GREMLIN Database
Q9HQX2 - Uncharacterized protein
UniProt: Q9HQX2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (273)
Sequences: 117 (95)
Seq/√Len: 5.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
275_M279_G3.1730.80
43_V127_D2.8560.72
58_V196_D2.7890.71
187_T191_T2.7250.69
130_F234_G2.6810.67
142_L193_F2.5700.64
193_F265_E2.4960.61
133_A167_L2.4450.60
171_G250_E2.4150.59
130_F270_R2.3900.58
38_S156_L2.3670.57
231_L236_S2.3340.56
182_T191_T2.3240.56
103_L107_L2.2890.54
30_W124_V2.2390.53
191_T283_A2.2150.52
122_G232_Y2.1950.51
267_V270_R2.1770.51
232_Y275_M2.1740.50
60_G205_S2.1100.48
42_I232_Y2.0150.45
9_A43_V2.0140.45
196_D208_T2.0090.45
177_L204_E2.0030.45
234_G270_R2.0020.45
40_K111_T1.9910.44
253_S257_R1.9690.43
104_Y263_V1.9030.41
9_A137_V1.8560.40
42_I80_I1.8110.38
91_S262_D1.7870.37
24_R172_D1.7760.37
219_E262_D1.7720.37
113_L135_I1.7550.36
115_V171_G1.7550.36
113_L224_E1.7340.36
10_D34_R1.7300.35
30_W270_R1.7050.35
73_K156_L1.6970.34
48_E142_L1.6790.34
169_V245_G1.6640.33
245_G262_D1.6480.33
60_G276_K1.6310.32
30_W130_F1.6120.32
82_M127_D1.6100.32
80_I154_V1.6070.32
46_G188_S1.5930.31
108_L125_V1.5780.31
169_V193_F1.5720.31
257_R265_E1.5680.30
122_G279_G1.5660.30
176_V233_S1.5510.30
80_I254_I1.5510.30
99_F125_V1.5330.29
90_V96_T1.5290.29
15_F33_G1.5220.29
234_G245_G1.5170.29
207_L233_S1.5010.29
173_T198_H1.4640.28
230_A280_R1.4580.27
33_G156_L1.4510.27
264_L276_K1.4330.27
38_S139_E1.4310.27
41_R284_S1.4270.26
206_L263_V1.4220.26
35_I39_N1.4210.26
123_G279_G1.4170.26
230_A234_G1.4150.26
121_E187_T1.3960.26
128_E227_V1.3880.25
76_N161_S1.3840.25
99_F224_E1.3810.25
88_M146_M1.3790.25
193_F273_V1.3770.25
87_V260_E1.3720.25
27_D51_R1.3690.25
91_S232_Y1.3680.25
30_W234_G1.3610.25
8_I14_K1.3600.25
10_D45_A1.3590.25
35_I73_K1.3560.25
58_V144_V1.3440.24
38_S226_R1.3360.24
84_N247_D1.3350.24
202_I274_T1.3340.24
84_N207_L1.3330.24
125_V189_V1.3260.24
229_M267_V1.3210.24
30_W267_V1.3140.24
5_E34_R1.3130.24
43_V58_V1.3070.23
97_E162_A1.2970.23
232_Y279_G1.2970.23
8_I142_L1.2960.23
123_G275_M1.2930.23
25_M137_V1.2890.23
53_L177_L1.2830.23
35_I152_V1.2700.22
199_T208_T1.2620.22
226_R233_S1.2570.22
109_D172_D1.2490.22
125_V138_D1.2480.22
144_V191_T1.2440.22
8_I194_A1.2410.22
58_V176_V1.2410.22
122_G275_M1.2360.22
38_S105_G1.2340.22
137_V163_E1.2160.21
172_D194_A1.2150.21
142_L189_V1.2120.21
50_K99_F1.2110.21
123_G232_Y1.2100.21
84_N233_S1.2070.21
173_T193_F1.1930.21
170_N174_K1.1800.20
136_K145_A1.1800.20
30_W229_M1.1780.20
43_V181_H1.1740.20
90_V159_V1.1720.20
84_N186_D1.1710.20
188_S287_I1.1700.20
60_G206_L1.1630.20
42_I184_N1.1630.20
5_E10_D1.1370.19
193_F262_D1.1370.19
162_A249_D1.1270.19
114_Q246_M1.1240.19
219_E261_V1.1190.19
103_L154_V1.1020.19
93_G97_E1.1020.19
147_S171_G1.0990.19
8_I188_S1.0920.18
89_L136_K1.0740.18
180_E243_F1.0660.18
114_Q132_R1.0570.18
33_G52_N1.0560.18
42_I121_E1.0560.18
51_R169_V1.0520.18
159_V210_E1.0370.17
175_P232_Y1.0340.17
32_K227_V1.0330.17
37_L108_L1.0270.17
138_D242_D1.0210.17
99_F228_L1.0190.17
203_L239_E1.0150.17
270_R273_V1.0120.17
33_G88_M1.0050.17
252_E256_E1.0020.17
58_V88_M0.9980.17
8_I245_G0.9910.16
114_Q203_L0.9890.16
128_E186_D0.9890.16
218_V251_V0.9880.16
58_V193_F0.9880.16
28_A115_V0.9870.16
41_R181_H0.9790.16
142_L226_R0.9770.16
168_E177_L0.9760.16
196_D199_T0.9750.16
218_V247_D0.9710.16
119_A122_G0.9700.16
43_V140_S0.9700.16
42_I187_T0.9700.16
190_Q287_I0.9700.16
47_S127_D0.9690.16
41_R54_P0.9680.16
276_K288_N0.9650.16
198_H258_L0.9640.16
137_V219_E0.9630.16
195_T236_S0.9620.16
104_Y135_I0.9600.16
234_G237_S0.9600.16
34_R118_P0.9550.16
261_V287_I0.9510.16
63_G121_E0.9510.16
198_H232_Y0.9490.16
6_Y266_E0.9390.15
87_V191_T0.9360.15
104_Y206_L0.9320.15
75_G163_E0.9310.15
8_I61_L0.9300.15
53_L167_L0.9250.15
64_R125_V0.9210.15
42_I129_Q0.9200.15
162_A215_Q0.9180.15
70_T156_L0.9120.15
60_G191_T0.9010.15
87_V187_T0.8950.15
216_G264_L0.8880.15
237_S273_V0.8830.14
257_R264_L0.8830.14
142_L221_S0.8800.14
36_L101_S0.8710.14
133_A243_F0.8690.14
138_D171_G0.8690.14
6_Y156_L0.8630.14
207_L227_V0.8630.14
199_T240_I0.8580.14
174_K224_E0.8540.14
239_E264_L0.8490.14
78_V263_V0.8480.14
168_E257_R0.8480.14
34_R45_A0.8470.14
44_L181_H0.8440.14
6_Y173_T0.8420.14
9_A85_E0.8410.14
8_I200_A0.8380.14
216_G254_I0.8370.14
226_R255_F0.8370.14
194_A222_E0.8230.13
33_G226_R0.8220.13
70_T159_V0.8220.13
59_Q221_S0.8170.13
166_S171_G0.8150.13
231_L248_V0.8150.13
61_L162_A0.8060.13
233_S279_G0.8050.13
220_L244_L0.8040.13
70_T142_L0.7980.13
48_E76_N0.7980.13
90_V133_A0.7980.13
252_E273_V0.7960.13
140_S180_E0.7950.13
84_N229_M0.7950.13
108_L189_V0.7910.13
165_A274_T0.7910.13
6_Y154_V0.7880.13
108_L247_D0.7880.13
37_L241_P0.7800.13
116_K284_S0.7790.13
180_E206_L0.7760.13
82_M218_V0.7750.13
220_L234_G0.7740.13
238_F251_V0.7740.13
167_L233_S0.7730.13
144_V190_Q0.7720.13
54_P265_E0.7710.13
109_D282_I0.7690.13
267_V286_A0.7690.13
33_G38_S0.7690.13
236_S280_R0.7640.13
152_V233_S0.7620.13
36_L44_L0.7610.12
5_E15_F0.7570.12
98_T162_A0.7540.12
115_V223_T0.7540.12
38_S160_G0.7500.12
168_E174_K0.7490.12
37_L230_A0.7480.12
10_D50_K0.7480.12
146_M173_T0.7470.12
28_A218_V0.7450.12
40_K262_D0.7450.12
161_S277_T0.7420.12
235_V283_A0.7410.12
11_G255_F0.7390.12
109_D287_I0.7350.12
158_D263_V0.7310.12
109_D182_T0.7300.12
89_L116_K0.7280.12
103_L264_L0.7230.12
33_G44_L0.7220.12
140_S264_L0.7210.12
31_S51_R0.7200.12
182_T251_V0.7190.12
156_L160_G0.7180.12
64_R74_V0.7180.12
254_I273_V0.7170.12
84_N273_V0.7150.12
133_A184_N0.7100.12
27_D84_N0.7100.12
28_A242_D0.7070.12
34_R117_H0.7040.12
231_L243_F0.6970.12
167_L200_A0.6960.12
61_L256_E0.6960.12
110_Q205_S0.6890.11
6_Y255_F0.6870.11
160_G180_E0.6860.11
56_S107_L0.6820.11
11_G199_T0.6810.11
220_L270_R0.6780.11
33_G271_R0.6600.11
135_I228_L0.6600.11
37_L117_H0.6570.11
120_V130_F0.6560.11
17_Q180_E0.6540.11
165_A276_K0.6530.11
103_L135_I0.6530.11
205_S226_R0.6490.11
29_Q80_I0.6490.11
33_G138_D0.6470.11
8_I62_S0.6440.11
99_F230_A0.6430.11
167_L232_Y0.6380.11
229_M236_S0.6380.11
248_V252_E0.6320.11
147_S256_E0.6300.11
197_S216_G0.6280.11
142_L194_A0.6280.11
246_M267_V0.6260.11
163_E186_D0.6260.11
70_T248_V0.6250.11
150_S226_R0.6230.11
124_V255_F0.6180.10
57_E106_A0.6180.10
131_E232_Y0.6170.10
171_G277_T0.6170.10
30_W243_F0.6160.10
151_F191_T0.6150.10
9_A255_F0.6150.10
158_D181_H0.6140.10
222_E232_Y0.6110.10
58_V96_T0.6050.10
56_S228_L0.6030.10
140_S247_D0.6030.10
227_V234_G0.6020.10
109_D204_E0.6010.10
31_S92_L0.6010.10
179_V255_F0.6010.10
162_A196_D0.6000.10
239_E252_E0.5970.10
36_L175_P0.5970.10
179_V193_F0.5970.10
168_E247_D0.5970.10
80_I219_E0.5950.10
76_N247_D0.5930.10
137_V225_K0.5920.10
235_V238_F0.5920.10
59_Q219_E0.5910.10
35_I76_N0.5910.10
78_V118_P0.5910.10
127_D170_N0.5880.10
202_I248_V0.5880.10
202_I261_V0.5870.10
212_E274_T0.5870.10
172_D254_I0.5860.10
45_A228_L0.5860.10
121_E283_A0.5850.10
94_D141_E0.5850.10
135_I165_A0.5840.10
230_A245_G0.5840.10
49_G277_T0.5810.10
266_E281_N0.5740.10
5_E33_G0.5720.10
35_I91_S0.5700.10
92_L96_T0.5690.10
108_L241_P0.5680.10
232_Y288_N0.5670.10
180_E230_A0.5670.10
29_Q243_F0.5670.10
23_R75_G0.5660.10
64_R152_V0.5660.10
75_G219_E0.5620.10
41_R152_V0.5610.10
42_I221_S0.5600.10
5_E40_K0.5580.10
219_E225_K0.5570.10
55_L103_L0.5560.10
251_V280_R0.5530.10
132_R180_E0.5520.10
80_I93_G0.5490.10
135_I154_V0.5460.10
36_L39_N0.5440.10
160_G202_I0.5440.10
150_S222_E0.5430.10
121_E150_S0.5420.10
10_D41_R0.5420.10
245_G251_V0.5410.10
200_A226_R0.5400.10
77_Y155_E0.5400.10
10_D43_V0.5380.09
57_E207_L0.5380.09
170_N197_S0.5370.09
276_K279_G0.5340.09
172_D249_D0.5310.09
8_I288_N0.5290.09
112_E147_S0.5290.09
208_T211_A0.5280.09
194_A244_L0.5280.09
121_E227_V0.5260.09
89_L188_S0.5240.09
117_H194_A0.5230.09
162_A165_A0.5210.09
228_L275_M0.5190.09
91_S156_L0.5180.09
177_L201_S0.5180.09
167_L226_R0.5160.09
120_V194_A0.5150.09
149_G192_Y0.5150.09
8_I201_S0.5140.09
232_Y264_L0.5140.09
189_V244_L0.5130.09
166_S219_E0.5130.09
218_V263_V0.5120.09
116_K282_I0.5110.09
58_V166_S0.5110.09
31_S254_I0.5090.09
76_N88_M0.5090.09
106_A175_P0.5090.09
70_T250_E0.5080.09
104_Y140_S0.5070.09
63_G205_S0.5040.09
92_L206_L0.5030.09
28_A225_K0.5030.09
13_G244_L0.5020.09
252_E270_R0.5020.09
154_V203_L0.5020.09
140_S144_V0.5020.09
130_F237_S0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1p4xA 1 0.3483 97.9 0.911 Contact Map
2frhA 2 0.3621 97.8 0.912 Contact Map
3fm5A 4 0.3621 97.8 0.912 Contact Map
3bpvA 2 0.3345 97.8 0.913 Contact Map
4mnuA 2 0.3414 97.8 0.913 Contact Map
2fbhA 2 0.331 97.8 0.913 Contact Map
3u2rA 4 0.3448 97.7 0.913 Contact Map
1lj9A 2 0.3345 97.7 0.914 Contact Map
1jgsA 2 0.3517 97.7 0.914 Contact Map
2a61A 2 0.3379 97.7 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.