GREMLIN Database
Q9HQU5 - Uncharacterized protein
UniProt: Q9HQU5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 69 (64)
Sequences: 187 (137)
Seq/√Len: 17.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_F41_G4.5561.00
22_L47_G2.7080.97
29_L46_V2.3080.93
38_A41_G2.2600.93
5_R53_Y2.2280.92
46_V50_V1.9540.86
8_S37_A1.9070.84
19_A22_L1.7960.80
27_A40_I1.7850.80
20_T41_G1.7510.79
5_R60_S1.5880.71
3_D60_S1.5600.70
9_A28_F1.5530.70
8_S60_S1.5070.67
14_S37_A1.4870.66
12_A49_T1.4770.65
12_A44_A1.4420.64
10_V42_V1.3770.60
52_Y55_W1.3620.59
53_Y63_S1.3270.57
39_K43_S1.2460.52
24_F44_A1.2230.51
54_L58_L1.1710.48
28_F32_G1.1000.43
6_Y14_S1.1000.43
33_E61_T1.0920.43
60_S65_G1.0910.43
3_D7_R1.0430.40
41_G64_W1.0330.40
5_R12_A1.0300.39
36_S39_K1.0220.39
19_A47_G0.9990.38
18_F21_T0.9920.37
60_S66_R0.9750.36
6_Y61_T0.9700.36
33_E36_S0.9580.35
19_A40_I0.9530.35
30_Y36_S0.9520.35
25_T29_L0.9270.34
20_T24_F0.9220.33
15_Y47_G0.9020.32
22_L51_L0.8800.31
27_A47_G0.8690.31
20_T52_Y0.8610.30
37_A60_S0.8490.30
9_A52_Y0.8280.29
44_A55_W0.8240.28
5_R64_W0.8220.28
20_T32_G0.8100.28
24_F38_A0.8030.27
5_R57_R0.7990.27
36_S49_T0.7790.26
3_D54_L0.7700.26
31_T40_I0.7680.26
4_S54_L0.7590.25
20_T55_W0.7420.25
20_T30_Y0.7380.24
13_A49_T0.7040.23
17_V25_T0.7030.23
7_R65_G0.6920.22
60_S63_S0.6840.22
7_R12_A0.6830.22
62_I65_G0.6740.22
63_S66_R0.6680.21
9_A61_T0.6600.21
24_F64_W0.6530.21
24_F53_Y0.6520.21
18_F33_E0.6480.21
18_F62_I0.6480.21
28_F38_A0.6460.20
50_V63_S0.6410.20
13_A44_A0.6280.20
19_A34_F0.6180.19
30_Y45_A0.6070.19
5_R65_G0.6070.19
19_A51_L0.6040.19
23_V55_W0.5990.19
44_A47_G0.5930.18
22_L40_I0.5870.18
15_Y22_L0.5850.18
4_S39_K0.5770.18
20_T53_Y0.5720.18
9_A36_S0.5720.18
22_L45_A0.5680.18
26_I30_Y0.5620.17
44_A53_Y0.5610.17
3_D62_I0.5460.17
26_I45_A0.5410.17
29_L50_V0.5410.17
28_F37_A0.5350.16
26_I43_S0.5340.16
15_Y45_A0.5280.16
22_L44_A0.5180.16
58_L61_T0.5170.16
42_V57_R0.5100.16
25_T50_V0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yikA 1 0.4203 7.6 0.921 Contact Map
1ia6A 1 0.4638 5.2 0.927 Contact Map
3wc3A 1 0.4638 4.1 0.931 Contact Map
2bt9A 3 0.5217 3.5 0.933 Contact Map
1g87A 2 0.4638 3.3 0.933 Contact Map
2mdtA 1 0.5072 3.1 0.935 Contact Map
1tf4A 1 0.4783 3.1 0.935 Contact Map
4i43B 1 0.8696 2.6 0.937 Contact Map
1ks8A 1 0.4638 2.4 0.938 Contact Map
1pp9J 1 0.7681 1.8 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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