Q9HQW2 - HALSA - GREMLIN Contacts

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Q9HQW2 - Uncharacterized protein

UniProt:	Q9HQW2	Sequences: MFPRLEYIDWLSGRPEVALYDLGSSALRGDRDRQPAVVPEPLAGLSDPPAGATLETQIAGEYGVHPEQVLVTPGASTANFVATAAALYPTAGTDENGDGGTPTALVEKPGYEPLVAAPRAVGGQTNRVLRPADDDYRISPARIAAAATEDTQVVTVTNRHNPSGRLADVDALADAAARAREVGARLLVDEVYAPFTETASDGPFGGPTAVGIDSAVVTGSLTKFFGLHDSGVGWLIADAEFVDRARSVLRHIPGPAASNRALGMRALHNRDALADRARSLVAENHGLLASFRDAHDDLVAGTVHEGAPYAFLDPREADGDAVAAAAWSEGVLVVPGRFFDDPGRIRVSLGRTPDHAVAALDALAGVLADGP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	371 (336)
Sequences:	43687 (29942)
Seq/√Len:	1633.5

ECOLI - ALAC YBDL ALAA MALY YDCR YJIR AVTA HIS8
BACSU - AAT1 YUGH MTNE AAT2 AAT3 PATA CBL YDFD YISV HIS8 YDEL YCXD YHDI GABR YDEF
HALSA - Q9HQW2 Q9HRM6 Q9HQK2 Q9HRX4 HIS8 Q9HPL0
SULSO - AAT Q97YX5 Y104 Q97TY7 HIS8 Q97ZX4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
103_T	124_Q	3.019	1.00
329_E	365_G	2.903	1.00
72_T	78_A	2.894	1.00
287_L	357_V	2.772	1.00
57_Q	268_H	2.750	1.00
282_A	286_G	2.723	1.00
169_V	173_A	2.671	1.00
300_A	313_D	2.647	1.00
144_A	181_E	2.634	1.00
87_L	123_G	2.565	1.00
283_E	353_P	2.522	1.00
358_A	362_A	2.425	1.00
98_D	152_Q	2.369	1.00
324_A	328_S	2.276	1.00
53_T	264_M	2.161	1.00
168_D	171_A	2.127	1.00
237_A	242_V	2.101	1.00
80_F	84_A	2.097	1.00
291_F	360_L	2.095	1.00
103_T	126_N	2.051	1.00
35_P	39_P	2.005	1.00
291_F	294_A	1.998	1.00
173_A	177_A	1.972	1.00
289_A	293_D	1.970	1.00
232_V	263_G	1.963	1.00
358_A	361_D	1.897	1.00
56_T	66_P	1.896	1.00
108_K	127_R	1.852	1.00
142_R	146_A	1.821	1.00
144_A	174_D	1.806	1.00
56_T	60_G	1.776	1.00
289_A	303_V	1.770	1.00
137_R	171_A	1.769	1.00
291_F	364_A	1.766	1.00
60_G	268_H	1.764	1.00
287_L	291_F	1.756	1.00
67_E	239_A	1.750	1.00
57_Q	60_G	1.747	1.00
187_L	218_T	1.743	1.00
291_F	295_H	1.740	1.00
118_P	123_G	1.726	1.00
139_S	142_R	1.713	1.00
290_S	294_A	1.707	1.00
59_A	66_P	1.701	1.00
286_G	290_S	1.693	1.00
52_A	56_T	1.685	1.00
141_A	174_D	1.680	1.00
68_Q	239_A	1.676	1.00
142_R	145_A	1.674	1.00
179_A	186_L	1.668	1.00
115_V	119_R	1.668	1.00
204_F	207_P	1.661	1.00
293_D	301_G	1.648	1.00
291_F	361_D	1.639	1.00
191_V	220_S	1.638	1.00
352_T	355_H	1.614	1.00
183_G	214_S	1.614	1.00
82_A	216_V	1.597	1.00
103_T	148_T	1.582	1.00
32_D	36_A	1.571	1.00
104_A	118_P	1.559	1.00
131_P	171_A	1.554	1.00
103_T	150_D	1.554	1.00
321_A	325_A	1.548	1.00
287_L	353_P	1.533	1.00
82_A	187_L	1.526	1.00
235_L	245_A	1.518	1.00
58_I	234_W	1.514	1.00
329_E	362_A	1.512	1.00
288_L	310_A	1.505	1.00
174_D	177_A	1.505	1.00
256_A	259_N	1.503	1.00
295_H	364_A	1.499	1.00
103_T	151_T	1.492	1.00
75_A	218_T	1.487	1.00
83_T	118_P	1.486	1.00
325_A	328_S	1.461	1.00
64_V	236_I	1.459	1.00
57_Q	264_M	1.458	1.00
275_D	279_S	1.457	1.00
108_K	129_L	1.448	1.00
333_V	345_I	1.440	1.00
115_V	127_R	1.436	1.00
20_Y	359_A	1.434	1.00
294_A	364_A	1.427	1.00
62_Y	236_I	1.407	1.00
147_A	178_R	1.393	1.00
289_A	310_A	1.388	1.00
140_P	174_D	1.388	1.00
289_A	301_G	1.378	1.00
318_D	321_A	1.374	1.00
51_G	261_A	1.373	1.00
49_P	246_R	1.360	1.00
324_A	366_V	1.360	1.00
171_A	174_D	1.356	1.00
288_L	360_L	1.356	1.00
221_L	263_G	1.351	1.00
179_A	184_A	1.341	1.00
280_L	283_E	1.337	1.00
291_F	357_V	1.336	1.00
249_L	253_P	1.334	1.00
140_P	178_R	1.330	1.00
53_T	268_H	1.326	1.00
129_L	142_R	1.322	1.00
317_A	321_A	1.315	1.00
49_P	55_E	1.315	1.00
177_A	181_E	1.312	1.00
170_D	173_A	1.303	1.00
106_V	125_T	1.299	1.00
144_A	182_V	1.291	1.00
317_A	320_D	1.283	1.00
320_D	324_A	1.283	1.00
178_R	182_V	1.281	1.00
15_P	330_G	1.279	1.00
70_L	242_V	1.275	1.00
264_M	268_H	1.271	1.00
361_D	365_G	1.266	1.00
105_L	151_T	1.260	1.00
357_V	361_D	1.257	1.00
280_L	353_P	1.255	1.00
311_F	336_G	1.255	1.00
153_V	187_L	1.254	1.00
219_G	234_W	1.252	1.00
244_R	247_S	1.251	1.00
65_H	68_Q	1.246	1.00
323_A	327_W	1.243	1.00
84_A	121_V	1.238	1.00
313_D	343_G	1.221	1.00
312_L	347_V	1.212	1.00
177_A	180_R	1.207	1.00
144_A	148_T	1.205	1.00
178_R	184_A	1.202	1.00
89_P	122_G	1.198	1.00
293_D	303_V	1.195	1.00
105_L	128_V	1.194	1.00
170_D	174_D	1.191	1.00
53_T	261_A	1.179	1.00
280_L	284_N	1.178	1.00
279_S	282_A	1.177	1.00
148_T	151_T	1.171	1.00
55_E	59_A	1.168	1.00
83_T	87_L	1.168	1.00
313_D	344_R	1.164	1.00
295_H	361_D	1.163	1.00
275_D	278_R	1.155	1.00
73_P	77_T	1.154	1.00
243_D	247_S	1.153	1.00
285_H	289_A	1.148	1.00
351_R	355_H	1.146	1.00
33_R	37_V	1.145	1.00
144_A	178_R	1.144	1.00
78_A	235_L	1.144	1.00
58_I	71_V	1.142	1.00
145_A	149_E	1.138	1.00
77_T	249_L	1.131	1.00
65_H	239_A	1.131	1.00
131_P	139_S	1.129	1.00
169_V	203_P	1.129	1.00
213_D	238_D	1.126	1.00
353_P	357_V	1.123	1.00
83_T	155_T	1.120	1.00
265_R	268_H	1.120	1.00
173_A	210_V	1.118	1.00
325_A	329_E	1.104	1.00
279_S	283_E	1.100	1.00
34_Q	38_V	1.098	1.00
87_L	104_A	1.097	1.00
85_A	248_V	1.093	1.00
131_P	142_R	1.083	1.00
52_A	66_P	1.081	1.00
285_H	349_L	1.078	1.00
185_R	216_V	1.075	1.00
284_N	287_L	1.075	1.00
216_V	235_L	1.075	1.00
319_G	337_R	1.071	1.00
36_A	40_E	1.059	1.00
198_T	305_E	1.059	1.00
180_R	212_I	1.051	1.00
355_H	358_A	1.046	1.00
265_R	269_N	1.046	1.00
169_V	207_P	1.043	1.00
32_D	35_P	1.042	1.00
118_P	125_T	1.040	1.00
321_A	324_A	1.030	1.00
62_Y	234_W	1.030	1.00
324_A	327_W	1.030	1.00
88_Y	98_D	1.026	1.00
53_T	56_T	1.022	1.00
290_S	293_D	1.022	1.00
58_I	69_V	1.011	1.00
176_A	215_A	1.008	1.00
287_L	290_S	1.003	1.00
276_R	280_L	1.001	1.00
68_Q	242_V	0.993	1.00
128_V	146_A	0.982	1.00
77_T	253_P	0.976	1.00
147_A	184_A	0.976	1.00
185_R	214_S	0.973	1.00
141_A	145_A	0.972	1.00
16_E	358_A	0.968	1.00
216_V	237_A	0.967	1.00
261_A	264_M	0.967	1.00
59_A	69_V	0.966	1.00
54_L	71_V	0.950	1.00
148_T	182_V	0.950	1.00
59_A	65_H	0.946	1.00
347_V	359_A	0.945	1.00
315_R	343_G	0.942	1.00
81_V	249_L	0.941	1.00
180_R	213_D	0.936	1.00
69_V	236_I	0.934	1.00
288_L	356_A	0.931	1.00
185_R	241_F	0.930	1.00
325_A	366_V	0.928	1.00
110_G	157_T	0.927	1.00
140_P	144_A	0.926	1.00
272_A	276_R	0.922	1.00
206_G	209_A	0.919	1.00
322_V	345_I	0.919	1.00
52_A	55_E	0.919	1.00
70_L	245_A	0.917	1.00
32_D	39_P	0.917	1.00
85_A	245_A	0.914	1.00
239_A	243_D	0.914	1.00
86_A	185_R	0.912	1.00
318_D	342_P	0.911	1.00
286_G	303_V	0.908	1.00
119_R	125_T	0.908	1.00
197_E	282_A	0.897	1.00
73_P	256_A	0.895	1.00
78_A	218_T	0.892	1.00
33_R	265_R	0.883	1.00
180_R	214_S	0.883	1.00
57_Q	61_E	0.878	1.00
206_G	210_V	0.877	1.00
242_V	246_R	0.873	1.00
273_L	276_R	0.871	1.00
276_R	279_S	0.870	1.00
317_A	322_V	0.870	1.00
75_A	220_S	0.870	1.00
300_A	315_R	0.867	1.00
51_G	260_R	0.863	1.00
75_A	191_V	0.863	1.00
284_N	352_T	0.860	1.00
196_T	199_A	0.859	1.00
51_G	264_M	0.857	1.00
68_Q	212_I	0.856	1.00
218_T	235_L	0.855	1.00
116_A	119_R	0.855	1.00
105_L	146_A	0.854	1.00
16_E	330_G	0.854	1.00
141_A	144_A	0.851	1.00
61_E	194_P	0.851	1.00
295_H	360_L	0.847	1.00
320_D	323_A	0.847	1.00
107_E	138_I	0.845	1.00
147_A	151_T	0.841	1.00
176_A	186_L	0.840	1.00
232_V	255_P	0.840	1.00
285_H	304_H	0.835	1.00
216_V	241_F	0.834	1.00
288_L	291_F	0.831	1.00
89_P	97_G	0.827	1.00
232_V	259_N	0.827	1.00
140_P	171_A	0.827	1.00
318_D	337_R	0.826	1.00
76_S	113_P	0.822	1.00
203_P	207_P	0.818	1.00
36_A	39_P	0.816	1.00
329_E	366_V	0.813	1.00
322_V	325_A	0.812	1.00
82_A	245_A	0.811	1.00
33_R	36_A	0.808	1.00
272_A	275_D	0.807	1.00
299_V	314_P	0.807	1.00
140_P	175_A	0.807	1.00
273_L	277_A	0.806	1.00
20_Y	356_A	0.796	1.00
54_L	58_I	0.791	1.00
314_P	345_I	0.790	1.00
151_T	184_A	0.790	1.00
42_L	261_A	0.789	1.00
290_S	357_V	0.787	1.00
130_R	160_H	0.787	1.00
283_E	286_G	0.785	1.00
331_V	362_A	0.781	1.00
107_E	128_V	0.774	1.00
105_L	143_I	0.774	1.00
319_G	323_A	0.774	1.00
203_P	206_G	0.773	1.00
362_A	365_G	0.773	1.00
283_E	287_L	0.773	1.00
169_V	208_T	0.771	1.00
333_V	347_V	0.770	1.00
194_P	224_F	0.770	1.00
61_E	225_F	0.765	1.00
319_G	335_P	0.758	1.00
138_I	171_A	0.752	1.00
204_F	208_T	0.750	1.00
287_L	360_L	0.749	1.00
38_V	41_P	0.749	1.00
180_R	210_V	0.745	1.00
213_D	240_E	0.742	1.00
286_G	289_A	0.741	1.00
190_E	217_V	0.740	1.00
35_P	38_V	0.739	1.00
205_G	208_T	0.738	1.00
27_L	280_L	0.736	1.00
126_N	146_A	0.732	1.00
77_T	81_V	0.731	1.00
154_V	184_A	0.728	1.00
322_V	333_V	0.728	1.00
70_L	235_L	0.728	1.00
133_D	137_R	0.728	1.00
271_D	275_D	0.726	1.00
59_A	64_V	0.724	1.00
160_H	163_S	0.724	1.00
81_V	245_A	0.723	1.00
108_K	340_D	0.722	1.00
299_V	312_L	0.720	1.00
104_A	123_G	0.720	1.00
331_V	363_L	0.718	1.00
224_F	274_A	0.718	1.00
337_R	342_P	0.713	1.00
86_A	153_V	0.713	1.00
207_P	210_V	0.712	1.00
288_L	349_L	0.711	1.00
131_P	137_R	0.711	1.00
311_F	344_R	0.709	1.00
274_A	278_R	0.708	1.00
192_Y	309_Y	0.699	1.00
237_A	245_A	0.699	1.00
137_R	168_D	0.698	1.00
285_H	303_V	0.693	1.00
354_D	357_V	0.693	1.00
106_V	118_P	0.693	1.00
205_G	215_A	0.693	1.00
64_V	68_Q	0.693	1.00
80_F	121_V	0.692	1.00
57_Q	267_L	0.691	1.00
317_A	342_P	0.690	1.00
84_A	248_V	0.688	1.00
76_S	111_Y	0.685	1.00
128_V	142_R	0.684	1.00
72_T	235_L	0.683	1.00
46_S	254_G	0.683	1.00
61_E	271_D	0.683	1.00
147_A	182_V	0.682	1.00
186_L	205_G	0.682	1.00
257_A	261_A	0.680	1.00
16_E	355_H	0.680	1.00
262_L	265_R	0.679	1.00
126_N	148_T	0.678	1.00
55_E	66_P	0.677	1.00
143_I	178_R	0.675	1.00
326_A	363_L	0.675	1.00
166_L	306_G	0.673	1.00
320_D	337_R	0.673	1.00
277_A	281_V	0.671	1.00
336_G	339_F	0.666	1.00
237_A	241_F	0.664	1.00
107_E	160_H	0.664	1.00
206_G	217_V	0.659	1.00
114_L	118_P	0.658	1.00
198_T	282_A	0.657	1.00
300_A	316_E	0.657	1.00
221_L	234_W	0.657	1.00
284_N	356_A	0.655	1.00
312_L	344_R	0.653	1.00
68_Q	237_A	0.653	1.00
62_Y	217_V	0.652	1.00
156_V	172_L	0.651	1.00
61_E	193_A	0.650	1.00
203_P	208_T	0.649	1.00
70_L	246_R	0.648	1.00
53_T	57_Q	0.648	1.00
243_D	246_R	0.648	1.00
19_L	24_S	0.645	1.00
74_G	231_G	0.643	1.00
361_D	364_A	0.639	1.00
197_E	285_H	0.639	1.00
114_L	154_V	0.639	1.00
198_T	285_H	0.637	1.00
103_T	152_Q	0.634	1.00
240_E	243_D	0.631	1.00
331_V	359_A	0.631	1.00
249_L	255_P	0.630	1.00
261_A	265_R	0.630	1.00
282_A	285_H	0.629	1.00
97_G	124_Q	0.629	1.00
323_A	335_P	0.627	1.00
71_V	232_V	0.626	1.00
212_I	215_A	0.626	1.00
80_F	117_A	0.624	1.00
284_N	353_P	0.624	1.00
83_T	123_G	0.623	1.00
158_N	190_E	0.623	1.00
173_A	208_T	0.622	1.00
167_A	171_A	0.622	1.00
137_R	165_R	0.622	1.00
313_D	316_E	0.618	1.00
193_A	219_G	0.618	1.00
196_T	202_G	0.618	1.00
278_R	282_A	0.616	1.00
246_R	249_L	0.614	1.00
287_L	356_A	0.614	1.00
292_R	312_L	0.613	1.00
326_A	333_V	0.610	1.00
126_N	151_T	0.609	1.00
352_T	357_V	0.609	1.00
83_T	121_V	0.608	1.00
322_V	326_A	0.608	1.00
26_A	284_N	0.607	1.00
50_A	55_E	0.606	1.00
87_L	98_D	0.604	1.00
47_D	52_A	0.604	1.00
132_A	300_A	0.603	1.00
167_A	172_L	0.603	1.00
129_L	139_S	0.599	1.00
106_V	127_R	0.599	1.00
336_G	344_R	0.597	1.00
197_E	306_G	0.593	1.00
27_L	30_D	0.592	1.00
87_L	153_V	0.592	1.00
145_A	148_T	0.590	1.00
81_V	248_V	0.588	1.00
106_V	115_V	0.587	1.00
80_F	252_I	0.587	1.00
209_A	212_I	0.585	1.00
358_A	365_G	0.584	1.00
148_T	181_E	0.582	1.00
129_L	146_A	0.580	1.00
54_L	263_G	0.577	1.00
132_A	313_D	0.576	1.00
55_E	246_R	0.575	1.00
179_A	183_G	0.575	1.00
155_T	187_L	0.575	1.00
294_A	357_V	0.574	1.00
56_T	59_A	0.573	1.00
79_N	117_A	0.573	1.00
221_L	267_L	0.572	1.00
260_R	264_M	0.571	1.00
204_F	217_V	0.569	1.00
46_S	51_G	0.568	1.00
18_A	358_A	0.568	1.00
56_T	268_H	0.567	1.00
227_L	266_A	0.565	1.00
73_P	255_P	0.564	1.00
195_F	281_V	0.563	1.00
19_L	22_L	0.563	1.00
195_F	278_R	0.561	1.00
78_A	233_G	0.560	1.00
25_S	281_V	0.560	1.00
320_D	335_P	0.559	1.00
83_T	153_V	0.559	1.00
82_A	218_T	0.558	1.00
209_A	213_D	0.558	1.00
159_R	306_G	0.558	1.00
319_G	343_G	0.557	1.00
83_T	117_A	0.551	1.00
98_D	150_D	0.551	1.00
201_D	204_F	0.551	1.00
112_E	338_F	0.551	1.00
34_Q	37_V	0.550	1.00
165_R	305_E	0.550	1.00
288_L	347_V	0.547	1.00
158_N	166_L	0.547	1.00
188_V	217_V	0.540	1.00
204_F	209_A	0.539	1.00
318_D	343_G	0.538	1.00
166_L	196_T	0.537	1.00
85_A	244_R	0.537	1.00
305_E	308_P	0.537	1.00
169_V	201_D	0.536	1.00
88_Y	152_Q	0.536	1.00
269_N	272_A	0.534	1.00
61_E	270_R	0.534	1.00
179_A	182_V	0.534	1.00
138_I	143_I	0.533	1.00
327_W	332_L	0.533	1.00
104_A	153_V	0.532	1.00
205_G	210_V	0.532	1.00
143_I	154_V	0.529	1.00
174_D	178_R	0.529	1.00
176_A	179_A	0.528	1.00
133_D	171_A	0.527	1.00
37_V	265_R	0.525	1.00
71_V	260_R	0.525	1.00
238_D	241_F	0.525	1.00
146_A	149_E	0.524	1.00
139_S	171_A	0.524	1.00
161_N	192_Y	0.522	1.00
128_V	138_I	0.521	1.00
179_A	214_S	0.519	1.00
190_E	193_A	0.519	1.00
46_S	257_A	0.516	1.00
277_A	280_L	0.513	1.00
356_A	359_A	0.510	1.00
82_A	86_A	0.507	1.00
17_V	332_L	0.506	1.00
288_L	359_A	0.502	1.00
222_T	231_G	0.502	1.00
291_F	356_A	0.501	1.00
197_E	349_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3piuA	2	0.9623	100	0.285	Contact Map
3dydA	2	0.9542	100	0.295	Contact Map
1bw0A	2	0.9569	100	0.308	Contact Map
2x5dA	3	0.965	100	0.311	Contact Map
1iayA	2	0.9596	100	0.315	Contact Map
1yizA	2	0.9623	100	0.315	Contact Map
1o4sA	2	0.9434	100	0.319	Contact Map
2gb3A	2	0.9515	100	0.32	Contact Map
3jtxA	2	0.9488	100	0.322	Contact Map
3pplA	2	0.9784	100	0.322	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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