Q9HQX8 - HALSA - GREMLIN Contacts

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Q9HQX8 - Htr15 transducer

UniProt:	Q9HQX8	Sequences: MLRIFRKLLGRGAGTPATDGGTAASAVSFEDADDAMAGLQERYSVDQRDLDPTLPADAADHFDGLLDETAPTPESYLPVYTAADVSAGAFVDAYTTPADAVVDAVFQQLREGGVDGAAVDHAERQLKTGMHAVVEDAATGVAAYETAAGPADDSSDGGTEEELNVDDDALLDSIGMPVFMLDATGSVVAWNETIEELTGCSKADAMGMDHASEAFYPDDRRVKTLADKVIESPRSAAAEFDIERSEEKAQLYADTSVMTDQGGTDRHIRFKASPIFDDDGELLAVAETIEDRTEDVRRADAVEELVDELSTTIDALSSGQLSKRASFEHEGIINEQLVSVVSALNGMADQFERLVGQVDGQTQELADTIERATADATDIADTVSSQNEMLSSAANEMENFSASMQEVAASSDQVASAAEQAQDAAESGLEASEGANQATNEVIDISDDLMESVSKLESRMDEIEDVVEVIAEVADQTNLLALNANIEAARAGEAGSGFAVVADEVKELANETREHTERIAGSISDVQQQANETVLAVEESHEQIHRAGDEIDDALTALEEIATSVDEAATGITEVARANDEQASTVEDVIVTIEDVQQQAEEAAAASDRIVSATQEQSTAVSQLSERVDKLTTDSQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	636 (517)
Sequences:	2841 (2651)
Seq/√Len:	116.6

ECOLI - AER MCP3 MCP2 MCP1 MCP4
BACSU - TLPA MCPA MCPB TLPB MCPC YVAQ YOAH TLPC HEMAT
HALSA - Q9HQX8 HTR4 HTR2 Q9HRA1 Q9HP10 Q9HRN6 Q9HR88 COST HTR7 Q9HS86 HTR9 Q9HPA2 HMAT Q9HPQ5 Q9HQT5 Q9HPW6 HTR1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
329_H	338_V	8.026	1.00
324_R	352_E	5.083	1.00
315_A	320_Q	4.712	1.00
414_V	572_I	3.898	1.00
313_I	347_M	3.497	1.00
442_V	547_A	3.289	1.00
464_E	527_Q	3.153	1.00
345_N	348_A	3.120	1.00
453_V	534_V	3.062	1.00
382_T	599_Q	3.022	1.00
436_N	555_L	3.003	1.00
106_F	110_R	2.789	1.00
469_V	515_H	2.786	1.00
512_T	516_T	2.739	1.00
452_S	533_T	2.710	1.00
507_E	510_N	2.670	1.00
453_V	533_T	2.644	1.00
93_A	98_A	2.548	1.00
341_V	345_N	2.476	1.00
313_I	343_A	2.456	1.00
309_L	341_V	2.450	1.00
302_V	305_L	2.418	1.00
446_S	537_V	2.405	1.00
617_Q	631_L	2.394	1.00
324_R	345_N	2.357	1.00
407_V	579_N	2.327	1.00
485_N	506_K	2.309	1.00
319_G	340_V	2.244	1.00
588_D	591_V	2.222	1.00
511_E	518_R	2.207	1.00
503_D	506_K	2.192	1.00
357_Q	623_Q	2.183	1.00
485_N	503_D	2.165	1.00
621_V	631_L	2.129	1.00
310_S	343_A	2.098	1.00
471_A	520_A	2.089	1.00
309_L	344_L	2.078	1.00
335_E	338_V	2.044	1.00
98_A	102_V	2.023	1.00
398_E	590_I	2.014	1.00
442_V	544_I	1.996	1.00
140_G	144_Y	1.987	1.00
163_L	171_L	1.980	1.00
316_L	347_M	1.949	1.00
252_Y	255_T	1.936	1.00
315_A	347_M	1.916	1.00
400_F	586_V	1.912	1.00
251_L	258_M	1.898	1.00
324_R	349_D	1.883	1.00
439_T	547_A	1.879	1.00
442_V	526_V	1.852	1.00
466_V	522_S	1.845	1.00
358_V	628_V	1.826	1.00
167_D	171_L	1.815	1.00
102_V	106_F	1.810	1.00
226_A	230_I	1.781	1.00
149_G	152_D	1.763	1.00
137_A	141_V	1.742	1.00
616_E	619_T	1.735	1.00
458_S	461_D	1.734	1.00
406_E	409_A	1.731	1.00
367_D	371_R	1.726	1.00
424_A	560_E	1.723	1.00
496_S	503_D	1.718	1.00
324_R	348_A	1.716	1.00
106_F	109_L	1.709	1.00
319_G	351_F	1.707	1.00
514_E	518_R	1.691	1.00
230_I	233_P	1.687	1.00
372_A	610_I	1.685	1.00
388_E	391_S	1.681	1.00
389_M	595_D	1.679	1.00
251_L	254_D	1.676	1.00
428_G	432_S	1.668	1.00
313_I	340_V	1.665	1.00
316_L	348_A	1.640	1.00
295_D	299_A	1.637	1.00
313_I	344_L	1.633	1.00
395_N	399_N	1.629	1.00
425_A	562_A	1.617	1.00
254_D	257_V	1.614	1.00
462_E	518_R	1.606	1.00
414_V	418_A	1.598	1.00
566_D	570_T	1.590	1.00
354_L	358_V	1.588	1.00
347_M	351_F	1.584	1.00
439_T	548_G	1.576	1.00
291_D	295_D	1.575	1.00
466_V	469_V	1.570	1.00
306_V	340_V	1.568	1.00
427_S	430_E	1.566	1.00
367_D	370_E	1.565	1.00
257_V	261_Q	1.554	1.00
446_S	544_I	1.552	1.00
567_E	570_T	1.545	1.00
460_M	530_A	1.538	1.00
301_A	305_L	1.538	1.00
347_M	350_Q	1.535	1.00
407_V	575_V	1.534	1.00
481_A	505_V	1.527	1.00
457_E	534_V	1.526	1.00
449_L	536_A	1.525	1.00
540_S	544_I	1.521	1.00
577_R	581_E	1.513	1.00
312_T	325_A	1.498	1.00
309_L	340_V	1.485	1.00
255_T	259_T	1.485	1.00
399_N	581_E	1.484	1.00
428_G	561_I	1.480	1.00
386_Q	582_Q	1.478	1.00
544_I	547_A	1.475	1.00
396_E	399_N	1.474	1.00
376_A	382_T	1.473	1.00
465_D	468_E	1.471	1.00
314_D	318_S	1.470	1.00
553_D	556_T	1.468	1.00
624_L	631_L	1.465	1.00
257_V	260_D	1.465	1.00
300_D	304_E	1.463	1.00
105_V	109_L	1.461	1.00
435_A	554_A	1.454	1.00
430_E	434_G	1.445	1.00
459_R	529_Q	1.443	1.00
226_A	229_V	1.432	1.00
365_L	620_A	1.431	1.00
440_N	552_D	1.410	1.00
262_G	266_R	1.407	1.00
316_L	321_L	1.401	1.00
369_I	614_T	1.396	1.00
350_Q	630_K	1.389	1.00
460_M	526_V	1.383	1.00
556_T	559_E	1.382	1.00
272_A	276_F	1.378	1.00
371_R	609_R	1.374	1.00
391_S	597_Q	1.362	1.00
309_L	313_I	1.361	1.00
386_Q	600_A	1.358	1.00
605_A	609_R	1.356	1.00
305_L	338_V	1.344	1.00
175_G	179_F	1.336	1.00
299_A	303_E	1.333	1.00
412_D	580_D	1.331	1.00
405_Q	587_E	1.309	1.00
468_E	472_E	1.303	1.00
563_T	567_E	1.295	1.00
455_K	458_S	1.295	1.00
399_N	402_A	1.285	1.00
100_A	103_D	1.285	1.00
314_D	343_A	1.281	0.99
224_T	228_K	1.273	0.99
423_D	427_S	1.273	0.99
325_A	345_N	1.270	0.99
510_N	514_E	1.264	0.99
93_A	99_D	1.263	0.99
432_S	554_A	1.263	0.99
371_R	374_A	1.262	0.99
162_E	166_D	1.260	0.99
386_Q	396_E	1.252	0.99
164_N	168_D	1.248	0.99
367_D	374_A	1.243	0.99
358_V	624_L	1.242	0.99
459_R	525_D	1.237	0.99
286_A	293_T	1.236	0.99
315_A	323_K	1.235	0.99
446_S	540_S	1.231	0.99
568_A	572_I	1.226	0.99
577_R	580_D	1.219	0.99
375_D	606_A	1.218	0.99
287_E	291_D	1.216	0.99
255_T	258_M	1.209	0.99
339_S	342_S	1.203	0.99
98_A	109_L	1.201	0.99
253_A	257_V	1.198	0.99
98_A	105_V	1.198	0.99
99_D	109_L	1.196	0.99
202_K	208_M	1.195	0.99
337_L	341_V	1.192	0.99
394_A	399_N	1.187	0.99
93_A	97_P	1.183	0.99
99_D	102_V	1.180	0.99
137_A	145_E	1.179	0.99
403_S	582_Q	1.178	0.99
93_A	109_L	1.173	0.99
443_I	548_G	1.172	0.99
542_E	546_R	1.170	0.99
314_D	339_S	1.169	0.99
251_L	256_S	1.166	0.99
549_D	553_D	1.165	0.99
612_S	616_E	1.163	0.99
414_V	582_Q	1.163	0.99
254_D	259_T	1.161	0.99
395_N	402_A	1.158	0.99
370_E	618_S	1.157	0.99
418_A	428_G	1.157	0.99
252_Y	256_S	1.156	0.99
310_S	340_V	1.156	0.99
295_D	298_R	1.154	0.99
168_D	172_D	1.151	0.99
469_V	523_I	1.147	0.99
472_E	475_D	1.147	0.99
485_N	505_V	1.147	0.99
93_A	105_V	1.145	0.99
452_S	532_E	1.142	0.99
455_K	529_Q	1.141	0.99
338_V	341_V	1.140	0.99
366_A	370_E	1.139	0.99
517_E	520_A	1.139	0.99
389_M	592_T	1.137	0.99
172_D	177_P	1.136	0.99
225_L	229_V	1.136	0.99
171_L	177_P	1.130	0.99
395_N	403_S	1.123	0.99
378_D	602_E	1.121	0.99
471_A	516_T	1.116	0.99
312_T	344_L	1.114	0.99
325_A	341_V	1.112	0.99
580_D	584_S	1.111	0.99
316_L	344_L	1.111	0.99
228_K	232_S	1.102	0.98
92_D	106_F	1.100	0.98
337_L	344_L	1.094	0.98
570_T	573_T	1.094	0.98
587_E	590_I	1.090	0.98
594_E	598_Q	1.090	0.98
92_D	102_V	1.089	0.98
428_G	554_A	1.087	0.98
494_A	507_E	1.086	0.98
463_I	523_I	1.085	0.98
579_N	582_Q	1.082	0.98
571_G	574_E	1.081	0.98
327_F	345_N	1.071	0.98
195_E	199_G	1.070	0.98
112_G	116_G	1.070	0.98
161_E	165_V	1.068	0.98
605_A	608_D	1.068	0.98
265_D	272_A	1.065	0.98
485_N	496_S	1.061	0.98
92_D	98_A	1.061	0.98
194_I	198_T	1.059	0.98
609_R	612_S	1.059	0.98
188_V	193_T	1.059	0.98
133_V	137_A	1.058	0.98
373_T	618_S	1.057	0.98
604_A	611_V	1.056	0.98
329_H	335_E	1.055	0.98
105_V	110_R	1.055	0.98
226_A	233_P	1.054	0.98
395_N	581_E	1.053	0.98
415_A	576_A	1.050	0.98
157_G	161_E	1.045	0.98
215_F	219_D	1.044	0.98
165_V	168_D	1.042	0.98
384_S	388_E	1.042	0.98
395_N	585_T	1.042	0.98
617_Q	621_V	1.038	0.98
98_A	101_V	1.036	0.98
376_A	607_S	1.034	0.98
617_Q	628_V	1.033	0.98
605_A	612_S	1.028	0.98
214_A	219_D	1.028	0.98
584_S	588_D	1.025	0.98
293_T	296_V	1.022	0.97
344_L	347_M	1.021	0.97
93_A	106_F	1.014	0.97
123_E	127_K	1.014	0.97
538_E	542_E	1.012	0.97
227_D	231_E	1.010	0.97
449_L	537_V	1.008	0.97
99_D	106_F	1.004	0.97
344_L	348_A	1.003	0.97
314_D	346_G	1.003	0.97
251_L	255_T	0.997	0.97
99_D	103_D	0.993	0.97
452_S	536_A	0.992	0.97
305_L	336_Q	0.992	0.97
394_A	585_T	0.991	0.97
268_I	275_I	0.988	0.97
138_A	142_A	0.987	0.97
171_L	174_I	0.987	0.97
445_I	539_E	0.986	0.97
98_A	106_F	0.985	0.97
394_A	593_I	0.984	0.97
461_D	531_N	0.983	0.97
327_F	342_S	0.981	0.97
257_V	262_G	0.979	0.97
526_V	530_A	0.978	0.97
274_P	277_D	0.976	0.97
264_T	267_H	0.975	0.97
266_R	270_F	0.974	0.97
201_S	204_D	0.964	0.96
413_Q	416_S	0.958	0.96
397_M	403_S	0.958	0.96
305_L	337_L	0.957	0.96
520_A	524_S	0.957	0.96
307_D	339_S	0.955	0.96
466_V	512_T	0.954	0.96
190_W	194_I	0.953	0.96
387_N	597_Q	0.951	0.96
188_V	197_L	0.951	0.96
144_Y	147_A	0.950	0.96
347_M	428_G	0.949	0.96
336_Q	339_S	0.948	0.96
262_G	265_D	0.948	0.96
460_M	529_Q	0.947	0.96
364_E	616_E	0.945	0.96
110_R	113_G	0.944	0.96
349_D	353_R	0.944	0.96
188_V	192_E	0.942	0.96
587_E	591_V	0.934	0.96
357_Q	627_R	0.934	0.96
365_L	617_Q	0.930	0.96
552_D	556_T	0.928	0.96
126_L	137_A	0.926	0.95
230_I	234_R	0.926	0.95
400_F	582_Q	0.926	0.95
282_L	286_A	0.924	0.95
190_W	197_L	0.923	0.95
425_A	561_I	0.920	0.95
374_A	378_D	0.919	0.95
186_S	189_A	0.919	0.95
303_E	307_D	0.917	0.95
396_E	585_T	0.916	0.95
251_L	257_V	0.915	0.95
205_A	208_M	0.914	0.95
377_T	381_D	0.913	0.95
252_Y	259_T	0.912	0.95
145_E	149_G	0.910	0.95
186_S	191_N	0.908	0.95
168_D	171_L	0.906	0.95
341_V	344_L	0.905	0.95
164_N	167_D	0.905	0.95
424_A	564_S	0.904	0.95
296_V	300_D	0.903	0.95
403_S	578_A	0.902	0.95
351_F	355_V	0.901	0.95
263_G	267_H	0.899	0.95
526_V	547_A	0.897	0.95
326_S	345_N	0.896	0.95
533_T	537_V	0.893	0.95
327_F	338_V	0.892	0.94
466_V	516_T	0.891	0.94
432_S	555_L	0.891	0.94
305_L	340_V	0.890	0.94
598_Q	602_E	0.889	0.94
181_L	185_G	0.889	0.94
351_F	354_L	0.886	0.94
416_S	419_E	0.885	0.94
92_D	96_T	0.883	0.94
369_I	621_V	0.883	0.94
97_P	101_V	0.881	0.94
197_L	201_S	0.879	0.94
158_G	162_E	0.879	0.94
107_Q	110_R	0.878	0.94
442_V	446_S	0.876	0.94
93_A	96_T	0.875	0.94
558_L	561_I	0.875	0.94
206_M	210_H	0.875	0.94
542_E	545_H	0.875	0.94
158_G	161_E	0.873	0.94
432_S	558_L	0.872	0.94
118_A	121_H	0.868	0.94
96_T	102_V	0.867	0.94
172_D	176_M	0.866	0.94
404_M	408_A	0.866	0.94
426_E	566_D	0.866	0.94
475_D	486_I	0.861	0.93
115_D	119_V	0.851	0.93
141_V	145_E	0.850	0.93
167_D	174_I	0.850	0.93
129_G	133_V	0.849	0.93
225_L	232_S	0.849	0.93
310_S	339_S	0.847	0.93
203_A	208_M	0.846	0.93
393_A	585_T	0.846	0.93
457_E	526_V	0.846	0.93
450_M	537_V	0.842	0.93
93_A	101_V	0.841	0.93
595_D	598_Q	0.839	0.92
400_F	571_G	0.837	0.92
325_A	329_H	0.834	0.92
322_S	632_T	0.834	0.92
126_L	129_G	0.833	0.92
421_A	554_A	0.831	0.92
404_M	579_N	0.831	0.92
156_D	159_T	0.830	0.92
98_A	103_D	0.826	0.92
412_D	416_S	0.826	0.92
408_A	583_A	0.826	0.92
435_A	558_L	0.825	0.92
152_D	155_S	0.824	0.92
250_Q	258_M	0.823	0.92
96_T	101_V	0.823	0.92
394_A	581_E	0.822	0.92
425_A	555_L	0.822	0.92
265_D	269_R	0.822	0.92
435_A	547_A	0.822	0.92
311_T	315_A	0.822	0.92
269_R	275_I	0.820	0.92
457_E	561_I	0.819	0.92
570_T	577_R	0.819	0.92
369_I	372_A	0.812	0.91
510_N	526_V	0.811	0.91
111_E	114_V	0.809	0.91
313_I	316_L	0.808	0.91
468_E	471_A	0.801	0.91
108_Q	112_G	0.797	0.90
606_A	609_R	0.797	0.90
460_M	463_I	0.797	0.90
307_D	336_Q	0.794	0.90
321_L	355_V	0.794	0.90
406_E	580_D	0.793	0.90
97_P	100_A	0.793	0.90
393_A	589_V	0.792	0.90
396_E	592_T	0.791	0.90
406_E	574_E	0.791	0.90
135_E	139_T	0.789	0.90
309_L	329_H	0.789	0.90
558_L	603_A	0.788	0.90
156_D	160_E	0.788	0.90
100_A	104_A	0.787	0.90
144_Y	148_A	0.782	0.90
460_M	466_V	0.782	0.90
400_F	585_T	0.781	0.90
602_E	605_A	0.780	0.89
109_L	113_G	0.778	0.89
110_R	114_V	0.777	0.89
250_Q	255_T	0.777	0.89
370_E	374_A	0.776	0.89
250_Q	253_A	0.774	0.89
366_A	618_S	0.774	0.89
160_E	164_N	0.773	0.89
411_S	575_V	0.772	0.89
127_K	134_V	0.772	0.89
166_D	169_A	0.771	0.89
177_P	183_A	0.770	0.89
105_V	108_Q	0.768	0.89
388_E	395_N	0.768	0.89
450_M	533_T	0.768	0.89
358_V	365_L	0.767	0.89
399_N	585_T	0.763	0.88
291_D	294_E	0.763	0.88
201_S	209_D	0.762	0.88
381_D	384_S	0.761	0.88
348_A	352_E	0.760	0.88
131_H	135_E	0.760	0.88
530_A	533_T	0.759	0.88
472_E	507_E	0.756	0.88
295_D	302_V	0.755	0.88
400_F	403_S	0.754	0.88
403_S	580_D	0.753	0.88
213_E	217_P	0.753	0.88
536_A	603_A	0.753	0.88
107_Q	111_E	0.752	0.88
204_D	208_M	0.751	0.88
457_E	461_D	0.751	0.88
352_E	356_G	0.749	0.87
158_G	165_V	0.748	0.87
93_A	102_V	0.745	0.87
421_A	432_S	0.745	0.87
368_T	371_R	0.742	0.87
340_V	344_L	0.742	0.87
466_V	523_I	0.741	0.87
366_A	369_I	0.741	0.87
309_L	312_T	0.741	0.87
360_G	363_Q	0.741	0.87
428_G	558_L	0.740	0.87
619_T	623_Q	0.739	0.87
382_T	386_Q	0.736	0.87
161_E	164_N	0.731	0.86
269_R	272_A	0.729	0.86
207_G	210_H	0.729	0.86
481_A	485_N	0.728	0.86
201_S	205_A	0.726	0.86
303_E	340_V	0.724	0.86
408_A	576_A	0.723	0.86
437_Q	440_N	0.721	0.85
133_V	141_V	0.721	0.85
386_Q	400_F	0.721	0.85
579_N	589_V	0.719	0.85
415_A	418_A	0.719	0.85
156_D	164_N	0.718	0.85
205_A	210_H	0.718	0.85
429_L	559_E	0.717	0.85
196_E	199_G	0.716	0.85
395_N	398_E	0.716	0.85
421_A	540_S	0.716	0.85
175_G	178_V	0.715	0.85
496_S	582_Q	0.715	0.85
264_T	269_R	0.715	0.85
406_E	576_A	0.714	0.85
496_S	511_E	0.713	0.85
453_V	537_V	0.711	0.85
517_E	521_G	0.711	0.85
428_G	547_A	0.711	0.85
426_E	430_E	0.708	0.84
540_S	547_A	0.707	0.84
187_V	191_N	0.706	0.84
107_Q	123_E	0.705	0.84
108_Q	111_E	0.705	0.84
432_S	435_A	0.704	0.84
125_Q	129_G	0.703	0.84
176_M	179_F	0.703	0.84
597_Q	601_E	0.702	0.84
315_A	350_Q	0.702	0.84
155_S	158_G	0.702	0.84
422_Q	569_A	0.702	0.84
177_P	182_D	0.699	0.84
112_G	115_D	0.699	0.84
417_A	435_A	0.699	0.84
348_A	351_F	0.699	0.84
106_F	119_V	0.698	0.84
160_E	163_L	0.698	0.84
167_D	175_G	0.698	0.84
420_Q	424_A	0.697	0.83
109_L	112_G	0.695	0.83
456_L	526_V	0.692	0.83
513_R	517_E	0.692	0.83
176_M	180_M	0.691	0.83
392_S	588_D	0.690	0.83
421_A	568_A	0.690	0.83
129_G	132_A	0.689	0.83
574_E	585_T	0.689	0.83
103_D	107_Q	0.688	0.83
201_S	206_M	0.687	0.83
590_I	594_E	0.687	0.83
216_Y	220_R	0.687	0.83
626_E	630_K	0.685	0.82
228_K	233_P	0.684	0.82
213_E	220_R	0.683	0.82
281_E	285_V	0.683	0.82
359_D	363_Q	0.683	0.82
96_T	103_D	0.683	0.82
402_A	406_E	0.680	0.82
385_S	389_M	0.680	0.82
516_T	522_S	0.679	0.82
97_P	116_G	0.677	0.82
379_I	515_H	0.677	0.82
177_P	180_M	0.675	0.81
435_A	442_V	0.674	0.81
254_D	258_M	0.674	0.81
546_R	549_D	0.672	0.81
479_L	490_R	0.672	0.81
322_S	348_A	0.671	0.81
421_A	565_V	0.671	0.81
449_L	540_S	0.670	0.81
313_I	337_L	0.669	0.81
187_V	201_S	0.669	0.81
120_D	123_E	0.668	0.81
182_D	186_S	0.666	0.81
96_T	105_V	0.663	0.80
401_S	586_V	0.660	0.80
487_E	490_R	0.658	0.80
105_V	113_G	0.657	0.80
163_L	174_I	0.655	0.80
479_L	487_E	0.654	0.79
101_V	104_A	0.653	0.79
456_L	466_V	0.648	0.79
393_A	628_V	0.648	0.79
160_E	167_D	0.648	0.79
341_V	347_M	0.648	0.79
320_Q	632_T	0.647	0.79
454_S	538_E	0.647	0.79
336_Q	341_V	0.647	0.79
409_A	413_Q	0.644	0.78
485_N	511_E	0.642	0.78
506_K	582_Q	0.641	0.78
585_T	588_D	0.640	0.78
385_S	388_E	0.640	0.78
157_G	170_L	0.638	0.78
305_L	335_E	0.636	0.78
469_V	485_N	0.635	0.77
92_D	101_V	0.634	0.77
336_Q	487_E	0.633	0.77
407_V	439_T	0.632	0.77
485_N	582_Q	0.632	0.77
420_Q	423_D	0.631	0.77
265_D	277_D	0.631	0.77
561_I	613_A	0.630	0.77
470_I	519_I	0.629	0.77
104_A	107_Q	0.628	0.77
432_S	603_A	0.627	0.77
434_G	437_Q	0.626	0.76
393_A	592_T	0.625	0.76
373_T	611_V	0.625	0.76
106_F	137_A	0.624	0.76
495_G	500_V	0.623	0.76
397_M	589_V	0.621	0.76
506_K	511_E	0.621	0.76
184_T	189_A	0.620	0.76
96_T	99_D	0.620	0.76
128_T	132_A	0.620	0.76
399_N	403_S	0.620	0.76
379_I	607_S	0.619	0.76
459_R	467_V	0.616	0.75
105_V	112_G	0.615	0.75
123_E	137_A	0.614	0.75
431_A	561_I	0.613	0.75
457_E	531_N	0.613	0.75
298_R	463_I	0.613	0.75
261_Q	264_T	0.613	0.75
252_Y	258_M	0.613	0.75
536_A	540_S	0.611	0.75
471_A	475_D	0.609	0.74
476_Q	515_H	0.609	0.74
285_V	289_I	0.608	0.74
431_A	557_A	0.607	0.74
394_A	397_M	0.607	0.74
434_G	553_D	0.607	0.74
92_D	99_D	0.607	0.74
397_M	404_M	0.606	0.74
531_N	535_L	0.606	0.74
130_M	137_A	0.606	0.74
558_L	576_A	0.603	0.74
225_L	233_P	0.602	0.74
419_E	573_T	0.602	0.74
322_S	352_E	0.600	0.73
408_A	577_R	0.600	0.73
414_V	568_A	0.599	0.73
372_A	606_A	0.599	0.73
151_A	154_S	0.598	0.73
203_A	206_M	0.596	0.73
581_E	584_S	0.596	0.73
418_A	565_V	0.596	0.73
494_A	505_V	0.595	0.73
196_E	201_S	0.595	0.73
460_M	547_A	0.595	0.73
503_D	512_T	0.594	0.73
462_E	525_D	0.593	0.72
418_A	568_A	0.591	0.72
183_A	189_A	0.591	0.72
133_V	140_G	0.591	0.72
511_E	582_Q	0.590	0.72
106_F	116_G	0.590	0.72
98_A	112_G	0.589	0.72
481_A	490_R	0.588	0.72
98_A	116_G	0.587	0.72
194_I	200_C	0.587	0.72
169_A	174_I	0.586	0.72
608_D	612_S	0.585	0.71
409_A	412_D	0.585	0.71
262_G	269_R	0.585	0.71
418_A	459_R	0.584	0.71
427_S	553_D	0.584	0.71
152_D	161_E	0.583	0.71
582_Q	589_V	0.583	0.71
439_T	466_V	0.583	0.71
186_S	190_W	0.582	0.71
213_E	216_Y	0.581	0.71
451_E	549_D	0.581	0.71
360_G	381_D	0.581	0.71
265_D	268_I	0.581	0.71
405_Q	409_A	0.580	0.71
227_D	230_I	0.579	0.71
286_A	290_E	0.578	0.71
565_V	572_I	0.578	0.71
105_V	116_G	0.578	0.71
533_T	540_S	0.577	0.70
447_D	451_E	0.577	0.70
303_E	310_S	0.577	0.70
127_K	137_A	0.577	0.70
621_V	624_L	0.577	0.70
404_M	411_S	0.576	0.70
134_V	137_A	0.576	0.70
256_S	260_D	0.574	0.70
136_D	140_G	0.573	0.70
393_A	435_A	0.573	0.70
123_E	133_V	0.572	0.70
421_A	515_H	0.570	0.70
447_D	541_H	0.570	0.70
432_S	544_I	0.569	0.69
225_L	230_I	0.567	0.69
356_G	360_G	0.567	0.69
400_F	414_V	0.566	0.69
398_E	401_S	0.566	0.69
141_V	148_A	0.566	0.69
389_M	396_E	0.565	0.69
189_A	200_C	0.565	0.69
445_I	536_A	0.564	0.69
392_S	585_T	0.563	0.69
557_A	561_I	0.560	0.68
255_T	260_D	0.560	0.68
354_L	362_T	0.559	0.68
556_T	560_E	0.558	0.68
316_L	350_Q	0.557	0.68
190_W	195_E	0.557	0.68
417_A	421_A	0.557	0.68
134_V	140_G	0.556	0.68
149_G	153_D	0.555	0.67
418_A	425_A	0.554	0.67
419_E	423_D	0.554	0.67
403_S	410_S	0.552	0.67
102_V	109_L	0.551	0.67
372_A	376_A	0.550	0.67
460_M	474_A	0.550	0.67
450_M	534_V	0.548	0.67
205_A	209_D	0.548	0.67
272_A	275_I	0.548	0.67
294_E	299_A	0.548	0.67
462_E	465_D	0.547	0.66
434_G	550_E	0.547	0.66
150_P	153_D	0.547	0.66
156_D	165_V	0.546	0.66
257_V	264_T	0.545	0.66
194_I	197_L	0.545	0.66
518_R	521_G	0.545	0.66
270_F	273_S	0.544	0.66
523_I	547_A	0.544	0.66
545_H	549_D	0.543	0.66
323_K	327_F	0.543	0.66
512_T	522_S	0.541	0.66
176_M	183_A	0.538	0.65
189_A	194_I	0.537	0.65
255_T	261_Q	0.536	0.65
396_E	400_F	0.536	0.65
572_I	592_T	0.536	0.65
186_S	198_T	0.535	0.65
255_T	262_G	0.534	0.65
202_K	207_G	0.533	0.64
418_A	572_I	0.533	0.64
389_M	392_S	0.532	0.64
565_V	569_A	0.531	0.64
431_A	550_E	0.531	0.64
576_A	580_D	0.531	0.64
365_L	407_V	0.530	0.64
442_V	578_A	0.529	0.64
463_I	538_E	0.529	0.64
432_S	562_A	0.528	0.64
92_D	105_V	0.528	0.64
337_L	343_A	0.527	0.64
380_A	608_D	0.526	0.63
159_T	163_L	0.523	0.63
336_Q	479_L	0.523	0.63
551_I	568_A	0.523	0.63
371_R	618_S	0.522	0.63
394_A	403_S	0.522	0.63
463_I	527_Q	0.522	0.63
523_I	527_Q	0.522	0.63
392_S	592_T	0.522	0.63
249_A	256_S	0.521	0.63
284_A	287_E	0.521	0.63
133_V	144_Y	0.520	0.63
464_E	516_T	0.520	0.63
204_D	210_H	0.520	0.63
313_I	351_F	0.519	0.62
257_V	266_R	0.519	0.62
345_N	352_E	0.518	0.62
383_V	603_A	0.518	0.62
440_N	444_D	0.518	0.62
175_G	180_M	0.517	0.62
114_V	118_A	0.517	0.62
574_E	580_D	0.517	0.62
379_I	513_R	0.516	0.62
398_E	585_T	0.516	0.62
313_I	348_A	0.516	0.62
265_D	275_I	0.515	0.62
117_A	120_D	0.514	0.62
148_A	153_D	0.513	0.61
125_Q	133_V	0.513	0.61
433_E	437_Q	0.512	0.61
401_S	407_V	0.512	0.61
98_A	110_R	0.512	0.61
249_A	254_D	0.511	0.61
327_F	341_V	0.510	0.61
249_A	258_M	0.510	0.61
92_D	109_L	0.509	0.61
372_A	607_S	0.508	0.61
379_I	383_V	0.507	0.61
279_D	283_L	0.506	0.60
346_G	350_Q	0.506	0.60
128_T	134_V	0.506	0.60
316_L	351_F	0.505	0.60
475_D	489_A	0.505	0.60
167_D	172_D	0.503	0.60
485_N	512_T	0.503	0.60
375_D	610_I	0.502	0.60
370_E	373_T	0.500	0.60

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zx6A	2	0.478	100	0.434	Contact Map
1qu7A	2	0.3569	100	0.551	Contact Map
2ch7A	2	0.4638	100	0.561	Contact Map
3g67A	2	0.3286	100	0.629	Contact Map
4i3mA	2	0.2311	99.9	0.769	Contact Map
4cq4A	4	0.1352	99.4	0.871	Contact Map
2f95B	2	0.0818	99.3	0.876	Contact Map
4gycB	2	0.0943	99.1	0.887	Contact Map
3zccA	2	0.1667	99	0.892	Contact Map
4i5sA	2	0.4623	98.5	0.909	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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