GREMLIN Database
Q9HQW2 - Uncharacterized protein
UniProt: Q9HQW2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (336)
Sequences: 43687 (29942)
Seq/√Len: 1633.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_T124_Q3.0191.00
329_E365_G2.9031.00
72_T78_A2.8941.00
287_L357_V2.7721.00
57_Q268_H2.7501.00
282_A286_G2.7231.00
169_V173_A2.6711.00
300_A313_D2.6471.00
144_A181_E2.6341.00
87_L123_G2.5651.00
283_E353_P2.5221.00
358_A362_A2.4251.00
98_D152_Q2.3691.00
324_A328_S2.2761.00
53_T264_M2.1611.00
168_D171_A2.1271.00
237_A242_V2.1011.00
80_F84_A2.0971.00
291_F360_L2.0951.00
103_T126_N2.0511.00
35_P39_P2.0051.00
291_F294_A1.9981.00
173_A177_A1.9721.00
289_A293_D1.9701.00
232_V263_G1.9631.00
358_A361_D1.8971.00
56_T66_P1.8961.00
108_K127_R1.8521.00
142_R146_A1.8211.00
144_A174_D1.8061.00
56_T60_G1.7761.00
289_A303_V1.7701.00
137_R171_A1.7691.00
291_F364_A1.7661.00
60_G268_H1.7641.00
287_L291_F1.7561.00
67_E239_A1.7501.00
57_Q60_G1.7471.00
187_L218_T1.7431.00
291_F295_H1.7401.00
118_P123_G1.7261.00
139_S142_R1.7131.00
290_S294_A1.7071.00
59_A66_P1.7011.00
286_G290_S1.6931.00
52_A56_T1.6851.00
141_A174_D1.6801.00
68_Q239_A1.6761.00
142_R145_A1.6741.00
179_A186_L1.6681.00
115_V119_R1.6681.00
204_F207_P1.6611.00
293_D301_G1.6481.00
291_F361_D1.6391.00
191_V220_S1.6381.00
352_T355_H1.6141.00
183_G214_S1.6141.00
82_A216_V1.5971.00
103_T148_T1.5821.00
32_D36_A1.5711.00
104_A118_P1.5591.00
131_P171_A1.5541.00
103_T150_D1.5541.00
321_A325_A1.5481.00
287_L353_P1.5331.00
82_A187_L1.5261.00
235_L245_A1.5181.00
58_I234_W1.5141.00
329_E362_A1.5121.00
288_L310_A1.5051.00
174_D177_A1.5051.00
256_A259_N1.5031.00
295_H364_A1.4991.00
103_T151_T1.4921.00
75_A218_T1.4871.00
83_T118_P1.4861.00
325_A328_S1.4611.00
64_V236_I1.4591.00
57_Q264_M1.4581.00
275_D279_S1.4571.00
108_K129_L1.4481.00
333_V345_I1.4401.00
115_V127_R1.4361.00
20_Y359_A1.4341.00
294_A364_A1.4271.00
62_Y236_I1.4071.00
147_A178_R1.3931.00
289_A310_A1.3881.00
140_P174_D1.3881.00
289_A301_G1.3781.00
318_D321_A1.3741.00
51_G261_A1.3731.00
49_P246_R1.3601.00
324_A366_V1.3601.00
171_A174_D1.3561.00
288_L360_L1.3561.00
221_L263_G1.3511.00
179_A184_A1.3411.00
280_L283_E1.3371.00
291_F357_V1.3361.00
249_L253_P1.3341.00
140_P178_R1.3301.00
53_T268_H1.3261.00
129_L142_R1.3221.00
317_A321_A1.3151.00
49_P55_E1.3151.00
177_A181_E1.3121.00
170_D173_A1.3031.00
106_V125_T1.2991.00
144_A182_V1.2911.00
317_A320_D1.2831.00
320_D324_A1.2831.00
178_R182_V1.2811.00
15_P330_G1.2791.00
70_L242_V1.2751.00
264_M268_H1.2711.00
361_D365_G1.2661.00
105_L151_T1.2601.00
357_V361_D1.2571.00
280_L353_P1.2551.00
311_F336_G1.2551.00
153_V187_L1.2541.00
219_G234_W1.2521.00
244_R247_S1.2511.00
65_H68_Q1.2461.00
323_A327_W1.2431.00
84_A121_V1.2381.00
313_D343_G1.2211.00
312_L347_V1.2121.00
177_A180_R1.2071.00
144_A148_T1.2051.00
178_R184_A1.2021.00
89_P122_G1.1981.00
293_D303_V1.1951.00
105_L128_V1.1941.00
170_D174_D1.1911.00
53_T261_A1.1791.00
280_L284_N1.1781.00
279_S282_A1.1771.00
148_T151_T1.1711.00
55_E59_A1.1681.00
83_T87_L1.1681.00
313_D344_R1.1641.00
295_H361_D1.1631.00
275_D278_R1.1551.00
73_P77_T1.1541.00
243_D247_S1.1531.00
285_H289_A1.1481.00
351_R355_H1.1461.00
33_R37_V1.1451.00
144_A178_R1.1441.00
78_A235_L1.1441.00
58_I71_V1.1421.00
145_A149_E1.1381.00
77_T249_L1.1311.00
65_H239_A1.1311.00
131_P139_S1.1291.00
169_V203_P1.1291.00
213_D238_D1.1261.00
353_P357_V1.1231.00
83_T155_T1.1201.00
265_R268_H1.1201.00
173_A210_V1.1181.00
325_A329_E1.1041.00
279_S283_E1.1001.00
34_Q38_V1.0981.00
87_L104_A1.0971.00
85_A248_V1.0931.00
131_P142_R1.0831.00
52_A66_P1.0811.00
285_H349_L1.0781.00
185_R216_V1.0751.00
284_N287_L1.0751.00
216_V235_L1.0751.00
319_G337_R1.0711.00
36_A40_E1.0591.00
198_T305_E1.0591.00
180_R212_I1.0511.00
355_H358_A1.0461.00
265_R269_N1.0461.00
169_V207_P1.0431.00
32_D35_P1.0421.00
118_P125_T1.0401.00
321_A324_A1.0301.00
62_Y234_W1.0301.00
324_A327_W1.0301.00
88_Y98_D1.0261.00
53_T56_T1.0221.00
290_S293_D1.0221.00
58_I69_V1.0111.00
176_A215_A1.0081.00
287_L290_S1.0031.00
276_R280_L1.0011.00
68_Q242_V0.9931.00
128_V146_A0.9821.00
77_T253_P0.9761.00
147_A184_A0.9761.00
185_R214_S0.9731.00
141_A145_A0.9721.00
16_E358_A0.9681.00
216_V237_A0.9671.00
261_A264_M0.9671.00
59_A69_V0.9661.00
54_L71_V0.9501.00
148_T182_V0.9501.00
59_A65_H0.9461.00
347_V359_A0.9451.00
315_R343_G0.9421.00
81_V249_L0.9411.00
180_R213_D0.9361.00
69_V236_I0.9341.00
288_L356_A0.9311.00
185_R241_F0.9301.00
325_A366_V0.9281.00
110_G157_T0.9271.00
140_P144_A0.9261.00
272_A276_R0.9221.00
206_G209_A0.9191.00
322_V345_I0.9191.00
52_A55_E0.9191.00
70_L245_A0.9171.00
32_D39_P0.9171.00
85_A245_A0.9141.00
239_A243_D0.9141.00
86_A185_R0.9121.00
318_D342_P0.9111.00
286_G303_V0.9081.00
119_R125_T0.9081.00
197_E282_A0.8971.00
73_P256_A0.8951.00
78_A218_T0.8921.00
33_R265_R0.8831.00
180_R214_S0.8831.00
57_Q61_E0.8781.00
206_G210_V0.8771.00
242_V246_R0.8731.00
273_L276_R0.8711.00
276_R279_S0.8701.00
317_A322_V0.8701.00
75_A220_S0.8701.00
300_A315_R0.8671.00
51_G260_R0.8631.00
75_A191_V0.8631.00
284_N352_T0.8601.00
196_T199_A0.8591.00
51_G264_M0.8571.00
68_Q212_I0.8561.00
218_T235_L0.8551.00
116_A119_R0.8551.00
105_L146_A0.8541.00
16_E330_G0.8541.00
141_A144_A0.8511.00
61_E194_P0.8511.00
295_H360_L0.8471.00
320_D323_A0.8471.00
107_E138_I0.8451.00
147_A151_T0.8411.00
176_A186_L0.8401.00
232_V255_P0.8401.00
285_H304_H0.8351.00
216_V241_F0.8341.00
288_L291_F0.8311.00
89_P97_G0.8271.00
232_V259_N0.8271.00
140_P171_A0.8271.00
318_D337_R0.8261.00
76_S113_P0.8221.00
203_P207_P0.8181.00
36_A39_P0.8161.00
329_E366_V0.8131.00
322_V325_A0.8121.00
82_A245_A0.8111.00
33_R36_A0.8081.00
272_A275_D0.8071.00
299_V314_P0.8071.00
140_P175_A0.8071.00
273_L277_A0.8061.00
20_Y356_A0.7961.00
54_L58_I0.7911.00
314_P345_I0.7901.00
151_T184_A0.7901.00
42_L261_A0.7891.00
290_S357_V0.7871.00
130_R160_H0.7871.00
283_E286_G0.7851.00
331_V362_A0.7811.00
107_E128_V0.7741.00
105_L143_I0.7741.00
319_G323_A0.7741.00
203_P206_G0.7731.00
362_A365_G0.7731.00
283_E287_L0.7731.00
169_V208_T0.7711.00
333_V347_V0.7701.00
194_P224_F0.7701.00
61_E225_F0.7651.00
319_G335_P0.7581.00
138_I171_A0.7521.00
204_F208_T0.7501.00
287_L360_L0.7491.00
38_V41_P0.7491.00
180_R210_V0.7451.00
213_D240_E0.7421.00
286_G289_A0.7411.00
190_E217_V0.7401.00
35_P38_V0.7391.00
205_G208_T0.7381.00
27_L280_L0.7361.00
126_N146_A0.7321.00
77_T81_V0.7311.00
154_V184_A0.7281.00
322_V333_V0.7281.00
70_L235_L0.7281.00
133_D137_R0.7281.00
271_D275_D0.7261.00
59_A64_V0.7241.00
160_H163_S0.7241.00
81_V245_A0.7231.00
108_K340_D0.7221.00
299_V312_L0.7201.00
104_A123_G0.7201.00
331_V363_L0.7181.00
224_F274_A0.7181.00
337_R342_P0.7131.00
86_A153_V0.7131.00
207_P210_V0.7121.00
288_L349_L0.7111.00
131_P137_R0.7111.00
311_F344_R0.7091.00
274_A278_R0.7081.00
192_Y309_Y0.6991.00
237_A245_A0.6991.00
137_R168_D0.6981.00
285_H303_V0.6931.00
354_D357_V0.6931.00
106_V118_P0.6931.00
205_G215_A0.6931.00
64_V68_Q0.6931.00
80_F121_V0.6921.00
57_Q267_L0.6911.00
317_A342_P0.6901.00
84_A248_V0.6881.00
76_S111_Y0.6851.00
128_V142_R0.6841.00
72_T235_L0.6831.00
46_S254_G0.6831.00
61_E271_D0.6831.00
147_A182_V0.6821.00
186_L205_G0.6821.00
257_A261_A0.6801.00
16_E355_H0.6801.00
262_L265_R0.6791.00
126_N148_T0.6781.00
55_E66_P0.6771.00
143_I178_R0.6751.00
326_A363_L0.6751.00
166_L306_G0.6731.00
320_D337_R0.6731.00
277_A281_V0.6711.00
336_G339_F0.6661.00
237_A241_F0.6641.00
107_E160_H0.6641.00
206_G217_V0.6591.00
114_L118_P0.6581.00
198_T282_A0.6571.00
300_A316_E0.6571.00
221_L234_W0.6571.00
284_N356_A0.6551.00
312_L344_R0.6531.00
68_Q237_A0.6531.00
62_Y217_V0.6521.00
156_V172_L0.6511.00
61_E193_A0.6501.00
203_P208_T0.6491.00
70_L246_R0.6481.00
53_T57_Q0.6481.00
243_D246_R0.6481.00
19_L24_S0.6451.00
74_G231_G0.6431.00
361_D364_A0.6391.00
197_E285_H0.6391.00
114_L154_V0.6391.00
198_T285_H0.6371.00
103_T152_Q0.6341.00
240_E243_D0.6311.00
331_V359_A0.6311.00
249_L255_P0.6301.00
261_A265_R0.6301.00
282_A285_H0.6291.00
97_G124_Q0.6291.00
323_A335_P0.6271.00
71_V232_V0.6261.00
212_I215_A0.6261.00
80_F117_A0.6241.00
284_N353_P0.6241.00
83_T123_G0.6231.00
158_N190_E0.6231.00
173_A208_T0.6221.00
167_A171_A0.6221.00
137_R165_R0.6221.00
313_D316_E0.6181.00
193_A219_G0.6181.00
196_T202_G0.6181.00
278_R282_A0.6161.00
246_R249_L0.6141.00
287_L356_A0.6141.00
292_R312_L0.6131.00
326_A333_V0.6101.00
126_N151_T0.6091.00
352_T357_V0.6091.00
83_T121_V0.6081.00
322_V326_A0.6081.00
26_A284_N0.6071.00
50_A55_E0.6061.00
87_L98_D0.6041.00
47_D52_A0.6041.00
132_A300_A0.6031.00
167_A172_L0.6031.00
129_L139_S0.5991.00
106_V127_R0.5991.00
336_G344_R0.5971.00
197_E306_G0.5931.00
27_L30_D0.5921.00
87_L153_V0.5921.00
145_A148_T0.5901.00
81_V248_V0.5881.00
106_V115_V0.5871.00
80_F252_I0.5871.00
209_A212_I0.5851.00
358_A365_G0.5841.00
148_T181_E0.5821.00
129_L146_A0.5801.00
54_L263_G0.5771.00
132_A313_D0.5761.00
55_E246_R0.5751.00
179_A183_G0.5751.00
155_T187_L0.5751.00
294_A357_V0.5741.00
56_T59_A0.5731.00
79_N117_A0.5731.00
221_L267_L0.5721.00
260_R264_M0.5711.00
204_F217_V0.5691.00
46_S51_G0.5681.00
18_A358_A0.5681.00
56_T268_H0.5671.00
227_L266_A0.5651.00
73_P255_P0.5641.00
195_F281_V0.5631.00
19_L22_L0.5631.00
195_F278_R0.5611.00
78_A233_G0.5601.00
25_S281_V0.5601.00
320_D335_P0.5591.00
83_T153_V0.5591.00
82_A218_T0.5581.00
209_A213_D0.5581.00
159_R306_G0.5581.00
319_G343_G0.5571.00
83_T117_A0.5511.00
98_D150_D0.5511.00
201_D204_F0.5511.00
112_E338_F0.5511.00
34_Q37_V0.5501.00
165_R305_E0.5501.00
288_L347_V0.5471.00
158_N166_L0.5471.00
188_V217_V0.5401.00
204_F209_A0.5391.00
318_D343_G0.5381.00
166_L196_T0.5371.00
85_A244_R0.5371.00
305_E308_P0.5371.00
169_V201_D0.5361.00
88_Y152_Q0.5361.00
269_N272_A0.5341.00
61_E270_R0.5341.00
179_A182_V0.5341.00
138_I143_I0.5331.00
327_W332_L0.5331.00
104_A153_V0.5321.00
205_G210_V0.5321.00
143_I154_V0.5291.00
174_D178_R0.5291.00
176_A179_A0.5281.00
133_D171_A0.5271.00
37_V265_R0.5251.00
71_V260_R0.5251.00
238_D241_F0.5251.00
146_A149_E0.5241.00
139_S171_A0.5241.00
161_N192_Y0.5221.00
128_V138_I0.5211.00
179_A214_S0.5191.00
190_E193_A0.5191.00
46_S257_A0.5161.00
277_A280_L0.5131.00
356_A359_A0.5101.00
82_A86_A0.5071.00
17_V332_L0.5061.00
288_L359_A0.5021.00
222_T231_G0.5021.00
291_F356_A0.5011.00
197_E349_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3piuA 2 0.9623 100 0.285 Contact Map
3dydA 2 0.9542 100 0.295 Contact Map
1bw0A 2 0.9569 100 0.308 Contact Map
2x5dA 3 0.965 100 0.311 Contact Map
1iayA 2 0.9596 100 0.315 Contact Map
1yizA 2 0.9623 100 0.315 Contact Map
1o4sA 2 0.9434 100 0.319 Contact Map
2gb3A 2 0.9515 100 0.32 Contact Map
3jtxA 2 0.9488 100 0.322 Contact Map
3pplA 2 0.9784 100 0.322 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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