GREMLIN Database
Q9HQX3 - Phycocyanin alpha phycocyanobilin lyase-like
UniProt: Q9HQX3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 353 (274)
Sequences: 5788 (4616)
Seq/√Len: 278.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
238_R268_E5.1141.00
152_R177_D3.5921.00
52_S57_L3.3601.00
177_D182_V3.1211.00
152_R156_V2.5541.00
49_N61_A2.4621.00
325_R329_L2.3731.00
325_R328_R2.3471.00
76_P79_K2.3411.00
276_F280_G2.2951.00
251_D254_T2.2641.00
309_M316_K2.2051.00
242_T280_G2.1681.00
246_G249_A2.1581.00
307_V310_A2.1311.00
156_V186_A2.1111.00
276_F279_T2.0951.00
324_Q327_E2.0881.00
154_T157_S2.0871.00
156_V160_G2.0731.00
146_D151_M2.0231.00
62_A66_G1.9671.00
239_R243_W1.9581.00
115_G120_V1.9491.00
311_A315_G1.9281.00
143_V155_A1.8821.00
125_A129_G1.8711.00
121_R146_D1.8531.00
90_R115_G1.8411.00
224_S228_I1.8201.00
60_A64_V1.8181.00
171_L189_S1.8181.00
163_E166_E1.8151.00
315_G318_G1.8141.00
269_D273_I1.7861.00
187_V191_I1.7751.00
83_T89_V1.7501.00
240_N243_W1.7251.00
246_G283_E1.6671.00
243_W276_F1.6631.00
278_A313_A1.6321.00
246_G280_G1.6321.00
318_G321_R1.6291.00
304_E308_A1.6261.00
58_R83_T1.6191.00
288_S291_T1.5971.00
312_F316_K1.5941.00
262_L280_G1.5911.00
185_A189_S1.5671.00
313_A316_K1.5431.00
95_R99_R1.5331.00
149_E153_R1.5301.00
91_A98_G1.5151.00
112_C124_A1.4881.00
309_M312_F1.4791.00
91_A95_R1.4691.00
35_D39_T1.4651.00
48_E52_S1.4481.00
79_K82_Q1.4451.00
264_E267_G1.4421.00
316_K319_G1.4341.00
232_G237_Q1.4341.00
89_V92_R1.4071.00
224_S227_E1.3921.00
324_Q329_L1.3921.00
312_F317_V1.3731.00
184_R187_V1.3721.00
296_V299_T1.3681.00
225_L244_M1.3421.00
108_I112_C1.3331.00
326_L329_L1.3301.00
53_E58_R1.3301.00
109_L127_S1.3191.00
54_T57_L1.3161.00
251_D255_K1.3161.00
296_V306_A1.3151.00
69_G72_D1.3131.00
94_A98_G1.3091.00
136_A140_L1.3001.00
126_E130_R1.2881.00
188_F191_I1.2871.00
192_E195_S1.2841.00
154_T161_R1.2801.00
154_T158_S1.2761.00
151_M154_T1.2691.00
324_Q328_R1.2621.00
87_V90_R1.2611.00
36_S39_T1.2601.00
40_W44_E1.2521.00
304_E307_V1.2511.00
49_N52_S1.2501.00
73_T77_L1.2401.00
307_V311_A1.2251.00
169_D174_R1.2231.00
157_S161_R1.2221.00
55_P60_A1.2221.00
35_D38_A1.2141.00
50_L65_L1.2081.00
66_G96_A1.2051.00
51_E76_P1.2001.00
182_V185_A1.1931.00
286_G289_V1.1851.00
265_L268_E1.1771.00
308_A316_K1.1741.00
308_A315_G1.1741.00
73_T80_Q1.1731.00
181_L185_A1.1671.00
250_G254_T1.1631.00
37_G41_A1.1561.00
188_F192_E1.1511.00
228_I237_Q1.1461.00
41_A45_A1.1361.00
251_D256_M1.1331.00
174_R177_D1.1241.00
268_E273_I1.1221.00
277_A280_G1.1181.00
181_L184_R1.1101.00
42_Q45_A1.1041.00
291_T294_L1.0991.00
274_A282_A1.0921.00
94_A112_C1.0911.00
92_R96_A1.0841.00
139_G143_V1.0831.00
275_Q279_T1.0811.00
170_A174_R1.0771.00
136_A139_G1.0751.00
293_L313_A1.0701.00
90_R95_R1.0661.00
268_E277_A1.0661.00
58_R62_A1.0651.00
77_L81_L1.0611.00
163_E167_P1.0561.00
48_E51_E1.0561.00
300_Q306_A1.0541.00
59_M62_A1.0521.00
242_T277_A1.0441.00
77_L80_Q1.0431.00
120_V123_E1.0401.00
142_S145_E1.0371.00
140_L155_A1.0351.00
44_E49_N1.0351.00
75_R78_A1.0281.00
299_T306_A1.0161.00
183_R187_V1.0131.00
136_A145_E1.0121.00
170_A177_D1.0081.00
92_R95_R1.0041.00
296_V310_A1.0041.00
49_N57_L1.0031.00
316_K320_D0.9951.00
95_R98_G0.9921.00
311_A314_L0.9901.00
63_N68_L0.9901.00
235_L273_I0.9881.00
242_T246_G0.9881.00
115_G124_A0.9841.00
80_Q83_T0.9791.00
46_F64_V0.9791.00
135_Q139_G0.9661.00
158_S161_R0.9641.00
37_G40_W0.9621.00
238_R265_L0.9491.00
259_I262_L0.9471.00
315_G321_R0.9471.00
78_A105_V0.9461.00
183_R186_A0.9301.00
279_T282_A0.9291.00
192_E196_N0.9281.00
74_A77_L0.9251.00
312_F318_G0.9231.00
40_W43_A0.9221.00
189_S193_I0.9191.00
111_D114_H0.9141.00
41_A48_E0.9081.00
307_V318_G0.9061.00
190_L194_L0.9011.00
154_T160_G0.9011.00
40_W48_E0.8971.00
223_K226_I0.8921.00
90_R101_E0.8921.00
243_W246_G0.8861.00
170_A173_E0.8851.00
36_S40_W0.8851.00
170_A175_L0.8841.00
317_V322_S0.8811.00
148_S151_M0.8791.00
152_R157_S0.8781.00
73_T78_A0.8771.00
238_R242_T0.8751.00
59_M63_N0.8731.00
242_T250_G0.8721.00
153_R157_S0.8701.00
285_G297_V0.8691.00
64_V67_L0.8691.00
139_G142_S0.8681.00
77_L96_A0.8681.00
122_R131_L0.8671.00
153_R156_V0.8631.00
145_E148_S0.8591.00
285_G289_V0.8541.00
146_D155_A0.8521.00
113_L125_A0.8521.00
124_A128_L0.8521.00
308_A312_F0.8511.00
253_R256_M0.8481.00
49_N64_V0.8451.00
35_D44_E0.8421.00
134_E142_S0.8411.00
224_S229_I0.8401.00
121_R125_A0.8391.00
87_V95_R0.8381.00
121_R124_A0.8371.00
123_E126_E0.8351.00
63_N66_G0.8321.00
56_E60_A0.8321.00
273_I277_A0.8291.00
35_D42_Q0.8281.00
164_T167_P0.8271.00
239_R270_D0.8261.00
306_A309_M0.8261.00
36_S42_Q0.8261.00
274_A277_A0.8241.00
149_E179_S0.8190.99
270_D273_I0.8180.99
243_W247_R0.8130.99
60_A67_L0.8130.99
129_G132_T0.8120.99
262_L293_L0.8110.99
129_G157_S0.8110.99
57_L61_A0.8080.99
240_N248_V0.7990.99
239_R242_T0.7970.99
306_A311_A0.7960.99
38_A45_A0.7960.99
257_D260_E0.7920.99
112_C115_G0.7870.99
118_L122_R0.7850.99
278_A282_A0.7800.99
233_T237_Q0.7790.99
191_I194_L0.7780.99
246_G279_T0.7760.99
186_A190_L0.7740.99
261_A264_E0.7720.99
274_A299_T0.7690.99
222_I245_L0.7680.99
138_D142_S0.7650.99
99_R102_Q0.7640.99
111_D116_E0.7620.99
97_L101_E0.7600.99
254_T257_D0.7590.99
102_Q130_R0.7580.99
42_Q64_V0.7580.99
153_R179_S0.7570.99
61_A64_V0.7520.99
120_V126_E0.7500.99
160_G188_F0.7480.99
287_A298_E0.7440.99
275_Q282_A0.7440.99
309_M318_G0.7420.99
91_A97_L0.7410.99
96_A101_E0.7400.99
316_K322_S0.7390.99
38_A42_Q0.7380.99
292_S295_E0.7370.99
147_D151_M0.7360.99
140_L151_M0.7350.99
53_E57_L0.7310.99
86_H90_R0.7300.99
235_L240_N0.7190.99
83_T105_V0.7190.99
315_G320_D0.7130.99
274_A280_G0.7120.99
49_N62_A0.7110.99
270_D280_G0.7090.99
98_G101_E0.7030.98
174_R186_A0.6990.98
240_N283_E0.6980.98
46_F65_L0.6980.98
88_G94_A0.6970.98
269_D274_A0.6950.98
108_I111_D0.6950.98
52_S65_L0.6940.98
252_Q280_G0.6940.98
300_Q311_A0.6920.98
286_G293_L0.6910.98
51_E60_A0.6910.98
232_G238_R0.6900.98
285_G296_V0.6890.98
98_G127_S0.6870.98
229_I241_A0.6860.98
271_D278_A0.6860.98
294_L320_D0.6850.98
266_L278_A0.6810.98
299_T310_A0.6780.98
36_S41_A0.6760.98
64_V68_L0.6760.98
230_D261_A0.6740.98
285_G291_T0.6710.98
38_A41_A0.6700.98
74_A78_A0.6690.98
247_R283_E0.6670.98
312_F315_G0.6650.98
244_M247_R0.6620.98
188_F196_N0.6550.98
257_D261_A0.6510.97
163_E172_V0.6510.97
225_L228_I0.6500.97
76_P80_Q0.6490.97
308_A314_L0.6490.97
62_A96_A0.6480.97
125_A155_A0.6470.97
135_Q138_D0.6470.97
260_E263_R0.6460.97
271_D275_Q0.6450.97
242_T249_A0.6440.97
222_I226_I0.6430.97
151_M155_A0.6420.97
311_A318_G0.6420.97
118_L121_R0.6390.97
240_N249_A0.6370.97
58_R68_L0.6370.97
109_L124_A0.6340.97
129_G158_S0.6330.97
239_R246_G0.6300.97
89_V101_E0.6290.97
50_L62_A0.6270.97
51_E79_K0.6260.97
94_A127_S0.6220.97
134_E138_D0.6210.97
235_L270_D0.6200.97
305_D312_F0.6170.96
41_A44_E0.6160.96
55_P64_V0.6160.96
275_Q305_D0.6150.96
193_I199_P0.6140.96
267_G295_E0.6120.96
288_S292_S0.6120.96
258_A268_E0.6120.96
234_Q237_Q0.6110.96
39_T44_E0.6100.96
39_T48_E0.6100.96
55_P59_M0.6090.96
222_I228_I0.6050.96
236_H239_R0.6040.96
266_L284_I0.6010.96
177_D183_R0.5980.96
280_G283_E0.5970.96
189_S192_E0.5930.96
239_R272_L0.5930.96
259_I277_A0.5930.96
309_M314_L0.5930.96
246_G258_A0.5910.95
45_A54_T0.5900.95
230_D264_E0.5880.95
62_A65_L0.5870.95
224_S237_Q0.5870.95
60_A66_G0.5850.95
187_V197_V0.5850.95
287_A300_Q0.5830.95
52_S58_R0.5830.95
45_A49_N0.5810.95
43_A49_N0.5800.95
310_A313_A0.5800.95
228_I232_G0.5770.95
59_M64_V0.5770.95
319_G322_S0.5760.95
308_A311_A0.5750.95
51_E82_Q0.5740.95
45_A48_E0.5690.94
247_R282_A0.5660.94
219_P223_K0.5650.94
270_D278_A0.5640.94
265_L273_I0.5640.94
157_S160_G0.5570.94
94_A123_E0.5540.94
139_G144_V0.5540.94
140_L144_V0.5480.93
141_L145_E0.5440.93
157_S185_A0.5410.93
148_S158_S0.5400.93
170_A190_L0.5390.93
289_V293_L0.5370.93
236_H249_A0.5360.93
224_S263_R0.5360.93
309_M315_G0.5340.92
51_E57_L0.5320.92
42_Q51_E0.5310.92
297_V310_A0.5300.92
152_R160_G0.5290.92
88_G118_L0.5280.92
65_L73_T0.5280.92
38_A43_A0.5230.92
152_R183_R0.5230.92
275_Q309_M0.5210.91
85_E90_R0.5200.91
273_I283_E0.5180.91
265_L270_D0.5170.91
188_F195_S0.5170.91
117_P122_R0.5170.91
37_G52_S0.5130.91
187_V244_M0.5120.91
94_A99_R0.5100.91
240_N246_G0.5100.91
51_E55_P0.5070.90
45_A51_E0.5060.90
57_L62_A0.5030.90
274_A306_A0.5030.90
134_E143_V0.5020.90
309_M322_S0.5020.90
240_N244_M0.5000.90
293_L310_A0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wa5B 1 0.9178 100 0.437 Contact Map
1b3uA 1 0.915 100 0.443 Contact Map
3tpoA 1 0.881 99.9 0.45 Contact Map
4b8jA 1 0.8612 99.9 0.484 Contact Map
2vglB 1 0.9547 99.9 0.491 Contact Map
3nowA 3 0.9603 99.9 0.497 Contact Map
4d4zA 1 0.8017 99.9 0.497 Contact Map
4uafB 1 0.8499 99.9 0.5 Contact Map
4rv1A 1 0.8414 99.9 0.5 Contact Map
1u6gC 1 0.8272 99.9 0.502 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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