GREMLIN Database
Q9HQU7 - Probable oxidoreductase
UniProt: Q9HQU7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 336 (279)
Sequences: 30890 (19680)
Seq/√Len: 1178.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_T307_S3.2671.00
44_E79_D3.0481.00
119_T159_L3.0151.00
82_S126_G2.9131.00
275_V321_Q2.8251.00
13_Q20_Q2.5381.00
118_I154_L2.5381.00
318_T321_Q2.5371.00
115_R153_D2.4531.00
48_H83_D2.4141.00
53_T57_A2.3991.00
115_R157_D2.3941.00
274_E324_R2.2911.00
152_N156_A2.1581.00
12_V23_A2.1521.00
269_D273_D2.1391.00
289_H322_M2.1071.00
48_H79_D2.0191.00
274_E321_Q2.0161.00
129_Y161_H2.0161.00
211_F215_Q1.9911.00
319_D323_A1.9601.00
153_D157_D1.9441.00
120_A124_R1.9421.00
270_A324_R1.9301.00
72_D75_R1.9051.00
25_Q61_Y1.8871.00
111_R153_D1.8841.00
303_P307_S1.8731.00
212_A219_V1.8721.00
53_T303_P1.8611.00
57_A307_S1.8361.00
277_A315_I1.8331.00
85_D88_R1.7921.00
134_Y192_V1.7711.00
93_S130_L1.7411.00
153_D156_A1.7381.00
267_V270_A1.7311.00
11_F20_Q1.7191.00
75_R124_R1.7121.00
91_I127_T1.7061.00
290_R326_T1.6931.00
111_R115_R1.6891.00
52_D84_R1.6841.00
278_S308_E1.6721.00
54_Y59_G1.6661.00
285_A315_I1.6571.00
323_A327_D1.6551.00
43_S46_R1.6481.00
57_A310_I1.6441.00
95_I133_L1.6391.00
48_H80_W1.6251.00
95_I114_I1.6151.00
48_H52_D1.6111.00
311_D314_T1.6081.00
93_S121_L1.6041.00
118_I133_L1.5991.00
92_A134_Y1.5961.00
53_T56_D1.5781.00
115_R119_T1.5761.00
28_T62_I1.5651.00
52_D83_D1.5641.00
150_T153_D1.5611.00
218_A295_A1.5601.00
116_N120_A1.5331.00
19_L162_Y1.5211.00
134_Y220_C1.5181.00
10_G23_A1.4991.00
152_N188_E1.4971.00
66_D117_R1.4631.00
55_A89_Y1.4621.00
46_R49_D1.4541.00
51_L80_W1.4391.00
207_D210_T1.4191.00
277_A281_Q1.4181.00
130_L160_V1.4071.00
44_E48_H1.4051.00
119_T123_D1.3801.00
52_D56_D1.3761.00
213_R291_D1.3631.00
177_R180_E1.3541.00
86_R127_T1.3501.00
210_T214_E1.3471.00
180_E184_A1.3441.00
19_L90_T1.3371.00
324_R327_D1.3351.00
160_V163_L1.3281.00
307_S311_D1.3251.00
267_V324_R1.3211.00
111_R149_R1.3141.00
115_R150_T1.3111.00
49_D53_T1.3051.00
120_A123_D1.2961.00
154_L160_V1.2891.00
277_A282_V1.2871.00
270_A274_E1.2861.00
155_V188_E1.2781.00
78_G126_G1.2751.00
195_P219_V1.2701.00
111_R150_T1.2671.00
179_N183_R1.2581.00
285_A289_H1.2541.00
118_I130_L1.2541.00
62_I77_I1.2401.00
278_S281_Q1.2171.00
74_E121_L1.2171.00
179_N211_F1.2131.00
162_Y191_S1.2081.00
125_L130_L1.2061.00
300_A305_Q1.1961.00
90_T132_V1.1941.00
179_N182_A1.1901.00
300_A306_L1.1801.00
75_R79_D1.1781.00
79_D126_G1.1781.00
269_D279_P1.1601.00
271_V282_V1.1571.00
45_Q49_D1.1551.00
209_L213_R1.1501.00
28_T77_I1.1461.00
304_D307_S1.1381.00
146_E149_R1.1371.00
179_N215_Q1.1301.00
50_L306_L1.1281.00
61_Y92_A1.1261.00
132_V192_V1.1251.00
287_L296_P1.1241.00
61_Y220_C1.1211.00
86_R129_Y1.1201.00
113_T116_N1.1171.00
196_R201_D1.1161.00
199_L325_L1.1001.00
266_D270_A1.0991.00
112_K116_N1.0991.00
60_R90_T1.0931.00
151_L163_L1.0881.00
49_D303_P1.0821.00
213_R292_G1.0821.00
135_I151_L1.0801.00
13_Q18_G1.0761.00
197_Y290_R1.0741.00
17_T162_Y1.0731.00
119_T157_D1.0731.00
266_D269_D1.0591.00
281_Q311_D1.0541.00
200_V265_H1.0441.00
202_R329_A1.0411.00
268_L279_P1.0391.00
270_A273_D1.0351.00
52_D80_W1.0251.00
81_L89_Y1.0241.00
155_V191_S1.0231.00
110_N113_T1.0221.00
152_N155_V1.0201.00
23_A288_L1.0021.00
199_L283_A0.9971.00
22_S60_R0.9921.00
288_L312_A0.9831.00
154_L159_L0.9821.00
149_R153_D0.9771.00
210_T213_R0.9761.00
16_D191_S0.9741.00
176_A180_E0.9651.00
55_A84_R0.9621.00
165_A190_F0.9561.00
281_Q308_E0.9531.00
111_R146_E0.9521.00
220_C295_A0.9521.00
192_V220_C0.9451.00
154_L157_D0.9441.00
75_R123_D0.9431.00
22_S59_G0.9351.00
17_T191_S0.9331.00
115_R118_I0.9331.00
51_L62_I0.9321.00
79_D83_D0.9311.00
131_D161_H0.9301.00
308_E311_D0.9271.00
304_D308_E0.9241.00
10_G316_D0.9231.00
320_D323_A0.9211.00
306_L310_I0.9191.00
98_Q108_G0.9181.00
323_A326_T0.9111.00
74_E124_R0.9101.00
163_L190_F0.9101.00
206_G210_T0.9091.00
116_N119_T0.9011.00
284_L312_A0.9001.00
150_T154_L0.8981.00
49_D52_D0.8961.00
213_R293_I0.8881.00
289_H316_D0.8881.00
115_R154_L0.8881.00
66_D113_T0.8861.00
271_V275_V0.8841.00
23_A313_A0.8771.00
290_R322_M0.8761.00
92_A220_C0.8741.00
149_R152_N0.8721.00
66_D99_V0.8681.00
167_T222_W0.8561.00
302_T305_Q0.8511.00
320_D324_R0.8501.00
193_L212_A0.8491.00
92_A132_V0.8461.00
26_F54_Y0.8421.00
17_T155_V0.8421.00
275_V318_T0.8401.00
235_S269_D0.8311.00
204_I219_V0.8261.00
209_L219_V0.8181.00
137_R167_T0.8131.00
202_R326_T0.8091.00
274_E318_T0.8081.00
175_I179_N0.8081.00
44_E72_D0.8071.00
28_T73_S0.8061.00
259_D263_D0.8041.00
211_F214_E0.7981.00
152_N163_L0.7941.00
26_F31_F0.7921.00
64_T77_I0.7891.00
285_A312_A0.7861.00
122_L159_L0.7851.00
224_P298_V0.7821.00
289_H319_D0.7711.00
57_A311_D0.7691.00
66_D124_R0.7611.00
283_A287_L0.7571.00
47_A76_W0.7521.00
45_Q48_H0.7501.00
25_Q298_V0.7481.00
12_V218_A0.7481.00
114_I154_L0.7471.00
59_G310_I0.7461.00
317_L322_M0.7401.00
117_R120_A0.7371.00
221_P296_P0.7371.00
267_V328_A0.7351.00
218_A294_T0.7341.00
165_A168_L0.7331.00
11_F60_R0.7311.00
202_R205_E0.7311.00
148_M190_F0.7301.00
197_Y209_L0.7231.00
24_L288_L0.7151.00
114_I147_L0.7141.00
176_A179_N0.7141.00
66_D120_A0.7121.00
273_D276_E0.7111.00
93_S133_L0.7111.00
122_L127_T0.7101.00
46_R303_P0.7071.00
31_F50_L0.7041.00
19_L161_H0.7041.00
118_I159_L0.7021.00
87_D129_Y0.7011.00
51_L55_A0.7011.00
301_R305_Q0.7011.00
55_A62_I0.7001.00
148_M163_L0.7001.00
286_W326_T0.6991.00
263_D266_D0.6961.00
165_A193_L0.6921.00
208_Y212_A0.6921.00
262_F266_D0.6921.00
50_L303_P0.6911.00
268_L283_A0.6901.00
53_T306_L0.6861.00
221_P224_P0.6811.00
277_A314_T0.6791.00
235_S266_D0.6791.00
275_V282_V0.6761.00
21_T295_A0.6741.00
282_V317_L0.6731.00
81_L84_R0.6731.00
183_R189_P0.6721.00
180_E183_R0.6711.00
280_P308_E0.6711.00
165_A178_A0.6711.00
156_A186_G0.6681.00
271_V321_Q0.6661.00
197_Y287_L0.6661.00
209_L290_R0.6651.00
236_R266_D0.6621.00
151_L155_V0.6601.00
60_R88_R0.6591.00
109_T135_I0.6581.00
202_R206_G0.6581.00
265_H269_D0.6551.00
287_L294_T0.6521.00
84_R88_R0.6521.00
268_L325_L0.6511.00
277_A311_D0.6481.00
212_A217_L0.6471.00
30_R227_Q0.6451.00
305_Q308_E0.6441.00
147_L150_T0.6431.00
31_F47_A0.6421.00
134_Y164_G0.6411.00
29_W223_S0.6401.00
121_L133_L0.6401.00
177_R181_L0.6381.00
272_A282_V0.6371.00
145_R181_L0.6301.00
57_A306_L0.6291.00
16_D216_G0.6291.00
144_A147_L0.6261.00
25_Q295_A0.6251.00
155_V162_Y0.6241.00
51_L77_I0.6241.00
72_D76_W0.6211.00
224_P287_L0.6191.00
321_Q324_R0.6161.00
148_M178_A0.6151.00
50_L300_A0.6151.00
115_R159_L0.6131.00
55_A88_R0.6131.00
277_A285_A0.6101.00
95_I109_T0.6101.00
114_I150_T0.6081.00
271_V324_R0.6051.00
236_R259_D0.6041.00
282_V325_L0.6031.00
16_D189_P0.6021.00
317_L321_Q0.6021.00
175_I182_A0.6011.00
282_V315_I0.5981.00
122_L130_L0.5981.00
272_A279_P0.5971.00
10_G314_T0.5951.00
21_T61_Y0.5951.00
130_L133_L0.5941.00
80_W84_R0.5921.00
271_V328_A0.5921.00
205_E210_T0.5921.00
62_I81_L0.5911.00
229_F265_H0.5881.00
200_V229_F0.5871.00
197_Y202_R0.5871.00
97_W100_R0.5861.00
64_T73_S0.5851.00
288_L296_P0.5841.00
11_F22_S0.5831.00
282_V321_Q0.5821.00
55_A60_R0.5821.00
67_V96_Y0.5791.00
155_V160_V0.5791.00
56_D303_P0.5781.00
63_D194_Q0.5771.00
44_E76_W0.5771.00
182_A211_F0.5761.00
118_I122_L0.5741.00
110_N147_L0.5741.00
263_D267_V0.5701.00
176_A211_F0.5681.00
122_L129_Y0.5681.00
32_G73_S0.5671.00
118_I150_T0.5671.00
14_L218_A0.5661.00
221_P293_I0.5651.00
138_W168_L0.5641.00
197_Y219_V0.5641.00
204_I209_L0.5611.00
55_A80_W0.5591.00
145_R184_A0.5591.00
56_D84_R0.5581.00
262_F265_H0.5581.00
143_T146_E0.5581.00
79_D82_S0.5571.00
272_A275_V0.5571.00
24_L313_A0.5551.00
135_I147_L0.5541.00
33_K76_W0.5531.00
108_G113_T0.5531.00
268_L272_A0.5531.00
169_Q177_R0.5521.00
71_G124_R0.5521.00
133_L160_V0.5501.00
223_S227_Q0.5501.00
95_I117_R0.5491.00
145_R149_R0.5471.00
175_I217_L0.5461.00
122_L128_E0.5441.00
281_Q315_I0.5431.00
155_V163_L0.5431.00
25_Q297_I0.5401.00
165_A175_I0.5401.00
290_R294_T0.5391.00
275_V315_I0.5381.00
74_E93_S0.5361.00
285_A316_D0.5361.00
29_W227_Q0.5351.00
199_L329_A0.5351.00
97_W137_R0.5351.00
61_Y90_T0.5311.00
178_A181_L0.5281.00
75_R126_G0.5251.00
195_P208_Y0.5251.00
197_Y294_T0.5171.00
303_P306_L0.5171.00
69_G72_D0.5161.00
271_V274_E0.5151.00
199_L286_W0.5141.00
26_F50_L0.5131.00
66_D96_Y0.5121.00
177_R182_A0.5111.00
14_L17_T0.5101.00
99_V113_T0.5101.00
133_L151_L0.5091.00
48_H76_W0.5071.00
54_Y62_I0.5061.00
221_P287_L0.5041.00
24_L312_A0.5021.00
14_L192_V0.5021.00
284_L309_N0.5011.00
152_N185_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pyfA 1 0.9256 100 0.127 Contact Map
4xk2A 5 0.8899 100 0.134 Contact Map
3n2tA 1 0.9405 100 0.135 Contact Map
1pz1A 1 0.9375 100 0.139 Contact Map
3v0sA 1 0.8065 100 0.14 Contact Map
1lqaA 2 0.9435 100 0.154 Contact Map
3n6qA 5 0.9077 100 0.156 Contact Map
3erpA 6 0.8988 100 0.159 Contact Map
3eauA 3 0.9345 100 0.163 Contact Map
3lutA 3 0.9345 100 0.166 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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