GREMLIN Database
Q9HQW3 - Uncharacterized protein
UniProt: Q9HQW3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 301 (297)
Sequences: 115 (105)
Seq/√Len: 6.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_A112_P4.0690.94
295_A298_F3.1580.82
273_A277_V2.8270.74
160_L229_S2.7780.73
26_G30_R2.6940.70
86_V230_I2.6200.68
160_L271_A2.6140.68
109_I112_P2.3530.59
120_G288_L2.3260.58
100_A112_P2.3090.58
183_A221_K2.2790.57
120_G278_V2.2360.55
8_A293_R2.2320.55
116_H222_A2.2170.54
181_T200_W2.2050.54
116_H119_A2.1960.54
143_S277_V2.1440.52
214_F293_R2.1310.51
160_L231_A2.1280.51
278_V288_L2.1040.50
214_F294_S2.0650.49
118_A132_G2.0480.48
206_V294_S2.0410.48
34_I113_F2.0280.48
10_D113_F2.0130.47
95_E127_R1.9960.47
78_V269_V1.9930.46
3_W287_S1.9680.46
111_A274_A1.9610.45
150_A227_G1.9290.44
185_V281_T1.9110.44
192_D283_L1.9100.44
140_L255_G1.9000.43
182_T284_R1.8870.43
116_H190_A1.8680.42
179_E298_F1.8200.40
140_L237_A1.8120.40
203_L207_V1.7760.39
185_V200_W1.7430.38
127_R293_R1.6820.36
287_S293_R1.6770.36
109_I241_V1.6770.36
99_V288_L1.6740.35
136_V139_A1.6540.35
83_V170_V1.6480.35
9_L19_L1.6470.35
99_V282_F1.6460.35
278_V285_Y1.6280.34
38_A285_Y1.6250.34
172_V183_A1.6250.34
3_W216_V1.6090.33
39_G277_V1.6070.33
99_V186_V1.6010.33
199_G268_G1.5830.33
37_F291_L1.5720.32
289_L293_R1.5620.32
195_G216_V1.5480.31
33_V249_L1.5410.31
260_V264_T1.5320.31
152_D245_A1.5180.31
193_G270_V1.5170.30
28_W195_G1.5110.30
241_V248_L1.4850.30
82_V186_V1.4710.29
242_P274_A1.4700.29
3_W117_L1.4680.29
94_M224_L1.4540.29
214_F299_A1.4520.29
6_V17_R1.4490.28
241_V275_V1.4360.28
213_E290_V1.4310.28
204_S282_F1.4250.28
11_D292_D1.4160.28
159_A243_F1.4050.27
249_L271_A1.3790.26
78_V168_V1.3750.26
34_I86_V1.3610.26
235_C260_V1.3550.26
212_Q298_F1.3530.26
64_V86_V1.3510.26
123_L291_L1.3390.25
85_T133_C1.3380.25
167_G213_E1.3370.25
179_E183_A1.3250.25
87_A174_A1.3150.25
47_T81_V1.3040.24
53_P82_V1.3010.24
25_L167_G1.3000.24
36_L152_D1.2950.24
101_A127_R1.2920.24
62_Q240_V1.2920.24
78_V109_I1.2870.24
40_L240_V1.2850.24
223_V260_V1.2830.24
3_W9_L1.2810.24
109_I218_V1.2720.24
79_T272_V1.2630.23
36_L297_A1.2510.23
78_V238_V1.2440.23
34_I94_M1.2440.23
114_R226_F1.2330.23
163_T166_L1.2330.23
110_A202_R1.2300.23
83_V161_V1.2230.22
100_A104_S1.2220.22
209_A258_A1.2170.22
6_V290_V1.2150.22
3_W210_D1.2070.22
43_P164_L1.2000.22
103_R292_D1.1950.22
94_M120_G1.1860.21
99_V221_K1.1860.21
90_L125_A1.1830.21
181_T290_V1.1830.21
172_V247_A1.1820.21
120_G285_Y1.1790.21
144_P165_P1.1790.21
98_L188_L1.1720.21
87_A168_V1.1610.21
81_V249_L1.1570.21
19_L114_R1.1560.21
181_T185_V1.1500.21
95_E288_L1.1480.21
176_L222_A1.1450.20
164_L173_G1.1430.20
134_G138_T1.1350.20
89_A193_G1.1340.20
44_Q164_L1.1340.20
228_A260_V1.1190.20
82_V109_I1.1180.20
203_L294_S1.1170.20
287_S292_D1.1140.20
186_V291_L1.1100.20
92_A120_G1.1090.20
40_L225_L1.1070.20
77_G176_L1.1060.20
95_E120_G1.1030.19
199_G264_T1.1030.19
73_V259_A1.0960.19
149_L209_A1.0950.19
127_R285_Y1.0830.19
32_A107_V1.0770.19
53_P296_V1.0750.19
139_A244_G1.0730.19
38_A99_V1.0690.19
214_F287_S1.0680.19
130_I234_F1.0650.19
25_L226_F1.0630.19
104_S222_A1.0620.19
84_A213_E1.0610.19
30_R73_V1.0600.19
293_R299_A1.0580.19
57_V140_L1.0530.18
15_E90_L1.0510.18
126_F185_V1.0510.18
96_F122_R1.0470.18
119_A190_A1.0440.18
37_F118_A1.0380.18
10_D84_A1.0350.18
98_L275_V1.0240.18
95_E285_Y1.0230.18
80_V273_A1.0220.18
234_F269_V1.0190.18
180_F214_F1.0180.18
126_F284_R1.0160.18
102_A118_A1.0080.17
17_R107_V1.0080.17
116_H181_T1.0070.17
159_A219_L1.0020.17
6_V246_G0.9910.17
76_I142_A0.9890.17
13_L218_V0.9880.17
6_V129_V0.9870.17
256_G264_T0.9860.17
68_E75_A0.9840.17
120_G240_V0.9830.17
19_L258_A0.9820.17
201_R279_S0.9790.17
173_G253_V0.9750.17
233_G273_A0.9720.17
75_A140_L0.9700.17
286_H292_D0.9680.17
91_G98_L0.9650.17
121_L129_V0.9620.17
241_V249_L0.9590.16
114_R180_F0.9570.16
136_V199_G0.9570.16
123_L186_V0.9550.16
106_V215_A0.9540.16
37_F224_L0.9510.16
91_G227_G0.9510.16
35_T156_W0.9480.16
132_G177_A0.9420.16
123_L285_Y0.9280.16
15_E292_D0.9270.16
264_T269_V0.9210.16
8_A23_L0.9200.16
128_I138_T0.9200.16
266_V295_A0.9190.16
17_R265_G0.9180.16
284_R288_L0.9180.16
248_L252_A0.9160.16
113_F117_L0.9120.16
72_A231_A0.9110.16
72_A118_A0.9060.15
73_V83_V0.9030.15
29_S89_A0.8970.15
9_L17_R0.8960.15
84_A171_G0.8900.15
103_R282_F0.8830.15
112_P214_F0.8800.15
10_D203_L0.8800.15
271_A281_T0.8790.15
102_A228_A0.8750.15
15_E105_Q0.8720.15
214_F289_L0.8710.15
130_I182_T0.8690.15
183_A286_H0.8640.15
9_L93_V0.8630.15
165_P218_V0.8570.15
95_E190_A0.8540.14
96_F288_L0.8500.14
78_V82_V0.8470.14
145_I188_L0.8440.14
3_W221_K0.8410.14
81_V244_G0.8380.14
6_V178_S0.8330.14
112_P127_R0.8310.14
3_W8_A0.8300.14
206_V254_S0.8260.14
3_W10_D0.8250.14
39_G81_V0.8250.14
9_L141_V0.8220.14
181_T204_S0.8210.14
121_L209_A0.8200.14
87_A132_G0.8180.14
104_S294_S0.8180.14
169_V226_F0.8150.14
284_R287_S0.8140.14
102_A119_A0.8130.14
150_A219_L0.8060.14
10_D253_V0.8060.14
143_S267_V0.8020.14
183_A284_R0.8020.14
260_V275_V0.8010.14
199_G253_V0.8010.14
172_V229_S0.8010.14
75_A180_F0.8000.14
264_T268_G0.7960.13
121_L186_V0.7950.13
9_L179_E0.7920.13
129_V212_Q0.7910.13
11_D202_R0.7910.13
125_A197_R0.7910.13
75_A255_G0.7910.13
179_E213_E0.7900.13
109_I173_G0.7890.13
118_A283_L0.7870.13
17_R282_F0.7860.13
226_F263_V0.7840.13
50_V76_I0.7830.13
101_A107_V0.7820.13
102_A200_W0.7790.13
41_S59_N0.7780.13
5_A286_H0.7780.13
125_A263_V0.7780.13
176_L201_R0.7720.13
69_I80_V0.7670.13
5_A213_E0.7640.13
74_A166_L0.7640.13
112_P241_V0.7550.13
65_T250_A0.7540.13
81_V131_V0.7520.13
76_I129_V0.7470.13
95_E199_G0.7450.13
136_V271_A0.7430.13
40_L271_A0.7390.13
162_V208_R0.7330.12
8_A162_V0.7320.12
6_V99_V0.7300.12
5_A200_W0.7300.12
199_G293_R0.7280.12
44_Q222_A0.7250.12
170_V231_A0.7200.12
170_V234_F0.7190.12
83_V90_L0.7180.12
25_L82_V0.7170.12
129_V275_V0.7150.12
46_P270_V0.7150.12
110_A292_D0.7150.12
179_E221_K0.7130.12
141_V222_A0.7130.12
189_M200_W0.7120.12
9_L169_V0.7080.12
11_D298_F0.7040.12
254_S261_L0.7020.12
94_M100_A0.7020.12
102_A106_V0.6980.12
221_K288_L0.6950.12
30_R100_A0.6940.12
62_Q86_V0.6930.12
5_A22_P0.6900.12
53_P130_I0.6880.12
99_V278_V0.6850.12
210_D223_V0.6840.12
56_A64_V0.6820.12
180_F263_V0.6790.12
117_L280_M0.6740.12
124_L275_V0.6730.12
208_R231_A0.6730.12
32_A97_V0.6720.12
95_E100_A0.6670.11
28_W32_A0.6670.11
189_M286_H0.6650.11
3_W112_P0.6640.11
51_D186_V0.6630.11
3_W108_R0.6620.11
30_R240_V0.6620.11
97_V141_V0.6600.11
200_W203_L0.6580.11
160_L195_G0.6570.11
23_L103_R0.6560.11
100_A116_H0.6560.11
113_F153_Q0.6550.11
25_L125_A0.6520.11
181_T291_L0.6520.11
137_A256_G0.6510.11
82_V225_L0.6510.11
66_T129_V0.6490.11
262_A277_V0.6480.11
3_W179_E0.6460.11
233_G237_A0.6370.11
163_T249_L0.6360.11
6_V35_T0.6340.11
238_V270_V0.6330.11
221_K287_S0.6300.11
203_L218_V0.6290.11
50_V56_A0.6290.11
99_V174_A0.6290.11
200_W204_S0.6280.11
30_R119_A0.6270.11
56_A148_A0.6260.11
77_G256_G0.6250.11
11_D295_A0.6240.11
36_L239_I0.6240.11
106_V152_D0.6210.11
4_D257_G0.6210.11
48_V163_T0.6180.11
37_F96_F0.6170.11
117_L275_V0.6160.11
265_G269_V0.6140.11
32_A101_A0.6120.11
91_G224_L0.6100.11
15_E221_K0.6070.11
102_A219_L0.6070.11
28_W123_L0.6040.11
99_V190_A0.6030.11
94_M97_V0.6030.11
170_V262_A0.6020.11
79_T83_V0.6010.11
130_I141_V0.6010.11
149_L168_V0.6000.11
9_L114_R0.5960.10
180_F239_I0.5950.10
232_V265_G0.5940.10
192_D235_C0.5940.10
52_A56_A0.5910.10
115_A224_L0.5900.10
108_R117_L0.5890.10
211_W277_V0.5890.10
94_M283_L0.5860.10
77_G164_L0.5840.10
203_L206_V0.5810.10
62_Q155_W0.5810.10
215_A244_G0.5790.10
249_L267_V0.5790.10
232_V251_G0.5770.10
23_L68_E0.5740.10
119_A222_A0.5730.10
34_I161_V0.5730.10
294_S299_A0.5700.10
136_V164_L0.5680.10
98_L172_V0.5660.10
70_R266_V0.5660.10
110_A278_V0.5650.10
27_V116_H0.5650.10
292_D299_A0.5640.10
32_A172_V0.5630.10
100_A293_R0.5560.10
21_T215_A0.5560.10
55_N83_V0.5540.10
237_A269_V0.5530.10
26_G87_A0.5510.10
226_F266_V0.5510.10
4_D92_A0.5500.10
74_A193_G0.5500.10
176_L275_V0.5490.10
186_V222_A0.5460.10
90_L146_G0.5430.10
73_V175_A0.5420.10
14_A227_G0.5420.10
218_V228_A0.5390.10
42_A152_D0.5370.10
3_W34_I0.5370.10
3_W289_L0.5360.10
58_I128_I0.5350.10
188_L270_V0.5350.10
112_P293_R0.5340.10
161_V213_E0.5340.10
162_V274_A0.5330.10
64_V133_C0.5330.10
116_H186_V0.5310.10
261_L290_V0.5290.10
82_V257_G0.5290.10
75_A177_A0.5270.10
76_I212_Q0.5260.10
81_V140_L0.5250.10
192_D242_P0.5250.10
79_T257_G0.5240.10
121_L142_A0.5240.10
144_P161_V0.5220.10
102_A179_E0.5220.10
23_L27_V0.5200.10
246_G267_V0.5200.10
86_V90_L0.5200.10
66_T258_A0.5190.09
137_A279_S0.5180.09
289_L294_S0.5180.09
109_I223_V0.5170.09
144_P231_A0.5160.09
13_L93_V0.5160.09
135_L144_P0.5160.09
14_A295_A0.5150.09
14_A109_I0.5140.09
254_S275_V0.5140.09
3_W21_T0.5120.09
134_G168_V0.5090.09
56_A74_A0.5090.09
129_V230_I0.5070.09
17_R237_A0.5070.09
82_V94_M0.5060.09
13_L225_L0.5050.09
57_V139_A0.5050.09
128_I253_V0.5010.09
101_A293_R0.5000.09
279_S293_R0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2khfA 1 0.0797 9.8 0.971 Contact Map
3zf7w 1 0.196 8.1 0.972 Contact Map
4bucA 1 0.1728 7.8 0.973 Contact Map
3b5xA 2 0.299 7.4 0.973 Contact Map
3j61F 1 0.196 7.3 0.973 Contact Map
2zkrw 1 0.1894 7 0.973 Contact Map
4w20F 1 0.196 6.9 0.973 Contact Map
4a17V 1 0.196 6.7 0.973 Contact Map
3j39F 1 0.196 6.4 0.974 Contact Map
3b60A 2 0.299 3.4 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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