GREMLIN Database
Q9HQV5 - Uncharacterized protein
UniProt: Q9HQV5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 340 (275)
Sequences: 35692 (28659)
Seq/√Len: 1728.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
293_I310_M5.0981.00
166_L212_I3.3351.00
57_S60_H3.3101.00
196_R311_D3.1371.00
284_A287_S2.7381.00
155_G292_A2.7241.00
158_N286_H2.6341.00
151_L285_S2.6181.00
292_A309_R2.5451.00
68_R82_Q2.5221.00
165_D235_R2.2521.00
177_E197_V2.2361.00
174_R205_N2.2301.00
165_D227_P2.1951.00
151_L161_L2.1931.00
191_G194_G2.1741.00
312_V318_K2.0621.00
36_R81_T2.0521.00
146_V211_Y2.0451.00
290_K323_K2.0421.00
124_D127_T2.0251.00
165_D226_E2.0101.00
175_T197_V1.9771.00
302_P305_A1.9441.00
153_H201_K1.8851.00
297_R306_V1.8681.00
205_N209_R1.8671.00
170_D173_E1.8461.00
65_K83_L1.8381.00
304_E307_S1.8131.00
36_R85_T1.8091.00
92_F96_I1.7941.00
34_K38_S1.7831.00
39_P82_Q1.7751.00
160_A196_R1.6911.00
199_S309_R1.6901.00
194_G313_S1.6811.00
14_K37_L1.6731.00
61_F104_S1.6451.00
310_M318_K1.5951.00
144_E244_N1.5951.00
156_M161_L1.5851.00
145_H149_E1.5791.00
18_L34_K1.5781.00
296_A301_V1.5691.00
316_V319_K1.5671.00
125_A295_H1.5591.00
292_A296_A1.5541.00
56_L90_I1.5011.00
298_R328_Q1.5001.00
171_N209_R1.4921.00
14_K89_F1.4881.00
200_L205_N1.4801.00
297_R322_D1.4781.00
165_D168_D1.4621.00
149_E207_I1.4511.00
166_L228_L1.4391.00
52_N55_D1.4261.00
29_T33_H1.4231.00
77_V81_T1.4161.00
317_L320_H1.4131.00
123_V291_G1.4011.00
147_I241_I1.3941.00
28_A31_K1.3921.00
170_D175_T1.3871.00
89_F93_C1.3861.00
158_N162_R1.3831.00
156_M178_V1.3821.00
158_N238_K1.3821.00
307_S315_D1.3811.00
152_W295_H1.3721.00
304_E308_E1.3681.00
13_A93_C1.3581.00
135_Q248_A1.3571.00
128_A152_W1.3561.00
153_H204_V1.3551.00
27_D31_K1.3551.00
11_Q15_E1.3531.00
296_A306_V1.3471.00
294_T323_K1.3451.00
168_D179_H1.3401.00
127_T130_A1.3341.00
69_R79_M1.3251.00
167_D226_E1.2951.00
227_P235_R1.2931.00
64_Y82_Q1.2911.00
48_G60_H1.2901.00
238_K242_R1.2711.00
136_R145_H1.2681.00
159_G163_A1.2521.00
181_R191_G1.2501.00
31_K35_Y1.2361.00
146_V207_I1.2241.00
132_I149_E1.2231.00
16_W20_N1.2181.00
40_F43_W1.2141.00
147_I161_L1.2081.00
13_A92_F1.2021.00
146_V210_D1.1991.00
91_D105_D1.1971.00
179_H195_Q1.1881.00
174_R202_P1.1861.00
152_W288_L1.1691.00
291_G295_H1.1691.00
83_L87_K1.1671.00
64_Y68_R1.1661.00
129_Q133_D1.1661.00
125_A299_S1.1581.00
78_T82_Q1.1501.00
164_V176_L1.1501.00
239_T242_R1.1481.00
237_S240_S1.1471.00
123_V283_H1.1461.00
307_S318_K1.1381.00
128_A295_H1.1371.00
298_R325_T1.1371.00
65_K69_R1.1331.00
43_W67_W1.1301.00
94_E99_V1.1261.00
80_A110_P1.1211.00
18_L30_Y1.1211.00
240_S243_S1.1201.00
293_I306_V1.1121.00
245_C249_T1.1111.00
17_Y88_V1.1101.00
157_R286_H1.1021.00
158_N242_R1.0961.00
134_Y251_P1.0931.00
62_H66_K1.0911.00
75_N78_T1.0861.00
314_A319_K1.0781.00
314_A317_L1.0771.00
244_N247_R1.0761.00
147_I229_L1.0751.00
130_A134_Y1.0721.00
249_T283_H1.0701.00
97_D101_P1.0561.00
177_E195_Q1.0561.00
202_P206_Q1.0551.00
30_Y34_K1.0541.00
134_Y252_C1.0511.00
13_A53_M1.0491.00
123_V131_I1.0491.00
43_W63_Q1.0451.00
328_Q331_K1.0361.00
201_K204_V1.0341.00
32_A36_R1.0331.00
122_Y291_G1.0261.00
36_R82_Q1.0211.00
292_A310_M1.0191.00
33_H85_T1.0101.00
150_L176_L1.0091.00
242_R246_Y1.0041.00
32_A35_Y0.9961.00
162_R238_K0.9911.00
152_W291_G0.9901.00
62_H96_I0.9881.00
167_D225_R0.9861.00
90_I99_V0.9841.00
35_Y39_P0.9821.00
28_A32_A0.9741.00
74_C82_Q0.9711.00
25_L30_Y0.9651.00
294_T322_D0.9651.00
153_H203_K0.9611.00
26_A29_T0.9541.00
149_E203_K0.9521.00
293_I322_D0.9511.00
11_Q42_E0.9491.00
69_R76_K0.9451.00
150_L229_L0.9421.00
135_Q148_F0.9421.00
95_S108_D0.9311.00
22_R30_Y0.9311.00
142_Q210_D0.9301.00
246_Y282_S0.9221.00
227_P230_T0.9191.00
308_E329_E0.9191.00
145_H207_I0.9181.00
125_A129_Q0.9181.00
203_K206_Q0.9171.00
43_W64_Y0.9161.00
87_K91_D0.9111.00
123_V127_T0.9111.00
91_D102_G0.9101.00
90_I103_L0.9101.00
330_M334_R0.9071.00
247_R251_P0.9061.00
295_H298_R0.9031.00
127_T281_S0.8991.00
58_G62_H0.8931.00
93_C98_A0.8921.00
125_A298_R0.8901.00
146_V229_L0.8861.00
40_F90_I0.8831.00
122_Y323_K0.8731.00
246_Y250_R0.8661.00
58_G95_S0.8641.00
15_E19_E0.8641.00
293_I297_R0.8631.00
170_D177_E0.8621.00
25_L33_H0.8541.00
67_W71_N0.8521.00
27_D30_Y0.8491.00
68_R79_M0.8481.00
179_H193_E0.8401.00
248_A251_P0.8371.00
38_S42_E0.8351.00
121_D287_S0.8331.00
11_Q46_T0.8291.00
81_T84_S0.8281.00
95_S106_Y0.8281.00
74_C78_T0.8261.00
16_W98_A0.8251.00
171_N205_N0.8241.00
32_A81_T0.8221.00
290_K320_H0.8191.00
90_I104_S0.8181.00
150_L204_V0.8181.00
242_R285_S0.8131.00
63_Q67_W0.8131.00
162_R241_I0.8121.00
303_I319_K0.8101.00
68_R74_C0.8091.00
158_N241_I0.8061.00
102_G105_D0.8001.00
327_K331_K0.7981.00
94_E102_G0.7971.00
40_F45_D0.7951.00
154_T198_V0.7921.00
164_V169_Y0.7901.00
210_D214_H0.7881.00
301_V305_A0.7871.00
142_Q214_H0.7851.00
305_A332_N0.7841.00
134_Y248_A0.7831.00
60_H63_Q0.7821.00
314_A318_K0.7791.00
37_L42_E0.7771.00
74_C79_M0.7741.00
307_S319_K0.7741.00
83_L104_S0.7681.00
156_M176_L0.7661.00
200_L204_V0.7661.00
11_Q47_E0.7631.00
15_E34_K0.7621.00
155_G310_M0.7601.00
16_W19_E0.7561.00
204_V207_I0.7501.00
209_R213_D0.7481.00
14_K18_L0.7391.00
45_D48_G0.7381.00
41_V45_D0.7331.00
13_A89_F0.7331.00
58_G97_D0.7311.00
315_D319_K0.7281.00
158_N285_S0.7251.00
209_R212_I0.7231.00
150_L161_L0.7221.00
315_D318_K0.7171.00
298_R327_K0.7161.00
94_E105_D0.7161.00
47_E60_H0.7131.00
151_L158_N0.7111.00
59_R63_Q0.7051.00
93_C99_V0.7051.00
66_K69_R0.7041.00
243_S247_R0.7021.00
240_S244_N0.7011.00
39_P64_Y0.7011.00
13_A96_I0.6991.00
293_I312_V0.6981.00
56_L61_F0.6981.00
305_A309_R0.6971.00
297_R325_T0.6951.00
97_D106_Y0.6911.00
331_K334_R0.6901.00
164_V228_L0.6901.00
244_N248_A0.6871.00
293_I318_K0.6861.00
35_Y38_S0.6851.00
130_A133_D0.6841.00
206_Q210_D0.6821.00
144_E248_A0.6791.00
239_T246_Y0.6781.00
123_V287_S0.6761.00
71_N74_C0.6761.00
126_E130_A0.6721.00
170_D174_R0.6721.00
246_Y249_T0.6721.00
150_L156_M0.6711.00
77_V80_A0.6701.00
61_F86_L0.6691.00
135_Q145_H0.6651.00
245_C285_S0.6641.00
245_C288_L0.6631.00
206_Q209_R0.6611.00
59_R96_I0.6571.00
131_I249_T0.6571.00
131_I148_F0.6531.00
142_Q146_V0.6531.00
65_K79_M0.6521.00
40_F64_Y0.6491.00
89_F92_F0.6471.00
309_R329_E0.6451.00
297_R304_E0.6451.00
283_H287_S0.6451.00
40_F86_L0.6381.00
44_C67_W0.6381.00
303_I315_D0.6361.00
66_K70_E0.6351.00
301_V306_V0.6351.00
87_K104_S0.6351.00
136_R149_E0.6351.00
142_Q145_H0.6331.00
62_H65_K0.6321.00
90_I94_E0.6301.00
149_E204_V0.6291.00
94_E101_P0.6281.00
12_E16_W0.6261.00
91_D94_E0.6221.00
241_I285_S0.6191.00
146_V150_L0.6181.00
207_I210_D0.6171.00
325_T328_Q0.6111.00
154_T201_K0.6101.00
80_A84_S0.6081.00
40_F71_N0.6061.00
126_E129_Q0.6051.00
16_W92_F0.6051.00
301_V332_N0.6031.00
148_F288_L0.6011.00
37_L89_F0.6011.00
43_W46_T0.6001.00
297_R302_P0.5981.00
211_Y214_H0.5981.00
12_E15_E0.5971.00
297_R303_I0.5971.00
157_R180_H0.5961.00
208_V228_L0.5951.00
45_D64_Y0.5951.00
304_E319_K0.5941.00
146_V208_V0.5921.00
132_I145_H0.5891.00
15_E42_E0.5881.00
64_Y86_L0.5841.00
191_G195_Q0.5841.00
239_T243_S0.5831.00
125_A291_G0.5831.00
326_K329_E0.5821.00
156_M160_A0.5821.00
87_K105_D0.5821.00
286_H290_K0.5811.00
122_Y294_T0.5791.00
128_A132_I0.5761.00
128_A291_G0.5761.00
169_Y176_L0.5761.00
287_S290_K0.5741.00
146_V204_V0.5731.00
40_F44_C0.5731.00
37_L85_T0.5711.00
248_A252_C0.5701.00
306_V322_D0.5681.00
163_A235_R0.5621.00
76_K80_A0.5611.00
327_K330_M0.5591.00
48_G55_D0.5581.00
94_E106_Y0.5581.00
169_Y208_V0.5581.00
64_Y67_W0.5571.00
92_F98_A0.5551.00
297_R324_R0.5541.00
83_L107_I0.5541.00
307_S314_A0.5521.00
120_D284_A0.5511.00
87_K109_P0.5501.00
16_W96_I0.5501.00
202_P334_R0.5481.00
165_D225_R0.5471.00
149_E153_H0.5461.00
143_R211_Y0.5441.00
137_N141_S0.5441.00
307_S317_L0.5431.00
86_L104_S0.5431.00
181_R192_K0.5411.00
53_M93_C0.5401.00
166_L208_V0.5401.00
20_N92_F0.5391.00
58_G96_I0.5321.00
160_A311_D0.5281.00
104_S107_I0.5281.00
42_E45_D0.5261.00
120_D290_K0.5251.00
151_L288_L0.5241.00
17_Y92_F0.5201.00
150_L208_V0.5181.00
223_S226_E0.5171.00
21_R25_L0.5161.00
123_V128_A0.5151.00
199_S330_M0.5131.00
67_W70_E0.5131.00
43_W47_E0.5121.00
143_R146_V0.5101.00
169_Y228_L0.5051.00
156_M164_V0.5051.00
171_N200_L0.5031.00
168_D180_H0.5031.00
255_G281_S0.5031.00
210_D213_D0.5021.00
85_T88_V0.5021.00
88_V91_D0.5011.00
303_I318_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a0pA 1 0.7853 100 0.219 Contact Map
2a3vA 3 0.8324 100 0.235 Contact Map
1z1bA 3 0.8382 100 0.251 Contact Map
1z19A 3 0.8265 100 0.254 Contact Map
1xo0A 3 0.8706 100 0.275 Contact Map
4a8eA 2 0.7676 100 0.286 Contact Map
3nkhA 2 0.5853 100 0.418 Contact Map
1ae9A 4 0.5029 100 0.499 Contact Map
1aihA 2 0.4912 99.9 0.534 Contact Map
4e0gA 2 0.8118 99.9 0.573 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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