GREMLIN Database
Q9HQW0 - Uncharacterized protein
UniProt: Q9HQW0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 484 (410)
Sequences: 523 (408)
Seq/√Len: 20.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
439_I447_I7.7721.00
162_A227_D7.6611.00
442_G447_I4.2811.00
176_A275_S4.1371.00
238_G258_E3.9531.00
375_L395_G3.7601.00
101_F104_A3.6121.00
421_A456_T3.3361.00
179_A278_L2.9650.99
216_T219_S2.8950.99
180_L230_A2.8870.99
215_L220_D2.8650.99
448_E454_R2.8390.99
231_L234_P2.8200.99
160_G190_D2.7900.99
101_F105_R2.7540.99
215_L219_S2.7340.99
231_L260_L2.6140.98
85_A104_A2.6050.98
439_I442_G2.5250.98
100_Q104_A2.5040.97
163_I191_A2.5030.97
453_N457_L2.4650.97
150_L248_I2.4330.97
158_E324_Y2.3480.96
158_E224_D2.3410.96
357_V388_I2.3110.96
401_I444_F2.2700.95
457_L460_L2.2550.95
348_L377_Q2.2390.95
275_S297_L2.1870.94
175_A275_S2.1740.94
93_I100_Q2.1470.94
297_L353_A2.1440.94
181_Q191_A2.1370.94
455_E459_D2.1120.93
154_V184_A2.0980.93
358_Q458_L2.0590.92
200_G203_E2.0020.91
100_Q105_R1.9920.91
79_M84_D1.9690.90
396_I417_V1.9660.90
332_L352_I1.9450.90
161_F236_K1.9020.89
93_I101_F1.8490.87
456_T460_L1.8470.87
392_A417_V1.8290.87
274_T377_Q1.8030.86
139_E143_L1.7140.83
340_M357_V1.6930.82
40_D61_V1.6800.81
161_F227_D1.6680.81
298_L327_A1.6630.81
160_G224_D1.6510.80
94_R98_D1.6310.79
333_E385_L1.6230.79
347_V374_A1.5930.78
40_D44_S1.5930.78
95_A190_D1.5920.78
202_Q211_L1.5870.78
85_A101_F1.5830.77
204_N321_A1.5620.76
403_L439_I1.5590.76
163_I193_I1.5510.76
350_E353_A1.5490.76
389_T411_R1.5350.75
250_I281_Y1.5270.75
253_Y404_D1.5230.74
295_T331_T1.5220.74
376_S382_L1.5210.74
79_M85_A1.5170.74
249_F438_E1.5100.74
93_I97_N1.5000.73
196_F229_I1.4960.73
153_V229_I1.4930.73
418_L436_S1.4860.73
412_L457_L1.4610.71
163_I357_V1.4530.71
359_G457_L1.4380.70
63_D67_A1.4340.70
162_A192_E1.4290.70
205_R213_I1.4240.69
318_T325_P1.4140.69
55_N60_N1.4090.68
167_D243_D1.4070.68
322_Y439_I1.4030.68
183_V285_F1.3950.68
338_P377_Q1.3950.68
184_A191_A1.3870.67
206_A211_L1.3690.66
103_V177_A1.3610.66
41_K44_S1.3520.65
173_S177_A1.3470.65
79_M104_A1.3360.64
75_V79_M1.3280.64
141_G376_S1.3250.64
236_K258_E1.3200.63
282_I290_S1.3160.63
356_E452_E1.3080.63
405_A418_L1.3080.63
101_F106_A1.3080.63
147_A283_Q1.3060.62
154_V161_F1.2970.62
459_D463_E1.2920.62
174_I208_V1.2900.61
439_I446_G1.2840.61
173_S384_N1.2820.61
279_T297_L1.2810.61
267_V303_A1.2800.61
279_T321_A1.2790.61
192_E227_D1.2620.60
56_A59_A1.2590.59
318_T321_A1.2580.59
240_V243_D1.2570.59
269_P348_L1.2450.59
453_N458_L1.2440.59
283_Q322_Y1.2440.59
239_A405_A1.2420.58
297_L437_A1.2400.58
141_G144_E1.2350.58
118_L122_V1.2280.58
78_V84_D1.2250.57
254_E419_A1.2230.57
312_T348_L1.2230.57
442_G452_E1.2220.57
404_D429_A1.2170.57
216_T220_D1.2150.57
78_V248_I1.2150.57
78_V86_N1.2130.57
115_L118_L1.2130.57
298_L302_R1.2100.56
402_Y436_S1.2050.56
253_Y429_A1.2040.56
93_I96_R1.2020.56
150_L230_A1.1980.56
195_Y208_V1.1970.56
272_S419_A1.1930.55
203_E213_I1.1840.55
90_V96_R1.1800.54
47_E56_A1.1770.54
56_A60_N1.1770.54
306_L380_S1.1750.54
394_F436_S1.1740.54
207_F296_A1.1630.53
143_L158_E1.1550.53
140_S143_L1.1540.53
439_I452_E1.1540.53
194_L221_V1.1530.53
351_A364_S1.1530.53
354_S403_L1.1440.52
310_R405_A1.1440.52
203_E206_A1.1440.52
161_F416_R1.1430.52
249_F267_V1.1410.52
184_A230_A1.1300.51
365_N444_F1.1240.51
121_D413_N1.1240.51
295_T333_E1.1170.50
314_P318_T1.1150.50
297_L339_N1.1150.50
61_V457_L1.1140.50
85_A88_A1.1090.50
180_L341_S1.1040.49
202_Q206_A1.1020.49
403_L453_N1.1020.49
270_S432_S1.0950.49
176_A338_P1.0940.49
304_E429_A1.0930.49
107_S436_S1.0920.49
73_R401_I1.0810.48
417_V457_L1.0760.48
202_Q205_R1.0730.47
163_I458_L1.0720.47
53_D60_N1.0710.47
299_Y336_E1.0680.47
434_Q453_N1.0610.47
180_L281_Y1.0570.46
76_V81_S1.0500.46
254_E272_S1.0480.46
80_A96_R1.0450.46
421_A447_I1.0450.46
169_P173_S1.0440.46
141_G284_E1.0400.45
224_D243_D1.0380.45
401_I416_R1.0350.45
377_Q432_S1.0350.45
85_A105_R1.0320.45
388_I448_E1.0310.45
76_V79_M1.0250.44
75_V94_R1.0230.44
253_Y304_E1.0210.44
77_L193_I1.0210.44
273_A376_S1.0190.44
235_A259_S1.0160.44
115_L122_V1.0130.44
55_N61_V1.0120.44
280_K315_A1.0060.43
219_S459_D1.0060.43
155_S187_L1.0030.43
234_P249_F1.0010.43
378_A457_L0.9990.43
79_M101_F0.9970.43
70_I76_V0.9970.43
82_D89_A0.9960.43
256_E417_V0.9950.42
76_V88_A0.9940.42
240_V256_E0.9940.42
158_E227_D0.9930.42
132_D439_I0.9930.42
234_P267_V0.9900.42
278_L281_Y0.9840.42
205_R211_L0.9840.42
361_H409_D0.9830.42
277_I403_L0.9780.41
235_A279_T0.9780.41
301_I447_I0.9720.41
205_R208_V0.9710.41
321_A397_V0.9700.41
404_D436_S0.9690.41
302_R432_S0.9660.41
142_E241_S0.9610.40
284_E313_T0.9590.40
212_D412_L0.9580.40
183_V234_P0.9580.40
229_I239_A0.9550.40
380_S409_D0.9540.40
123_V285_F0.9520.40
119_G122_V0.9510.40
200_G213_I0.9500.40
127_S190_D0.9490.40
208_V455_E0.9480.40
270_S313_T0.9470.39
354_S444_F0.9450.39
161_F230_A0.9450.39
171_P321_A0.9410.39
176_A355_R0.9390.39
451_E455_E0.9380.39
117_E362_L0.9370.39
171_P298_L0.9360.39
79_M105_R0.9320.39
44_S57_Q0.9310.38
76_V80_A0.9290.38
97_N100_Q0.9290.38
157_T228_T0.9250.38
222_D447_I0.9210.38
243_D352_I0.9190.38
63_D66_V0.9180.38
126_P266_D0.9180.38
182_A293_V0.9160.38
412_L417_V0.9160.38
447_I452_E0.9150.37
124_I235_A0.9130.37
80_A86_N0.9100.37
39_V75_V0.9090.37
153_V228_T0.9080.37
184_A285_F0.9080.37
178_A296_A0.9070.37
295_T336_E0.9020.37
136_R313_T0.9010.37
86_N90_V0.9000.37
161_F184_A0.8970.36
365_N445_T0.8940.36
163_I340_M0.8940.36
236_K256_E0.8910.36
401_I439_I0.8900.36
132_D135_L0.8900.36
108_D112_S0.8870.36
169_P298_L0.8860.36
77_L245_D0.8820.35
163_I177_A0.8760.35
57_Q140_S0.8700.35
249_F378_A0.8680.35
297_L433_T0.8660.35
441_L446_G0.8650.34
50_R211_L0.8640.34
46_V54_L0.8630.34
298_L337_S0.8610.34
376_S399_D0.8570.34
267_V401_I0.8540.34
330_D455_E0.8540.34
184_A351_A0.8510.34
310_R418_L0.8490.34
174_I212_D0.8480.33
75_V88_A0.8470.33
77_L339_N0.8430.33
338_P367_G0.8420.33
50_R58_V0.8400.33
310_R433_T0.8390.33
89_A92_N0.8370.33
98_D211_L0.8370.33
374_A378_A0.8350.33
336_E394_F0.8320.33
189_I385_L0.8320.33
306_L409_D0.8310.33
79_M88_A0.8310.33
291_Q401_I0.8300.32
190_D219_S0.8250.32
444_F457_L0.8230.32
225_N275_S0.8220.32
429_A436_S0.8210.32
379_A393_V0.8140.32
163_I366_A0.8130.31
139_E324_Y0.8110.31
170_D253_Y0.8090.31
66_V231_L0.8070.31
163_I181_Q0.8040.31
235_A373_D0.8040.31
151_A155_S0.8030.31
254_E276_T0.8030.31
351_A366_A0.8010.31
355_R382_L0.8000.31
331_T351_A0.7970.31
279_T296_A0.7960.31
291_Q328_D0.7950.30
278_L282_I0.7950.30
226_Y360_S0.7950.30
250_I278_L0.7950.30
103_V106_A0.7950.30
71_D106_A0.7930.30
108_D111_T0.7920.30
40_D101_F0.7830.30
146_K157_T0.7820.30
148_R269_P0.7810.30
204_N373_D0.7810.30
133_A136_R0.7800.30
177_A232_V0.7780.30
86_N302_R0.7780.30
83_V93_I0.7760.29
117_E152_D0.7750.29
108_D115_L0.7720.29
57_Q60_N0.7720.29
116_T270_S0.7710.29
136_R280_K0.7710.29
234_P351_A0.7680.29
182_A185_R0.7660.29
298_L371_D0.7630.29
99_D102_V0.7620.29
188_G216_T0.7600.29
206_A213_I0.7590.29
39_V59_A0.7590.29
95_A106_A0.7560.28
46_V52_Q0.7560.28
365_N448_E0.7530.28
181_Q372_R0.7520.28
235_A433_T0.7490.28
212_D388_I0.7470.28
396_I457_L0.7450.28
46_V56_A0.7440.28
50_R339_N0.7420.28
132_D208_V0.7410.28
288_S345_L0.7390.27
334_Q408_K0.7390.27
298_L380_S0.7370.27
51_D77_L0.7360.27
278_L302_R0.7340.27
88_A93_I0.7330.27
141_G293_V0.7330.27
215_L340_M0.7310.27
169_P281_Y0.7280.27
75_V104_A0.7270.27
245_D297_L0.7260.27
81_S85_A0.7230.27
86_N105_R0.7220.27
40_D119_G0.7190.26
200_G204_N0.7190.26
447_I461_T0.7190.26
146_K266_D0.7160.26
337_S436_S0.7150.26
94_R102_V0.7130.26
420_D456_T0.7130.26
341_S364_S0.7130.26
192_E226_Y0.7120.26
314_P385_L0.7110.26
412_L462_E0.7090.26
371_D374_A0.7080.26
74_D455_E0.7060.26
168_S395_G0.7030.26
74_D135_L0.7020.26
109_P112_S0.7010.26
394_F444_F0.7000.26
156_G274_T0.7000.26
163_I180_L0.6970.25
55_N62_R0.6970.25
75_V84_D0.6970.25
403_L418_L0.6950.25
197_G452_E0.6940.25
75_V85_A0.6940.25
52_Q55_N0.6930.25
122_V419_A0.6930.25
193_I389_T0.6920.25
48_A52_Q0.6910.25
114_E432_S0.6890.25
183_V378_A0.6860.25
200_G211_L0.6860.25
86_N195_Y0.6850.25
66_V188_G0.6830.25
177_A456_T0.6810.25
262_A307_D0.6800.25
118_L165_T0.6800.25
354_S364_S0.6790.24
86_N104_A0.6780.24
195_Y256_E0.6770.24
95_A451_E0.6770.24
87_E91_E0.6740.24
58_V63_D0.6740.24
304_E404_D0.6730.24
119_G407_S0.6730.24
136_R153_V0.6730.24
146_K409_D0.6720.24
344_T454_R0.6720.24
255_L265_A0.6720.24
176_A247_D0.6710.24
457_L461_T0.6710.24
298_L329_H0.6700.24
154_V176_A0.6700.24
229_I234_P0.6690.24
183_V314_P0.6690.24
78_V102_V0.6660.24
152_D158_E0.6660.24
183_V209_N0.6660.24
205_R341_S0.6650.24
168_S204_N0.6640.24
46_V49_L0.6630.24
306_L403_L0.6630.24
372_R395_G0.6610.24
75_V86_N0.6610.24
194_L255_L0.6600.24
92_N97_N0.6590.24
193_I385_L0.6580.23
284_E376_S0.6580.23
75_V91_E0.6560.23
90_V93_I0.6560.23
354_S369_I0.6560.23
197_G354_S0.6550.23
208_V441_L0.6540.23
138_L453_N0.6500.23
90_V94_R0.6480.23
87_E462_E0.6480.23
197_G387_G0.6450.23
79_M100_Q0.6450.23
356_E454_R0.6440.23
446_G452_E0.6420.23
67_A82_D0.6420.23
39_V95_A0.6420.23
311_D436_S0.6410.23
94_R445_T0.6410.23
266_D372_R0.6410.23
114_E267_V0.6410.23
85_A90_V0.6390.23
394_F448_E0.6370.23
223_I443_I0.6360.22
454_R457_L0.6360.22
89_A387_G0.6340.22
137_A293_V0.6340.22
214_E341_S0.6290.22
180_L378_A0.6280.22
261_T356_E0.6280.22
311_D432_S0.6250.22
166_H233_D0.6240.22
193_I209_N0.6230.22
169_P340_M0.6230.22
85_A93_I0.6210.22
356_E448_E0.6200.22
458_L461_T0.6170.22
118_L121_D0.6170.22
168_S176_A0.6150.22
141_G264_F0.6130.21
150_L250_I0.6130.21
108_D317_L0.6110.21
85_A100_Q0.6100.21
72_T75_V0.6090.21
399_D459_D0.6080.21
197_G373_D0.6070.21
151_A212_D0.6060.21
364_S389_T0.6060.21
263_E283_Q0.6050.21
202_Q214_E0.6030.21
209_N212_D0.6030.21
415_G419_A0.6020.21
292_T388_I0.6020.21
100_Q103_V0.6020.21
185_R364_S0.6020.21
322_Y453_N0.6020.21
124_I281_Y0.6020.21
338_P403_L0.6000.21
190_D245_D0.6000.21
70_I87_E0.6000.21
420_D459_D0.6000.21
285_F366_A0.5990.21
123_V438_E0.5990.21
348_L448_E0.5980.21
75_V81_S0.5960.21
177_A373_D0.5950.21
57_Q249_F0.5950.21
168_S174_I0.5950.21
443_I446_G0.5940.21
215_L412_L0.5940.21
118_L273_A0.5930.21
195_Y386_E0.5930.21
180_L364_S0.5930.21
314_P325_P0.5920.21
108_D225_N0.5920.21
40_D43_E0.5910.20
124_I375_L0.5910.20
229_I277_I0.5880.20
60_N63_D0.5860.20
277_I409_D0.5860.20
126_P345_L0.5860.20
97_N101_F0.5860.20
173_S191_A0.5850.20
417_V440_P0.5850.20
203_E375_L0.5850.20
176_A274_T0.5850.20
140_S154_V0.5810.20
133_A434_Q0.5800.20
125_N178_A0.5770.20
117_E136_R0.5760.20
136_R315_A0.5760.20
305_T382_L0.5760.20
200_G205_R0.5750.20
195_Y198_D0.5740.20
108_D118_L0.5730.20
149_Q315_A0.5730.20
267_V352_I0.5720.20
189_I193_I0.5710.20
77_L197_G0.5710.20
95_A99_D0.5700.20
253_Y436_S0.5690.20
115_L326_F0.5690.20
177_A339_N0.5680.20
203_E207_F0.5680.20
212_D452_E0.5670.19
103_V153_V0.5670.19
194_L231_L0.5670.19
205_R216_T0.5670.19
163_I378_A0.5660.19
40_D85_A0.5630.19
40_D79_M0.5630.19
139_E280_K0.5610.19
136_R446_G0.5600.19
235_A267_V0.5570.19
335_V348_L0.5570.19
170_D429_A0.5570.19
161_F228_T0.5540.19
188_G341_S0.5540.19
340_M346_D0.5530.19
133_A295_T0.5520.19
80_A85_A0.5520.19
219_S222_D0.5520.19
148_R151_A0.5500.19
165_T326_F0.5480.19
298_L409_D0.5480.19
77_L162_A0.5480.19
178_A391_T0.5470.19
209_N355_R0.5460.19
330_D341_S0.5460.19
136_R270_S0.5450.19
129_V204_N0.5450.19
93_I105_R0.5450.19
273_A276_T0.5440.19
39_V96_R0.5430.19
256_E303_A0.5410.18
191_A291_Q0.5410.18
39_V54_L0.5400.18
166_H429_A0.5390.18
219_S244_R0.5390.18
214_E401_I0.5380.18
183_V282_I0.5370.18
177_A375_L0.5360.18
146_K298_L0.5350.18
154_V432_S0.5340.18
39_V53_D0.5330.18
420_D440_P0.5330.18
81_S436_S0.5330.18
204_N211_L0.5330.18
49_L59_A0.5320.18
155_S223_I0.5320.18
42_D60_N0.5300.18
143_L148_R0.5290.18
209_N439_I0.5270.18
86_N101_F0.5260.18
260_L417_V0.5250.18
42_D55_N0.5250.18
454_R458_L0.5250.18
328_D379_A0.5230.18
312_T320_A0.5230.18
443_I452_E0.5230.18
215_L373_D0.5220.18
231_L267_V0.5210.18
176_A318_T0.5200.18
86_N100_Q0.5190.18
232_V378_A0.5180.18
151_A243_D0.5180.18
169_P360_S0.5180.18
119_G419_A0.5160.17
206_A212_D0.5150.17
346_D364_S0.5130.17
214_E290_S0.5130.17
113_D116_T0.5120.17
88_A95_A0.5110.17
454_R459_D0.5110.17
96_R216_T0.5090.17
211_L420_D0.5090.17
70_I105_R0.5070.17
108_D387_G0.5060.17
348_L386_E0.5050.17
177_A374_A0.5050.17
270_S391_T0.5040.17
211_L344_T0.5030.17
183_V296_A0.5030.17
357_V399_D0.5020.17
333_E380_S0.5020.17
381_Q385_L0.5010.17
459_D462_E0.5000.17
117_E296_A0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4py9A 2 0.6467 100 0.662 Contact Map
4ls9A 2 0.6219 100 0.663 Contact Map
3devA 2 0.6178 100 0.68 Contact Map
4rpaA 3 0.5888 100 0.729 Contact Map
2hawA 2 0.5909 100 0.732 Contact Map
1k20A 2 0.5909 100 0.74 Contact Map
2eb0A 2 0.5682 100 0.756 Contact Map
1wpnA 2 0.3698 100 0.777 Contact Map
2zxrA 1 0.6942 100 0.781 Contact Map
2qb7A 1 0.6529 100 0.784 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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