GREMLIN Database
Q9HQX1 - Uncharacterized protein
UniProt: Q9HQX1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 287 (271)
Sequences: 114 (90)
Seq/√Len: 5.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_I130_G3.2610.81
73_I252_L3.1370.78
270_L274_G2.9890.74
229_I234_P2.8780.71
100_V104_L2.7130.66
130_G162_R2.6730.65
166_G248_R2.6500.64
127_F265_D2.6190.63
127_F232_S2.5200.60
36_V124_D2.3200.54
172_L199_G2.3060.53
31_S151_L2.3030.53
33_R108_T2.2800.52
181_G185_T2.2030.50
177_M185_T2.1890.49
23_P121_R2.1860.49
35_I230_Y2.1860.49
139_L187_L2.1460.48
243_G260_E2.1400.47
230_Y270_L2.1250.47
187_L263_T2.0740.45
23_P265_D2.0580.45
7_A36_V2.0200.43
190_S194_K1.9890.42
119_G230_Y1.9610.41
6_I139_L1.9580.41
35_I73_I1.9460.41
17_T167_S1.9360.41
7_A134_L1.9260.40
23_P127_F1.9250.40
8_D27_R1.9010.40
13_F26_G1.8870.39
202_I231_S1.8870.39
164_V187_L1.8780.39
110_V132_L1.8720.39
185_T278_V1.8640.38
53_D200_R1.8360.37
20_H44_T1.8290.37
134_L223_I1.8210.37
26_G151_L1.8010.36
132_L142_T1.7970.36
34_R47_P1.7420.34
122_I183_I1.7340.34
35_I181_G1.7270.34
232_S265_D1.7270.34
139_L183_I1.7110.34
228_A232_S1.7040.33
119_G274_G1.6850.33
221_E224_E1.6680.32
37_L211_Q1.6530.32
36_V51_V1.6510.32
139_L194_K1.6410.31
112_A166_G1.5740.30
224_E231_S1.5680.29
18_A134_L1.5590.29
23_P232_S1.5090.28
119_G270_L1.4920.27
101_F261_L1.4730.27
125_Q225_A1.4680.27
168_N187_L1.4650.27
51_V171_L1.4550.26
194_K203_R1.4540.26
251_M255_D1.4530.26
52_F219_T1.4240.25
230_Y274_G1.4080.25
187_L268_I1.3740.24
72_T87_E1.3700.24
184_T282_I1.3660.24
228_A275_R1.3580.24
73_I216_V1.3580.24
161_D164_V1.3500.24
174_V218_L1.3410.23
120_G274_G1.3340.23
111_Y129_K1.3320.23
190_S203_R1.3280.23
26_G45_T1.3020.22
8_D38_A1.2940.22
110_V222_E1.2930.22
66_F151_L1.2920.22
142_T154_V1.2720.22
232_S243_G1.2720.22
85_V133_A1.2690.22
118_R181_G1.2640.22
167_S188_A1.2550.21
224_E253_L1.2520.21
255_D263_T1.2480.21
141_I185_T1.2440.21
94_D157_F1.2360.21
157_F247_S1.2290.21
170_Q230_Y1.2250.21
22_E73_I1.2240.21
31_S102_K1.2090.20
39_A182_P1.2080.20
161_D166_G1.2050.20
36_V137_G1.2050.20
40_D124_D1.1950.20
201_Y261_L1.1930.20
53_D201_Y1.1910.20
81_R255_D1.1880.20
130_G179_S1.1870.20
165_N169_K1.1860.20
6_I188_A1.1750.20
35_I118_R1.1670.19
164_V243_G1.1580.19
163_E172_L1.1550.19
237_S262_V1.1530.19
71_V81_R1.1510.19
220_S230_Y1.1430.19
53_D185_T1.1410.19
105_V122_I1.1310.19
75_Y124_D1.1290.19
106_H177_M1.1240.19
61_G65_R1.1210.18
6_I196_N1.1190.18
30_M105_V1.1180.18
6_I12_S1.1140.18
51_V187_L1.1080.18
30_M228_A1.0970.18
216_V249_V1.0890.18
53_D63_L1.0820.18
41_D139_L1.0770.18
171_L231_S1.0750.18
216_V245_D1.0750.18
155_S175_R1.0710.17
101_F132_L1.0690.17
31_S136_P1.0690.17
144_D279_S1.0680.17
21_V112_A1.0620.17
262_V271_T1.0620.17
100_V132_L1.0620.17
83_V185_T1.0570.17
36_V176_H1.0540.17
255_D262_V1.0470.17
6_I55_Q1.0430.17
65_R83_V1.0430.17
41_D51_V1.0400.17
106_H167_S1.0390.17
21_V240_A1.0380.17
28_V263_T1.0360.17
167_S252_L1.0330.17
9_F88_G1.0290.17
6_I243_G1.0260.17
105_V183_I1.0230.17
171_L234_P1.0200.16
122_I135_S1.0190.16
88_G253_L1.0170.16
6_I54_V1.0040.16
105_V245_D1.0020.16
187_L260_E1.0000.16
154_V205_Q0.9910.16
25_R94_D0.9880.16
69_D245_D0.9820.16
8_D43_K0.9800.16
68_E163_E0.9760.16
54_V198_L0.9670.16
218_L232_S0.9590.15
250_T254_N0.9560.15
96_F228_A0.9460.15
113_K279_S0.9430.15
184_T261_L0.9370.15
24_V252_L0.9350.15
51_V141_I0.9340.15
202_I216_V0.9340.15
226_L270_L0.9270.15
118_R225_A0.9270.15
112_A221_E0.9200.15
31_S224_E0.9100.15
23_P250_T0.9100.15
73_I149_I0.9090.15
215_D245_D0.9070.14
9_F86_I0.9000.14
218_L265_D0.8960.14
46_I100_V0.8960.14
193_R230_Y0.8940.14
4_S151_L0.8920.14
190_S201_Y0.8840.14
6_I283_E0.8840.14
17_T142_T0.8820.14
53_D271_T0.8800.14
51_V98_T0.8780.14
34_R176_H0.8750.14
120_G230_Y0.8740.14
249_V275_R0.8720.14
105_V239_A0.8680.14
186_E262_V0.8660.14
96_F226_L0.8650.14
96_F222_E0.8600.14
220_S248_R0.8590.14
41_D69_D0.8520.14
9_F82_H0.8450.13
164_V279_S0.8440.13
30_M239_A0.8430.13
33_R260_E0.8390.13
120_G270_L0.8380.13
139_L188_A0.8370.13
175_R241_V0.8350.13
147_T231_S0.8350.13
230_Y262_V0.8310.13
46_I162_R0.8310.13
183_I242_L0.8310.13
72_T224_E0.8270.13
84_A124_D0.8230.13
38_A226_L0.8190.13
201_Y214_A0.8180.13
112_A197_L0.8170.13
101_F201_Y0.8160.13
232_S235_N0.8160.13
100_V271_T0.8150.13
26_G266_D0.8140.13
70_T150_D0.8140.13
47_P263_T0.8130.13
228_A243_G0.8130.13
160_V271_T0.8120.13
26_G224_E0.8110.13
21_V223_I0.8080.13
116_A119_G0.8030.13
118_R278_V0.8010.13
51_V147_T0.7960.13
54_V254_N0.7950.13
227_V234_P0.7940.13
106_H199_G0.7930.13
24_V260_E0.7900.13
100_V197_L0.7860.13
34_R279_S0.7860.13
11_S242_L0.7860.13
142_T211_Q0.7850.13
25_R217_T0.7830.13
4_S168_N0.7810.12
63_L151_L0.7810.12
252_L257_I0.7800.12
160_V269_A0.7760.12
4_S264_D0.7740.12
9_F194_K0.7730.12
136_P187_L0.7730.12
29_V170_Q0.7710.12
29_V98_T0.7670.12
229_I246_A0.7650.12
134_L158_E0.7650.12
134_L231_S0.7650.12
51_V178_G0.7550.12
135_S240_A0.7530.12
149_I271_T0.7510.12
93_V231_S0.7490.12
48_L100_V0.7460.12
132_L270_L0.7380.12
141_I184_T0.7350.12
61_G97_V0.7350.12
23_P227_V0.7340.12
34_R225_A0.7340.12
163_E209_L0.7260.12
34_R85_V0.7240.12
128_E230_Y0.7230.12
157_F227_V0.7210.12
27_R38_A0.7210.12
156_H272_S0.7170.12
124_D152_S0.7160.12
22_E241_V0.7160.12
16_D68_E0.7160.12
237_S250_T0.7140.12
141_I162_R0.7140.12
7_A253_L0.7130.12
259_K282_I0.7130.12
231_S281_H0.7050.11
57_E233_G0.7050.11
236_A249_V0.7050.11
61_G261_L0.7040.11
227_V282_I0.7020.11
50_G202_I0.7010.11
163_E169_K0.7000.11
138_D148_T0.6990.11
85_V153_T0.6990.11
30_M114_H0.6990.11
54_V252_L0.6980.11
67_F261_L0.6980.11
130_G282_I0.6950.11
52_F175_R0.6930.11
182_P282_I0.6920.11
35_I85_V0.6910.11
169_K222_E0.6900.11
249_V262_V0.6900.11
29_V193_R0.6880.11
234_P275_R0.6830.11
115_P151_L0.6830.11
108_T158_E0.6830.11
27_R115_P0.6820.11
50_G103_A0.6810.11
17_T84_A0.6770.11
139_L160_V0.6760.11
230_Y260_E0.6740.11
112_A193_R0.6720.11
70_T250_T0.6670.11
35_I38_A0.6660.11
39_A134_L0.6650.11
139_L242_L0.6650.11
229_I241_V0.6630.11
137_G175_R0.6620.11
225_A241_V0.6610.11
132_L149_I0.6600.11
40_D148_T0.6590.11
160_V257_I0.6570.11
227_V268_I0.6570.11
264_D276_A0.6550.11
49_N104_L0.6540.11
8_D34_R0.6510.11
52_F201_Y0.6510.11
236_A278_V0.6460.11
149_I209_L0.6460.11
124_D176_H0.6440.11
27_R114_H0.6440.11
95_R157_F0.6420.11
94_D143_G0.6400.11
9_F253_L0.6390.11
28_V32_K0.6360.10
174_V187_L0.6350.10
271_T274_G0.6340.10
19_T35_I0.6320.10
163_E255_D0.6310.10
28_V69_D0.6300.10
37_L176_H0.6290.10
195_M198_L0.6270.10
117_R127_F0.6270.10
121_R253_L0.6260.10
35_I226_L0.6250.10
124_D165_N0.6230.10
6_I195_M0.6220.10
222_E260_E0.6190.10
136_P151_L0.6150.10
8_D36_V0.6150.10
129_K175_R0.6110.10
193_R256_L0.6100.10
174_V219_T0.6090.10
35_I126_P0.6010.10
238_L259_K0.6010.10
31_S230_Y0.6000.10
165_N188_A0.5990.10
172_L186_E0.5980.10
54_V105_V0.5940.10
30_M100_V0.5940.10
22_E168_N0.5940.10
132_L160_V0.5930.10
112_A187_L0.5910.10
138_D190_S0.5900.10
10_V91_S0.5870.10
25_R132_L0.5850.10
117_R188_A0.5840.10
95_R180_T0.5830.10
143_G166_G0.5800.10
229_I236_A0.5800.10
106_H139_L0.5790.10
224_E230_Y0.5780.10
222_E259_K0.5750.10
130_G241_V0.5740.10
114_H188_A0.5730.10
175_R201_Y0.5720.10
245_D253_L0.5710.10
6_I17_T0.5710.10
174_V253_L0.5700.10
29_V32_K0.5690.10
235_N250_T0.5690.10
162_R231_S0.5680.10
39_A179_S0.5680.10
55_Q152_S0.5680.10
35_I219_T0.5620.10
14_I58_T0.5610.10
237_S249_V0.5590.10
226_L264_D0.5580.10
262_V266_D0.5580.10
162_R224_E0.5580.10
265_D268_I0.5550.09
22_E88_G0.5550.09
153_T261_L0.5540.09
125_Q223_I0.5540.09
15_P30_M0.5530.09
232_S250_T0.5530.09
111_Y244_V0.5530.09
162_R230_Y0.5520.09
12_S181_G0.5460.09
33_R279_S0.5450.09
164_V211_Q0.5450.09
157_F213_L0.5430.09
73_I88_G0.5400.09
104_L259_K0.5390.09
235_N268_I0.5380.09
56_H59_A0.5380.09
54_V243_G0.5370.09
26_G31_S0.5370.09
144_D258_E0.5350.09
47_P214_A0.5330.09
188_A242_L0.5320.09
132_L226_L0.5300.09
30_M179_S0.5270.09
25_R225_A0.5240.09
64_A213_L0.5220.09
72_T199_G0.5210.09
42_E214_A0.5200.09
141_I222_E0.5180.09
76_E153_T0.5160.09
21_V141_I0.5120.09
167_S247_S0.5070.09
127_F189_L0.5070.09
136_P210_K0.5060.09
156_H222_E0.5050.09
108_T237_S0.5040.09
142_T165_N0.5040.09
110_V204_L0.5010.09
42_E202_I0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2frhA 2 0.3624 97.8 0.912 Contact Map
1p4xA 1 0.3449 97.8 0.912 Contact Map
3fm5A 4 0.3624 97.8 0.913 Contact Map
3u2rA 4 0.3449 97.8 0.913 Contact Map
3g3zA 2 0.3345 97.7 0.913 Contact Map
2fxaA 4 0.3693 97.7 0.914 Contact Map
1lj9A 2 0.3345 97.7 0.915 Contact Map
2ethA 4 0.3484 97.7 0.915 Contact Map
3bpvA 2 0.3345 97.7 0.915 Contact Map
3bj6A 2 0.3728 97.6 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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