00
41_A	115_H	4.185	1.00
32_A	234_A	4.084	1.00
33_L	117_V	3.969	1.00
216_P	219_D	3.803	1.00
175_R	203_H	3.611	1.00
27_A	52_L	3.472	1.00
25_T	230_Y	3.227	1.00
224_S	227_A	2.842	1.00
13_V	29_L	2.824	1.00
30_G	119_L	2.680	1.00
201_V	226_A	2.607	1.00
23_S	55_L	2.444	1.00
9_Y	139_G	2.334	1.00
38_F	117_V	2.243	1.00
23_S	52_L	2.237	1.00
39_E	116_D	2.221	1.00
22_K	124_A	1.987	1.00
35_D	231_D	1.903	0.99
15_S	143_V	1.901	0.99
36_E	235_A	1.892	0.99
12_A	134_M	1.869	0.99
45_V	120_L	1.861	0.99
13_V	26_T	1.856	0.99
23_S	27_A	1.839	0.99
51_N	149_N	1.807	0.99
143_V	174_T	1.799	0.99
29_L	234_A	1.791	0.99
30_G	52_L	1.780	0.99
43_V	118_V	1.779	0.99
17_K	20_V	1.776	0.99
40_V	116_D	1.775	0.99
12_A	122_A	1.725	0.99
25_T	174_T	1.697	0.99
22_K	46_D	1.683	0.99
42_L	119_L	1.661	0.99
207_V	226_A	1.639	0.98
25_T	172_V	1.633	0.98
25_T	201_V	1.628	0.98
174_T	230_Y	1.624	0.98
41_A	78_A	1.585	0.98
11_F	117_V	1.576	0.98
206_A	209_L	1.562	0.98
32_A	218_V	1.557	0.98
103_S	107_V	1.508	0.97
15_S	125_G	1.496	0.97
141_L	172_V	1.470	0.97
89_G	123_G	1.455	0.97
43_V	108_V	1.432	0.96
199_V	233_L	1.406	0.96
17_K	22_K	1.375	0.95
139_G	170_G	1.368	0.95
237_L	249_P	1.354	0.95
49_M	153_D	1.326	0.94
24_T	211_V	1.314	0.94
52_L	86_V	1.294	0.94
76_D	181_F	1.293	0.93
8_G	112_R	1.281	0.93
34_A	84_V	1.278	0.93
185_E	189_A	1.261	0.93
80_D	85_T	1.259	0.93
50_A	89_G	1.246	0.92
34_A	83_G	1.236	0.92
51_N	153_D	1.236	0.92
33_L	119_L	1.229	0.92
41_A	118_V	1.212	0.91
152_T	214_G	1.211	0.91
217_V	237_L	1.201	0.91
11_F	67_V	1.190	0.90
58_L	86_V	1.182	0.90
63_T	66_D	1.167	0.89
16_G	143_V	1.151	0.89
182_D	186_G	1.147	0.89
42_L	56_F	1.142	0.88
142_L	158_G	1.138	0.88
45_V	129_D	1.123	0.88
172_V	233_L	1.121	0.87
16_G	199_V	1.112	0.87
240_S	243_M	1.109	0.87
49_M	124_A	1.105	0.87
9_Y	138_D	1.094	0.86
231_D	235_A	1.079	0.85
21_G	30_G	1.078	0.85
78_A	109_T	1.078	0.85
67_V	70_G	1.078	0.85
191_L	210_A	1.072	0.85
134_M	140_V	1.058	0.84
155_T	159_Q	1.048	0.84
46_D	124_A	1.045	0.83
182_D	190_A	1.039	0.83
23_S	174_T	1.026	0.82
15_S	49_M	1.014	0.82
13_V	141_L	1.013	0.81
36_E	234_A	1.008	0.81
199_V	204_D	0.988	0.80
20_V	51_N	0.987	0.80
18_G	46_D	0.983	0.79
249_P	252_S	0.979	0.79
145_T	175_R	0.972	0.79
9_Y	181_F	0.966	0.78
48_G	51_N	0.963	0.78
33_L	125_G	0.957	0.78
27_A	55_L	0.947	0.77
15_S	22_K	0.947	0.77
186_G	190_A	0.945	0.77
235_A	239_D	0.938	0.76
16_G	154_A	0.932	0.76
13_V	119_L	0.932	0.76
67_V	77_A	0.929	0.75
183_D	190_A	0.926	0.75
107_V	111_L	0.925	0.75
19_G	22_K	0.924	0.75
15_S	90_S	0.920	0.75
78_A	196_A	0.919	0.75
119_L	137_A	0.916	0.74
21_G	174_T	0.906	0.74
78_A	115_H	0.899	0.73
56_F	84_V	0.896	0.73
111_L	114_D	0.891	0.72
125_G	145_T	0.888	0.72
16_G	125_G	0.887	0.72
26_T	228_R	0.881	0.72
16_G	153_D	0.874	0.71
201_V	246_P	0.869	0.70
186_G	214_G	0.864	0.70
182_D	187_I	0.855	0.69
165_D	243_M	0.854	0.69
24_T	122_A	0.851	0.69
51_N	152_T	0.851	0.69
38_F	116_D	0.849	0.69
14_A	122_A	0.845	0.68
118_V	126_L	0.844	0.68
75_A	114_D	0.844	0.68
122_A	133_A	0.841	0.68
28_N	31_V	0.840	0.68
48_G	124_A	0.835	0.67
156_K	187_I	0.835	0.67
171_A	247_Q	0.832	0.67
51_N	124_A	0.830	0.67
47_L	129_D	0.828	0.67
38_F	238_A	0.827	0.67
32_A	118_V	0.825	0.66
55_L	149_N	0.821	0.66
223_E	250_A	0.821	0.66
148_L	212_R	0.817	0.66
129_D	237_L	0.816	0.66
199_V	236_S	0.816	0.66
11_F	28_N	0.813	0.65
78_A	244_T	0.811	0.65
38_F	82_H	0.808	0.65
204_D	224_S	0.806	0.65
101_A	171_A	0.802	0.64
12_A	133_A	0.800	0.64
85_T	88_P	0.798	0.64
64_L	226_A	0.798	0.64
46_D	125_G	0.797	0.64
23_S	144_T	0.797	0.64
150_S	154_A	0.795	0.64
29_L	237_L	0.793	0.63
27_A	149_N	0.789	0.63
11_F	200_S	0.789	0.63
49_M	93_L	0.786	0.63
91_T	199_V	0.782	0.62
204_D	210_A	0.780	0.62
188_A	196_A	0.780	0.62
114_D	235_A	0.779	0.62
30_G	42_L	0.778	0.62
55_L	207_V	0.776	0.62
43_V	120_L	0.775	0.62
49_M	53_A	0.770	0.61
66_D	71_D	0.766	0.61
16_G	57_G	0.759	0.60
17_K	51_N	0.755	0.60
23_S	86_V	0.755	0.60
40_V	84_V	0.752	0.59
50_A	90_S	0.751	0.59
80_D	86_V	0.750	0.59
110_R	185_E	0.750	0.59
134_M	138_D	0.746	0.59
30_G	120_L	0.745	0.59
50_A	156_K	0.743	0.58
235_A	238_A	0.741	0.58
104_L	107_V	0.739	0.58
248_P	252_S	0.739	0.58
30_G	56_F	0.738	0.58
124_A	153_D	0.736	0.58
52_L	157_T	0.736	0.58
231_D	239_D	0.735	0.58
28_N	42_L	0.732	0.57
105_H	111_L	0.732	0.57
53_A	132_M	0.723	0.56
183_D	186_G	0.722	0.56
36_E	231_D	0.721	0.56
93_L	107_V	0.721	0.56
79_Y	158_G	0.721	0.56
152_T	159_Q	0.715	0.55
64_L	107_V	0.714	0.55
49_M	126_L	0.714	0.55
56_F	67_V	0.707	0.55
151_L	220_L	0.703	0.54
192_G	248_P	0.702	0.54
76_D	251_D	0.701	0.54
196_A	236_S	0.701	0.54
173_F	176_T	0.698	0.54
14_A	161_V	0.695	0.53
43_V	87_V	0.695	0.53
49_M	143_V	0.693	0.53
217_V	226_A	0.692	0.53
47_L	153_D	0.687	0.52
235_A	247_Q	0.686	0.52
42_L	52_L	0.683	0.52
22_K	51_N	0.681	0.52
151_L	187_I	0.681	0.52
32_A	231_D	0.679	0.52
73_S	219_D	0.674	0.51
28_N	216_P	0.671	0.51
46_D	147_E	0.671	0.51
123_G	211_V	0.667	0.50
30_G	88_P	0.663	0.50
38_F	80_D	0.661	0.50
23_S	88_P	0.658	0.49
87_V	99_A	0.652	0.49
16_G	150_S	0.647	0.48
46_D	127_S	0.644	0.48
23_S	93_L	0.643	0.48
13_V	76_D	0.637	0.47
63_T	71_D	0.636	0.47
147_E	211_V	0.634	0.47
246_P	249_P	0.634	0.47
229_A	246_P	0.633	0.47
7_E	141_L	0.633	0.47
90_S	127_S	0.631	0.47
11_F	112_R	0.629	0.46
131_A	172_V	0.622	0.46
203_H	207_V	0.621	0.46
78_A	111_L	0.617	0.45
184_V	189_A	0.616	0.45
45_V	50_A	0.615	0.45
42_L	171_A	0.614	0.45
17_K	145_T	0.610	0.44
147_E	183_D	0.607	0.44
68_L	103_S	0.606	0.44
125_G	153_D	0.606	0.44
123_G	214_G	0.606	0.44
32_A	119_L	0.605	0.44
33_L	141_L	0.605	0.44
247_Q	252_S	0.603	0.44
31_V	84_V	0.603	0.44
142_L	206_A	0.603	0.44
100_D	103_S	0.602	0.44
187_I	191_L	0.602	0.44
26_T	87_V	0.601	0.43
26_T	209_L	0.601	0.43
109_T	114_D	0.598	0.43
108_V	228_R	0.598	0.43
17_K	121_D	0.596	0.43
16_G	147_E	0.594	0.43
232_R	240_S	0.589	0.42
45_V	133_A	0.588	0.42
9_Y	241_I	0.588	0.42
39_E	119_L	0.587	0.42
34_A	64_L	0.587	0.42
108_V	136_V	0.587	0.42
25_T	143_V	0.583	0.42
222_P	227_A	0.582	0.41
16_G	124_A	0.581	0.41
7_E	247_Q	0.581	0.41
50_A	117_V	0.575	0.41
46_D	57_G	0.570	0.40
11_F	169_V	0.570	0.40
108_V	164_L	0.570	0.40
93_L	160_L	0.568	0.40
16_G	22_K	0.567	0.40
14_A	45_V	0.566	0.40
238_A	249_P	0.566	0.40
15_S	153_D	0.563	0.40
112_R	171_A	0.563	0.40
22_K	150_S	0.563	0.40
88_P	133_A	0.562	0.39
112_R	138_D	0.562	0.39
49_M	125_G	0.561	0.39
141_L	205_D	0.560	0.39
144_T	208_K	0.559	0.39
200_S	246_P	0.558	0.39
66_D	83_G	0.558	0.39
71_D	112_R	0.558	0.39
97_A	127_S	0.558	0.39
183_D	187_I	0.557	0.39
83_G	232_R	0.557	0.39
52_L	96_F	0.555	0.39
133_A	155_T	0.553	0.39
23_S	167_P	0.553	0.39
40_V	100_D	0.553	0.39
33_L	218_V	0.552	0.38
51_N	155_T	0.552	0.38
15_S	27_A	0.551	0.38
31_V	35_D	0.549	0.38
70_G	137_A	0.549	0.38
17_K	201_V	0.548	0.38
10_V	168_V	0.548	0.38
213_K	223_E	0.548	0.38
134_M	173_F	0.548	0.38
69_S	72_A	0.548	0.38
201_V	229_A	0.546	0.38
127_S	157_T	0.546	0.38
204_D	226_A	0.545	0.38
74_P	87_V	0.545	0.38
171_A	239_D	0.542	0.37
127_S	130_I	0.538	0.37
26_T	30_G	0.537	0.37
39_E	112_R	0.536	0.37
39_E	114_D	0.536	0.37
173_F	184_V	0.535	0.37
22_K	149_N	0.534	0.37
197_V	201_V	0.533	0.37
218_V	227_A	0.532	0.36
238_A	245_P	0.532	0.36
239_D	242_G	0.532	0.36
15_S	174_T	0.530	0.36
55_L	147_E	0.528	0.36
16_G	145_T	0.528	0.36
23_S	85_T	0.526	0.36
47_L	122_A	0.526	0.36
51_N	150_S	0.526	0.36
78_A	85_T	0.525	0.36
86_V	232_R	0.524	0.36
36_E	243_M	0.523	0.36
64_L	157_T	0.523	0.36
12_A	210_A	0.521	0.35
106_R	110_R	0.521	0.35
39_E	214_G	0.520	0.35
8_G	135_S	0.520	0.35
104_L	167_P	0.520	0.35
23_S	42_L	0.520	0.35
227_A	231_D	0.519	0.35
12_A	86_V	0.519	0.35
7_E	215_H	0.518	0.35
120_L	167_P	0.517	0.35
52_L	145_T	0.517	0.35
70_G	73_S	0.515	0.35
154_A	239_D	0.514	0.35
7_E	109_T	0.513	0.35
53_A	124_A	0.512	0.34
189_A	243_M	0.512	0.34
51_N	123_G	0.511	0.34
74_P	142_L	0.511	0.34
56_F	214_G	0.511	0.34
11_F	75_A	0.509	0.34
93_L	96_F	0.507	0.34
14_A	19_G	0.507	0.34
115_H	118_V	0.507	0.34
158_G	193_T	0.506	0.34
43_V	119_L	0.505	0.34
197_V	200_S	0.504	0.34
45_V	64_L	0.504	0.34
51_N	125_G	0.504	0.34
8_G	118_V	0.504	0.34
89_G	186_G	0.503	0.34
155_T	190_A	0.503	0.34
249_P	253_E	0.503	0.34
50_A	202_P	0.502	0.34
209_L	213_K	0.502	0.34
74_P	109_T	0.500	0.33
235_A	242_G	0.500	0.33

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1g3qA	1	0.7214	100	0.378	Contact Map
4rz3A	2	0.7214	100	0.382	Contact Map
3ea0A	2	0.7183	100	0.382	Contact Map
1hyqA	1	0.709	100	0.393	Contact Map
4pfsA	1	0.7028	100	0.397	Contact Map
4v03A	2	0.6966	100	0.402	Contact Map
1wcv1	2	0.7152	100	0.403	Contact Map
3q9lA	2	0.7368	100	0.407	Contact Map
3pg5A	2	0.6502	100	0.408	Contact Map
3ez9A	2	0.6378	100	0.424	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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