GREMLIN Database
IMDH - Inosine-5'-monophosphate dehydrogenase
UniProt: Q9HQU4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 499 (469)
Sequences: 2845 (1085)
Seq/√Len: 50.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_V235_G6.4581.00
49_N283_D4.6561.00
88_T248_A4.2551.00
459_S462_A4.0911.00
201_N205_H4.0081.00
19_E471_R3.7141.00
114_A137_V3.5871.00
358_A451_G3.5641.00
225_A233_R3.2391.00
337_V340_P3.2331.00
296_E300_D3.2331.00
366_D464_K3.1471.00
65_T80_G3.1141.00
43_A51_E3.0421.00
45_R51_E3.0181.00
267_L271_D2.8791.00
361_I448_I2.8191.00
176_A199_I2.7971.00
34_R267_L2.7831.00
247_T251_E2.6781.00
296_E337_V2.6701.00
81_V256_V2.6571.00
462_A466_D2.6531.00
277_K284_V2.6281.00
289_V295_A2.6071.00
250_D282_A2.5861.00
246_A276_I2.5271.00
32_E297_A2.5221.00
32_E267_L2.4671.00
293_E468_E2.4451.00
352_R477_Q2.4441.00
458_E462_A2.4041.00
56_V441_L2.4001.00
460_I464_K2.3721.00
289_V294_A2.3381.00
295_A334_V2.3371.00
87_D90_R2.3271.00
295_A299_V2.3201.00
118_Q122_A2.3091.00
299_V338_A2.2791.00
94_E97_R2.2781.00
294_A334_V2.2661.00
238_V246_A2.2651.00
235_G256_V2.2521.00
42_V445_V2.2411.00
289_V334_V2.2351.00
163_D167_E2.2171.00
18_P333_Q2.1971.00
370_L374_F2.1941.00
121_E125_E2.1921.00
277_K303_D2.1901.00
181_T184_D2.1471.00
257_L282_A2.1391.00
47_S283_D2.1271.00
46_V256_V2.1051.00
246_A257_L2.0901.00
137_V165_V2.0351.00
461_P465_A2.0091.00
370_L373_Y1.9931.00
69_L437_L1.9791.00
79_L256_V1.9650.99
271_D274_R1.9490.99
45_R342_G1.9290.99
67_S94_E1.9140.99
46_V285_V1.9090.99
358_A463_F1.9080.99
427_V485_V1.8880.99
357_A368_V1.8850.99
461_P464_K1.8850.99
297_A300_D1.8820.99
114_A165_V1.8810.99
114_A123_V1.8750.99
177_P202_D1.8610.99
115_A118_Q1.8400.99
158_E163_D1.8370.99
402_G428_E1.8290.99
338_A345_V1.8150.99
121_E162_S1.8100.99
276_I284_V1.7570.99
295_A345_V1.7500.99
95_V254_A1.7350.99
141_D205_H1.7030.98
247_T280_V1.7020.98
123_V148_I1.6970.98
273_A286_V1.6910.98
73_M441_L1.6790.98
117_E164_A1.6770.98
116_P145_R1.6660.98
54_V445_V1.6650.98
261_C269_V1.6620.98
247_T279_S1.6510.98
187_E191_E1.6450.98
114_A118_Q1.6390.98
164_A167_E1.6370.98
259_I273_A1.6350.98
373_Y444_L1.6000.98
361_I460_I1.5950.98
256_V285_V1.5920.98
56_V370_L1.5860.98
292_R337_V1.5720.97
262_A454_Y1.5530.97
307_V345_V1.5430.97
57_L367_A1.5350.97
296_E340_P1.5260.97
299_V343_V1.5240.97
47_S304_G1.5130.97
125_E129_R1.5070.97
81_V258_F1.4970.97
177_P180_I1.4890.96
178_E207_V1.4860.96
56_V374_F1.4830.96
90_R94_E1.4600.96
284_V302_A1.4590.96
295_A338_A1.4580.96
43_A53_E1.4580.96
46_V235_G1.4480.96
374_F437_L1.4400.96
422_Y450_S1.4370.96
339_A464_K1.4330.96
270_I274_R1.4320.96
451_G463_F1.4230.95
143_T205_H1.4120.95
300_D341_A1.4040.95
117_E166_R1.3870.95
176_A180_I1.3800.95
457_A467_A1.3720.94
123_V127_M1.3680.94
58_S65_T1.3630.94
184_D187_E1.3630.94
48_T344_P1.3620.94
290_G325_M1.3490.94
292_R336_D1.3460.94
148_I168_A1.3450.94
296_E341_A1.3400.94
246_A280_V1.3370.94
46_V367_A1.3350.93
332_S336_D1.3340.93
378_D436_S1.3180.93
331_V347_A1.3060.93
299_V341_A1.3050.93
57_L285_V1.2890.92
286_V302_A1.2800.92
34_R458_E1.2780.92
384_V391_K1.2740.92
259_I286_V1.2680.92
95_V236_V1.2680.92
49_N281_D1.2620.91
378_D433_Y1.2620.91
338_A341_A1.2450.91
48_T303_D1.2360.91
304_G367_A1.2340.90
361_I464_K1.2320.90
138_V141_D1.2320.90
254_A282_A1.2290.90
49_N228_Q1.2170.90
84_Q268_N1.2170.90
335_A345_V1.2150.90
361_I463_F1.2060.89
115_A145_R1.1990.89
427_V491_A1.1930.89
344_P366_D1.1840.89
180_I184_D1.1830.88
190_Y193_K1.1820.88
36_E268_N1.1820.88
242_D272_S1.1770.88
319_V477_Q1.1700.88
452_M460_I1.1690.88
457_A462_A1.1590.87
292_R296_E1.1570.87
69_L374_F1.1530.87
42_V449_Q1.1490.87
58_S73_M1.1460.87
112_V137_V1.1450.87
46_V57_L1.1450.87
243_T275_E1.1430.87
132_V135_A1.1420.87
122_A125_E1.1400.87
339_A465_A1.1360.86
41_D51_E1.1360.86
160_G163_D1.1280.86
39_D458_E1.1270.86
58_S80_G1.1180.85
139_D145_R1.1160.85
362_A467_A1.1120.85
463_F467_A1.1090.85
244_E247_T1.1060.85
119_T164_A1.1030.85
295_A337_V1.1010.85
28_L455_V1.1010.85
178_E202_D1.0990.84
46_V304_G1.0940.84
275_E279_S1.0930.84
124_D161_E1.0890.84
299_V337_V1.0870.84
56_V445_V1.0860.84
159_V187_E1.0850.84
363_A469_F1.0850.84
259_I269_V1.0820.84
259_I276_I1.0780.83
274_R278_A1.0650.83
228_Q233_R1.0550.82
44_T54_V1.0500.82
305_I338_A1.0490.82
105_V199_I1.0420.81
139_D142_D1.0410.81
357_A444_L1.0380.81
257_L261_C1.0350.81
20_A470_V1.0300.80
336_D340_P1.0230.80
60_A306_K1.0230.80
67_S97_R1.0230.80
152_D198_P1.0230.80
277_K302_A1.0180.80
299_V340_P1.0180.80
75_R101_A1.0150.79
31_A468_E1.0140.79
23_F331_V1.0100.79
21_L471_R1.0100.79
295_A305_I1.0070.79
304_G344_P1.0060.79
116_P148_I1.0040.79
246_A282_A1.0030.79
482_P485_V1.0020.79
31_A466_D0.9990.78
135_A165_V0.9940.78
366_D461_P0.9880.78
274_R300_D0.9860.77
47_S256_V0.9850.77
189_M197_V0.9840.77
292_R333_Q0.9830.77
200_V204_Q0.9790.77
182_A186_L0.9780.77
368_V374_F0.9740.77
374_F476_G0.9730.76
374_F441_L0.9720.76
319_V482_P0.9650.76
57_L79_L0.9510.75
457_A466_D0.9510.75
21_L328_I0.9490.75
273_A302_A0.9420.74
457_A482_P0.9410.74
177_P184_D0.9400.74
377_T437_L0.9390.74
185_A197_V0.9390.74
185_A198_P0.9340.73
370_L444_L0.9320.73
50_V233_R0.9310.73
289_V305_I0.9290.73
236_V254_A0.9260.73
121_E161_E0.9230.73
216_L220_E0.9230.73
331_V345_V0.9220.72
270_I297_A0.9210.72
302_A305_I0.9180.72
48_T343_V0.9170.72
334_V337_V0.9130.72
119_T122_A0.9130.72
76_E438_A0.9120.72
45_R48_T0.9110.72
120_V158_E0.9110.72
337_V341_A0.9090.71
290_G309_I0.9080.71
116_P138_V0.9070.71
339_A366_D0.9060.71
238_V257_L0.9050.71
139_D143_T0.9040.71
361_I467_A0.9020.71
29_R33_S0.9000.71
84_Q407_G0.9000.71
176_A188_L0.8970.70
338_A366_D0.8950.70
93_A96_E0.8950.70
131_D150_A0.8940.70
246_A250_D0.8920.70
282_A303_D0.8790.69
33_S263_H0.8780.69
31_A457_A0.8770.69
243_T279_S0.8740.68
265_H297_A0.8740.68
116_P166_R0.8730.68
238_V259_I0.8700.68
112_V132_V0.8700.68
90_R93_A0.8680.68
48_T283_D0.8670.68
283_D304_G0.8660.68
114_A122_A0.8560.67
450_S453_G0.8520.66
273_A284_V0.8480.66
202_D205_H0.8460.66
174_I192_H0.8460.66
139_D205_H0.8440.66
118_Q135_A0.8430.66
328_I467_A0.8430.66
26_V363_A0.8370.65
144_V196_R0.8370.65
321_T480_G0.8360.65
472_V477_Q0.8350.65
63_T66_E0.8300.64
273_A294_A0.8250.64
114_A126_M0.8210.64
117_E139_D0.8200.63
270_I286_V0.8150.63
422_Y442_H0.8140.63
56_V73_M0.8120.63
53_E225_A0.8110.63
289_V345_V0.8090.62
457_A465_A0.8070.62
182_A188_L0.8050.62
31_A455_V0.8040.62
436_S439_S0.8030.62
399_G412_Y0.8020.62
271_D275_E0.8000.61
176_A198_P0.7990.61
437_L441_L0.7990.61
40_A459_S0.7970.61
387_M430_A0.7960.61
105_V113_T0.7920.61
120_V163_D0.7900.61
328_I363_A0.7900.61
272_S275_E0.7890.60
257_L321_T0.7890.60
290_G334_V0.7890.60
69_L73_M0.7880.60
122_A165_V0.7870.60
370_L437_L0.7870.60
329_T332_S0.7840.60
334_V345_V0.7840.60
354_S444_L0.7820.60
110_N206_L0.7820.60
124_D128_D0.7800.60
114_A482_P0.7790.59
216_L352_R0.7760.59
81_V262_A0.7750.59
92_V248_A0.7690.58
248_A251_E0.7660.58
75_R439_S0.7610.58
186_L218_R0.7580.57
352_R407_G0.7580.57
385_I430_A0.7570.57
44_T460_I0.7550.57
233_R256_V0.7540.57
79_L367_A0.7540.57
319_V470_V0.7530.57
103_E106_I0.7500.57
186_L193_K0.7460.56
338_A477_Q0.7460.56
29_R468_E0.7440.56
45_R366_D0.7430.56
122_A135_A0.7410.56
187_E284_V0.7410.56
329_T333_Q0.7400.56
69_L441_L0.7390.55
259_I295_A0.7390.55
23_F309_I0.7380.55
158_E161_E0.7380.55
124_D148_I0.7380.55
250_D280_V0.7370.55
240_P422_Y0.7360.55
82_L95_V0.7350.55
178_E201_N0.7350.55
72_A441_L0.7330.55
59_A306_K0.7310.55
92_V96_E0.7310.55
103_E226_R0.7290.54
204_Q207_V0.7260.54
476_G480_G0.7260.54
42_V448_I0.7260.54
334_V338_A0.7250.54
115_A139_D0.7230.54
106_I182_A0.7180.53
29_R455_V0.7170.53
377_T440_E0.7160.53
335_A342_G0.7160.53
250_D254_A0.7160.53
270_I294_A0.7150.53
127_M197_V0.7150.53
127_M132_V0.7150.53
44_T367_A0.7120.53
93_A129_R0.7120.53
455_V467_A0.7110.53
185_A210_V0.7110.53
91_V254_A0.7100.52
127_M135_A0.7090.52
303_D343_V0.7090.52
243_T246_A0.7080.52
182_A215_I0.7080.52
96_E207_V0.7060.52
409_S416_D0.7060.52
100_R150_A0.7060.52
357_A370_L0.7050.52
240_P272_S0.7000.51
385_I489_D0.6990.51
42_V54_V0.6990.51
20_A329_T0.6990.51
240_P273_A0.6980.51
50_V283_D0.6980.51
73_M374_F0.6960.51
29_R309_I0.6960.51
185_A209_L0.6960.51
59_A433_Y0.6950.51
473_S476_G0.6940.51
292_R335_A0.6940.51
176_A212_M0.6930.51
311_P316_T0.6920.51
39_D68_R0.6920.51
87_D434_K0.6910.51
92_V252_A0.6900.50
105_V112_V0.6900.50
124_D153_I0.6890.50
115_A166_R0.6840.50
76_E221_H0.6800.49
115_A140_D0.6800.49
38_D415_D0.6790.49
46_V52_L0.6780.49
420_E439_S0.6780.49
247_T250_D0.6770.49
254_A257_L0.6770.49
118_Q165_V0.6760.49
423_V450_S0.6760.49
394_Q442_H0.6760.49
300_D340_P0.6760.49
429_A485_V0.6730.49
75_R482_P0.6710.48
321_T478_T0.6700.48
107_D229_N0.6670.48
239_G242_D0.6670.48
358_A361_I0.6660.48
385_I392_Y0.6660.48
84_Q309_I0.6640.48
46_V329_T0.6630.48
244_E248_A0.6630.48
259_I284_V0.6610.47
51_E233_R0.6610.47
268_N271_D0.6610.47
261_C294_A0.6600.47
399_G411_R0.6600.47
72_A437_L0.6590.47
261_C268_N0.6580.47
47_S285_V0.6570.47
120_V168_A0.6510.46
73_M79_L0.6500.46
180_I188_L0.6490.46
56_V294_A0.6490.46
246_A284_V0.6480.46
177_P207_V0.6480.46
101_A221_H0.6480.46
334_V366_D0.6470.46
60_A295_A0.6460.46
22_T328_I0.6450.46
319_V480_G0.6450.46
101_A130_S0.6440.46
152_D169_M0.6440.46
241_F420_E0.6430.46
357_A448_I0.6430.46
118_Q166_R0.6430.46
304_G343_V0.6420.45
290_G396_R0.6400.45
47_S50_V0.6400.45
144_V200_V0.6390.45
126_M135_A0.6390.45
100_R392_Y0.6380.45
321_T472_V0.6370.45
46_V79_L0.6360.45
113_T199_I0.6360.45
152_D170_T0.6350.45
29_R470_V0.6350.45
105_V179_D0.6340.45
180_I185_A0.6330.45
93_A97_R0.6330.45
333_Q336_D0.6310.44
153_I161_E0.6310.44
242_D409_S0.6290.44
105_V385_I0.6290.44
106_I188_L0.6280.44
149_S170_T0.6270.44
35_V40_A0.6260.44
134_G196_R0.6260.44
198_P206_L0.6250.44
113_T135_A0.6240.44
23_F133_S0.6240.44
114_A176_A0.6230.44
300_D337_V0.6230.44
71_I175_T0.6220.43
103_E427_V0.6210.43
143_T203_E0.6200.43
155_P396_R0.6200.43
296_E299_V0.6200.43
352_R390_K0.6190.43
110_N158_E0.6180.43
458_E466_D0.6180.43
262_A321_T0.6180.43
48_T304_G0.6180.43
23_F347_A0.6160.43
239_G246_A0.6150.43
233_R283_D0.6150.43
185_A385_I0.6150.43
123_V165_V0.6150.43
267_L274_R0.6130.43
85_N399_G0.6120.42
96_E129_R0.6110.42
273_A374_F0.6090.42
258_F262_A0.6070.42
29_R333_Q0.6070.42
283_D344_P0.6070.42
118_Q137_V0.6050.42
79_L283_D0.6050.42
323_S470_V0.6040.42
82_L94_E0.6030.42
204_Q457_A0.6030.42
321_T454_Y0.6030.42
246_A259_I0.6020.41
102_D226_R0.6020.41
151_T196_R0.6010.41
294_A297_A0.6000.41
384_V434_K0.6000.41
29_R56_V0.5980.41
233_R367_A0.5980.41
72_A76_E0.5960.41
267_L270_I0.5950.41
150_A185_A0.5950.41
112_V135_A0.5940.41
278_A300_D0.5930.41
96_E137_V0.5930.41
37_P85_N0.5890.40
129_R274_R0.5880.40
180_I197_V0.5870.40
243_T272_S0.5860.40
48_T340_P0.5860.40
143_T204_Q0.5860.40
65_T73_M0.5840.40
76_E223_S0.5820.39
73_M80_G0.5820.39
269_V453_G0.5820.39
373_Y440_E0.5810.39
115_A138_V0.5800.39
44_T285_V0.5790.39
96_E130_S0.5780.39
151_T195_E0.5780.39
58_S64_V0.5780.39
79_L304_G0.5770.39
278_A459_S0.5770.39
75_R467_A0.5760.39
79_L233_R0.5760.39
277_K304_G0.5760.39
140_D205_H0.5740.39
85_N453_G0.5730.39
44_T343_V0.5720.39
225_A228_Q0.5720.39
464_K467_A0.5710.38
275_E278_A0.5710.38
21_L221_H0.5700.38
124_D145_R0.5690.38
292_R340_P0.5680.38
46_V81_V0.5680.38
487_I490_E0.5640.38
45_R344_P0.5640.38
186_L230_G0.5630.38
21_L26_V0.5620.38
263_H453_G0.5620.38
135_A221_H0.5610.37
289_V384_V0.5610.37
40_A457_A0.5610.37
177_P203_E0.5600.37
75_R380_A0.5600.37
123_V218_R0.5600.37
44_T52_L0.5590.37
105_V189_M0.5590.37
261_C290_G0.5590.37
201_N207_V0.5580.37
155_P190_Y0.5570.37
283_D367_A0.5570.37
404_M421_E0.5560.37
448_I452_M0.5550.37
45_R67_S0.5550.37
388_N482_P0.5550.37
142_D205_H0.5550.37
331_V335_A0.5550.37
284_V303_D0.5540.37
183_R186_L0.5540.37
193_K277_K0.5520.37
72_A185_A0.5520.37
20_A471_R0.5520.37
394_Q430_A0.5510.36
251_E274_R0.5510.36
259_I272_S0.5500.36
236_V249_V0.5490.36
98_V255_D0.5480.36
313_S451_G0.5480.36
37_P453_G0.5480.36
415_D419_D0.5470.36
28_L86_M0.5470.36
111_V264_A0.5470.36
67_S473_S0.5460.36
451_G455_V0.5450.36
38_D416_D0.5450.36
217_E226_R0.5440.36
51_E228_Q0.5440.36
276_I458_E0.5430.36
73_M76_E0.5420.36
136_P206_L0.5420.36
124_D219_R0.5410.36
286_V304_G0.5410.36
240_P268_N0.5410.36
103_E110_N0.5410.36
284_V342_G0.5400.35
442_H450_S0.5400.35
138_V205_H0.5390.35
86_M406_S0.5390.35
85_N412_Y0.5380.35
401_V473_S0.5380.35
167_E191_E0.5370.35
373_Y434_K0.5350.35
72_A307_V0.5350.35
69_L434_K0.5330.35
311_P318_R0.5330.35
366_D436_S0.5330.35
127_M185_A0.5320.35
339_A342_G0.5320.35
423_V453_G0.5320.35
130_S150_A0.5300.35
336_D468_E0.5300.35
96_E100_R0.5280.34
149_S152_D0.5280.34
184_D188_L0.5270.34
299_V344_P0.5260.34
40_A231_R0.5250.34
459_S467_A0.5250.34
69_L225_A0.5250.34
262_A449_Q0.5240.34
344_P402_G0.5240.34
384_V439_S0.5230.34
306_K318_R0.5230.34
147_I170_T0.5230.34
304_G307_V0.5220.34
235_G258_F0.5220.34
44_T124_D0.5220.34
264_A289_V0.5210.34
180_I207_V0.5210.34
38_D268_N0.5210.34
374_F444_L0.5210.34
39_D463_F0.5200.34
296_E336_D0.5200.34
343_V366_D0.5200.34
270_I273_A0.5190.34
163_D168_A0.5190.34
289_V337_V0.5180.33
289_V336_D0.5180.33
104_L107_D0.5180.33
190_Y194_I0.5180.33
293_E297_A0.5180.33
391_K434_K0.5170.33
388_N430_A0.5160.33
329_T388_N0.5160.33
134_G149_S0.5150.33
62_D83_H0.5150.33
457_A463_F0.5150.33
295_A341_A0.5150.33
82_L294_A0.5150.33
183_R187_E0.5140.33
40_A269_V0.5130.33
40_A57_L0.5120.33
59_A148_I0.5120.33
362_A486_M0.5120.33
87_D257_L0.5120.33
76_E370_L0.5120.33
48_T367_A0.5120.33
68_R466_D0.5110.33
69_L72_A0.5110.33
184_D238_V0.5110.33
142_D358_A0.5100.33
186_L215_I0.5090.33
321_T476_G0.5090.33
42_V459_S0.5080.33
148_I289_V0.5080.33
334_V361_I0.5080.33
145_R181_T0.5080.33
90_R406_S0.5080.33
56_V368_V0.5080.33
119_T162_S0.5080.33
101_A106_I0.5070.32
105_V226_R0.5070.32
43_A142_D0.5070.32
305_I345_V0.5060.32
79_L235_G0.5060.32
143_T274_R0.5050.32
311_P356_D0.5050.32
84_Q239_G0.5050.32
343_V365_A0.5050.32
165_V392_Y0.5050.32
103_E253_G0.5040.32
48_T57_L0.5040.32
18_P329_T0.5040.32
106_I144_V0.5030.32
395_Y399_G0.5030.32
173_V198_P0.5030.32
44_T225_A0.5020.32
47_S367_A0.5020.32
235_G238_V0.5020.32
250_D257_L0.5010.32
44_T304_G0.5010.32
405_Q440_E0.5010.32
81_V282_A0.5000.32
100_R388_N0.5000.32
306_K311_P0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3usbA 4 0.8617 100 0.456 Contact Map
2cu0A 4 0.7134 100 0.473 Contact Map
4af0A 3 0.7134 100 0.485 Contact Map
1vrdA 3 0.6353 100 0.49 Contact Map
1jcnA 6 0.7575 100 0.507 Contact Map
1zfjA 4 0.9399 100 0.523 Contact Map
1me8A 3 0.6774 100 0.54 Contact Map
4fxsA 3 0.9238 100 0.567 Contact Map
5ahnA 3 0.5872 100 0.57 Contact Map
4zqmA 3 0.6573 100 0.641 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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